Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic ApoE -/-/LDL receptor -/- mice

Diabetes

Volumn 61, Issue 2, 2012, Pages 463-473

  Wang, Zhi Hao ^a,b   Shang, Yuan Yuan ^a,b   Zhang, Shun ^c   Zhong, Ming ^a,b   Wang, Xu Ping ^a,b   Deng, Jing Ti ^d   Pan, Jie ^c   Zhang, Yun ^a,b   Zhang, Wei ^a,b  

^a Qilu Hospital of Shandong University   (China)

^b SHANDONG UNIVERSITY   (China)

^c SHANDONG NORMAL UNIVERSITY   (China)

^d SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; DIABETES MELLITUS; GENE; GENE SILENCING; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STREPTOZOCIN DIABETES; TRIBBLES HOMOLOG 3 GENE; ULTRASOUND;

ANIMALS; APOLIPOPROTEINS E; APOPTOSIS; ATHEROSCLEROSIS; CELL ADHESION; CELL CYCLE PROTEINS; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; GENE SILENCING; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PLAQUE, ATHEROSCLEROTIC; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, LDL;

EID: 84863012411     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0518     Document Type: Article

References (24)

1. Milicevic Z, Raz I, Beattie SD, et al. Natural history of cardiovascular disease in patients with diabetes: role of hyperglycemia. Diabetes Care 2008;31(Suppl. 2):S155-S160
2. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 2006;444:875-880 (Pubitemid 46028447)
3. Du K, Herzig S, Kulkarni RN, Montminy M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 2003;300:1574-1577 (Pubitemid 36682889)
4. Qi L, Heredia JE, Altarejos JY, et al. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 2006;312:1763-1766 (Pubitemid 43962887)
5. Liew CW, Bochenski J, Kawamori D, et al. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest 2010;120:2876-2888
6. Okamoto H, Latres E, Liu R, et al. Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis. Diabetes 2007;56:1350-1356 (Pubitemid 46715621)
7. Oberkofler H, Pfeifenberger A, Soyal S, et al. Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans. Diabetologia 2010;53:1971-1975
8. Liu J, Wu X, Franklin JL, et al. Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance. Am J Physiol Endocrinol Metab 2010;298:E565-E576
9. Prudente S, Scarpelli D, Chandalia M, et al. The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes. J Clin Endocrinol Metab 2009;94:190-196
10. Prudente S, Hribal ML, Flex E, et al. The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy. Diabetes 2005;54:2807-2811 (Pubitemid 41233606)
11. Gong HP, Wang ZH, Jiang H, et al. TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis. Diabetes Care 2009;32:1311-1313
12. Shang YY, Wang ZH, Zhang LP, et al. TRB3, upregulated by ox-LDL, mediates human monocyte-derived macrophage apoptosis. FEBS J 2009;276:2752-2761
13. Liang CP, Han S, Senokuchi T, Tall AR. The macrophage at the crossroads of insulin resistance and atherosclerosis. Circ Res 2007;100:1546-1555 (Pubitemid 46897258)
14. Mu J, Woods J, Zhou YP, et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes 2006;55:1695-1704 (Pubitemid 44324122)
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419 (Pubitemid 15018832)
16. Marsili A, Aguayo-Mazzucato C, Chen T, et al. Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity. PLoS ONE 2011;6:e20832
17. Shiomi M, Ito T, Hirouchi Y, Enomoto M. Fibromuscular cap composition is important for the stability of established atherosclerotic plaques in mature WHHL rabbits treated with statins. Atherosclerosis 2001;157:75-84 (Pubitemid 32539356)
18. Johnson JL, Jackson CL. Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse. Atherosclerosis 2001;154:399-406 (Pubitemid 32146612)
19. Yao XH, Nyomba BL. Hepatic insulin resistance induced by prenatal alcohol exposure is associated with reduced PTEN and TRB3 acetylation in adult rat offspring. Am J Physiol Regul Integr Comp Physiol 2008;294:R1797-R1806
20. Deng J, James CH, Patel L, et al. Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro. Clin Sci (Lond) 2009;116:241-248
21. Shang YY, Zhong M, Zhang LP, et al. Tribble 3, a novel oxidized low-density lipoprotein-inducible gene, is induced via the activating transcription factor 4-C/EBP homologous protein pathway. Clin Exp Pharmacol Physiol 2010;37:51-55
22. Gautier EL, Huby T, Witztum JL, et al. Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage. Circulation 2009;119:1795-1804
23. Rekhter MD. How to evaluate plaque vulnerability in animal models of atherosclerosis? Cardiovasc Res 2002;54:36-41 (Pubitemid 34327933)
24. Kume T, Akasaka T, Kawamoto T, et al. Measurement of the thickness of the fibrous cap by optical coherence tomography . Am Heart J 2006;152:755.e1-755. e4.