Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes

Brain Research

Volumn 1148, Issue 1, 2007, Pages 15-27

  Zhong, Yinghui ^a   Bellamkonda, Ravi V ^a  

^a Emory University   (United States)

Author keywords

Chondroitin sulfate proteoglycan; Coating; Electrode; Glial scar; Inflammation

Indexed keywords

DEXAMETHASONE; PROTEOCHONDROITIN SULFATE; PYROXYLIN; SILICON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN; CELL LOSS; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMPLANTATION; INFLAMMATION; MACROPHAGE; MALE; MATERIAL COATING; MECHANICAL PROBE; MICROGLIA; NERVE CELL; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TISSUE REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTROCYTES; BIOLOGICAL MARKERS; CHONDROITIN SULFATES; COLLODION; DEXAMETHASONE; ECTODYSPLASINS; ELECTRODES, IMPLANTED; ENCEPHALITIS; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; INFUSION PUMPS, IMPLANTABLE; MACROPHAGES; MALE; MICROGLIA; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEUROFILAMENT PROTEINS; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME;

RATTUS;

EID: 34247331898     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.02.024     Document Type: Article

References (56)

1. Alonso G. NG2 proteoglycan-expressing cells of the adult rat brain: possible involvement in the formation of glial scar astrocytes following stab wound. Glia 49 (2005) 318-338
2. Asher R.A., Morgenstern D.A., Fidler P.S., Adcock K.H., Oohira A., Braistead J.E., Levine J.M., Margolis R.U., Rogers J.H., and Fawcett J.W. Neurocan is upregulated in injured brain and in cytokine-treated astrocytes. J. Neurosci. 20 (2000) 2427-2438
3. Biran R., Martin D.C., and Tresco P.A. Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays. Exp. Neurol. 195 (2005) 115-126
4. Bradbury E.J., Moon L.D., Popat R.J., King V.R., Bennett G.S., Patel P.N., Fawcett J.W., and McMahon S.B. Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 416 (2002) 636-640
5. Bruccoleri A., Brown H., and Harry G.J. Cellular localization and temporal elevation of tumor necrosis factor-alpha, interleukin-1 alpha, and transforming growth factor-beta 1 mRNA in hippocampal injury response induced by trimethyltin. J. Neurochem. 71 (1998) 1577-1587
6. Chao C.C., Hu S., Close K., Choi C.S., Molitor T.W., Novick W.J., and Peterson P.K. Cytokine release from microglia: differential inhibition by pentoxifylline and dexamethasone. J. Infect. Dis. 166 (1992) 847-853
7. Crossin K.L., Tai M.H., Krushel L.A., Mauro V.P., and Edelman G.M. Glucocorticoid receptor pathways are involved in the inhibition of astrocyte proliferation. Proc. Natl. Acad. Sci. 94 6 (1997) 2687-2692
8. De Scheerder I., Wang K., Wilczek K., van Dorpe J., Verbeken E., Desmet W., Schacht E., and Piessens J. Local methylprednisolone inhibition of foreign body response to coated intracoronary stents. Coron. Artery Dis. 7 2 (1996) 161-166
9. Donoghue J.P. Connecting cortex to machines: recent advances in brain interfaces. Nat. Neurosci. 5 (2002) 1085-1088 (Suppl.)
10. Edell D.J., Toi V.V., McNeil V.M., and Clark L.D. Factors influencing the biocompatibility of insertable silicon microshafts in cerebral cortex. IEEE Trans. Biomed. Eng. 39 (1992) 635-643
11. Fawcett J.W., and Asher R.A. The glial scar and central nervous system repair. Brain Res. Bull. 49 (1999) 377-391
12. Fitch M.T., and Silver J. Activated macrophages and the blood-brain barrier: inflammation after CNS injury leads to increase in putative inhibitory molecules. Exp. Neurol. 148 (1997) 587-603
13. Gilbert R.J., McKeon R.J., Darr A., Calabro A., Hascall V.C., and Bellamkonda R.V. CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. Mol. Cell. Neurosci. 29 (2005) 545-558
