Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: Involvement of PKC-dependent GluN1 phosphorylation

British Journal of Pharmacology

Volumn 163, Issue 8, 2011, Pages 1707-1720

  Roh, Dae Hyun ^a   Choi, Sheu Ran ^a   Yoon, Seo Yeon ^b   Kang, Suk Yun ^a   Moon, Ji Young ^a   Kwon, Soon Gu ^a   Han, Ho Jae ^c   Beitz, Alvin J ^d   Lee, Jang Hern ^a  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c Chonnam National University   (South Korea)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

hypersensitivity; nitric oxide synthase; NMDA receptor; phosphorylation; sigma 1 receptor

Indexed keywords

1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; 7 NITROINDAZOLE; GLUTAMATE RECEPTOR 1; GUANYLATE CYCLASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR GLUN1 SUBUNIT; N(G) NITROARGININE METHYL ESTER; NEURONAL NITRIC OXIDE SYNTHASE; PROTEIN KINASE C; SIGMA 1 OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HYPERSENSITIVITY; IMAGE ANALYSIS; IMMUNOPRECIPITATION; MALE; MECHANICAL HYPERSENSITIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THERMAL HYPERSENSITIVITY; WESTERN BLOTTING;

ANALGESICS, OPIOID; ANIMALS; CONTROL GROUPS; ENZYME INHIBITORS; GUANYLATE KINASE; HYPERALGESIA; INJECTIONS, SPINAL; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED ICR; MORPHOLINES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE I; PAIN; PAIN MEASUREMENT; PHOSPHORYLATION; PROTEIN KINASE C; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SIGMA; SPINAL CORD;

EID: 79960896680     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01316.x     Document Type: Article

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