메뉴 건너뛰기




Volumn 22, Issue 3, 2008, Pages 215-224

Metformin: Effects on micro and macrovascular complications in type 2 diabetes

Author keywords

Hyperglycaemia; Macrovascular complications; Metformin; Microvascular complications; Type 2 diabetes

Indexed keywords

ANTICOAGULANT AGENT; ANTIDIABETIC AGENT; C REACTIVE PROTEIN; CELL ADHESION MOLECULE; CYTOKINE; GLIBENCLAMIDE; GLYCERYL TRINITRATE; INSULIN; LOW DENSITY LIPOPROTEIN; METFORMIN; PLACEBO; ROSIGLITAZONE; SULFONYLUREA;

EID: 48349116165     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10557-008-6092-0     Document Type: Review
Times cited : (105)

References (99)
  • 2
    • 33745780301 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy
    • Nathan DM, Buse JB, Davidson MB, Heine RJ, et al. Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. Diabetologia. 2006;49:1711-21.
    • (2006) Diabetologia , vol.49 , pp. 1711-1721
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Heine, R.J.4
  • 3
    • 13644263258 scopus 로고    scopus 로고
    • Oral antidiabetic agents: Current role in type 2 diabetes mellitus
    • Krentz AJ, Bailey CJ. Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs. 2005;65:384-411.
    • (2005) Drugs , vol.65 , pp. 384-411
    • Krentz, A.J.1    Bailey, C.J.2
  • 4
    • 0026682478 scopus 로고
    • Biguanides and NIDDM
    • Bailey CJ. Biguanides and NIDDM. Diabetes Care. 1992;15:755-72.
    • (1992) Diabetes Care , vol.15 , pp. 755-772
    • Bailey, C.J.1
  • 6
    • 0032697674 scopus 로고    scopus 로고
    • The antihyperglycaemic effect of metformin: Therapeutic and cellular mechanisms
    • Wiernsperger NF, Bailey CJ. The antihyperglycaemic effect of metformin: therapeutic and cellular mechanisms. Drugs. 1999;58:31-9.
    • (1999) Drugs , vol.58 , pp. 31-39
    • Wiernsperger, N.F.1    Bailey, C.J.2
  • 7
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001;108:1167-74.
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 8
    • 0031762953 scopus 로고    scopus 로고
    • Metformin: A review of its metabolic effects
    • Cusi K, DeFronzo RA. Metformin: a review of its metabolic effects. Diabetes Revs. 1998;6:89-130.
    • (1998) Diabetes Revs , vol.6 , pp. 89-130
    • Cusi, K.1    Defronzo, R.A.2
  • 9
    • 0032985166 scopus 로고    scopus 로고
    • Risk-benefit assessment of metformin in type 2 diabetes
    • Howlett HCS, Bailey CJ. Risk-benefit assessment of metformin in type 2 diabetes. Drug Safety. 1999;20:489-503.
    • (1999) Drug Safety , vol.20 , pp. 489-503
    • Howlett, H.C.S.1    Bailey, C.J.2
  • 10
    • 0037092995 scopus 로고    scopus 로고
    • Diabetes and atherosclerosis. Epidemiology, pathophysiology and management
    • Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis. Epidemiology, pathophysiology and management. JAMA. 2002;287:2570-81.
    • (2002) JAMA , vol.287 , pp. 2570-2581
    • Beckman, J.A.1    Creager, M.A.2    Libby, P.3
  • 12
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837-53.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 13
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 1998;352:854-65.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 15
    • 2542425599 scopus 로고    scopus 로고
    • Relation of metformin treatment to clinical events in diabetic patients undergoing percutaneous intervention
    • Kao J, Tobis J, McClelland RL, et al. Relation of metformin treatment to clinical events in diabetic patients undergoing percutaneous intervention. Am J Cardiol. 2004;93:1347-50.
    • (2004) Am J Cardiol , vol.93 , pp. 1347-1350
    • Kao, J.1    Tobis, J.2    McClelland, R.L.3
  • 16
    • 33845405222 scopus 로고    scopus 로고
    • Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • Kahn SE, Haffner SM, Heise MA, Herman WH, et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 2006;355:2427-43.
    • (2006) N Engl J Med , vol.355 , pp. 2427-2443
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3    Herman, W.H.4
  • 17
    • 34648843711 scopus 로고    scopus 로고
    • Thiazolidinediones, deadly sins, surrogates and elephants
    • Cleland JGF, Atkin SL. Thiazolidinediones, deadly sins, surrogates and elephants. Lancet. 2007;370:1103-4.
    • (2007) Lancet , vol.370 , pp. 1103-1104
    • Cleland, J.G.F.1    Atkin, S.L.2
  • 18
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813-8.
    • (2001) Nature , vol.414 , pp. 813-818
    • Brownlee, M.1
  • 19
    • 33646422782 scopus 로고    scopus 로고
    • Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: A comparison of patients treated with sulphonylureas and metformin
    • Evans JM, Ogston SA, Emslie-Smith MA, Morris A. Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulphonylureas and metformin. Diabetologia. 2006;49:930-6.
