Decreased vascular reactivity in metformin-treated fructose- hypertensive rats

Metabolism: Clinical and Experimental

Volumn 45, Issue 9, 1996, Pages 1053-1055

  Verma, Subodh ^a   Bhanot, Sanjay ^a   McNeill, John H ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSE; METFORMIN; NORADRENALIN;

ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; HYPERINSULINEMIA; HYPERTENSION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SUPERIOR MESENTERIC ARTERY; VASODILATATION;

EID: 0029761801     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90000-1     Document Type: Article

References (12)

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2. Bhanot S, Bryer-Ash M, Cheung A, et al: Bis(maltolato)oxovanadium (IV) attenuates hyperinsulinemia and hypertension in spontaneously hypertensive rats. Diabetes 43:857-861, 1994
3. Verma S, Bhanot S, McNeill JH: Metformin decreases plasma insulin levels and blood pressure in spontaneously hypertensive rats. Am J Physiol 36:H1250-H1253, 1994
4. Verma S, Bhanot S, McNeill JH: Antihypertensive effects of metformin in fructose-fed hyperinsulinemic, hypertensive rats. J Pharmacol Exp Ther 271:1334-1337, 1994
5. Landin K, Tengborn L, Smith M: Treating insulin resistance in hypertension with metformin reduces both blood pressure and metabolic risk factors. J Int Med 229:181-187, 1992
6. Baron AD: Hemodynamic actions of insulin. Am J Physiol 267:E187-E202, 1994
7. Petersen J, Dibona GF: Sympathoinhibitory actions of metformin in spontaneously hypertensive rats. Hypertension 26:559, 1995 (abstr)
8. Sharma RV, Bhalla RC: Metformin attenuates agonist-stimulated calcium transients in vascular smooth muscle cells. Clin Exp Hypertens 17:913-929, 1995
9. Verma S, Bhanot S, Yao L, et al: Defective endothelium-dependent relaxation in fructose hypertensive rats. Am J Hypertens 9:370-376, 1996
10. Agrawal DK, McNeill JH: Vascular responses to agonists in rat mesenteric artery from diabetic rats. Can J Physiol Pharmacol 65:1484-1490, 1987
11. Hwang I, Ho H, Hoffman BB, et al: Fructose-induced insulin resistance and hypertension in rats. Hypertension 10:512-516, 1987
12. Wambach GK, Liu D: Insulin attenuates vasoconstriction by noradrenaline, serotonin and potassium chloride in rat mesenteric arterioles. Clin Exp Hypertens [A] 14:733-740, 1992