Technical report: Modification of a cochlear implant electrode for drug delivery to the inner ear

Otology and Neurotology

Volumn 24, Issue 2, 2003, Pages 222-227

  Paasche, G ^a   Gibson, P ^a   Averbeck, T ^a   Becker, H ^b   Lenarz, T ^a   Stöver, Timo ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Research and Technology Labs   (Australia)

Author keywords

Contour electrode; Electrode modification; Fluid leakage; Inner ear drug delivery; Osmotic pump

Indexed keywords

ARTICLE; COCHLEA PROSTHESIS; DRUG DELIVERY SYSTEM; ELECTRODE; ELECTROSTIMULATION; FORCE; INNER EAR DISEASE; OSMOTIC PUMP; PRIORITY JOURNAL; TEMPORAL BONE; TREATMENT PLANNING;

COCHLEAR IMPLANTATION; DRUG DELIVERY SYSTEMS; EAR DISEASES; EQUIPMENT DESIGN; FEASIBILITY STUDIES; HUMANS; TEMPORAL BONE;

EID: 0037339944     PISSN: 15317129     EISSN: None     Source Type: Journal    
DOI: 10.1097/00129492-200303000-00016     Document Type: Article

References (20)

1. Strauss-Schier A, Battmer RD, Rost U, et al. Speech-tracking results for adults. Ann Otol Rhinol Laryngol Suppl 1995;166:88-91.
2. van Dijk JE, van Olphen AF, Langereis MC, et al. Predictors of cochlear implant performance. Audiology 1999;38:109-16.
3. Manrique M, Cervera-Paz FJ, Huarte A, et al. Cerebral auditory plasticity and cochlear implants. Int J Pediatr Otorhinolaryngol 1999;49(Suppl 1):S193-7.
4. Lenarz T, Hartrampf R, Battmer RD, et al. Cochlear implant management of young children [in German]. Laryngorhinootologie 1996;75:719-26.
5. Pfingst BE, Sutton D. Relation of cochlear implant function to histopathology in monkeys. Ann N Y Acad Sci 1983;405:224-39.
6. Incesulu A, Nadol JB Jr. Correlation of acoustic threshold measures and spiral ganglion cell survival in severe to profound sensorineural hearing loss: Implications for cochlear implantations. Ann Otol Rhinol Laryngol 1998;107(11 Pt 1):906-11.
7. Spoendlin H. Factors inducing retrograde degeneration of the cochlear nerve. Ann Otol Rhinol Laryngol Suppl 1984;112:76-82.
8. Lenarz T, Kuzma J, Weber BP, et al. New Clarion electrode with positioner: Insertion studies. Ann Otol Rhinol Laryngol Suppl 2000;185:16-8.
9. Tykocinski M, Saunders E, Cohen LT, et al. The contour electrode array: safety study and initial patient trials of a new perimodiolar design. Otol Neurotol 2001:22:33-41.
10. Yagi M, Kanzaki S, Kawamoto K, et al. Spiral ganglion neurons are protected from degeneration by GDNF gene therapy. J Assoc Res Otolaryngol 2000;1:315-25.
11. Miller JM, Chi DH, O'Keeffe LJ, et al. Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss. Int J Dev Neurosci 1997;15:631-43.
12. Yagi M, Magal E, Sheng Z, et al. Hair cell protection from aminoglycoside ototoxicity by adenovirus-mediated overexpression of glial cell line-derived neurotrophic factor. Hum Gene Ther 1999;10:813-23.
13. Shoji F, Miller AL, Mitchell A, et al. Differential protective effects of neurotrophins in the attenuation of noise-induced hair cell loss. Hear Res 2000;146:134-42.
14. Dazert S, Kim D, Luo L, et al. Focal delivery of fibroblast growth factor-1 by transfected cells induces spiral ganglion neurite targeting in vitro. J Cell Physiol 1998;177:123-9.
15. Marzella PL, Gillespie LN, Clark GM, et al. The neurotrophins act synergistically with LIF and members of the TGF-beta superfamily to promote the survival of spiral ganglia neurons in vitro. Hear Res 1999;138:73-80.
16. Stöver T, Yagi M, Raphael Y. Transduction of the contralateral ear after adenovirus-mediated cochlear gene transfer. Gene Ther 2000;7:377-83.
17. Brown JN, Miller JM, Altschuler RA, et al. Osmotic pump implant for chronic infusion of drugs into the inner ear. Hear Res 1993;70:167-72.
18. Prieskorn DM, Miller JM. Technical report: chronic and acute intracochlear infusion in rodents. Hear Res 2000;140:212-5.
19. Salt AN, Ma Y. Quantification of solute entry into cochlear perilymph through the round window membrane. Hear Res 2001;154:88-97.
20. Rogowski M, Reiss G, Lehnhardt E. Morphologic study of the guinea pig cochlea after cochlear implantation using the "soft surgery" technique. Ann Otol Rhinol Laryngol Suppl 1995;166:434-6.