Controlled delivery for neuro-bionic devices

Advanced Drug Delivery Reviews

Volumn 65, Issue 4, 2013, Pages 559-569

  Yue, Zhilian ^a,b   Moulton, Simon E ^a   Cook, Mark ^a,c,d   O'Leary, Stephen ^e   Wallace, Gordon G ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b HEARing CRC   (Australia)

^c ST VINCENT S HOSPITAL   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e ROYAL VICTORIAN EYE AND EAR HOSPITAL   (Australia)

Author keywords

Controlled release; Drug eluting coatings; Electrode neural interfacing; Foreign body response; Nerve preservation; Neuro bionics; Organic conductive polymers

Indexed keywords

CONDUCTIVE POLYMER; CONTROLLED RELEASE; ELECTRODE-NEURAL INTERFACING; FOREIGN BODY RESPONSE; NEURO-BIONICS;

BIOMIMETICS; BIONICS; DRUG DELIVERY; PLASTIC COATINGS; TISSUE;

ORGANIC POLYMERS;

ALPHA INTERMEDIN; ANTIINFLAMMATORY AGENT; BIOACTIVE MOLECULE; BRAIN DERIVED NEUROTROPHIC FACTOR; DEXAMETHASONE; DRUG; FIBRONECTIN; LAMININ; NEUROACTIVE MOLECULE; NEUROTROPHIN 3; ORGANIC CONDUCTIVE POLYMER; POLYMER; PYROXYLIN; SILICON; UNCLASSIFIED DRUG;

BIOCOMPATIBILITY; COCHLEA PROSTHESIS; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; ELECTRODE; HUMAN; HYDROGEL; IMPLANT; MATERIAL COATING; MEDICAL DEVICE; NERVE CELL; NERVE CONDUCTION; NERVE FIBER GROWTH; NEURO BIONIC DEVICE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TISSUE REACTION;

BIOENGINEERING; DRUG DELIVERY SYSTEMS; ELECTRODES, IMPLANTED; HUMANS; POLYMERS;

EID: 84877043675     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2012.06.002     Document Type: Review

References (90)

