Vision rehabilitation in the case of blindness

Expert Review of Medical Devices

Volumn 1, Issue 1, 2004, Pages 139-153

  Veraart, Claude ^a   Duret, Florence ^a   Brelén, Mårten ^a   Oozeer, Medhy ^a   Delbeke, Jean ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Blindness; Macular degeneration; Rehabilitation engineering; Retinitis Pigmentosa; Sensory substitution; Visual development; Visual prosthesis

Indexed keywords

BIOCOMPATIBILITY; BLINDNESS; BRAIN DEPTH STIMULATION; CATARACT; ELECTRODE; GLAUCOMA; HUMAN; MATHEMATICAL MODEL; MEDICAL ETHICS; NERVE STIMULATION; NONHUMAN; OCCIPITAL CORTEX; ONSET AGE; OPTIC NERVE; PREVALENCE; REHABILITATION CENTER; RETINA MACULA DEGENERATION; RETINITIS PIGMENTOSA; RETINOPATHY; REVIEW; SAFETY; SIMULATION; SOCIAL PSYCHOLOGY; STARGARDT DISEASE; TRACHOMA; VISUAL ACUITY; VISUAL AID; VISUAL PROSTHESIS;

EID: 13544250804     PISSN: 17434440     EISSN: None     Source Type: Journal    
DOI: 10.1586/17434440.1.1.139     Document Type: Review

References (129)

1. Thylefors B, Negrel AD, Pararajasegaram R. Epidemiologic aspects of global blindness prevention. Curr. Opin. Ophthalmol. 3(6), 824-834 (1992).
2. Thylefors B, Negrel AD, Pararajasegaram R, Dadzie KY. Global data on blindness. Bull. World Health Organ. 73(1), 115-121 (1995 ).
3. Thylefors B. Avoidable blindness. Bull World Health Organ. 77(6), 453 (1999).
4. Kocur I, Resnikoff S. Visual impairment and blindness in Europe and their prevention. Br. J. Ophthalmol. 86(7), 716-722 (2002).
5. Easty LE, Sparrow JM. Oxford textbook of Ophthalmology. Oxford University Press, Oxford, UK (1999).
6. Klein R, Klein BE, Linton KL. Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology 99(6), 933-943 (1992).
7. Rakic P, Bourgeois JP, Eckenhoff MF, Zecevic N, Goldman-Rakic PS. Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex. Science 232(4747), 232-235 (1986).
8. Blakemore C, Van Sluyters RC. Reversal of the physiological effects of monocular deprivation in kittens: further evidence for a sensitive period. J. Physiol. 237(1), 195-216 (1974).
9. Buisseret P, Imbert M. Visual cortical cells: their developmental properties in normal and dark reared kittens. J. Physiol (Lond). 255(2), 511-525 (1976).
10. Wanet-Defalque MC, Veraart C, De Volder AL et al. High metabolic activity in the visual cortex of early blind human subjects. Brain Res. 446(2), 369-373 (1988).
11. Veraart C, De Volder AG, Wanet-Defalque MC et al. Glucose utilization in human visual cortex is abnormally elevated in blindness of early onset but decreased in blindness of late onset. Brain Res. 510(1), 115-121 (1990).
12. Berardi N, Pizzorusso T, Maffei L. Critical periods during sensory development. Curr. Opin. Neurobiol. 10(1), 138-145 (2000).
13. De Volder AG, Bol A, Blin J et al. Brain energy metabolism in early blind subjects: neural activity in the visual cortex. Brain Res. 750(1-2), 235-244 (1997).
14. Cynader M, Mitchell DE. Prolonged sensitivity to monocular deprivation in dark-reared cats. J. Neurophysiol. 43(4), 1026-1040 (1980).
15. Lee WC, Nedivi E. Extended plasticity of visual cortex in dark-reared animals may result from prolonged expression of cpg15-like genes. J. Neurosci. 22(5), 1807-1815 (2002).
16. Sadato N, Pascual-Leone A, Grafman J et al. Activation of the primary visual cortex by Braille reading in blind subjects. Nature 380(6574), 526-528 (1996).
17. Buchel C, Price C, Frackowiak RS, Friston K. Different activation patterns in the visual cortex of late and congenitally blind subjects. Brain 121(3), 409-419 (1998).
18. Weeks R, Horwitz B, Aziz-Sultan A et al. A positron emission tomographic study of auditory localization in the congenitally blind. J. Neurosci. 20(7), 2664-2672 (2000).
