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Volumn 62, Issue 2, 2013, Pages 195-201

IL-17 in psoriasis: Implications for therapy and cardiovascular co-morbidities

Author keywords

Cardiovascular disease; IL 17A; Psoriasis; Skin; Th17

Indexed keywords

ABATACEPT; ALEFACEPT; ANTIPSORIASIS AGENT; BRODALUMAB; CD3 ANTIBODY; CD4 ANTIBODY; COLECALCIFEROL; CORTICOSTEROID; CYCLOSPORIN; CYCLOSPORIN A; DENILEUKIN DIFTITOX; DITHRANOL; ETRETIN; HU MAX; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 23; IXEKIZUMAB; METHOTREXATE; MK 3222; PLACEBO; RETINOL; TACROLIMUS; TUMOR NECROSIS FACTOR INHIBITOR; UNCLASSIFIED DRUG;

EID: 84876816203     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2013.03.013     Document Type: Review
Times cited : (71)

References (117)
  • 2
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • Zheng Y., Danilenko D.M., Valdez P., Kasman I., Eastham-Anderson J., Wu J., et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007, 445:648-651.
    • (2007) Nature , vol.445 , pp. 648-651
    • Zheng, Y.1    Danilenko, D.M.2    Valdez, P.3    Kasman, I.4    Eastham-Anderson, J.5    Wu, J.6
  • 5
    • 72849131815 scopus 로고    scopus 로고
    • Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
    • Eyerich S., Eyerich K., Pennino D., Carbone T., Nasorri F., Pallotta S., et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 2009, 119:3573-3585.
    • (2009) J Clin Invest , vol.119 , pp. 3573-3585
    • Eyerich, S.1    Eyerich, K.2    Pennino, D.3    Carbone, T.4    Nasorri, F.5    Pallotta, S.6
  • 6
    • 77953611927 scopus 로고    scopus 로고
    • Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions
    • Davidovici B.B., Sattar N., Prinz J., Puig L., Emery P., Barker J.N., et al. Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. J Invest Dermatol 2010, 130:1785-1796.
    • (2010) J Invest Dermatol , vol.130 , pp. 1785-1796
    • Davidovici, B.B.1    Sattar, N.2    Prinz, J.3    Puig, L.4    Emery, P.5    Barker, J.N.6
  • 10
    • 79960208264 scopus 로고    scopus 로고
    • Psoriasis is associated with clinically significant cardiovascular risk: a Danish nationwide cohort study
    • Ahlehoff O., Gislason G.H., Charlot M., Jorgensen C.H., Lindhardsen J., Olesen J.B., et al. Psoriasis is associated with clinically significant cardiovascular risk: a Danish nationwide cohort study. J Intern Med 2011, 270:147-157.
    • (2011) J Intern Med , vol.270 , pp. 147-157
    • Ahlehoff, O.1    Gislason, G.H.2    Charlot, M.3    Jorgensen, C.H.4    Lindhardsen, J.5    Olesen, J.B.6
  • 11
    • 77951099590 scopus 로고    scopus 로고
    • Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the general practice research database
    • Mehta N.N., Azfar R.S., Shin D.B., Neimann A.L., Troxel A.B., Gelfand J.M. Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the general practice research database. Eur Heart J 2010, 31:1000-1006.
    • (2010) Eur Heart J , vol.31 , pp. 1000-1006
    • Mehta, N.N.1    Azfar, R.S.2    Shin, D.B.3    Neimann, A.L.4    Troxel, A.B.5    Gelfand, J.M.6
  • 12
    • 77956930550 scopus 로고    scopus 로고
    • Incidence of psoriasis and association with comorbidities in Italy: a 5-year observational study from a national primary care database
    • Vena G.A., Altomare G., Ayala F., Berardesca E., Calzavara-Pinton P., Chimenti S., et al. Incidence of psoriasis and association with comorbidities in Italy: a 5-year observational study from a national primary care database. Eur J Dermatol 2010, 20:593-598.
    • (2010) Eur J Dermatol , vol.20 , pp. 593-598
    • Vena, G.A.1    Altomare, G.2    Ayala, F.3    Berardesca, E.4    Calzavara-Pinton, P.5    Chimenti, S.6
  • 14
    • 58149336900 scopus 로고    scopus 로고
    • The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: results from NHANES 2003-2004
    • Kurd S.K., Gelfand J.M. The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: results from NHANES 2003-2004. J Am Acad Dermatol 2009, 60:218-224.
    • (2009) J Am Acad Dermatol , vol.60 , pp. 218-224
    • Kurd, S.K.1    Gelfand, J.M.2
  • 15
    • 34447539622 scopus 로고    scopus 로고
    • Pathogenesis and clinical features of psoriasis
    • Griffiths C.E., Barker J.N. Pathogenesis and clinical features of psoriasis. Lancet 2007, 370:263-271.
