Potentiation of morphine-induced mechanical antinociception by σ1 receptor inhibition: Role of peripheral σ1 receptors

Neuropharmacology

Volumn 70, Issue , 2013, Pages 348-358

  Sánchez Fernández, Cristina ^a   Nieto, Francisco Rafael ^a   González Cano, Rafael ^a   Artacho Cordón, Antonia ^a   Romero, Lucía ^a   Montilla García, Ángeles ^a   Zamanillo, Daniel ^b   Baeyens, José Manuel ^a   Entrena, José Manuel ^a   Cobos, Enrique José ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b Drug Discovery and Preclinical Development   (Spain)

Author keywords

Gastrointestinal transit; Hyperlocomotion; Morphine; Pain; Peripheral antinociception; Sigma 1 ( 1) receptors

Indexed keywords

1 [2 (3,4 DICHLOROPHENYL)ETHYL] 4 METHYLPIPERAZINE; 2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; 4 [2 [[5 METHYL 1 (2 NAPHTALENYL) 1H PYRAOL 3 YL]OXY]ETHYL]MORPHOLINE; BD 1063; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; MORPHINE; MU OPIATE RECEPTOR; N [2 (3,4 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; OPIATE; OPIATE ANTAGONIST; SIGMA 1 OPIATE RECEPTOR; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENTIATION; FEMALE; GASTROINTESTINAL TRANSIT; LOCOMOTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION;

ANALGESICS, OPIOID; ANIMALS; DRUG SYNERGISM; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GASTROINTESTINAL MOTILITY; HINDLIMB; HYPERALGESIA; LOCOMOTION; MALE; MICE; MICE, KNOCKOUT; MORPHINE; PROSENCEPHALON; RECEPTORS, SIGMA; SPINAL CORD; TRITIUM;

EID: 84876998778     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.03.002     Document Type: Article

References (59)