19. De Volder A, Toyama A, Kimura M et al. Auditory triggered mental imagery of shape involves visual association areas in early blind humans. Neuroimage 14, 129-139 (2001).
20. Vanlierde A, Devolder A, Wanet-Defalque MC, Veraart C. occipito-parietal cortex activation during visuo-spatial imagery in early blind humans. Neuroimage 19(3), 698-709 (2003).
21. Arno P, De Volder AG, Vanlierde A et al. Occipital activation by pattern recognition in the early blind using auditory substitution of vision. Neuroimage 13(4), 632-645 (2001).
22. Renier L, Collignon O, Tranduy D et al. Visual cortex activation in early blind and sighted subjects using an auditory visual substitution device to perceive depth. Proceedings of 10th annual meeting of the Organization for Human Brain Mapping. Budapest, Hungary, TU 364 (2004).
23. Lessard N, Pare M, Lepore F, Lassonde M. Early-blind human subjects localize sound sources better than sighted subjects. Nature 395(6699), 278-280 (1998).
24. Goldreich D, Kanics IM. Tactile acuity is enhanced in blindness. J. Neurosci. 23(8), 3439-3445 (2003).
25. Collignon O, Renier L, Bruyer R. Thanduy D, Veraart C. Crossmodal compensation for spatial attention in early blind subjects. Proceeding of the 5th Annual meeting of the International Multisensory Research Forum (IMRF). Barcelone, Spain (2004).
26. Theoret H, Merabet L, Pascual-Leone A. Behavioral and neuroplastic changes in the blind: evidence for functionally relevant cross-modal interactions. J. Physiol. In press (2004).
27. Thinus-Blanc C, Gaunet F. Representation of space in blind persons: vision as a spatial sense? Psychol. Bull. 121(1), 20-42 (1997).
28. Hoover RE. The cane as a travel aid. In: Blindness. Zahl PA (Ed.), Princeton University Press, Princeton, USA (1950).
29. Kay L. A sonar aid to enhance spatial perception of the blind: engineering, design and evaluation. The Radio and Electronic Engineer 44, 605-627 (1974).
30. Farmer LW. Mobility devices. Bull. Prosthet. Res. 47-118 (1978).
31. Bliss JC. A relatively high-resolution reading aid for the blind. IEEE Trans Man-Machine Sys. 10, 1-9 (1969).
32. Brabyn JA. New developments in mobility and orientation aids for the blind. IEEE Trans Biomed. Eng. 29(4), 285-289 (1982).
33. Massof RW, Rickman DL. Obstacles encountered in the development of the low vision enhancement system. Optom. Vis. Sci. 69(1), 32-41 (1992).
34. Bach-Y-Rita P, Collins CC, Saunders FA, White B, Scadden L. Vision substitution by tactile image projection. Trans. Pac. Coast. Otoophthalmol. Soc. Ann. Meet. 50, 83-91 (1969).
35. Bach-Y-Rita P, Tyler ME. Tongue man-machine interface. Stud. Health Technol. Inform. 70, 17-19 (2000).
36. Capelle C, Trullemans C, Arno P, Veraart C. A real-time experimental prototype for enhancement of vision rehabilitation using auditory substitution. IEEE Trans Biomed Eng. 45(10), 1279-1293 (1998).
37. Veraart C. Neurophysiological approach to the design of visual prostheses: a theoretical discussion. J. Med. Eng. Technol. 13(1-2), 57-62 (1989).
38. Arno P, Capelle C, Wanet-Defalque MC, Catalàn-Ahumada M, Veraart C. Auditory coding of visual patterns for the blind. Perception 28(8), 1013-1029 (1999).
39. Arno P, Vanlierde A, Streel E et al. Auditory substitution of vision: Pattern recognition by the blind. Applied Cognitive Psychology 15(5), 509-519 (2001).
40. Brindley GS, Lewin WS. The sensations produced by electrical stimulation of the visual cortex. J. Physiol. (Lond.) 196(2), 479-493 (1968).
41. Lau D, McGee LH, Zhou S et al. Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2. Invest. Ophthalmol. Vis. Sci. 41(11), 3622-3633 (2000).
42. Acland GM, Aguirre GD, Ray J et al. Gene therapy restores vision in a canine model of childhood blindness. Nature Genet. 28(1), 92-95 (2001).
43. Weleber RG, Kurz DE, Trzupek KM. Treatment of retinal and choroidal degenerations and dystrophies: current status and prospects for gene-based therapy. Ophthalmol. Clin. North Am. 16(4), 583-593 (2003).
