Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses

Journal of Controlled Release

Volumn 145, Issue 3, 2010, Pages 196-202

  Mercanzini, André ^a   Reddy, Sai T ^a,b   Velluto, Diana ^a,b   Colin, Philippe ^a,c   Maillard, Anne ^a,c   Bensadoun, Jean Charles ^a,c   Hubbell, Jeffrey A ^a,b   Renaud, Philippe ^a  

^a EPFL   (Switzerland)

^b Laboratory for Regenerative Medicine and Pharmacobiology   (Switzerland)

^c Neurodegenerative Diseases Laboratory   (Switzerland)

Author keywords

Microfabrication; Nanoparticles; Neuroprosthesis

Indexed keywords

ANTI-INFLAMMATORY DRUGS; COATING PROCESS; CONTROL DEVICE; CONTROLLED RELEASE; DEXAMETHASONES; ELECTRICAL IMPEDANCE SPECTROSCOPY; ELECTRODE SURFACES; IMPLANT INTERFACES; MATRIX; MICROFABRICATED; NEURO-PROSTHESIS; NEUROPROSTHESES; TISSUE REACTIONS; TISSUE RESPONSE;

ETHYLENE; MICROANALYSIS; MICROFABRICATION; MICROMACHINING; NANOPARTICLES; PLATINUM; POLYETHYLENE OXIDES; POLYIMIDES; PROPYLENE; TISSUE;

COATINGS;

DEXAMETHASONE; MACROGOL; NANOPARTICLE; PLATINUM; POLOXAMER; POLY(PROPYLENE SULFIDE); POLYIMIDE; POLYPROPYLENE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; MACROGOL DERIVATIVE; POLYMER; SULFIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED RELEASE FORMULATION; DRUG COATING; DRUG DELIVERY SYSTEM; FEMALE; HISTOLOGY; IMPEDANCE; IMPLANTATION; INFLAMMATION; NEUROPROSTHESIS; NONHUMAN; PRIORITY JOURNAL; PROSTHESIS; RAT; RELIABILITY; SPECTROSCOPY; TISSUE REACTION; ANIMAL; BRAIN; CHEMISTRY; ELECTRODE IMPLANT; METABOLISM; MICROELECTRODE; PROCEDURES; PROSTHESES AND ORTHOSES; ULTRASTRUCTURE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BRAIN; DEXAMETHASONE; DRUG DELIVERY SYSTEMS; ELECTRIC IMPEDANCE; ELECTRODES, IMPLANTED; FEMALE; MICROELECTRODES; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYMERS; PROSTHESES AND IMPLANTS; RATS; SULFIDES;

EID: 77954316270     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.04.025     Document Type: Article

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