1. Davis K.A., Sturges B.K., Vite C.H., Ruedebusch V., Worrell G., Gardner A.B., Leyde K., Sheffield W.D., Litt B. A novel implanted device to wirelessly record and analyze continuous intracranial canine EEG. Epilepsy Res. 2011, 96:116-122.
2. Boockvar J.A., Telfeian A., Baltuch G.H., Skolnick B., Simuni T., Stern M., Schmidt M.L., Trojanowski J.Q. Long-term deep brain stimulation in a patient with essential tremor: clinical response and postmortem correlation with stimulator termination sites in ventral thalamus. J. Neurosurg. 2000, 93:140-144.
3. Wise K.D. Silicon microsystems for neuroscience and neural prostheses: interfacing with the central nervous system at the cellular level. IEEE Eng. Med. Biol. Mag. 2005, 24:22-29.
4. Uthman B.M., Wilder B.J., Hammond E.J., Reid S.A. Efficacy and safety of vagus nerve stimulation in patients with complex partial seizures. Epilepsia 1990, 31(Suppl. 2):44-50.
5. Gildenberg P.L. History of electrical neuromodulation for chronic pain. Pain Med. 2006, 7:S7-S13.
6. Yakovlev A.E., Resch B.E., Karasev S.A. Treatment of cancer-related chest wall pain using spinal cord stimulation. Am J Hosp Palliat Care 2010, 27:552-556.
7. Frazier O.H., Corry P.M. Induction of hyperthermia using implanted electrodes. Cancer Res. 1984, 44:4864s-4866s. (Suppl.).
8. Maleki T., Cao N., Song S.H., Kao C., Ko S.-C., Ziaie B. An ultrasonically powered implantable micro-oxygen generator (IMOG). IEEE Trans. Biomed. Eng. 2011, 58:3104-3111.
9. Clark G.M. Cochlear Implants: Fundamentals and Applications 2003, Spinger-Verlag, New York.
10. Humayun M.S., Weiland J.D., Fujii G.Y., Greenberg R., Williamson R., Little J., Mech B., Cimmarusti V., Van Boemel G., Dagnelie G., de Juan E.J. Visual perception in a blind subject with a chronic microelectronic retinal prosthesis. Vision Res. 2003, 43:2573-2581.
11. Dobelle W.H., Mladejovsky M.G., Girvin J.P. Artificial vision for the blind: electrical stimulation of visual cortex offers hope for a functional prosthesis. Science 1974, 183:440-444.
12. O'Doherty J.E., Lebedev A.M., Ifft P.J., Zhuang K.Z., Shokur S., Bleuler H., Nicolelis M.A.L. Active tactile exploration using a brain-machine-brain interface. Nature 2001, 476:228-231.
13. Perel S., Schwartz A.B., Spalding M.C., Velliste M., Whitford A.S. Cortical control of a prosthetic arm for self-feeding. Nature 2008, 453:1098-1101.
14. Fetz E.E., Moritz C.T., Perlmutter S.I. Direct control of paralysed muscles by cortical neurons. Nature 2008, 456:639-643.
15. Hochberg L.R., Serruya M.D., Friehs G.M., Mukand J.A., Saleh M., Caplan A.H., Branner A., Chen D., Penn R.D., Donoghue J.P. Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature 2006, 442:164-171.
16. Wallace G.G., Moulton S.E., Clark G.M. Electrode-cellular interface. Science 2009, 324:185-186.
17. Norman S.A. Technology insight: future neuroprosthetic therapies for disorders of the nervous system. Nat. Clin. Pract. Neurol. 2007, 3:444-452.
18. Polikov V.S., Tresco P.A., Reichert W.M. Response of brain tissue to chronically implanted neural electrodes. J. Neurosci. Methods 2005, 148:1-18.
19. Shepherd R.K. Special issues on medical bionics. J. Neural Eng. 2009, 6:060201.
20. Veraart C., Duret F., Brelen M., Oozeer M., Delbeke J. Vision rehabilitation in the case of blindness. Expert Rev. Med. Devices 2004, 1:139-153.
21. Zhong Y., Bellamkonda R.V. Controlled release of anti-inflammatory agent α-MSH from neural implants. J. Control. Release 2005, 106:309-318.
22. Zhong Y., McConnell G.C., Ross J.D., DeWeerth S.P., Bellamkonda R.V. A novel dexamethasone-releasing, anti-inflammatory coating for neural implants, Proceeding of the 2nd International IEEE EMBS Conference on Neural Engineering 2005, Arlington, USA, pp. 522-525.
23. Zhong Y., Bellamkonda R.V. Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes. Brain Res. 2007, 1148:15-27.
24. Kim D.H., Martin D.C. Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery. Biomaterials 2006, 27:3031-3037.
25. Mercanzini A., Reddy S.T., Velluto D., Colin P., Maillard A., Bensadoun J.-C., Hubbell J.A., Renaud P. Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses. J. Control. Release 2010, 145:196-202.