44. Yagi T, Ito Y, Kanda H, Tanaka S, Watanabe M, Uchikawa Y. Hybrid retinal implant: Fusion of engineering and neuroscience. Proceedings of the IEEE Int. Conf. on Systems, Man and Cybernetics. IV, 382-385 (1999).
45. Peterman MC, Mehenti NZ, Bilbao KV et al. The Artificial Synapse Chip: a flexible retinal interface based on directed retinal cell growth and neurotransmitter stimulation. Artif. Organs 27(11), 975-985 (2003).
46. Iezzi R, Walraven TL, McAllister JP et al. Biocompatibility of Caging Chromophores for Use in Retinal and Cortical Visual Prostheses. Invest. Ophthalmol. Vis. Sci. 43, E-Abstract 4478 (2002).
47. Graham-Rowe D. Popeye cure for blindness. New Scientist 182(2445), 8 (2004).
48. Gothe J, Brandt SA, Irlbacher K et al. Changes in visual cortex excitability in blind subjects as demonstrated by transcranial magnetic stimulation. Brain 125(3), 479-490 (2002).
49. De Volder AG, Catalàn-Ahumada M, Robert A et al. Changes in occipital cortex activity in early blind humans using a sensory substitution device. Brain Res. 826(1), 128-134 (1999).
50. Collignon O, Lassonde M, Lepore F et al. Functional involvement of ocipital cortex for sound processing in early blind subjects using a sensory substitution prosthesis. Proceedings of The 34th Annual meeting of the Society for Neurosciences. San Diego, USA. In Press (2004).
51. McConkey RA, Koch DB, Osberger MJ, Zimmerman-Phillips S, Kishon-Rabin L. Effect of age at cochlear implantation on auditory skill development in infants and toddlers. Arch. Otolaryngol. Head Neck Surg. 130(5), 570-574 (2004).
52. Zwolan TA, Ashbaugh CM, Alarfaj A et al. Pediatric cochlear implant patient performance as a function of age at implantation. Otol. Neurotol. 25(2), 112-120 (2004).
53. Uhlig CE, Taneri S, Benner FP, Gerding H. Electrical stimulation of the visual system. From empirical approach to visual prostheses (in German). Ophthalmologe 98(11), 1089-1096 (2001).
54. Zrenner E. Will retinal implants restore vision? Science 295(5557), 1022-1025 (2002).
55. Dobelle WH. Artificial vision for the blind by connecting a television camera to the visual cortex. ASAIO J. 46(1), 3-9 (2000 ).
56. Stone JL, Barlow WE, Humayun MS, de Juan E, Jr, Milam AH. Morphometric analysis of macular photoreceptors and ganglion cells in retinas with Retinitis Pigmentosa. Arch. Ophthalmol. 110(11), 1634-1639 (1992).
57. Humayun MS, Propst R. de JE, Jr, McCormick K, Hickingbotham D. Bipolar surface electrical stimulation of the vertebrate retina. Arch. Ophthalmol. 112(1), 110-116 (1994).
58. Rizzo Jf, Socha M, Edell D, Antkowiak B, Brock D. Development of a silicon retinal implant - surgical methods and mechanical design. Invest. Ophthalmol. Vis. Sci. 35(4), 1535-1535 (1994).
59. Chow AY. Electrical stimulation of the rabbit retina with subretinal electrodes and high density micro-photodiode array implants. Invest. Ophthalmol. Vis. Sci. 34 (1993).
60. Zrenner E, Miliczek KD, Gabel VP, et al. The development of subretinal microphotodiodes for replacement of degenerated photoreceptors. Ophthalmic Res. 29(5), 269-280 (1997).
61. Hambrecht FT. Visual prostheses based on direct interfaces with the visual system. Baillieres Clin. Neurol. 4(1), 147-165 (1995).
62. Tanghe SJ, Najafi K, Wise KD. A planar iro multichannel stimulating electrode for use in neural prostheses. Sensors Actuators B-Chemical 1(1-6), 464-467 (1990).
63. Jones KE, Campbell PK, Normann RA. A glass/silicon composite intracortical electrode array. Ann. Biomed. Eng. 20(4), 423-437 (1992).
64. Naples GG, Mortimer JT, Scheiner A, Sweeney JD. A spiral nerve cuff electrode for peripheral nerve stimulation. IEEE Trans. Biomed. Eng. 35(11), 905-916 (1988).