14. Golde S., Coles A., Lindquist J.A., and Compston A. Decreased iNOS synthesis mediates DEX-induced protection of neurons from inflammatory injury in vitro. Eur. J. Neurosci. 18 (2003) 2527-2537
15. Hampton D.W., Rhodes K.E., Zhao C., Franklin R.J.M., and Fawcett J.W. The responses of oligodendrocyte precursor cells, astrocytes and microglia to a cortical stab injury, in the brain. Neuroscience 127 (2004) 813-820
16. Hanisch U.K. Microglia as a source and target of cytokines. Glia 40 2 (2002) 140-155
17. Hays S.J. Therapeutic approaches to the treatment of neuroinflammatory diseases. Curr. Pharm. Des. 4 (1998) 335-348
18. Henze D.A., Borhegyi Z., Csicsvari J., Mamiya A., Harris K.D., and Buzsaki G. Intracellular features predicted by extracellular recordings in the hippocampus in vivo. J. Neurophysiol. 84 (2000) 390-400
19. Hermens W.T., and Verhaagen J. Suppression of inflammation by DEX prolongs adenoviral vector-mediated transgene expression in the facial nucleus of the rat. Brain. Res. Bull. 47 (1998) 133-140
20. Holmin S., and Mathiesen T. DEX and colchicine reduce inflammation and delayed oedema following experimental brain contusion. Acta Neurochir. 138 (1996) 418-424
21. Huang Y., Wang L., Verweire I., Qiang B., Liu X., Verbeken E., Schacht E., and De Scheerder I. Optimization of local methylprednisolone delivery to inhibit inflammatory reaction and neointimal hyperplasia of coated coronary stents. J. Invasive Cardiol. 14 9 (2002) 505-513
22. John G.R., Lee S.C., Song X., Rivieccio M., and Brosnan C.F. IL-1-regulated responses in astrocytes: relevance to injury and recovery. Glia 49 (2005) 161-176
23. Jones L.L., Yamaguchi Y., Stallcup W.B., and Tuszynski M.H. NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J. Neurosci. 22 (2002) 2792-2803
24. Kaal E.C., and Vecht C.J. The management of brain edema in brain tumors. Curr. Opin. Oncol. 16 (2004) 593-600
25. Kato H., and Walz W. The initiation of the microglial responses. Brain Pathol. 10 (2000) 137-143
26. Kim D.H., and Martin D.C. Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery. Biomaterials 27 (2006) 3031-3037
27. Kim Y.T., Hitchcock R.W., Bridge M.J., and Tresco P.A. Chronic response of adult rat brain tissue to implants anchored to the skull. Biomaterials 25 (2004) 2229-2237
28. Koehler P.J. Use of corticosteroids in neuro-oncology. Anticancer Drugs 6 (1995) 19-33
29. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19 (1996) 312-318
30. Kyrkanides S., O'Banion M.K., Whiteley P.E., Daeschner J.C., and Olschowka J.A. Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury. J. Neuroimmunol. 119 (2001) 269-277
31. Lee S.C., Dickson D.W., and Brosnan C.F. Interleukin-1, nitric oxide and reactive astrocytes. Brain Behav. Immun. 9 4 (1995) 345-354
32. Levine J.M., Reynolds R., and Fawcett J.W. The oligodendrocyte precursor cell in health and disease. Trends Neurosci. 24 (2001) 39-47
33. Liu X., McCreery D.B., Carter R.R., Bullara L.A., Yuen T.G., and Agnew W.F. Stability of the interface between neural tissue and chronically implanted intracortical microelectrodes. IEEE Trans. Rehabil. Eng. 7 (1999) 315-326
34. Logan A., and Berry M. Cellular and molecular determinants of glial scar formation. In: Alzheimer C. (Ed). Molecular and Cellular Biology of Neuroprotection in the CNS (2002), Kluwer Academic 115-137
35. McConnell, G.C., Schneider, T.M., Owens, D.J., Bellamkonda, R.V., in press. Extraction force and cortical tissue reaction of silicon microelectrode arrays implanted in the rat brain. IEEE Trans. Biomed. Eng.
