Valerenic acid derivatives as novel subunit-selective GABA A receptor ligands - In vitro and in vivo characterization

British Journal of Pharmacology

Volumn 161, Issue 1, 2010, Pages 65-78

  Khom, S ^a   Strommer, B ^a   Ramharter, J ^a   Schwarz, T ^a   Schwarzer, C ^b   Erker, T ^a   Ecker, Gf ^a   Mulzer, J ^a   Hering, S ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

2 microelectrode voltage clamp technique; behavioural pharmacology; GABA A receptors; structure activity relationship; valerenic acid derivatives

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; ANXIOLYTIC AGENT; CARBOXYL GROUP; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG; VALERENIC ACID; VALERENIC ACID AMIDE; VALERENIC ACID BUTYLAMIDE; VALERENIC ACID DIETHYLAMIDE; VALERENIC ACID DIMETHYLAMIDE; VALERENIC ACID ETHYLAMIDE; VALERENIC ACID ETHYLATE; VALERENIC ACID ISOPROPYLAMIDE; VALERENIC ACID METHLYAMIDE; VALERENIC ACID MORPHOLINE AMIDE; VALERENIC ACID PIPERIDINE AMIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MAZE TEST; MICROELECTRODE; MOUSE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY; VOLTAGE CLAMP; XENOPUS;

ANIMALS; ANTI-ANXIETY AGENTS; GABA AGONISTS; GABA ANTAGONISTS; INDENES; LIGANDS; MICE; MOLECULAR STRUCTURE; PROTEIN SUBUNITS; RECEPTORS, GABA-A; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955791538     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00865.x     Document Type: Article

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