The use of a dual PEDOT and RGD-functionalized alginate hydrogel coating to provide sustained drug delivery and improved cochlear implant function

Biomaterials

Volumn 33, Issue 7, 2012, Pages 1982-1990

  Chikar, Jennifer A ^a   Hendricks, Jeffrey L ^b,c   Richardson Burns, Sarah M ^b,c   Raphael, Yehoash ^a   Pfingst, Bryan E ^a   Martin, David C ^b,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c Biotectix LLC   (United States)

Author keywords

Alginate; Drug delivery; Electroactive polymer; Growth factor; Hydrogel; Neural prosthesis

Indexed keywords

ALGINATE HYDROGELS; ARGININE-GLYCINE-ASPARTIC ACIDS; AUDITORY NERVES; BIOLOGICAL STABILITY; COCHLEAR IMPLANT USERS; DEVICE DESIGN; DEVICE PERFORMANCE; ELECTRO-ACTIVE POLYMERS; ELECTRODE COATING; ELECTRODE IMPEDANCE; ELECTRODE SIZE; FUNCTIONALIZED; GROWTH FACTOR; HAIR CELLS; IN-VITRO; IN-VIVO; INNER EAR; NEURAL PROSTHESIS; POLY(3 ,4-ETHYLENEDIOXYTHIOPHENE);

ALGINATE; AMINO ACIDS; AUDITION; CONDUCTING POLYMERS; DRUG DELIVERY; FUNCTIONAL POLYMERS; HYDROGELS; PLASTIC COATINGS;

COCHLEAR IMPLANTS;

ALGINIC ACID; ARGINYLGLYCYLASPARTIC ACID; POLY(3,4 ETHYLENEDIOXYTHIOPHENE); POLYMER; RECOMBINANT BRAIN DERIVED NEUROTROPHIC FACTOR; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ACOUSTIC IMPEDANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCHLEA PROSTHESIS; CONTROLLED STUDY; ELECTRIC CURRENT; ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY; IN VITRO STUDY; IN VIVO STUDY; MALE; MATERIAL COATING; MATERIALS TESTING; NONHUMAN; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION;

ALGINATES; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN-DERIVED NEUROTROPHIC FACTOR; COATED MATERIALS, BIOCOMPATIBLE; COCHLEAR IMPLANTATION; COCHLEAR IMPLANTS; COCHLEAR NERVE; DEAFNESS; DRUG DELIVERY SYSTEMS; ELECTROCHEMISTRY; ELECTRODES; GLUCURONIC ACID; GUINEA PIGS; HEXURONIC ACIDS; HUMANS; HYDROGELS; MALE; MATERIALS TESTING; OLIGOPEPTIDES; POLYMERS; SURFACE PROPERTIES;

EID: 84855732800     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.11.052     Document Type: Article

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