    • (2006) Diabetologia , vol.49 , pp. 930-936
    • Evans, J.M.1    Ogston, S.A.2    Emslie-Smith, M.A.3    Morris, A.4
  • 20
    • 12744255091 scopus 로고    scopus 로고
    • The incidence of congestive heart failure associated with antidiabetic therapies
    • Nichols GA, Koro CE, Gullion CM, et al. The incidence of congestive heart failure associated with antidiabetic therapies. Diabetes Metab Res Rev. 2005;21:51-7.
    • (2005) Diabetes Metab Res Rev , vol.21 , pp. 51-57
    • Nichols, G.A.1    Koro, C.E.2    Gullion, C.M.3
  • 21
    • 34547549434 scopus 로고    scopus 로고
    • Coronary heart disease outcomes in patients receiving antidiabetic agents
    • McAfee AT, Koro C, Landon J, et al. Coronary heart disease outcomes in patients receiving antidiabetic agents. Pharmacoepidemiol Drug Safety. 2007;16:711-25.
    • (2007) Pharmacoepidemiol Drug Safety , vol.16 , pp. 711-725
    • McAfee, A.T.1    Koro, C.2    Landon, J.3
  • 22
    • 0038279359 scopus 로고    scopus 로고
    • Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes
    • Johnson JA, Majumdar SR, Simpson SH, Toth EL. Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes. Diabetes Care. 2002;25:2244-8.
    • (2002) Diabetes Care , vol.25 , pp. 2244-2248
    • Johnson, J.A.1    Majumdar, S.R.2    Simpson, S.H.3    Toth, E.L.4
  • 23
    • 17144384777 scopus 로고    scopus 로고
    • Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with type 2 diabetes
    • Johnson JA, Simpson SH, Toth EL, Majumbar SR. Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with type 2 diabetes. Diabetic Med. 2005;22:497-502.
    • (2005) Diabetic Med , vol.22 , pp. 497-502
    • Johnson, J.A.1    Simpson, S.H.2    Toth, E.L.3    Majumbar, S.R.4
  • 24
    • 25644459350 scopus 로고    scopus 로고
    • Improved clinical outcomes associated with metformin in patients with diabetes and heart failure
    • Eurich DT, Majumdar SR, McAlister FA, et al. Improved clinical outcomes associated with metformin in patients with diabetes and heart failure. Diabetes Care. 2005;28:2345-51.
    • (2005) Diabetes Care , vol.28 , pp. 2345-2351
    • Eurich, D.T.1    Majumdar, S.R.2    McAlister, F.A.3
  • 25
    • 13444272949 scopus 로고    scopus 로고
    • Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: An observational study
    • Masudi FA, Inzucchi SE, Wang Y, et al. Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study. Circulation. 2005;111:583-90.
    • (2005) Circulation , vol.111 , pp. 583-590
    • Masudi, F.A.1    Inzucchi, S.E.2    Wang, Y.3
  • 26
    • 34548603259 scopus 로고    scopus 로고
    • Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: Systematic review
    • DOI 10.1136/bmj.39314.620174.80.
    • Eurich DT, McAlister FA, Blackburn DF, et al. Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review. Br Med J. 2007;335:458-9. DOI 10.1136/bmj.39314.620174.80.
    • (2007) Br Med J , vol.335 , pp. 458-459
    • Eurich, D.T.1    McAlister, F.A.2    Blackburn, D.F.3
  • 27
    • 34247253225 scopus 로고    scopus 로고
    • The safety of metformin in heart failure
    • Roberts F, Ryan GJ. The safety of metformin in heart failure. Ann Pharmacother. 2007;41:462-6.
    • (2007) Ann Pharmacother , vol.41 , pp. 462-466
    • Roberts, F.1    Ryan, G.J.2
  • 29
    • 25644440023 scopus 로고    scopus 로고
    • Metformin and heart failure: Innocent until proven guilty
    • Inzucchi SE. Metformin and heart failure: innocent until proven guilty. Diabetes Care. 2005;28:2585-7.
    • (2005) Diabetes Care , vol.28 , pp. 2585-2587
    • Inzucchi, S.E.1
  • 30
    • 28444452977 scopus 로고    scopus 로고
    • Contraindications can damage your health-is metformin a case in point?
    • Holstein A, Stumvoll M. Contraindications can damage your health-is metformin a case in point? Diabetologia. 2005;48:2454-9.
    • (2005) Diabetologia , vol.48 , pp. 2454-2459
    • Holstein, A.1    Stumvoll, M.2
  • 31
    • 12144259447 scopus 로고    scopus 로고
    • Metformin and gliclazide rather than glibenclamide attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes
    • Katakami N, Yamaski Y, Hayaishi-Okano R, et al. Metformin and gliclazide rather than glibenclamide attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes. Diabetologia. 2004;47:1906-13.
