SNX-2112, a novel Hsp90 inhibitor, induces G2/M cell cycle arrest and apoptosis in MCF-7 cells

Bioscience, Biotechnology and Biochemistry

Volumn 75, Issue 8, 2011, Pages 1540-1545

  Wang, Shao Xiang ^a   Ju, Huai Qiang ^a   Liu, Kai Sheng ^a   Zhang, Jia Xuan ^a   Wang, Xiao ^b   Xiang, Yang Fei ^a   Wang, Rui ^a   Liu, Jin Yun ^b   Liu, Qiu Ying ^a   Xia, Min ^a   Xing, Guo Wen ^c   Liu, Zhong ^a   Wang, Yi Fei ^a  

^a JINAN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c BEIJING NORMAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell cycle arrest; Hsp90 shock protein 90 (Hsp90); MCF 7; SNX 2112

Indexed keywords

ALLYLAMINO; ANTICANCER PROPERTIES; APOPTOTIC PATHWAYS; BCL-2 AND BCL-XL; CELL CYCLE; CELL CYCLE ARREST; CLINICAL TRIAL; DOSE-DEPENDENT MANNER; DOWN-REGULATION; FLOW-CYTOMETRIC ANALYSIS; G2/M CELL CYCLE ARREST; HEAT SHOCK PROTEIN; HUMAN BREAST CANCER CELLS; HUMAN EPIDERMAL GROWTH FACTOR; MCF-7; MCF-7 CELLS; MOLECULAR MECHANISM; NUCLEAR FACTORS; POLY(ADP-RIBOSE) POLYMERASE; SHOCK PROTEINS; SNX- 2112; UP-REGULATION; WESTERN BLOTS;

BROMINE COMPOUNDS; CELL GROWTH; DEGRADATION; DISEASES; GROWTH KINETICS; PROTEINS;

CELL DEATH;

17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN; ANTINEOPLASTIC AGENT; BENZOQUINONE DERIVATIVE; CASPASE 9; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FUSED HETEROCYCLIC RINGS; HEAT SHOCK PROTEIN 90; MACROCYCLIC LACTAM; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL X; PROTEIN KINASE B; RAF PROTEIN; SNX 2112; TANESPIMYCIN;

APOPTOSIS; ARTICLE; BREAST TUMOR; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MITOCHONDRION; TUMOR CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BENZOQUINONES; BLOTTING, WESTERN; BREAST NEOPLASMS; CASPASE 9; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MITOCHONDRIA; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; RECEPTOR, ERBB-2;

EID: 80051965142     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.110225     Document Type: Article

References (35)