26. Winter J.O., Cogan S.F., Rizzo J.F. Neurotrophin-eluting hydrogel coatings for neural stimulating electrodes. J. Biomed. Mater. Res. B Appl. Biomater. 2007, 81:551-563.
27. Winter J.O., Gokhale M., Jensen R.J., Cogan S.F., Rizzo J.F. Tissue engineering applied to the retinal prosthesis: neurotrophin-eluting hydrogel coatings. Mater. Sci. Eng. C Mater. Biol. Appl. 2008, 28:448-453.
28. Rao S.S., Han N., Winter J.O. Polylysine-modified PEG-based hydrogels to enhance the neuro-electrode interface. J. Biomater. Sci. 2011, 22:611-625.
29. Han N., Rao S.S., Johnson J., Parikh K.S., Bradly P.A., Lannutti J.J., Winter J.O. Hydrogel-electrospun fiber mat composite coating for neural prostheses. Front. Neuroenerg. 2011, 4:2.
30. Jun S.B., Hynd M.R., Dowell-Mefin N.M., Al-Kofahi Y., Roysam B., Shain W., Kim S.J. Modulation of cultured neural networks using neurotrophin release from hydrogel coated microelectrode arrays. J. Neural Eng. 2008, 5:203-213.
31. Jhaveri S.J., Hynd M.R., Dowell-Mefin N.M., Turner J.N., Shain W., Ober C.K. Release of nerve growth factor from HEMA hydrogel-coated substrates and its effect on the differentiation of neural cells. Biomacromolecules 2009, 10:174-183.
32. Chen J., Wise K.D., Hetke J.F., Bledsoe S.C. A multichannel neural probe for selective chemical delivery at the cellular level. IEEE Trans. Biomed. Eng. 1997, 44:760-769.
33. Retterer S.T., Smith K.L., Bjornsson C.S., Neeves K.B., Spence A.J.H., Turner J.N., Shain W., Isaacson M.S. Model neural prostheses with integrated microfluidics: a potential intervention strategy for controlling reactive cell and tissue responses. IEEE Trans. Biomed. Eng. 2004, 51:2063-2073.
34. Takeuchi S., Ziegler D., Yoshida Y., Mabuchi K., Suzuki T. Parylene flexible neural probes integrated with microfluidic channels. Lab. Chip 2005, 5:519-523.
35. Ziegler D., Suzuki T., Takeuchi S. Fabrication of flexible neural probes with built-in microfluidic channels by thermal bonding of parylene. J. Microelectromech. Syst. 2006, 15:1477-1482.
36. Shepherd R.K., Xu J. A multichannel scala tympani electrode array incorporating a drug delivery system for chronic intracochlear infusion. Hear. Res. 2002, 172:92-98.
37. Paasche G., Gibson P., Averbeck T., Becker H., Lenarz T., Stöver T. Technical report: modification of a cochlear implant electrode for drug delivery to the inner ear. Otol. Neurotol. 2003, 24:222-227.
38. Hochmair I., Nopp P., Jolly C., Schmidt M., Schöβer H., Garnham C. MED-EL cochlear implants: state of the art and a glimpse into the future. Trends Amplif. 2006, 10:201-220.
39. Rebscher S.J., Hetherington A.M., Snyder R.L., Leake P.A., Bonham B.H. Design and fabrication of multichannel cochlear implants for animal research. J. Neurosci. Methods 2007, 166:1-12.
40. Thompson B.C., Moulton S.E., Ding J., Richardson R., Cameron A., O'Leary S., Wallace G.G., Clark G.M. Optimising the incorporation and release of a neurotrophic factor using conducting polymers. J. Control. Release 2006, 116:285-294.
41. Richardson R.T., Thompson B., Moulton S., Newbold C., Lum M.G., Cameron A., Wallace G., Kapsa R., Clark G., O'Leary S. The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons. Biomaterials 2007, 28:513-523.
42. Evans A.J., Thompson B.C., Wallace G.G., Millard R., O'Leary S.J., Clark G.M., Kapsa R.K., Richardson R.T. Promoting neurite outgrowth from spiral ganglion neuron explants using polypyrrole/BDNF-coated electrodes. J. Biomed. Mater. Res. A 2009, 91:241-250.
43. Richardson R.T., Wise A.K., Thompson B.C., Flynn B.O., Atkinson P.J., Fretwell N.J., Fallon J.B., Wallace G.G., Kapsa R.K., Clark G.M., O'Leary S.J. Polypyrrole-coated electrode for the delivery of charge and neurotrophins to cochlea neurons. Biomaterials 2009, 30:2614-2624.
44. Thompson B.C., Moulton S.E., Richardson R.T., Wallace G.G. Effect of the dopant anion in polypyrrole on nerve growth and release of a neurotrophic protein. Biomaterials 2011, 32:3822-3831.
45. Wadhwa R., Lagenaur C.F., Cui X.T. Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode. J. Control. Release 2006, 110:531-541.
46. Abidian M.R., Kim D.H., Martin D.C. Conducting-polymer nanotubes for controlled drug release. Adv. Mater. 2006, 18:405-409.