    • (2004) Diabetologia , vol.47 , pp. 1906-1913
    • Katakami, N.1    Yamaski, Y.2    Hayaishi-Okano, R.3
  • 32
    • 2342446628 scopus 로고    scopus 로고
    • Metformin attenuates progression of carotid arterial wall thickness in patients with type 2 diabetes
    • Matsumoto K, Sera Y, Abbe Y, et al. Metformin attenuates progression of carotid arterial wall thickness in patients with type 2 diabetes. Diabetes Res Clin Prac. 2004;64:2205-8.
    • (2004) Diabetes Res Clin Prac , vol.64 , pp. 2205-2208
    • Matsumoto, K.1    Sera, Y.2    Abbe, Y.3
  • 33
    • 27744599917 scopus 로고    scopus 로고
    • Improvement in endothelial structure and function after metformin treatment in young normal weight women with polycystic ovary syndrome: Results of a 6-month study
    • Orio F, Palomba S, Cascella T, et al. Improvement in endothelial structure and function after metformin treatment in young normal weight women with polycystic ovary syndrome: results of a 6-month study. J Clin Endocrinol Metab. 2005;90:6072-6.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6072-6076
    • Orio, F.1    Palomba, S.2    Cascella, T.3
  • 34
    • 21344456357 scopus 로고    scopus 로고
    • Signalling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: Inhibitory effect of metformin
    • Li L, Mamputu JC, Wiernsperger N, Renier G. Signalling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin. Diabetes. 2005;54:2227-34.
    • (2005) Diabetes , vol.54 , pp. 2227-2234
    • Li, L.1    Mamputu, J.C.2    Wiernsperger, N.3    Renier, G.4
  • 35
    • 0021209972 scopus 로고
    • Metformin improves peripheral vascular in nonhyperlipidemic patients with arterial disease
    • Sirtori CR, Franceschini G, Gianfranceschi G, et al. Metformin improves peripheral vascular in nonhyperlipidemic patients with arterial disease. J Cardiovasc Pharmacol. 1984;6:914-23.
    • (1984) J Cardiovasc Pharmacol , vol.6 , pp. 914-923
    • Sirtori, C.R.1    Franceschini, G.2    Gianfranceschi, G.3
  • 36
    • 0001856714 scopus 로고
    • Efficacy of the long-term administration of metformin in hyperlipidaemic patients
    • Montaguti U, Cellin D, Ceredi C, Descovitch GC. Efficacy of the long-term administration of metformin in hyperlipidaemic patients. Res Clin Forums. 1979;1:95-103.
    • (1979) Res Clin Forums , vol.1 , pp. 95-103
    • Montaguti, U.1    Cellin, D.2    Ceredi, C.3    Descovitch, G.C.4
  • 37
    • 0037900056 scopus 로고    scopus 로고
    • Pathophysiological implications of insulin resistance on vascular endothelial function
    • Wheatcroft SB, Williams IL, Shah AM, Kearney MT. Pathophysiological implications of insulin resistance on vascular endothelial function. Diabetic Med. 2003;20:255-68.
    • (2003) Diabetic Med , vol.20 , pp. 255-268
    • Wheatcroft, S.B.1    Williams, I.L.2    Shah, A.M.3    Kearney, M.T.4
  • 38
    • 13844298724 scopus 로고    scopus 로고
    • Endothelial inflammation in insulin resistance
    • Sjoholm A, Nystrom T. Endothelial inflammation in insulin resistance. Lancet. 2005;365:610-2.
    • (2005) Lancet , vol.365 , pp. 610-612
    • Sjoholm, A.1    Nystrom, T.2
  • 39
    • 0038577223 scopus 로고    scopus 로고
    • Adiposity, inflammation and atherogenesis
    • Lyon CJ, Law RE, Hsueh WA. Adiposity, inflammation and atherogenesis. Endocrinology. 2003;144:2195-200.
    • (2003) Endocrinology , vol.144 , pp. 2195-2200
    • Lyon, C.J.1    Law, R.E.2    Hsueh, W.A.3
  • 41
    • 18144449351 scopus 로고    scopus 로고
    • Do effects on blood pressure contribute to improved clinical outcomes with metformin?
    • Schafers RF. Do effects on blood pressure contribute to improved clinical outcomes with metformin? Diabetes Metab. 2003;29:62-70.
    • (2003) Diabetes Metab , vol.29 , pp. 62-70
    • Schafers, R.F.1
  • 42
    • 3042541843 scopus 로고    scopus 로고
    • The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: A systematic review
    • Wulffele MG, Kooy A, de Zeeuw D, et al. The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: a systematic review. J Intern Med. 2004;256:1-14.
    • (2004) J Intern Med , vol.256 , pp. 1-14
    • Wulffele, M.G.1    Kooy, A.2    De Zeeuw, D.3
  • 43
    • 1042268743 scopus 로고    scopus 로고
    • Favorable effects of pioglitazone and metformin compared with gliclazide on lipoprotein subfractions in overweight patients with early type 2 diabetes
    • Lawrence JM, Reid J, Taylor GJ, et al. Favorable effects of pioglitazone and metformin compared with gliclazide on lipoprotein subfractions in overweight patients with early type 2 diabetes. Diabetes Care. 2004;27:41-6.
