Subtype selectivity of α+β- site ligands of GABAA receptors: Identification of the first highly specific positive modulators at α6β2/3γ2 receptors

British Journal of Pharmacology

Volumn 169, Issue 2, 2013, Pages 384-399

  Varagic, Zdravko ^a   Ramerstorfer, Joachim ^a   Huang, Shengming ^b   Rallapalli, Sundari ^b   Sarto Jackson, Isabella ^a   Cook, James ^b   Sieghart, Werner ^a   Ernst, Margot ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

+ binding site; benzodiazepine binding site; CGS 9895; GABAA receptors; null modulators; positive modulators; pyrazolopyridinones; pyrazoloquinolinones

Indexed keywords

2 (4 BROMOPHENYL) 2H PYRAZOLO[4,3 C]PYRIDIN 3(5H) ONE; 2 (4 BROMOPHENYL) 6 (TERT BUTYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 2 (4 BROMOPHENYL) 7,7,10,10 TETRAMETHYL 7,8,9,10 TETRAHYDRO 2H BENZO[G]PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 2 (4 CHLOROPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 2 (4 CHLOROPHENYL) 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; 2 (4 METHOXYPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 2 [4 [(TRIMETHYLSILYL)ETHYNYL]PHENYL] 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 2 PHENYL 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; 2,3,5,6,7,8,9,10 OCTAHYDRO 2 (4 METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4 D]PYRIDIN 3 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 5,6,7,8,9,10 HEXAHYDRO 2 (4 METHOXYPHENYL)CYCLOHEPTA[B]PYRAZOLO[3,4 D]PYRIDIN 3(2H) ONE; 7 BROMO 2 (4 BROMOPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 7 METHOXY 2 (4 METHOXYPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 7 METHOXY 2 PHENYL 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 CHLORO 2 (4 METHOXYPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 METHOXY 2 PHENYL 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 TERTBUTYL 2 (4 ETHYLPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 TERTBUTYL 2 (4 FLUOROPHENYL) 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 TERTBUTYL 2 [4 (5,5 DIMETHYLHEXA 1,3 DIYNYL)PHENYL] 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; 8 TERTBUTYL 2 [4 [(TRIMETHYLSILYL)ETHINYL]PHENYL] 2H PYRAZOLO[4,3 C]QUINOLIN 3(5H) ONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FEMALE; NONHUMAN; OOCYTE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ANIMALS; BINDING SITES; FEMALE; GABA MODULATORS; HUMANS; LIGANDS; OOCYTES; PATCH-CLAMP TECHNIQUES; PYRAZOLES; RECEPTORS, GABA-A; XENOPUS LAEVIS;

EID: 84876893599     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12153     Document Type: Article

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