1. Pearl LH and Prodromou C, Annu. Rev. Biochem., 75, 271-294 (2006).
2. Pearl LH, Prodromou C, and Workman P, Biochem. J., 410, 439-453 (2008).
3. Zhao R, Davey M, Hsu YC, Kaplanek P, Tong A, Parsons AB, Krogan N, Cagney G, Mai D, Greenblatt J, Boone C, Emili A, and Houry WA, Cell, 120, 715-727 (2005).
4. Porter JR, Fritz CC, and Depew KM, Curr. Opin. Chem. Biol., 14, 412-420 (2010).
5. Whitesell L and Lindquist SL, Nat. Rev. Cancer, 5, 761-772 (2005).
6. Cysyk RL, Parker RJ, Barchi JJJr, Steeg PS, Hartman NR, and Strong JM, Chem. Res. Toxicol., 19, 376-381 (2006).
7. Jin L, Xiao CL, Lu CH, Xia M, Xing GW, Xiong S, Liu QY, Liu H, Li YC, Ge F, Wang QD, He QY, and Wang YF, FEBS Lett., 583, 1859-1866 (2009).
8. Steed PM, Fadden P, and Hall S, Am. Soc. Clin. Oncol., 24, 13067 (2006).
9. Chandarlapaty S, Sawai A, Ye Q, Scott A, Silinski M, Huang K, Fadden P, Partdrige J, Hall S, Steed P, Norton L, Rosen N, and Solit DB, Clin. Cancer Res., 14, 240-248 (2008).
10. Zhai QQ, Gong GQ, Liu Z, Luo Y, Xia M, Xing GW, You XF, and Wang YF, Biomed. Pharmacother., 65, 132-136 (2010).
11. Zhai QQ, Gong GQ, Luo Y, Wang QD, Xia M, Xing GW, Li YC, Jiang JH, Liu Z, Liu QY, and Wang YF, J. Pharm. Biomed. Anal., 53, 1048-1052 (2010).
12. Rice JW, Veal JM, Barabasz A, Foley B, Fadden P, Scott A, Huang K, Steed P, and Hall S, Oncol. Res., 18, 229-242 (2009).
13. Barta TE, Veal JM, Rice JW, Partridge JM, Fadden RP, Ma W, Jenks M, Geng L, Hanson GJ, Huang KH, Barabasz AF, Foley BE, Otto J, and Hall SE, Bioorg. Med. Chem. Lett. 18, 3517-3521 (2008).
14. Mosmann T, J. Immunol. Methods, 65, 55-63 (1983).
15. Yang YP, Kuo HS, Tsai HD, Peng YC, and Lin YL, Breast Cancer Res., 7, R19-R27 (2005).
16. Wuerzberger SM, Pink JJ, Planchon SM, Byers KL, Bornmann WG, and Boothman DA, Cancer Res., 58, 1876-1885 (1998).
17. Jemal A, Siegel R, Ward E, Hao Y, Xu J, and Thun MJ, CA Cancer J. Clin., 59, 225-249 (2009).
18. Konecny G, Untch M, Slamon D, Beryt M, Kahlert S, Felber M, Langer E, Lude S, Hepp H, and Pegram M, Breast Cancer Res. Treat., 67, 223-233 (2001).
19. Okawa Y, Hideshima T, Steed P, Vallet S, Hall S, Huang K, Rice J, Barabasz A, Foley B, Ikeda H, Raje N, Kiziltepe T, Yasui H, Enatsu S, and Anderson KC, Blood, 113, 846-855 (2009).
20. Senju M, Sueoka N, Sato A, Iwanaga K, Sakao Y, Tomimitsu S, Tominaga M, Irie K, Hayashi S, and Sueoka E, J. Cancer Res. Clin. Oncol., 132, 150-158 (2006).
21. Jeffy BD, Chen EJ, Gudas JM, and Romagnolo DF, Neoplasia, 2, 460-470 (2000).
22. Yin HJ, Cheng LS, and Duan JL, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 23, 260-263 (2007).
23. Tsujimoto Y, J. Cell. Physiol., 195, 158-167 (2003).
24. Hetz C, Adv. Exp. Med. Biol., 687, 7-8 (2010).
25. Bull EE, Dote H, Brady KJ, Burgan WE, Carter DJ, Cerra MA, Oswald KA, Hollingshead MG, Camphausen K, and Tofilon PJ, Clin. Cancer Res., 10, 8077-8084 (2004).
26. Radanyi C, Le Bras G, Marsaud V, Peyrat JF, Messaoudi S, Catelli MG, Brion JD, Alami M, and Renoir JM, Cancer Lett., 274, 88-94 (2009).
27. Chiosis G, Timaul MN, Lucas B, Munster PN, Zheng FF, Sepp-Lorenzino L, and Rosen N, Chem. Biol., 8, 289-299 (2001).
28. Kumar R, Mandal M, Lipton A, Harvey H, and Thompson CB, Clin. Cancer Res., 2, 1215-1219 (1996).
29. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, and McGuire WL, Science, 235, 177-182 (1987).
30. Kumar N, Afeyan R, Kim HD, and Lauffenburger DA, Mol. Pharmacol., 73, 1668-1678 (2008).
31. Page C, Lin HJ, Jin Y, Castle VP, Nunez G, Huang M, and Lin J, Anticancer Res., 20, 407-416 (2000).
32. Cheng JQ, Lindsley CW, Cheng GZ, Yang H, and Nicosia SV, Oncogene, 24, 7482-7492 (2005).
33. Park K, Choi K, Kim H, Kim K, Lee MH, Lee JH, and Kim Rim JC, Exp. Mol. Med., 41, 371-381 (2009).
34. Davis JM, Navolanic PM, Weinstein-Oppenheimer CR, Steelman LS, Hu W, Konopleva M, Blagosklonny MV, and McCubrey JA, Clin. Cancer Res., 9, 1161-1170 (2003).
35. Kobzdej M, Matuszyk J, and Strzadala L, Leuk. Res., 24, 33-38 (2000).