    • (2004) Diabetes Care , vol.27 , pp. 41-46
    • Lawrence, J.M.1    Reid, J.2    Taylor, G.J.3
  • 44
    • 34548400893 scopus 로고    scopus 로고
    • Effect of metformin on serum lipoprotein lipase mass levels and LDL particle size in type 2 diabetes mellitus patients
    • Ohira M, Miyashita Y, Ebisuno M, et al. Effect of metformin on serum lipoprotein lipase mass levels and LDL particle size in type 2 diabetes mellitus patients. Diabetes Res Clin Pract. 2007;78:34-41.
    • (2007) Diabetes Res Clin Pract , vol.78 , pp. 34-41
    • Ohira, M.1    Miyashita, Y.2    Ebisuno, M.3
  • 45
    • 0036517747 scopus 로고    scopus 로고
    • Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes
    • Chu NV, Kong AP, Kim DD, et al. Differential effects of metformin and troglitazone on cardiovascular risk factors in patients with type 2 diabetes. Diabetes Care. 2002;25:542-9.
    • (2002) Diabetes Care , vol.25 , pp. 542-549
    • Chu, N.V.1    Kong, A.P.2    Kim, D.D.3
  • 46
    • 0035312620 scopus 로고    scopus 로고
    • Improved endothelial function with metformin in type 2 diabetes mellitus
    • Mather KJ, Verma S, Anderson TJ. Improved endothelial function with metformin in type 2 diabetes mellitus. J Am Coll Cardiol. 2001;37:1344-50.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1344-1350
    • Mather, K.J.1    Verma, S.2    Anderson, T.J.3
  • 47
    • 33746340623 scopus 로고    scopus 로고
    • Metformin improves endothelial vascular reactivity in first degree relatives of type 2 diabetic patients with metabolic syndrome and normal glucose tolerance
    • De Aguiar LG, Bahia LR, Villela N, et al. Metformin improves endothelial vascular reactivity in first degree relatives of type 2 diabetic patients with metabolic syndrome and normal glucose tolerance. Diabetes Care. 2006;29:1083-9.
    • (2006) Diabetes Care , vol.29 , pp. 1083-1089
    • De Aguiar, L.G.1    Bahia, L.R.2    Villela, N.3
  • 48
    • 24144488274 scopus 로고    scopus 로고
    • Metformin improves endothelial function in patients with metabolic syndrome
    • Vitale C, Mercuro G, Cornoldi F, et al. Metformin improves endothelial function in patients with metabolic syndrome. J Intern Med. 2005;258:250-6.
    • (2005) J Intern Med , vol.258 , pp. 250-256
    • Vitale, C.1    Mercuro, G.2    Cornoldi, F.3
  • 49
    • 0029778182 scopus 로고    scopus 로고
    • Metformin improves hemodynamic and fheological responses to L-arginine in NIDDM patients
    • Marfella R, Acampora R, Verrazzo G, et al. Metformin improves hemodynamic and fheological responses to L-arginine in NIDDM patients. Diabetes Care. 1996;19:934-9.
    • (1996) Diabetes Care , vol.19 , pp. 934-939
    • Marfella, R.1    Acampora, R.2    Verrazzo, G.3
  • 50
    • 0036063752 scopus 로고    scopus 로고
    • Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes
    • Asagami T, Abbasi F, Stuelinger M, et al. Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes. Metabolism. 2002;51:843-6.
    • (2002) Metabolism , vol.51 , pp. 843-846
    • Asagami, T.1    Abbasi, F.2    Stuelinger, M.3
  • 51
    • 2542424151 scopus 로고    scopus 로고
    • Vascular effects of improving metabolic control with metformin or rosiglitazone in type 2 diabetes
    • Natale A, Baldeweg S, Toschi E, et al. Vascular effects of improving metabolic control with metformin or rosiglitazone in type 2 diabetes. Diabetes Care. 2004;27:1349-57.
    • (2004) Diabetes Care , vol.27 , pp. 1349-1357
    • Natale, A.1    Baldeweg, S.2    Toschi, E.3
  • 52
    • 33746899676 scopus 로고    scopus 로고
    • Insulin sensitivity during oral glucose tolerance test and its relation to parameters of glucose metabolism and endothelial function in type 2 diabetes subjects under metformin of thiazolidinedione
    • Kautzky-Willer A, ra A, Winzer C, et al. Insulin sensitivity during oral glucose tolerance test and its relation to parameters of glucose metabolism and endothelial function in type 2 diabetes subjects under metformin of thiazolidinedione. Diab Obesity Metab. 2006;8:561-7.
    • (2006) Diab Obesity Metab , vol.8 , pp. 561-567
    • Kautzky-Willer, A.1    Ra, A.2    Winzer, C.3
  • 53
    • 0030810531 scopus 로고    scopus 로고
    • Adherence of mononuclear cells to endothelium in vitro is increased in NIDDM
    • Carantoni M, Abbasi F, Chu L, et al. Adherence of mononuclear cells to endothelium in vitro is increased in NIDDM. Diabetes Care. 1997;20:1462-6.