47. Abidian M.R., Ludwig K.A., Marzullo T.C., Martin D.C., Kipke D.R. Interfacing conducting polymer nanotubes with the central nervous system: chronic neural recording using poly(3,4-ethylenedioxythiophene) nanotubes. Adv. Mater. 2009, 21:3764-3770.
48. Luo X., Matranga C., Tan S., Alba N., Cui X.T. Carbon nanotube nanoreservior for controlled release of anti-inflammatory dexamethasone. Biomaterials 2011, 32:6316-6323.
49. Kim D.H., Wiler J.A., Anderson D.J., Kipke D.R., Martin D.C. Conducting polymers on hydrogel-coated neural electrode provide sensitive neural recording in auditory cortex. Acta Biomater. 2010, 6:57-62.
50. Chikar J.A., Hendricks J.L., Richardson-Burns S.M., Raphael Y., Pfingst B.E., Martin D.C. The use of a dual PEDOT and GRD-functionalized alginate hydrogel coating to provide sustained drug delivery and improved cochlear implant function. Biomaterials 2012, 33:1982-1990.
51. Kwon G., Naito M., Yokoyama M., Okano T., Sakurai Y., Kataoka K. Block copolymer micelles for drug delivery: loading and release of doxorubicin. J. Control. Release 1997, 48:195-201.
52. Retterer S.T., Smoth K.L., Bjornsson C.S., Turner J.N., Isaacson M.S., Shain W. Constant pressure fluid infusion into rat neocortex from implantable microfluidic devices. J. Neural Eng. 2008, 5:385-391.
53. Pearce T.M., Williams J.J., Kruzel S.P., Gidden M.J., Williams J.C. Dynamic control of extracellular environment in in vitro neural recording systems. IEEE Trans. Neural Syst. Rehabil. Eng. 2005, 13:207-212.
54. Neeves K.B., Lo C.T., Foley C.P., Saltzman W.M., Olbricht W.L. Fabrication and characterisation of microfluidic probes for convection enhanced drug delivery. J. Control. Release 2006, 111:252-262.
55. Passche G., Bögel L., Leinung M., Lenarz T., Stöver T. Substance distribution in a cochlear model using different pump rates for cochlear implant drug delivery electrode prototypes. Hear. Res. 2006, 212:74-82.
56. Stöver T., Passche G., Lenarz T. Development of a drug delivery device: using the femtosecond laser to modify cochlear implant electrodes. Cochlear Implants Int. 2007, 8:38-52.
57. Williams J.C., Holecko M.M., Massia S.P., Rousche P., Kipke D.R. Multi-site incorporation of bioactive matrices into MEMS-based neural probes. J. Neural Eng. 2005, 2:L23-L278.
58. Ghasemi-Mobarakeh L., Prabhakaran M.P., Morshed M., Nasr-Esfahani M.H., Baharvand H., Kiani S., Al-Deyab S., Ramakrishna S. Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering. J. Tissue Eng. Regen. Med. 2011, 5:e17-e35.
59. Huang L., Hu J., Lang L., Wang X., Zhang P., Jing X., Wang X., Chen X., Lelkes P.I., MacDiarmid A.G., Wei Y. Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer. Biomaterials 2007, 28:1741-1751.
60. Rivers T.J., Hudson T.W., Schmidt C.W. Synthesis of a novel biodegradable electrically conducting polymer for biomedical applications. Adv. Funct. Mater. 2002, 12:33-37.
61. Shi G., Rouabhia M., Meng S., et al. Electrical stimulation enhances viability of human cutaneous fibroblasts on conductive biodegradable substrates. J. Biomed. Mater. Res. A 2007, 84A:1026-1037.
62. George P.M., LaVan D.A., Burdick J.A., Chen C.-Y., Liang E., Langer R. Electrically controlled drug delivery from biotin-doped conductive polypyrrole. Adv. Mater. 2006, 18:577-581.
63. Schmidt C.E., Shastri V.R., Vacanti J.P., Langer R. Stimulation of neurite outgrowth using an electrically conducting polymer. Proc. Natl. Acad. Sci. U. S. A 1997, 94:8948-8953.
64. Richardson R.T., Thompson B., Moulton S., Newbold C., Lum M.G., Cameron A. The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons. Biomaterials 2007, 28:513-523.
65. Zhang L., Stauffer W.R., Jane E.P., Sammak P.J., Cui X.T. Enhanced differentiation of embryonic and neural stem cells to neuronal fates on laminin peptides doped polypyrrole. Macromol. Biosci. 2010, 10:1456-1464.
66. George P.M., Lyckman A.W., LaVan D.A., Hegde A., Leung Y., Avasare R., Testa C., Alexander P.M., Langer R., Sur M. Fabrication and biocompatibility of polypyrrole implants suitable for neural prosthetics. Biomaterials 2005, 26:3511-3519.
67. Asplund M., Thaning E., Lundberg J., Sandberg-Nordqvist A.C., Kostyszyn B., Inganäs O., Von Holst H. Toxicity evaluation of PEDOT/biomolecular composites intended for neural communication electrodes. Biomed. Mater. 2009, 4:045009.
