Principal component analysis on molecular descriptors as an alternative point of view in the search of new Hsp90 inhibitors

Computational Biology and Chemistry

Volumn 33, Issue 5, 2009, Pages 386-390

  Lauria, Antonino ^a   Ippolito, Mario ^a   Almerico, Anna Maria ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Binding database; Heat shock protein; Molecular descriptors; Molecular docking; Principal component analysis

Indexed keywords

BINDING AFFINITIES; BINDING DATABASE; BINDING INTERACTION; CANCER CELLS; CANCER THERAPY; CELLULAR GROWTH; CLUSTERIZATION; DESCRIPTORS; FACTOR SCORES; HEAT SHOCK PROTEIN; MATRIX; MOLECULAR CHAPERONE PROTEINS; MOLECULAR DESCRIPTORS; MOLECULAR DOCKING; MOLECULAR TARGETS; PUBLIC DATABASE; SIGNAL TRANSDUCTION PATHWAYS; STRESS RESPONSE; STRUCTURAL CLASS;

BACTERIOPHAGES; BINDING ENERGY; DATABASE SYSTEMS; DOCKING; MOLECULAR MODELING; PROTEIN FOLDING; SIGNAL TRANSDUCTION;

PRINCIPAL COMPONENT ANALYSIS;

HEAT SHOCK PROTEIN 90; ISOXAZOLE DERIVATIVE; NAPHTHOL DERIVATIVE; PURINE DERIVATIVE; PYRAZOLE DERIVATIVE;

ARTICLE; BINDING SITE; BIOLOGY; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; DRUG SCREENING; FACTUAL DATABASE; METABOLISM; METHODOLOGY; PRINCIPAL COMPONENT ANALYSIS; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DATABASES, FACTUAL; DRUG EVALUATION, PRECLINICAL; HSP90 HEAT-SHOCK PROTEINS; ISOXAZOLES; NAPHTHOLS; PRINCIPAL COMPONENT ANALYSIS; PROTEIN CONFORMATION; PURINES; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 70349194386     PISSN: 14769271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.compbiolchem.2009.07.010     Document Type: Article

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