    • (1997) Diabetes Care , vol.20 , pp. 1462-1466
    • Carantoni, M.1    Abbasi, F.2    Chu, L.3
  • 54
    • 0042878553 scopus 로고    scopus 로고
    • Metformin inhibits monocyte adhesion to endothelial cells and foam cell formation
    • Mamputu JC, Wiernsperger N, Renier G. Metformin inhibits monocyte adhesion to endothelial cells and foam cell formation. Br J Diabetes Vasc Dis. 2003;3:302-10.
    • (2003) Br J Diabetes Vasc Dis , vol.3 , pp. 302-310
    • Mamputu, J.C.1    Wiernsperger, N.2    Renier, G.3
  • 55
    • 19944433033 scopus 로고    scopus 로고
    • Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: A randomized placebo-controlled trial
    • De Jager J, Kooy A, Lehert P. Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized placebo-controlled trial. J Intern Med. 2005;257:100-9.
    • (2005) J Intern Med , vol.257 , pp. 100-109
    • De Jager, J.1    Kooy, A.2    Lehert, P.3
  • 56
    • 36148971179 scopus 로고    scopus 로고
    • Oxidative stress and endothelium influenced by metformin in type 2 diabetes mellitus
    • Skrha J, Praznv M, Milgertova J, et al. Oxidative stress and endothelium influenced by metformin in type 2 diabetes mellitus. Eur J Clin Pharmacol. 2007;63:1107-14.
    • (2007) Eur J Clin Pharmacol , vol.63 , pp. 1107-1114
    • Skrha, J.1    Praznv, M.2    Milgertova, J.3
  • 57
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868-74.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 58
    • 24044543259 scopus 로고    scopus 로고
    • Metformin reduces C-reactive protein but not complement factor C3 in overweight patients with type 2 diabetes mellitus
    • Carter AM, Bennett CE, Bostock JA, Grant PJ. Metformin reduces C-reactive protein but not complement factor C3 in overweight patients with type 2 diabetes mellitus. Diabetic Med. 2005;22:1282-4.
    • (2005) Diabetic Med , vol.22 , pp. 1282-1284
    • Carter, A.M.1    Bennett, C.E.2    Bostock, J.A.3    Grant, P.J.4
  • 59
    • 0038064504 scopus 로고    scopus 로고
    • Effect of metformin and sulfonylurea on C-reactive protein level in well-controlled type 2 diabetics with metabolic syndrome
    • Akbar DH. Effect of metformin and sulfonylurea on C-reactive protein level in well-controlled type 2 diabetics with metabolic syndrome. Endocrine. 2005;20:215-8.
    • (2005) Endocrine , vol.20 , pp. 215-218
    • Akbar, D.H.1
  • 60
    • 0242351851 scopus 로고    scopus 로고
    • Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome
    • Morin-Papunen L, Rautio K, Ruokonen A, et al. Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2003;88:4649-54.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4649-4654
    • Morin-Papunen, L.1    Rautio, K.2    Ruokonen, A.3
  • 61
    • 4043162976 scopus 로고    scopus 로고
    • The differential effects of metformin on markers of endothelial activation and inflammation in subjects with impaired glucose tolerance: A placebo-controlled, randomized clinical trial
    • Caballero AE, Degado A, Aguillar-Salinas CA, et al. The differential effects of metformin on markers of endothelial activation and inflammation in subjects with impaired glucose tolerance: a placebo-controlled, randomized clinical trial. J Clin Endocrinol Metab. 2004;89:3943-8.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3943-3948
    • Caballero, A.E.1    Degado, A.2    Aguillar-Salinas, C.A.3
  • 62
    • 33744976813 scopus 로고    scopus 로고
    • Metformin inhibits cytokine-induced nuclear factor kappa B activation via AMP-activated protein kinase activation in vascular endothelial cells
    • Hattori Y, Suzuki K, Hattori S, et al. Metformin inhibits cytokine-induced nuclear factor kappa B activation via AMP-activated protein kinase activation in vascular endothelial cells. Hypertension. 2006;47:1183-8.
    • (2006) Hypertension , vol.47 , pp. 1183-1188
    • Hattori, Y.1    Suzuki, K.2    Hattori, S.3
  • 63
    • 33746920337 scopus 로고    scopus 로고
    • Advanced glycation end products: Sparking the development of diabetic vascular injury
    • Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation. 2006;114:597-605.
    • (2006) Circulation , vol.114 , pp. 597-605
    • Goldin, A.1    Beckman, J.A.2    Schmidt, A.M.3    Creager, M.A.4
  • 64
    • 33750711575 scopus 로고    scopus 로고
    • Nonenzymatical glycation of protein in vitro and its inhibition by aminoguanidine or metformin
    • Meifen C, Jie X, Linuo Z, et al. Nonenzymatical glycation of protein in vitro and its inhibition by aminoguanidine or metformin. Acta Acad Med Shanghai. 1998;25:35-8.
    • (1998) Acta Acad Med Shanghai , vol.25 , pp. 35-38
    • Meifen, C.1    Jie, X.2    Linuo, Z.3
  • 65
    • 0032939905 scopus 로고    scopus 로고
    • Metformin reduces systemic methylglyoxal levels in type 2 diabetes
    • Beisswenger P, Howell S, Touchette A, et al. Metformin reduces systemic methylglyoxal levels in type 2 diabetes. Diabetes. 1999;48:198-202.