68. Lee J.Y., Bashur C.A., Goldstein A.S., Schmidt C.E. Polypyrrole-coated electrospun PLGA nanofibers for neural tissue applications. Biomaterials 2009, 30:4325-4335.
69. Quigley A.F., Razal J.M., Thompson B.C., Moulton S.E., Kita M., Kennedy E.L., Clark G.M., Wallace G.G., Kapsa R.M.I. A conducting-polymer platform with biodegradable fibers for stimulation and guidance of axonal growth. Adv. Mater. 2009, 21:4393-4397.
70. Lee J.Y., Lee J.W., Schmidt C.E. Neuroactive conducting scaffolds: nerve growth factor conjugation on active ester functionalized polypyrrole. J. R. Soc. Interface 2009, 6:801-810.
71. Anthony G.-E. Electroconductive hydrogels: synthesis, characterization and biomedical applications. Biomaterials 2010, 31:2701-2716.
72. Chen G.Z., Shaffer M.S.P., Coleby D., Dixon G., Zhou W., Fray D.J., Windle A.H. Carbon nanotube and polypyrrole composites: coating and doping. Adv. Mater. 2000, 12:522-526.
73. Lu Y., Li T., Zhao X., Li M., Cao Y., Yang H., Duan Y.Y. Electrodeposited polypyrrole/carbon nanotubes composite films electrodes for neural interfaces. Biomaterials 2010, 31:5169-5181.
74. Luo X., Weaver C.L., Zhou D.D., Greenberg R., Cui X.T. Highly stable carbon nanotube doped poly(3,4-ethylenedioxythiophene) for chronic neural stimulation. Biomaterials 2011, 32:5551-5557.
75. Cui X.T., Zhou D.D. Poly (3,4-ethylenedioxythiophene) for chronic neural stimulation. IEEE Trans. Neural Syst. Rehabil. Eng. 2007, 15:502-508.
76. Jan E., Hendricks J.L., Husaini V., Richardson-Burns S.M., Sereno A., Martin D.C., Kotov N.A. Layered carbon nanotube-polyelectrolyte electrodes outperform traditional neural interface materials. Nano Lett. 2009, 9:4012-4018.
77. Thompson B.C., Richardson R.T., Moulton S.E., Evans A.J., O'Leary S., Clark G.M., Wallace G.G. Conducting polymers, dual neurotrophins and pulsed electrical stimulation - dramatic effects on neurite outgrowth. J. Control. Release 2010, 141:161-167.
78. Shepherd R.K., Coco A., Epp S.B. Neurotrophins and electrical stimulation for protection and repair of spiral ganglion neurons following sensorineural hearing loss. Hear. Res. 2008, 242:100-109.
79. Chikar J.A., Colesa D.J., Swiderski D.L., Polo A.D., Rapael Y., Pfingst B.E. Over-expression of BDNF by adenovirus with concurrent electrical stimulation improves cochlear implant thresholds and survival of auditory neurons. Hear. Res. 2008, 245:24-34.
80. He W., Bellamkonda R.V. Nanoscale neuro-integrative coatings for neural implants. Biomaterials 2005, 26:2983-2990.
81. Marin C., Fernández E. Biocompatibility of intracortical microelectrodes: current status and future prospects. Front. Neuroenerg. 2010, 3:8.
82. Leach J.B., Achyuta A.K.H., Murthy S.K. Bridging the divide between neuroprosthetic design, tissue engineering and neurobiology. Front. Neuroenerg. 2010, 2:18.
83. Liu X., Yue Z., Higgins M.J., Wallace G.G. Conducting polymers with immobilized fibrillar collagen for enhanced neural interfacing. Biomaterials 2011, 32:7309-7317.
84. Yue Z., Liu X., Molino P., Wallace G.G. Bio-functionalization of polydimethylsiloxane with hyaluronic acid and hyaluronic acid-collagen conjugate for neural interfacing. Biomaterials 2011, 32:4714-4724.
85. Cui X., Lee V.A., Raphael Y., Wiler J.A., Hetke J.F., Anderson D.J., Martin D.C. Surface modification of neural recording electrodes with conducting polymer/biomolecule blends. J. Biomed. Mater. Res. 2001, 56:261-272.
86. Stauffer W.R., Cui X.T. Polypyrrole doped with 2 peptide sequences from laminin. Biomaterials 2006, 27:2405-2413.
87. Kim D.H., Abidian M., Martin D.C. Conducting polymers grown in hydrogel scaffolds coated on neural prosthetic devices. J. Biomed. Mater. Res. 2004, 71A:577-585.
88. Abidian M.R., Martin D.C. Multifunctional nanobiomaterials for neural interfaces. Adv. Funct. Mater. 2009, 19:573-585.
89. Green R.A., Baek S., Poole-Warren L.A., Martens P.J. Conducting polymer-hydrogels for medical electrode application. Sci. Technol. Adv. Mater. 2010, 11:014107.
90. Kim B.C., Spinks G.M., Wallace G.G. Electroformation of conducting polymers in a hydrogel supported matrix. Polymer 2000, 41:1783-1790.