Studies of molecular Pharmacophore/Receptor models for GABA(A)/BzR subtypes: Binding affinities of symmetrically substituted pyrazolo[4,3-c]quinolin-3-ones at recombinant αxβ3γ2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis

Drug Design and Discovery

Volumn 16, Issue 1, 1999, Pages 77-91

  He, Xiaohui ^a   Huang, Qi ^a   Yu, Shu ^a   Ma, Chunrong ^a   McKernan, Ruth ^b   Cook, James M ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

CoMFA; GABA(A) BzR; Pyrazoloquinolinone; Subtype selectivity

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR; QUINOLINE DERIVATIVE; RECEPTOR SUBTYPE; RECOMBINANT RECEPTOR; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; NONHUMAN; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOSPECIFICITY;

BINDING SITES; COMPUTER SIMULATION; HYDROLYSIS; LIGANDS; PROTEIN ISOFORMS; PYRAZOLES; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032867210     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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