    • (1999) Diabetes , vol.48 , pp. 198-202
    • Beisswenger, P.1    Howell, S.2    Touchette, A.3
  • 66
    • 35848952277 scopus 로고    scopus 로고
    • 50 years later: Is metformin a vascular drug with antidiabetic properties?
    • Wiernsperger NF. 50 years later: is metformin a vascular drug with antidiabetic properties? Br J Diabetes Vasc Dis. 2007;7:204-10.
    • (2007) Br J Diabetes Vasc Dis , vol.7 , pp. 204-210
    • Wiernsperger, N.F.1
  • 67
    • 0034527379 scopus 로고    scopus 로고
    • Effect of four-week metformin treatment on plasma and erythrocyte antioxidative defense enzymes in newly diagnosed obese patients with type 2 diabetes
    • Pavlovic D, Kocic R, Kocic G, et al. Effect of four-week metformin treatment on plasma and erythrocyte antioxidative defense enzymes in newly diagnosed obese patients with type 2 diabetes. Diabetes Obesity Metab. 2000;2:251-6.
    • (2000) Diabetes Obesity Metab , vol.2 , pp. 251-256
    • Pavlovic, D.1    Kocic, R.2    Kocic, G.3
  • 68
    • 19444380162 scopus 로고    scopus 로고
    • Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells
    • Ouslimani N, Peynet J, Bonnefont-Rousselot D, et al. Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells. Metabolism. 2005;54:829-34.
    • (2005) Metabolism , vol.54 , pp. 829-834
    • Ouslimani, N.1    Peynet, J.2    Bonnefont-Rousselot, D.3
  • 69
    • 33744926469 scopus 로고    scopus 로고
    • Metformin reduces angiotensin-mediated intracellular production of reactive oxygen species in endothelial cells through the inhibition of protein kinase C
    • Mahrouf M, Ouslimani N, Peynet J, et al. Metformin reduces angiotensin-mediated intracellular production of reactive oxygen species in endothelial cells through the inhibition of protein kinase C. Biochem Pharmacol. 2006;72:176-83.
    • (2006) Biochem Pharmacol , vol.72 , pp. 176-183
    • Mahrouf, M.1    Ouslimani, N.2    Peynet, J.3
  • 70
    • 33751192093 scopus 로고    scopus 로고
    • Metformin does not prevent DNA damage in lymphocytes despite its antioxidant properties against cumene hydroperoxide-induced oxidative stress
    • Onaran I, Guven GS, Ozdas SB, et al. Metformin does not prevent DNA damage in lymphocytes despite its antioxidant properties against cumene hydroperoxide-induced oxidative stress. Mutation Res. 2006;611:1-8.
    • (2006) Mutation Res , vol.611 , pp. 1-8
    • Onaran, I.1    Guven, G.S.2    Ozdas, S.B.3
  • 71
    • 0036255463 scopus 로고    scopus 로고
    • Metformin decreases platelet superoxide anion production in diabetic patients
    • Gargiulo P, Caccese D, Pignatelli P, et al. Metformin decreases platelet superoxide anion production in diabetic patients. Diabetes Metabolism Res Revs. 2002;18:156-9.
    • (2002) Diabetes Metabolism Res Revs , vol.18 , pp. 156-159
    • Gargiulo, P.1    Caccese, D.2    Pignatelli, P.3
  • 72
    • 0032995666 scopus 로고    scopus 로고
    • Effects of gliclazide versus metformin on the clinical profile and lipid peroxidation markers in type 2 diabetes
    • Tessier D, Maheux P, Khalil A, Fulop T. Effects of gliclazide versus metformin on the clinical profile and lipid peroxidation markers in type 2 diabetes. Metabolism. 1999;48:897-903.
    • (1999) Metabolism , vol.48 , pp. 897-903
    • Tessier, D.1    Maheux, P.2    Khalil, A.3    Fulop, T.4
  • 73
    • 0034086934 scopus 로고    scopus 로고
    • Metformin: Intrinsic vasculoprotective properties
    • Wiernsperger NF. Metformin: intrinsic vasculoprotective properties. Diabetes Technol Therap. 2000;2:259-72.
    • (2000) Diabetes Technol Therap , vol.2 , pp. 259-272
    • Wiernsperger, N.F.1
  • 74
    • 18144447850 scopus 로고    scopus 로고
    • Antiatherogenic properties of metformin: The experimental evidence
    • Mamputu JC, Wiernsperger NF, Renier G. Antiatherogenic properties of metformin: the experimental evidence. Diabetes Metab. 2003;29:6S71-76.
    • (2003) Diabetes Metab , vol.29
    • Mamputu, J.C.1    Wiernsperger, N.F.2    Renier, G.3
  • 75
    • 0017858366 scopus 로고
    • Effect of metformin on lipid metabolism in the rabbit aortic wall
    • Marquie G. Effect of metformin on lipid metabolism in the rabbit aortic wall. Atherosclerosis. 1978;30:165-70.
