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Volumn 46, Issue 2, 2013, Pages 51-58

TGF-β signaling regulates pancreatic β-cell proliferation through control of cell cycle regulator p27 expression

Author keywords

HIT T15 cells; Inhibition; P27; Pancreatic cell proliferation; Signaling; TGF

Indexed keywords


EID: 84877050767     PISSN: 00445991     EISSN: 13475800     Source Type: Journal    
DOI: 10.1267/ahc.12035     Document Type: Article
Times cited : (30)

References (46)
  • 2
    • 0037204990 scopus 로고    scopus 로고
    • Signal transduction by the TGF-beta superfamily
    • Attisano, L. and Wrana, J. L. (2002) Signal transduction by the TGF-beta superfamily. Science 296; 1646-1647.
    • (2002) Science , vol.296 , pp. 1646-1647
    • Attisano, L.1    Wrana, J.L.2
  • 3
    • 52749088737 scopus 로고    scopus 로고
    • HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro
    • Bar, Y., Russ, H. A., Knoller, S., Ouziel-Yahalom, L. and Efrat, S. (2008) HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro. Diabetes 57; 2413-2420.
    • (2008) Diabetes , vol.57 , pp. 2413-2420
    • Bar, Y.1    Russ, H.A.2    Knoller, S.3    Ouziel-Yahalom, L.4    Efrat, S.5
  • 4
    • 0342460497 scopus 로고    scopus 로고
    • Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas
    • Bottinger, E. P., Jakubczak, J. L., Roberts, I. S., Mumy, M., Hemmati, P., Bagnall, K., Merlino, G. and Wakefield, L. M. (1997) Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas. EMBO J. 16; 2621-2633.
    • (1997) EMBO J , vol.16 , pp. 2621-2633
    • Bottinger, E.P.1    Jakubczak, J.L.2    Roberts, I.S.3    Mumy, M.4    Hemmati, P.5    Bagnall, K.6    Merlino, G.7    Wakefield, L.M.8
  • 5
    • 63049137246 scopus 로고    scopus 로고
    • Slow and steady is the key to beta-cell replication
    • Brennand, K. and Melton, D. (2009) Slow and steady is the key to beta-cell replication. J. Cell. Mol. Med. 13; 472-487.
    • (2009) J. Cell. Mol. Med , vol.13 , pp. 472-487
    • Brennand, K.1    Melton, D.2
  • 6
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A. and Butler, P. C. (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52; 102-110.
    • (2003) Diabetes , vol.52 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 8
    • 35448986170 scopus 로고    scopus 로고
    • The replication of beta cells in normal physiology, in disease and for therapy
    • Diabetes 52; 2304-2314. 8. Butler, P. C., Meier, J. J., Butler, A. E. and Bhushan, A. (2007) The replication of beta cells in normal physiology, in disease and for therapy. Nat. Clin. Pract. Endocrinol. Metab. 3; 758-768.
    • (2007) Nat. Clin. Pract. Endocrinol. Metab , vol.3 , pp. 758-768
    • Butler, P.C.1    Meier, J.J.2    Butler, A.E.3    Bhushan, A.4
  • 9
    • 48549098685 scopus 로고    scopus 로고
    • Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1
    • Cen, B., Deguchi, A. and Weinstein, I. B. (2008) Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1. Cancer Res. 68; 5355- 5362.
    • (2008) Cancer Res , vol.68 , pp. 5355
    • Cen, B.1    Deguchi, A.2    Weinstein, I.B.3
  • 12
    • 0029073142 scopus 로고
    • Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
    • Datto, M. B., Li, Y., Panus, J. F., Howe, D. J., Xiong, Y. and Wang, X. F. (1995) Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. U S A 92; 5545-5549.
    • (1995) Proc. Natl. Acad. Sci. U S A , vol.92 , pp. 5545-5549
    • Datto, M.B.1    Li, Y.2    Panus, J.F.3    Howe, D.J.4    Xiong, Y.5    Wang, X.F.6
  • 13
    • 0037382330 scopus 로고    scopus 로고
    • Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas
    • Dichmann, D. S., Miller, C. P., Jensen, J., Scott Heller, R. and Serup, P. (2003) Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev. Dyn. 226; 663-674.
    • (2003) Dev. Dyn , vol.226 , pp. 663-674
    • Dichmann, D.S.1    Miller, C.P.2    Jensen, J.3    Scott Heller, R.4    Serup, P.5
  • 14
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor, Y., Brown, J., Martinez, O. I. and Melton, D. A. (2004) Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429; 41-46.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 16
    • 9644266753 scopus 로고    scopus 로고
    • Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass
    • Georgia, S. and Bhushan, A. (2004) Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J. Clin. Invest. 114; 963-968.
    • (2004) J. Clin. Invest , vol.114 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 17
