Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface

British Journal of Pharmacology

Volumn 169, Issue 2, 2013, Pages 371-383

  Varagic, Zdravko ^a   Wimmer, Laurin ^b   Schnürch, Michael ^b   Mihovilovic, Marko D ^b   Huang, Shengming ^c   Rallapalli, Sundari ^c   Cook, James M ^c   Mirheydari, Pantea ^a   Ecker, Gerhard F ^d   Sieghart, Werner ^a   Ernst, Margot ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

^c UW ^*  (United States)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

+ binding site; benzodiazepine binding site; CGS 9895; GABAA receptors; null modulators; positive modulators; pyrazolopyridinones; pyrazoloquinolinones

Indexed keywords

2 (4 BROMOPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 2 (4 CHLOROPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 2 (4 CHLOROPHENYL) 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; 2 (4 ETHYLYPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 2 (4 METHOXYPHENYL) 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; 2 PHENYL 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 2 PHENYL 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; 4 (8 CHLORO 3 OXO 3,5 DIHYDRO 2H PYRAZOLO[4,3 C]QUINOLIN 2 YL)BENZONITRILE; 4 (8 METHOXY 3 OXO 3,5 DIHYDRO 2H PYRAZOLO[4,3 C]QUINOLIN 2 YL)BENZOATE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA; 4 AMINOBUTYRIC ACID A RECEPTOR BETA; 7 BROMO 2 (4 BROMOPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 7 METHOXY 2 (4 METHOXYPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 7 METHOXY 2 PHENYL 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 (TERT BUTYL) 2 [4[(3 TRIMETHYLSILYL)PROP 1 YN 1 YL]PHENYL] 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 (TERT BUTYL) 2 [4[(TRIMETHYLSILYL)ETHINYL]PHENYL] 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 CHLORO 2 (3 METHOXYPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 CHLORO 2 (4 AMINOPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 CHLORO 2 (4 METHOXYPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 CHLORO 2 (4 METHYLPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 CHLORO 2 (4 NITROPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 CHLORO 2 PHENYL 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 METHOXY 2 (4 METHOXYPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 METHOXY 2 PHENYL 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 TERT BUTYL 2 (4 BROMOPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 TERT BUTYL 2 (4 ETHYNYLPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 TERT BUTYL 2 (4 FLUOROPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 TERT BUTYL 2 [4 (5,5 DIMETHYLHEXA 1,3 DIYNYL)PHENYL] 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; ETHYL 4 (8 CHLORO 3,5 DIHYDRO 3 OXO 2H PYRAZOLO[4,3 C]QUINOLIN 2 YL)BENZOATE; LAU 156; LAU 157; LAU 159; LAU 161; LAU 162; LAU 163; LAU 176; LAU 177; LAU 206; PWZ 007A; PWZ 009A 1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IC 50; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; FEMALE; GABA MODULATORS; OOCYTES; PATCH-CLAMP TECHNIQUES; PYRAZOLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, GABA-A; XENOPUS LAEVIS;

EID: 84876887730     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12151     Document Type: Article

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