    • (1978) Atherosclerosis , vol.30 , pp. 165-170
    • Marquie, G.1
  • 76
    • 0020639876 scopus 로고
    • Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits
    • Marquie G. Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits. Atherosclerosis. 1983;47:7-17.
    • (1983) Atherosclerosis , vol.47 , pp. 7-17
    • Marquie, G.1
  • 77
    • 0001172619 scopus 로고
    • Fibrinolytic effect of metformin in coronary artery disease
    • Chakrabarti R, Hocking ED, Fearnley GR. Fibrinolytic effect of metformin in coronary artery disease. Lancet. 1965;II:256-9.
    • (1965) Lancet , vol.2 , pp. 256-259
    • Chakrabarti, R.1    Hocking, E.D.2    Fearnley, G.R.3
  • 79
    • 0023595143 scopus 로고
    • Metformin decreases the high plasminogen activation inhibitor activity, plasma insulin and triglyceride levels in non-diabetic obese subjects
    • Vague PH, Juhan-Vague I, Alessi MC, et al. Metformin decreases the high plasminogen activation inhibitor activity, plasma insulin and triglyceride levels in non-diabetic obese subjects. Thromb Haemostasis. 1987;57:326-8.
    • (1987) Thromb Haemostasis , vol.57 , pp. 326-328
    • Vague, P.H.1    Juhan-Vague, I.2    Alessi, M.C.3
  • 80
    • 0025726560 scopus 로고
    • Metformin causes a reduction in basal and post-venous occlusion plasminogen activator inhibitor-1 in type 2 diabetic patients
    • Grant PJ, Strickl;and MH, Booth NA, Prentice CRM. Metformin causes a reduction in basal and post-venous occlusion plasminogen activator inhibitor-1 in type 2 diabetic patients. Diabetic Med. 1991;8:361-5.
    • (1991) Diabetic Med , vol.8 , pp. 361-365
    • Grant, P.J.1    Strickl2    And, M.H.3    Booth, N.A.4    Prentice, C.R.M.5
  • 81
    • 0027399661 scopus 로고
    • Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects
    • Nagi DK, Yudkin JS. Effects of metformin on insulin resistance, risk factors for cardiovascular disease, and plasminogen activator inhibitor in NIDDM subjects. Diabetes Care. 1993;16:621-9.
    • (1993) Diabetes Care , vol.16 , pp. 621-629
    • Nagi, D.K.1    Yudkin, J.S.2
  • 82
    • 0030022720 scopus 로고    scopus 로고
    • The effect of high- and medium-dose metformin therapy on cardiovascular risk factors in patients with type II diabetes
    • Grant PJ. The effect of high- and medium-dose metformin therapy on cardiovascular risk factors in patients with type II diabetes. Diabetes Care. 1996;19:64-6.
    • (1996) Diabetes Care , vol.19 , pp. 64-66
    • Grant, P.J.1
  • 83
    • 0031901216 scopus 로고    scopus 로고
    • Metformin reduces circulating factor VII concentrations in patients with type 2 diabetes mellitus
    • Grant PJ. Metformin reduces circulating factor VII concentrations in patients with type 2 diabetes mellitus. Thromb Haemostasis 1998;80:209.
    • (1998) Thromb Haemostasis , vol.80 , pp. 209
    • Grant, P.J.1
  • 84
    • 0037247643 scopus 로고    scopus 로고
    • Metformin, but not thiazolidinediones, inhibits plasminogen activator inhibitor-1 production in human adipose tissue
    • He G, Pedersen SB, Bruun JM, et al. Metformin, but not thiazolidinediones, inhibits plasminogen activator inhibitor-1 production in human adipose tissue. Horm Metab Res. 2003;35:18-23.
    • (2003) Horm Metab Res , vol.35 , pp. 18-23
    • He, G.1    Pedersen, S.B.2    Bruun, J.M.3
  • 85
    • 0036091884 scopus 로고    scopus 로고
    • The effect of dimethyl biguanide on thrombin activity FXIII activation, fibrin polymerization and fibrin clot formation
    • Standeven KF, Ariens RAS, Whitaker P, et al. The effect of dimethyl biguanide on thrombin activity FXIII activation, fibrin polymerization and fibrin clot formation. Diabetes. 2002;51:189-97.
    • (2002) Diabetes , vol.51 , pp. 189-197
    • Standeven, K.F.1    Ariens, R.A.S.2    Whitaker, P.3
  • 86
    • 18144451494 scopus 로고    scopus 로고
    • Beneficial effects of metformin on haemostasis and vascular function in man
    • Grant PJ. Beneficial effects of metformin on haemostasis and vascular function in man. Diabetes Metab. 2003;29:6S44-52.
    • (2003) Diabetes Metab , vol.29
    • Grant, P.J.1
  • 87
    • 0022296323 scopus 로고
    • Platelet and endothelial function tests during metformin treatment in diabetes mellitus
    • Janka HU. Platelet and endothelial function tests during metformin treatment in diabetes mellitus. Horm Metab Res. 1985;12:120-2.