    • 33845513370 scopus 로고    scopus 로고
    • Regulates the transition of beta-cells from quiescence to proliferation
    • Georgia, S. and Bhushan, A. (2006) p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes 55; 2950- 2956.
    • Diabetes , vol.55 , pp. 2950-2956
    • Georgia, S.1    Bhushan, A.2
  • 18
    • 77951152217 scopus 로고    scopus 로고
    • Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents
    • Georgia, S., Hinault, C., Kawamori, D., Hu, J., Meyer, J., Kanji, M., Bhushan, A. and Kulkarni, R. N. (2010) Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes 59; 987-996.
    • (2010) Diabetes , vol.59 , pp. 987-996
    • Georgia, S.1    Hinault, C.2    Kawamori, D.3    Hu, J.4    Meyer, J.5    Kanji, M.6    Bhushan, A.7    Kulkarni, R.N.8
  • 19
    • 79959726397 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation
    • Hakonen, E., Ustinov, J., Mathijs, I., Palgi, J., Bouwens, L., Miettinen, P. J. and Otonkoski, T. (2011) Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation. Diabetologia 54; 1735-1743.
    • (2011) Diabetologia , vol.54 , pp. 1735-1743
    • Hakonen, E.1    Ustinov, J.2    Mathijs, I.3    Palgi, J.4    Bouwens, L.5    Miettinen, P.J.6    Otonkoski, T.7
  • 20
    • 0028168242 scopus 로고    scopus 로고
    • P15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
    • Hannon, G. J. and Beach, D. (1994) p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 371; 257- 261.
    • Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 21
    • 33748935803 scopus 로고    scopus 로고
    • Intrinsic regulators of pancreatic beta-cell proliferation
    • Heit, J. J., Karnik, S. K. and Kim, S. K. (2006) Intrinsic regulators of pancreatic beta-cell proliferation. Annu. Rev. Cell Dev. Biol. 22; 311-338.
    • (2006) Annu. Rev. Cell Dev. Biol , vol.22 , pp. 311-338
    • Heit, J.J.1    Karnik, S.K.2    Kim, S.K.3
  • 22
    • 0036085920 scopus 로고    scopus 로고
    • SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    • Inman, G. J., Nicolas, F. J., Callahan, J. F., Harling, J. D., Gaster, L. M., Reith, A. D., Laping, N. J. and Hill, C. S. (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol. Pharmacol. 62; 65-74.
    • (2002) Mol. Pharmacol , vol.62 , pp. 65-74
    • Inman, G.J.1    Nicolas, F.J.2    Callahan, J.F.3    Harling, J.D.4    Gaster, L.M.5    Reith, A.D.6    Laping, N.J.7    Hill, C.S.8
  • 23
  • 24
    • 0033853921 scopus 로고    scopus 로고
    • Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy
    • Kassem, S. A., Ariel, I., Thornton, P. S., Scheimberg, I. and Glaser, B. (2000) Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy. Diabetes 49; 1325-1333.
    • (2000) Diabetes , vol.49 , pp. 1325-1333
    • Kassem, S.A.1    Ariel, I.2    Thornton, P.S.3    Scheimberg, I.4    Glaser, B.5
  • 27
    • 0038036800 scopus 로고    scopus 로고
    • The Ski-binding protein C184M negatively regulates tumor growth factor-beta signaling by sequestering the Smad proteins in the cytoplasm
    • Kokura, K., Kim, H., Shinagawa, T., Khan, M. M., Nomura, T. and Ishii, S. (2003) The Ski-binding protein C184M negatively regulates tumor growth factor-beta signaling by sequestering the Smad proteins in the cytoplasm. J. Biol. Chem. 278; 20133- 20139.
    • (2003) J. Biol. Chem , vol.278 , pp. 20133
    • Kokura, K.1    Kim, H.2    Shinagawa, T.3    Khan, M.M.4    Nomura, T.5    Ishii, S.6
  • 29
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • Massague, J., Blain, S. W. and Lo, R. S. (2000) TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103; 295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 30
    • 33646562542 scopus 로고    scopus 로고
    • The logic of TGFbeta signaling
    • Massague, J. and Gomis, R. R. (2006) The logic of TGFbeta signaling. FEBS Lett. 580; 2811-2820.
    • (2006) FEBS Lett , vol.580 , pp. 2811-2820
    • Massague, J.1    Gomis, R.R.2
  • 32
    • 0030756064 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the human p27Kip1 gene promoter
    • Minami, S., Ohtani-Fujita, N., Igata, E., Tamaki, T. and Sakai, T. (1997) Molecular cloning and characterization of the human p27Kip1 gene promoter. FEBS Lett. 411; 1-6.
    • (1997) FEBS Lett , vol.411 , pp. 1-6
    • Minami, S.1    Ohtani-Fujita, N.2    Igata, E.3    Tamaki, T.4    Sakai, T.5
  • 33
    • 0037621860 scopus 로고    scopus 로고
    • Regulation of TGF-beta signaling and its roles in progression of tumors
    • Miyazono, K., Suzuki, H. and Imamura, T. (2003) Regulation of TGF-beta signaling and its roles in progression of tumors. Cancer Sci. 94; 230-234.
