Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure

PLoS Computational Biology

Volumn 9, Issue 4, 2013, Pages

  Wan, Xiaobo ^a,b   Ma, Yue ^c   McClendon, Christopher L ^d   Huang, Lily Jun Shen ^c   Huang, Niu ^a,b  

^a GRADUATE SCHOOL OF PEKING UNION MEDICAL COLLEGE   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BARIUM COMPOUNDS; CELL CULTURE; CELL PROLIFERATION; CHEMICAL ACTIVATION; ENZYMES;

AB INITIO MODELLING; COMPLEXES STRUCTURE; CYTOKINE RECEPTOR; EXPERIMENTAL ASSESSMENT; JANUS KINASE 2; KINASE ACTIVITY; MODEL ASSESSMENT; ONCOGENESIS; PSEUDOKINASE; TRANSMITTING SIGNAL;

CRYSTAL STRUCTURE;

JANUS KINASE 2; PHOSPHOTRANSFERASE; PSEUDOKINASE; UNCLASSIFIED DRUG;

ALLOSTERISM; ALPHA HELIX; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL TRANSFORMATION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME STABILITY; ENZYME STRUCTURE; INHIBITION KINETICS; MOLECULAR DYNAMICS; PROCESS MODEL; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

EID: 84876910676     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003022     Document Type: Article

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