Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening

Journal of Medicinal Chemistry

Volumn 56, Issue 8, 2013, Pages 3424-3428

  Lauria, Antonino ^a   Abbate, Ilenia ^a   Gentile, Carla ^a   Angileri, Francesca ^a   Martorana, Annamaria ^a   Almerico, Anna Maria ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 72; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING ASSAY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PHARMACOPHORE; PROTEIN DEGRADATION; UPREGULATION;

AMINOPYRIDINES; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP; USER-COMPUTER INTERFACE;

EID: 84876843252     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4002023     Document Type: Article

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