    • (2003) Cancer Sci , vol.94 , pp. 230-234
    • Miyazono, K.1    Suzuki, H.2    Imamura, T.3
  • 34
    • 33646345376 scopus 로고    scopus 로고
    • Ubiquitin ligases: Cell-cycle control and cancer
    • Nakayama, K. I. and Nakayama, K. (2006) Ubiquitin ligases: cell-cycle control and cancer. Nat. Rev. Cancer 6; 369-381.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 369-381
    • Nakayama, K.I.1    Nakayama, K.2
  • 35
    • 0030614715 scopus 로고    scopus 로고
    • The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2
    • Reynisdottir, I. and Massague, J. (1997) The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2. Genes Dev. 11; 492-503.
    • (1997) Genes Dev , vol.11 , pp. 492-503
    • Reynisdottir, I.1    Massague, J.2
  • 36
    • 0029153609 scopus 로고
    • Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
    • Reynisdottir, I., Polyak, K., Iavarone, A. and Massague, J. (1995) Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev. 9; 1831-1845.
    • (1995) Genes Dev , vol.9 , pp. 1831-1845
    • Reynisdottir, I.1    Polyak, K.2    Iavarone, A.3    Massague, J.4
  • 38
    • 0028172289 scopus 로고
    • TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro
    • Sanvito, F., Herrera, P. L., Huarte, J., Nichols, A., Montesano, R., Orci, L. and Vassalli, J. D. (1994) TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro. Development 120; 3451-3462.
    • (1994) Development , vol.120 , pp. 3451-3462
    • Sanvito, F.1    Herrera, P.L.2    Huarte, J.3    Nichols, A.4    Montesano, R.5    Orci, L.6    Vassalli, J.D.7
  • 39
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr, C. J. and Roberts, J. M. (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13; 1501-1512.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 40
    • 33244464960 scopus 로고    scopus 로고
    • Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus
    • Smart, N. G., Apelqvist, A. A., Gu, X., Harmon, E. B., Topper, J. N., MacDonald, R. J. and Kim, S. K. (2006) Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus. PLoS Biol. 4; e39.
    • (2006) PLoS Biol , vol.e39 , pp. 4
    • Smart, N.G.1    Apelqvist, A.A.2    Gu, X.3    Harmon, E.B.4    Topper, J.N.5    Macdonald, R.J.6    Kim, S.K.7
  • 41
    • 79951605740 scopus 로고    scopus 로고
    • GSK-3 inactivation or depletion promotes beta-cell replication via down regulation of the CDK inhibitor, p27 (Kip1)
    • Stein, J., Milewski, W. M., Hara, M., Steiner, D. F. and Dey, A. (2011) GSK-3 inactivation or depletion promotes beta-cell replication via down regulation of the CDK inhibitor, p27 (Kip1). Islets 3; 21-34.
    • (2011) Islets , vol.3 , pp. 21-34
    • Stein, J.1    Milewski, W.M.2    Hara, M.3    Steiner, D.F.4    Dey, A.5
  • 42
    • 38149033464 scopus 로고    scopus 로고
    • Multiple mechanisms for p27(Kip1) translocation and degradation
    • Susaki, E. and Nakayama, K. I. (2007) Multiple mechanisms for p27(Kip1) translocation and degradation. Cell Cycle 6; 3015- 3020.
    • (2007) Cell Cycle , vol.6 , pp. 3015
    • Susaki, E.1    Nakayama, K.I.2
  • 44
    • 34247638529 scopus 로고    scopus 로고
    • TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas
    • Tulachan, S. S., Tei, E., Hembree, M., Crisera, C., Prasadan, K., Koizumi, M., Shah, S., Guo, P., Bottinger, E. and Gittes, G. K. (2007) TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas. Dev. Biol. 305; 508-521.
    • (2007) Dev. Biol , vol.305 , pp. 508-521
    • Tulachan, S.S.1    Tei, E.2    Hembree, M.3    Crisera, C.4    Prasadan, K.5    Koizumi, M.6    Shah, S.7    Guo, P.8    Bottinger, E.9    Gittes, G.K.10
  • 45
    • 0035156083 scopus 로고    scopus 로고
    • Transforming growth factorbeta signal transduction in epithelial cells
    • Yue, J. and Mulder, K. M. (2001) Transforming growth factorbeta signal transduction in epithelial cells. Pharmacol. Ther. 91; 1-34.
    • (2001) Pharmacol. Ther , vol.91 , pp. 1-34
    • Yue, J.1    Mulder, K.M.2
  • 46
    • 34948821871 scopus 로고    scopus 로고
    • Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells
    • Zhong, L., Georgia, S. Tschen, S. I., Nakayama, K. and Bhushan, A. (2007) Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. J. Clin. Invest. 117; 2869-2876.
    • (2007) J. Clin. Invest , vol.117 , pp. 2869-2876
    • Zhong, L.1    Georgia, S.2    Tschen, S.I.3    Nakayama, K.4    Bhushan, A.5


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