65. Veraart C, Grill WM, Mortimer JT. Selective control of muscle activation with a multipolar nerve cuff electrode. IEEE Trans. Biomed. Eng. 40(7), 640-653 (1993).
66. Veraart C, Raftopoulos C, Mortimer JT et al. Visual sensations produced by optic nerve stimulation using an implanted self-sizing spiral cuff electrode. Brain Res. 813, 181-186 (1998).
67. Troyk P, Bak M, Berg J et al. A model for intracortical visual prosthesis research. Artif. Organs. 27(11), 1005-1015 (2003).
68. Brindley GS. The variability of the human striate cortex. J. Physiol. (Lond.) 225(2), 1P-3P (1972).
69. Schmidt EM, Bak MJ, Hambrecht FT et al. Feasibility of a visual prosthesis for the blind based on intracortical microstimulation of the visual cortex. Brain 119(2), 507-522 (1996).
70. Normann RA, Warren DJ, Ammermuller J, Fernandez E, Guillory S. High-resolution spatiotemporal mapping of visual pathways using multi-electrode arrays. Vision Res. 41 (10-11), 1261-1275 (2001).
71. Kim SY, Sadda S, Pearlman J et al. Morphometric analysis of the macula in eyes with disciform age-related macular degeneration. Retina 22(4), 471-477 (2002).
72. Kim SY, Sadda S, Humayun MS et al. Morphometric analysis of the macula in eyes with geographic atrophy due to age-related macular degeneration. Retina 22(4), 464-470 (2002).
73. Medeiros NE, Curcio CA. Preservation of ganglion cell layer neurons in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 42(3), 795-803 (2001).
74. Humayun MS, de Juan E Jr, Weiland JD et al. Pattern electrical stimulation of the human retina. Vision Res. 39(15), 2569-2576 (1999).
75. Margalit E, Maia M, Weiland JD et al. Retinal prosthesis for the blind. Surv. Ophthalmol. 47(4), 335-356 (2002).
76. Hetling JR, Baig-Silva MS. Neural prostheses for vision: designing a functional interface with retinal neurons. Neurol. Res. 26(1), 21-34 (2004).
77. Delbeke J, Pins D, Michaux G et al. Electrical stimulation of anterior visual pathways in retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 42(1), 291-297 (2001).
78. Zrenner E, Stett A, Weiss S et al. Can subretinal microphotodiodes successfully replace degenerated photoreceptors? Vision Res. 39(15), 2555-2567 (1999).
79. Stett A, Barth W, Weiss S, Haemmerle H, Zrenner E. Electrical multisite stimulation of the isolated chicken retina. Vision Res. 40(13), 1785-1795 (2000).
80. Guenther E, Troger B, Schlosshauer B, Zrenner E. Long-term survival of retinal cell cultures on retinal implant materials. Vision Res. 39(24), 3988-3994 (1999).
81. Chow AY, Pardue MT, Chow VY et al. Implantation of silicon chip microphotodiode arrays into the cat subretinal space. IEEE Trans. Neural Syst. Rehabil. Eng. 9(1), 86-95 (2001).
82. Pardue MT, Stubbs EB Jr, Perlman JI et al. Immunohistochemical studies of the retina following long-term implantation with subretinal microphotodiode arrays. Exp. Eye Res. 73(3), 333-343 (2001).
83. Schwahn HN, Gekeler F, Kohler K et al. Studies on the feasibility of a subretinal visual prosthesis: data from Yucatan micropig and rabbit. Graefes Arch. Clin. Exp. Ophthalmol. 239(12), 961-967 (2001).
84. Chow AY, Chow VY, Packo KH et al. The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa. Arch. Ophthalmol. 122(4), 460-469 (2004).
85. Liu W, Sivaprakasam M, Singh PR, Bashirullah R, Wang G. Electronic visual prosthesis. Artif. Organs 27(11), 986-995 (2003 ).
86. Grumet AE, Wyatt JL Jr, Rizzo JF. Multi-electrode stimulation and recording in the isolated retina. J. Neurosci. Methods 101(1), 31-42 (2000).
87. Schanze T, Wilms M, Eger M, Hesse L, Eckhorn R. Activation zones in cat visual cortex evoked by electrical retina stimulation. Graefes Arch. Clin. Exp. Ophthalmol. 240(11), 947-954 (2002).
88. Wilms M, Eger M, Schanze T, Eckhorn R. Visual resolution with epi-retinal electrical stimulation estimated from activation profiles in cat visual cortex. Vis. Neurosci. 20(5), 543-555 (2003).