1. R. Al-Hasani, and M.R. Bruchas Molecular mechanisms of opioid receptor-dependent signaling and behavior Anesthesiology 115 2011 1363 1381
2. 1 receptor in the adult rat central nervous system Neuroscience 97 2000 155 170
3. E. Aydar, C.P. Palmer, V.A. Klyachko, and M.B. Jackson The sigma receptor as a ligand-regulated auxiliary potassium channel subunit Neuron 34 2002 399 410
4. A. Baamonde, V. Curto-Reyes, L. Juárez, A. Meana, A. Hidalgo, and L. Menéndez Antihyperalgesic effects induced by the IL-1 receptor antagonist anakinra and increased IL-1beta levels in inflamed and osteosarcoma-bearing mice Life Sci. 81 2007 673 682
5. 2-adrenoceptors in the rat brain Mol. Pharmacol. 42 1992 846 855
6. C.M. Cendán, J.M. Pujalte, E. Portillo-Salido, and J.M. Baeyens Antinociceptive effects of haloperidol and its metabolites in the formalin test in mice Psychopharmacology (Berl.) 182 2005 485 493
7. 1 receptor knockout mice Eur. J. Pharmacol. 511 2005 73 74
8. 1 system Eur. J. Pharmacol. 250 1993 R7 R8
9. C.C. Chien, and G.W. Pasternak Selective antagonism of opioid analgesia by a sigma system J. Pharmacol. Exp. Ther. 271 1994 1583 1590
10. M.J. Christie, M. Connor, C.W. Vaughan, S.L. Ingram, and E.E. Bagley Cellular actions of opioids and other analgesics: implications for synergism in pain relief Clin. Exp. Pharmacol. Physiol. 27 2000 520 523
11. 1 receptors of guinea pig brain Synapse 55 2005 192 195
12. E.J. Cobos, E. del Pozo, and J.M. Baeyens Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells J. Neurochem. 102 2007 812 825
13. 1 receptor ligands Curr. Neuropharmacol. 6 2008 344 366
14. E.J. Cobos, N. Ghasemlou, D. Araldi, D. Segal, K. Duong, and C.J. Woolf Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia Pain 153 2012 876 884
15. 3H]NE-100 Synapse 59 2006 152 161
16. B. De la Puente, X. Nadal, E. Portillo-Salido, R. Sánchez-Arroyos, S. Ovalle, G. Palacios, A. Muro, L. Romero, J.M. Entrena, J.M. Baeyens, J.A. López-García, R. Maldonado, D. Zamanillo, and J.M. Vela Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury Pain 145 2009 294 303
17. 1 receptor antagonists: identification of 4-{2-[5-methyl-1- (naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862) J. Med. Chem. 55 2012 8211 8224
18. K. Elhabazi, J.M. Trigo, C. Mollereau, L. Moulédous, J.M. Zajac, F. Bihel, M. Schmitt, J.J. Bourguignon, H. Meziane, B. Petit-demoulière, F. Bockel, R. Maldonado, and F. Simonin Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments Br. J. Pharmacol. 165 2012 424 435
19. J.M. Entrena, E.J. Cobos, F.R. Nieto, C.M. Cendán, J.M. Baeyens, and E. Del Pozo Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors Psychopharmacology (Berl.) 205 2009 21 33
20. J.M. Entrena, E.J. Cobos, F.R. Nieto, C.M. Cendán, G. Gris, E. Del Pozo, D. Zamanillo, and J.M. Baeyens Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: studies with selective sigma-1 ligands and sigma-1 knockout mice Pain 143 2009 252 261
21. X. Guitart, X. Codony, and X. Monroy Sigma receptors: biology and therapeutic potential Psychopharmacology (Berl.) 174 2004 301 319
22. T. Hayashi, and T.P. Su Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders CNS Drugs 18 2004 269 284
23. T.S. Hnasko, B.N. Sotak, and R.D. Palmiter Morphine reward in dopamine-deficient mice Nature 438 2005 854 857
24. B.I. Khalefa, M. Shaqura, M. Al-Khrasani, S. Fürst, S.A. Mousa, and M. Schäfer Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids Eur. J. Pain 16 2012 690 705
25. 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding Mol. Pharmacol. 77 2010 695 703
26. 1 receptor antagonists reduces formalin-induced phosphorylation of NMDA receptor subunit 1 and the second phase of formalin test in mice Br. J. Pharmacol. 148 2006 490 498
27. H.W. Kim, D.H. Roh, S.Y. Yoon, H.S. Seo, Y.B. Kwon, H.J. Han, K.W. Kim, A.J. Beitz, and J.H. Lee Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice Br. J. Pharmacol. 154 2008 1125 1134
28. 1 receptor Eur. J. Pharmacol. 331 1997 R5 R6
29. 1) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy J. Chem. Neuroanat. 20 2000 375 387
30. Y.A. Kolesnikov, I. Chereshnev, and G.W. Pasternak Analgesic synergy between topical lidocaine and topical opioids J. Pharmacol. Exp. Ther. 295 2000 546 551
31. Y.A. Kolesnikov, S. Jain, R. Wilson, and G.W. Pasternak Peripheral morphine analgesia: synergy with central sites and a target of morphine tolerance J. Pharmacol. Exp. Ther. 279 1996 502 506
32. Y. Kuraishi, N. Hirota, M. Satoh, and H. Takagi Antinociceptive effects of intrathecal opioids, noradrenaline and serotonin in rats: mechanical and thermal algesic tests Brain Res. 326 1985 168 171
33. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurements with the folin phenol reagent J. Biol. Chem. 193 1951 265 271
34. J. Mao, M.S. Gold, and M.M. Backonja Combination drug therapy for chronic pain: a call for more clinical studies J. Pain 12 2011 157 166
35. A. Marrazzo, E.J. Cobos, C. Parenti, G. Aricò, G. Marrazzo, S. Ronsisvalle, L. Pasquinucci, O. Prezzavento, N.A. Colabufo, M. Contino, L.G. González, G.M. Scoto, and G. Ronsisvalle Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties J. Med. Chem. 54 2011 3669 3673
36. A. Marrazzo, C. Parenti, V. Scavo, S. Ronsisvalle, G.M. Scoto, and G. Ronsisvalle In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia Life Sci. 78 2006 2449 2453
37. R.R. Matsumoto, W.D. Bowen, M.A. Tom, V.N. Vo, D.D. Truong, and B.R. De Costa Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism Eur. J. Pharmacol. 280 1995 301 310
38. 1 receptor modulation of opioid analgesia in the mouse J. Pharmacol. Exp. Ther. 300 2002 1070 1074
39. 1 receptors: a microinjection study J. Pharmacol. Exp. Ther. 322 2007 1278 1285
40. L. Menéndez, A. Lastra, A. Meana, A. Hidalgo, and A. Baamonde Analgesic effects of loperamide in bone cancer pain in mice Pharmacol. Biochem. Behav. 81 2005 114 121
41. 1 ligands J. Med. Chem. 42 1999 3965 3970
42. M. Narita, S. Ozaki, M. Ioka, H. Mizoguchi, H. Nagase, L. Tseng, and T. Suzuki Different motivational effects induced by the endogenous μ-opioid receptor ligands endomorphin-1 and -2 in the mouse Neuroscience 105 2001 213 218
43. F.R. Nieto, C.M. Cendán, C. Sánchez-Fernández, E.J. Cobos, J.M. Entrena, M.,A. Tejada, D. Zamanillo, J.M. Vela, and J.M. Baeyens Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice J. Pain 13 2012 1107 1121
44. M. Ohsawa, A. Carlsson, M. Asato, T. Koizumi, Y. Nakanishi, R. Fransson, A. Sandström, M. Hallberg, F. Nyberg, and J. Kamei The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system Mol. Pain 31 2011 7 11
45. 1 receptor J. Neurochem. 70 1998 2279 2285
46. D.H. Roh, S.R. Choi, S.Y. Yoon, S.Y. Kang, J.Y. Moon, S.G. Kwon, H.J. Han, A.J. Beitz, and J.H. Lee Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation Br. J. Pharmacol. 163 2011 1707 1720
47. 1 receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain Anesthesiology 109 2008 879 889
48. D.H. Roh, S.Y. Yoon, H.S. Seo, S.Y. Kang, J.Y. Moon, S. Song, A.J. Beitz, and J.H. Lee Sigma-1 receptor-induced increase in murine spinal NR1 phosphorylation is mediated by the PKCα and É, but not the PKCξ, isoforms Neurosci. Lett. 477 2010 95 99
49. R. Romero, D. Zamanillo, X. Nadal, R. Sánchez-Arroyos, I. Rivera-Arconada, A. Dordal, A. Montero, A. Muro, A. Bura, C. Segalés, M. Laloya, E. Hernández, E. Portillo-Salido, M. Escriche, X. Codony, G. Encina, J. Burgueño, M. Merlos, J.M. Baeyens, J. Giraldo, J.A. López-García, R. Maldonado, C.R. Plata-Salamán, and J.M. Vela Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization Br. J. Pharmacol. 166 2012 2289 2306
50. G. Ronsisvalle, A. Marrazzo, O. Prezzavento, A. Cagnotto, T. Mennini, C. Parenti, and G.M. Scoto Opioid and sigma receptor studies. New developments in the design of selective sigma ligands Pure Appl. Chem. 73 2001 1499 1509
51. 1-opioid receptors to morphine-induced antinociception Eur. J. Pharmacol. 369 1999 183 187
52. N. Sehgal, H.S. Smith, and L. Manchikanti Peripherally acting opioids and clinical implications for pain control Pain Physician 14 2011 249 258
53. C. Stein, M. Schäfer, and H. Machelska Attacking pain at its source: new perspectives on opioids Nat. Med. 9 2003 1003 1008
54. T.P. Su, X.Z. Wu, E.J. Cone, K. Shukla, T.M. Gund, A.L. Dodge, and D.W. Parish Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand J. Pharmacol. Exp. Ther. 259 1991 543 550
55. J. Thomas, S. Karver, G.A. Cooney, B.H. Chamberlain, C.K. Watt, N.E. Slatkin, N. Stambler, A.B. Kremer, and R.J. Israel Methylnaltrexone for opioid-induced constipation in advanced illness N. Engl. J. Med. 358 2008 2332 2343
56. L.F. Tseng, K.A. Collins, and Q. Wang Differential ontogenesis of thermal and mechanical antinociception induced by morphine and β-endorphin Eur. J. Pharmacol. 277 1995 71 76
57. H. Ueda, M. Inoue, A. Yoshida, K. Mizuno, H. Yamamoto, J. Maruo, K. Matsuno, and S. Mita Metabotropic neurosteroid/σ-receptor involved in stimulation of nociceptor endings of mice J. Pharmacol. Exp. Ther. 298 2001 703 710
58. S. Wegert, M.H. Ossipov, M.L. Nichols, D. Bian, T.W. Vanderah, T.P. Malan Jr., and F. Porreca Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats Pain 71 1997 57 64
59. M. Waldhoer, S.E. Bartlett, and J.L. Whistler Opioid receptors Annu. Rev. Biochem. 73 2004 953 990