Lead optimization through VLAK protocol: New annelated pyrrolo-pyrimidine derivatives as antitumor agents

European Journal of Medicinal Chemistry

Volumn 55, Issue , 2012, Pages 375-383

  Lauria, Antonino ^a   Patella, Chiara ^a   Abbate, Ilenia ^a   Martorana, Annamaria ^a   Almerico, Anna Maria ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Annelated pyrrolo pyrimidines; Anticancer drugs; Developmental Therapeutics Program (DTP); VLAK protocol

Indexed keywords

7 (3 CHLOROPROPYL) 9 METHYL 5 (METHYLSULFANYL) 8 PHENYL 3H IMIDAZO[1,2 C]PYRROLO[3,2 E]PYRIMIDIN 2(7H) ONE; 8 [3 (PIPERIDINO)PROPYL] 4,10 DIMETHYL 9 PHENYL 6 (METHYLSULFANYL) 3,4 DIHYDROPYRIMIDO[1,2 C]PYRROLO[3,2 E]PYRIMIDIN 2(8H) ONE; ANTINEOPLASTIC AGENT; PYRROLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG EFFICACY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LEUKEMIA;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; INFORMATICS; PYRIMIDINES; PYRROLES;

EID: 84865744931     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.07.046     Document Type: Article

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