89. Majji AB, Humayun MS, Weiland JD et al. Long-term histological and electrophysiological results of an inactive epiretinal electrode array implantation in dogs. Invest. Ophthalmol. Vis. Sci. 40(9), 2073-2081 (1999).
90. Rizzo JF, III, Wyatt J, Loewenstein J, Kelly S, Shire D. Methods and perceptual thresholds for short-term electrical stimulation of human retina with microelectrode arrays. Invest. Ophthalmol. Vis. Sci. 44(12), 5355-5361 (2003).
91. Rizzo JF III, Wyatt J, Loewenstein J, Kelly S, Shire D. Perceptual efficacy of electrical stimulation of human retina with a microelectrode array during short-term surgical trials. Invest. Ophthalmol. Vis. Sci. 44(12), 5362-5369 (2003).
92. Elfar SD, Cottaris NP, Iezzi R, Abrams GW. rapid mapping of cortical multi-electrode arrays and its application for the evaluation of retinal prostheses. Invest. Ophthalmol. Vis. Sci. 45, E-Abstract 3403 (2004).
93. Humayun MS, Weiland JD, Fujii GY et al. Visual perception in a blind subject with a chronic microelectronic retinal prosthesis. Vision Res. 43(24), 2573-2581 (2003).
94. Peterman MC, Noolandi J, Blumenkranz MS, Fishman HA. Fluid flow past an aperture in a microfluidic channel. Anal. Chem. 76(7 , 1850-1856 (2004).
95. Peterman MC, Bloom DM, Lee C et al. Localized neurotransmitter release for use in a prototype retinal interface. Invest. Ophthalmol. Vis. Sci. 44(7), 3144-3149 (2003).
96. Delbeke J, Oozeer M, Veraart C. Position, size and luminosity of phosphenes generated by direct optic nerve stimulation. Vision Res. 43(9), 1091-1102 (2003).
97. Delbeke J, Wanet-Defalque MC, Gerard B et al. The microsystems based visual prosthesis for optic nerve stimulation. Artif. Organs 26(3), 232-234 (2002).
98. Oozeer M, Legat V, Veraart C, Delbeke J. Anodal blocking in selective electrical nerve stimulation. Pflügers Archiv Eur. J. Physiol. 447, R7 (2004).
99. Veraart C, Wanet-Defalque MC, Gérard B, Vanlierde A, Delbeke J. Pattern recognition with the optic nerve visual prosthesis. Artif. Organs 27, 996-1004 (2003).
100. Lambert V, Laloyaux C, Schmitt C, Gérard B, Delbeke J, Veraart C. Localization, discrimination, and grasping of daily life objects with an implanted optic nerve prosthesis. Invest. Ophthalmol. Vis. Sci. 44, E-Abstract 3585 (2003).
101. Duret F, Delbeke J, Gerard B, Veraart C. Strategies of objects recognition performed using a chronically implanted optic nerve prosthesis. Invest. Ophthalmol. Vis. Sci. 45, E-Abstract 4187 (2004).
102. Weiland JD, Anderson DJ. Chronic neural stimulation with thin-film, iridium oxide electrodes. IEEE Trans. Biomed. Eng. 47(7), 911-918 (2000).
103. Brummer SB, Robblee LS, Hambrecht FT. Criteria for selecting electrodes for electrical stimulation: theoretical and practical considerations. Ann. NY Acad. Sci. 405, 159-171 (1983).
104. Weiland JD, Anderson DJ, Humayun MS. In vitro electrical properties for iridium oxide versus titanium nitride stimulating electrodes. IEEE Trans. Biomed. Eng. 49(12), 1574-1579 (2002).
105. Mortimer JT, Agnew WF, Horch K et al. Perspectives on new electrode technology for stimulating peripheral nerves with implantable motor prostheses. IEEE Trans. Rehabil. Eng. 3(2), 145-153 (1995).
106. Shannon RV. A model of safe levels for electrical stimulation. IEEE Trans Biomed Eng. 39(4), 424-426 (1992).
107. McCreery DB, Agnew WF, Yuen TG, Bullara LA. Comparison of neural damage induced by electrical stimulation with faradaic and capacitor electrodes. Ann. Biomed. Eng. 16(5), 463-481 (1988).
108. Agnew WF, McCreery DB, Yuen TG, Bullara LA. Histologic and physiologic evaluation of electrically stimulated peripheral nerve: considerations for the selection of parameters. Ann. Biomed. Eng. 17(1), 39-60 (1989).