36. Merrill J.E., and Benveniste E.N. Cytokines in inflammatory brain lesions: helpful and harmful. Glia 19 (1996) 331-338
37. Norton W.T. Cell reactions following acute brain injury: a review. Neurochem. Res. 24 (1999) 213-218
38. Otto K.J., Vetter R.J., Marzullo T.C., and Kipke D.R. Brain-machine interfaces in rat motor cortex. Proceedings of the 1st International IEEE EMBS Conference on Neural Engineering, Capri Island, Italy (2003)
39. Polikov V.S., Tresco P.A., and Reichert W.M. Response of brain tissue to chronically implanted neural electrodes. J. Neurosci. Methods 148 (2005) 1-18
40. Properzi F., and Fawcett J.W. Proteoglycans and brain repair. News Physiol. Sci. 19 (2004) 33-38
41. Properzi F., Asher R.A., and Fawcett J.W. Chondroitin sulphate proteoglycans in the central nervous system: changes and synthesis after injury. Biochem. Soc. Trans. 31 (2003) 335-336
42. Sanchez J.C., Carmena J.M., Lebedev M.A., Nicolelis M.A.L., Harris J.G., and Principle J.C. Ascertaining the importance of neurons to develop better brain-machine interfaces. IEEE Trans. Biomed. Eng. 51 (2004) 943-953
43. Schwartz A.B. Cortical neural prosthetics. Annu. Rev. Neurosci. 27 (2004) 487-507
44. Shain W., Spataro L., Dilgen J., Haverstick K., Retterer S., Isaacson M., Saltzman M., and Turner J.N. Controlling cellular reactive responses around neural prosthetic devices using peripheral and local intervention strategies. IEEE Trans. Neural Syst. Rehabil. Eng. 11 (2003) 186-188
45. Spataro L., Dilgen J., Retterer S., Spence A.J., Isaacson M., Turner J.N., and Shain W. DEX treatment reduces astroglia responses to inserted neuroprosthetic devices in rat neocortex. Exp. Neurol. 194 (2005) 289-300
46. Szarowski D.H., Andersen M.D., Retterer S., Spence A.J., Isaacson M., Craighead H.G., Turner J.N., and Shain W. Brain responses to micro-machined silicon devices. Brain Res. 983 (2003) 23-35
47. Takeuchi A., Miyaishi O., Kiuchi K., and Isobe K. Macrophage colony-stimulating factor is expressed in neuron and microglia after focal brain injury. J. Neurosci. Res. 65 (2001) 38-44
48. Tanaka J., Fujita H., Matsuda S., Toku K., Sakanaka M., and Maeda N. Glucocorticoid- and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids. Glia 20 (1997) 23-37
49. Tang X., Davies J.E., and Davies S.J.A. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. J. Neurosci. Res. 71 (2003) 427-444
50. Tatsumi K., Haga S., Matsuyoshi H., Inoue M., Manabe T., Makinodan M., and Wanaka A. Characterization of cells with proliferative activity after a brain injury. Neurochem. Int. 46 (2005) 381-389
51. Turner J.N., Shain W., Szarowski D.H., Andersen M., Martins S., Isaacson M., and Craighead H. Cerebral astrocyte response to micromachined silicon implants. Exp. Neurol. 156 (1999) 33-49
52. Twycross R. The risks and benefits of corticosteroids in advanced cancer. Drug Safety 11 (1994) 163-178
53. Ughrin Y.M., Chen Z.J., and Levine J.M. Multiple regions of the NG2 proteoglycan inhibit neurite growth and induce growth cone collapse. J. Neurosci. 23 (2003) 175-186
54. Wadhwa R., Lagenaur C.F., and Cui X.T. Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode. J. Control. Release 110 (2006) 531-541
55. Zhong, Y., 2006. Development and characterization of anti-inflammatory coatings for implanted neural probes. Ph.D. Dissertation, Georgia Institute of Technology, Atlanta, GA.
56. Zhong Y., McConnell G.C., Ross J.D., DeWeerth S.P., and Bellamkonda R.V. A novel DEX-releasing, anti-inflammatory coating for neural implants. Proceedings of the 2nd International IEEE EMBS Conference on Neural Engineering. Arlington, USA (2005) 522-525