    • (1985) Horm Metab Res , vol.12 , pp. 120-122
    • Janka, H.U.1
  • 88
    • 0033368928 scopus 로고    scopus 로고
    • Poorly controlled elderly type 2 diabetic patients: The effects of increasing sulphonylurea dosages or adding metformin
    • Gregorio F, Ambrosi F, Manfrini S. Poorly controlled elderly type 2 diabetic patients: the effects of increasing sulphonylurea dosages or adding metformin. Diabetic Med. 1999;16:1016-24.
    • (1999) Diabetic Med , vol.16 , pp. 1016-1024
    • Gregorio, F.1    Ambrosi, F.2    Manfrini, S.3
  • 89
    • 0001482015 scopus 로고
    • Antithrombotic effects of metformin in laser injured arteries
    • Weichert W, Breddin K. Antithrombotic effects of metformin in laser injured arteries. Diabetes Metab. 1988;14:540-43.
    • (1988) Diabetes Metab , vol.14 , pp. 540-543
    • Weichert, W.1    Breddin, K.2
  • 90
    • 0013625610 scopus 로고
    • Antithrombic drugs in a carotid occlusion model: Beneficial effect of the antidiabetic agent metformin
    • Massad L, Plotkine M, Allix M, Boulu RG. Antithrombic drugs in a carotid occlusion model: beneficial effect of the antidiabetic agent metformin. Diabetes Metab. 1988;14:544-48.
    • (1988) Diabetes Metab , vol.14 , pp. 544-548
    • Massad, L.1    Plotkine, M.2    Allix, M.3    Boulu, R.G.4
  • 91
    • 0028944962 scopus 로고
    • Hyperglycemia and microvascular and macrovascular disease in diabetes
    • Klein R. Hyperglycemia and microvascular and macrovascular disease in diabetes. Diabetes Care. 1995;18:258-68.
    • (1995) Diabetes Care , vol.18 , pp. 258-268
    • Klein, R.1
  • 92
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • Diabetes Control and complications Trial Research Group
    • Diabetes Control and complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-86.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 93
    • 18144441478 scopus 로고    scopus 로고
    • Microcirculation in insulin resistance and diabetes: More than just a complication
    • Wiernsperger NF, Bouskela E. Microcirculation in insulin resistance and diabetes: more than just a complication. Diabetes Metab. 2003;29:6S77-87.
    • (2003) Diabetes Metab , vol.29
    • Wiernsperger, N.F.1    Bouskela, E.2
  • 94
    • 0029088711 scopus 로고
    • Microvascular function in human diabetes: A physiological perspective
    • Tooke JE. Microvascular function in human diabetes: a physiological perspective. Diabetes. 1995;44:721-6.
    • (1995) Diabetes , vol.44 , pp. 721-726
    • Tooke, J.E.1
  • 96
    • 24344454347 scopus 로고    scopus 로고
    • Metformin treatment restores the altered micro-vascular reactivity in neonatal streptozotocin-induced diabetic rats by increasing NOS activity, but not NOS expression
    • Sartoretto JL, Melo GA, Carvalho MH, et al. Metformin treatment restores the altered micro-vascular reactivity in neonatal streptozotocin-induced diabetic rats by increasing NOS activity, but not NOS expression. Life Sci. 2005;77:2676-89.
    • (2005) Life Sci , vol.77 , pp. 2676-2689
    • Sartoretto, J.L.1    Melo, G.A.2    Carvalho, M.H.3
  • 97
    • 0141525599 scopus 로고
    • Effect of metformin on diabetic erythrocyte deformability in the presence of insulin: In vitro study on erythrocytes from diabetic patients
    • Rapin JR, Lespinasse P, Yoa R. Effect of metformin on diabetic erythrocyte deformability in the presence of insulin: in vitro study on erythrocytes from diabetic patients. Diabetes Metab. 1988;14:610-12.
    • (1988) Diabetes Metab , vol.14 , pp. 610-612
    • Rapin, J.R.1    Lespinasse, P.2    Yoa, R.3
  • 98
    • 0028999481 scopus 로고
    • The effects of metformin on the capillary permeability to albumin in women patients with cyclic edema
    • Valensi P, Behar A, Andre P, et al. The effects of metformin on the capillary permeability to albumin in women patients with cyclic edema. Angiology. 1995;46:401-8.
    • (1995) Angiology , vol.46 , pp. 401-408
    • Valensi, P.1    Behar, A.2    Andre, P.3
  • 99
    • 0032455072 scopus 로고    scopus 로고
    • Effects of metformin on collagen glycation and diastolic dysfunction in diabetic myocardium
    • Jyothirmayi GN, Soni BJ, Masurekar M, et al. Effects of metformin on collagen glycation and diastolic dysfunction in diabetic myocardium. J Cardiovasc Pharmacol Therap. 1998;3:319-26.
    • (1998) J Cardiovasc Pharmacol Therap , vol.3 , pp. 319-326
    • Jyothirmayi, G.N.1    Soni, B.J.2    Masurekar, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.