109. Xu J, Shepherd RK, Millard RE, Clark GM. Chronic electrical stimulation of the auditory nerve at high stimulus rates: a physiological and histopathological study. Hear. Res. 105(1-2), 1-29 (1997).
110. Yuen TGH, Agnew WF, Bullara LA, McCreery DB. Biocompatibility of electrodes and materials in the central nervous system. In: Neural prostheses. Fundamental studies. Agnew WF, McCreery DB (Eds), Prentice Hall, Englewood Cliffs, NJ, USA, 197-224 (1990).
111. Romero E, Denef JF, Delbeke J, Robert A, Veraart C. Neural morphological effects of long-term implantation of the self-sizing spiral cuff nerve electrode. Med. Biol. Eng. Comput. 39, 90-100 (2001).
112. Vince V, Thil M-A, Veraart C, Colin IM, Delbeke J. Biocompatibility of platinum metallized silicone rubber: in vitro and in vivo evaluation. J. Biomater. Sci. (Polymer Edition) 15(2), 173-188 (2004).
113. Thil M-A, Vince V, Delbeke J, Colin IM. Differential expression of nitric oxide synthase isoforms in the rat sciatic nerve following spiral cuff implantation. Pflügers Archiv Eur. J. Physiol. 447, R7 (2004).
114. Bataille L, Judas D, Rocher P et al. In vitro and in vivo biocompatibility of stainless steel as a function of surface treatments: roughness and surfacing with hydroxyapatite. Rev. Stomatol. Chir. Maxillofac. 98(Suppl. 1), 58-60 (1997).
115. Beard RB, Hung BN, Schmukler R. Biocompatibility considerations at stimulating electrode interfaces. Ann. Biomed. Eng. 20(3), 395-410 (1992).
116. Peachey NS, Chow AY. Subretinal implantation of semiconductor-based photodiodes: progress and challenges. J. Rehabil. Res. Dev. 36(4), 371-376 (1999).
117. Hammerle H, Kobuch K, Kohler K et al. Biostability of micro-photodiode arrays for subretinal implantation. Biomaterials 23(3), 797-804 (2002).
118. Sommerhalder J, Oueghlani E, Bagnoud M et al. Simulation of artificial vision: I. Eccentric reading of isolated words, and perceptual learning. Vision Res. 43(3), 269-283 (2003).
119. Sommerhalder J, Rappaz B, De Haller R et al. Simulation of artificial vision: II. Eccentric reading of full-page text and the learning of this task. Vision Res. 44(14), 1693-1706 (2004).
120. Thompson RW Jr, Barnett GD, Humayun MS, Dagnelie G. Facial recognition using simulated prosthetic pixelized vision. Invest. Ophthalmol. Vis. Sci. 44(11), 5035-5042 (2003).
121. Hayes JS, Yin VT, Piyathaisere D et al. Visually guided performance of simple tasks using simulated prosthetic vision. Artif. Organs 27(11), 1016-1028 (2003).
122. Rattay F, Lutter P, Felix H. A model of the electrically excited human cochlear neuron. I. Contribution of neural substructures to the generation and propagation of spikes. Hear. Res. 153(1-2), 43-63 (2001).
123. Greenberg RJ, Velte TJ, Humayun MS, Scarlatis GN, de Juan E Jr. A computational model of electrical stimulation of the retinal ganglion cell. IEEE Trans. Biomed. Eng. 46(5), 505-514 (1999).
124. Rattay F, Resatz S, Lutter P et al. Mechanisms of electrical stimulation with neural prostheses. Neuromod 6(1), 42-56 (2003).
125. Parrini S, Delbeke J, Legat V, Veraart C. Modeling analysis of human optic nerve fiber excitation based on experimental data. Med. Biol. Eng. Comput. 38(4), 454-464 (2000).
126. Archambeau C, Delbeke J, Veraart C, Verleysen M. Prediction of visual perceptions with artificial neural networks in a visual prosthesis for the blind. Artif. Intell. Med. In Press (2004).
127. Veraart C, Wanet-Defalque MC. Representation of locomotor space by the blind. Percept. Psychophys. 42(2), 132-139 (1987).
128. Cavuoto J. Neural engineering's image problem. IEEE Spectrum 41, 20-25 (2004).
129. Bailey IL, Lovie JE. New design principles for visual acuity letter charts. Am. J. Optom. Physiol. Opt. 53(11), 740-745 (1976).