Combined use of PCA and QSAR/QSPR to predict the drugs mechanism of action. An application to the NCI ACAM database

QSAR and Combinatorial Science

Volumn 28, Issue 4, 2009, Pages 387-395

  Lauria, Antonino ^a   Ippolito, Mario ^a   Almerico, Anna Maria ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Anti cancer Agent Mechanism database; Mechanism of action; PCA; QSAR QSPR

Indexed keywords

CELL CULTURE; COMPUTATIONAL CHEMISTRY; DIAGNOSIS; DISEASES; FORECASTING; MULTIVARIANT ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; TUMORS;

AMOUNT OF INFORMATION; ANTI-CANCER AGENT MECHANISM DATABASE; ANTI-CANCER AGENTS; COMPLEX PROTOCOLS; DRUG-SCREENING; MECHANISM OF ACTION; NATIONAL CANCER INSTITUTE; PRINCIPAL-COMPONENT ANALYSIS; QSAR/QSPR; TRAINING SETS;

DATABASE SYSTEMS;

ALKYLATING AGENT; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; DNA TOPOISOMERASE INHIBITOR; GYRASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DATA BASE; DNA DETERMINATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; NATIONAL HEALTH ORGANIZATION; PREDICTION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; QUANTITATIVE STRUCTURE PROPERTY RELATION; RELIABILITY; STRUCTURE ANALYSIS;

EID: 66149154668     PISSN: 1611020X     EISSN: 16110218     Source Type: Journal    
DOI: 10.1002/qsar.200810062     Document Type: Article

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