    • (2007) Lancet , vol.370 , pp. 263-271
    • Griffiths, C.E.1    Barker, J.N.2
  • 17
    • 33847279025 scopus 로고    scopus 로고
    • Pathogenesis and therapy of psoriasis
    • Lowes M.A., Bowcock A.M., Krueger J.G. Pathogenesis and therapy of psoriasis. Nature 2007, 445:866-873.
    • (2007) Nature , vol.445 , pp. 866-873
    • Lowes, M.A.1    Bowcock, A.M.2    Krueger, J.G.3
  • 18
    • 0027980960 scopus 로고
    • Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis
    • Detmar M., Brown L.F., Claffey K.P., Yeo K.T., Kocher O., Jackman R.W., et al. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med 1994, 180:1141-1146.
    • (1994) J Exp Med , vol.180 , pp. 1141-1146
    • Detmar, M.1    Brown, L.F.2    Claffey, K.P.3    Yeo, K.T.4    Kocher, O.5    Jackman, R.W.6
  • 19
    • 0030689770 scopus 로고    scopus 로고
    • Quality of life in patients with psoriasis: the contribution of clinical variables and psoriasis-specific stress
    • Fortune D.G., Main C.J., O'Sullivan T.M., Griffiths C.E. Quality of life in patients with psoriasis: the contribution of clinical variables and psoriasis-specific stress. Br J Dermatol 1997, 137:755-760.
    • (1997) Br J Dermatol , vol.137 , pp. 755-760
    • Fortune, D.G.1    Main, C.J.2    O'Sullivan, T.M.3    Griffiths, C.E.4
  • 20
    • 33745933352 scopus 로고    scopus 로고
    • The mechanism of lithium and beta-blocking agents in inducing and exacerbating psoriasis
    • O'Brien M., Koo J. The mechanism of lithium and beta-blocking agents in inducing and exacerbating psoriasis. J Drugs Dermatol 2006, 5:426-432.
    • (2006) J Drugs Dermatol , vol.5 , pp. 426-432
    • O'Brien, M.1    Koo, J.2
  • 21
    • 17744365558 scopus 로고    scopus 로고
    • Family history of psoriasis, stressful life events, and recent infectious disease are risk factors for a first episode of acute guttate psoriasis: results of a case-control study
    • Naldi L., Peli L., Parazzini F., Carrel C.F. Family history of psoriasis, stressful life events, and recent infectious disease are risk factors for a first episode of acute guttate psoriasis: results of a case-control study. J Am Acad Dermatol 2001, 44:433-438.
    • (2001) J Am Acad Dermatol , vol.44 , pp. 433-438
    • Naldi, L.1    Peli, L.2    Parazzini, F.3    Carrel, C.F.4
  • 22
    • 80051931752 scopus 로고    scopus 로고
    • Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells
    • Penaranda C., Tang Q., Bluestone J.A. Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol 2011, 187:2015-2022.
    • (2011) J Immunol , vol.187 , pp. 2015-2022
    • Penaranda, C.1    Tang, Q.2    Bluestone, J.A.3
  • 24
    • 30044435436 scopus 로고    scopus 로고
    • Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
    • Lowes M.A., Chamian F., Abello M.V., Fuentes-Duculan J., Lin S.L., Nussbaum R., et al. Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc Natl Acad Sci USA 2005, 102:19057-19062.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 19057-19062
    • Lowes, M.A.1    Chamian, F.2    Abello, M.V.3    Fuentes-Duculan, J.4    Lin, S.L.5    Nussbaum, R.6
  • 25
    • 33749151636 scopus 로고    scopus 로고
    • An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis
    • Toichi E., Torres G., McCormick T.S., Chang T., Mascelli M.A., Kauffman C.L., et al. An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis. J Immunol 2006, 177:4917-4926.
    • (2006) J Immunol , vol.177 , pp. 4917-4926
    • Toichi, E.1    Torres, G.2    McCormick, T.S.3    Chang, T.4    Mascelli, M.A.5    Kauffman, C.L.6
  • 26
    • 0035954670 scopus 로고    scopus 로고
    • Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes
    • Ellis C.N., Krueger G.G. Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med 2001, 345:248-255.
    • (2001) N Engl J Med , vol.345 , pp. 248-255
    • Ellis, C.N.1    Krueger, G.G.2
  • 27
    • 0028990380 scopus 로고
    • Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis
    • Gottlieb S.L., Gilleaudeau P., Johnson R., Estes L., Woodworth T.G., Gottlieb A.B., et al. Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis. Nat Med 1995, 1:442-447.
    • (1995) Nat Med , vol.1 , pp. 442-447
    • Gottlieb, S.L.1    Gilleaudeau, P.2    Johnson, R.3    Estes, L.4    Woodworth, T.G.5    Gottlieb, A.B.6
  • 28
    • 73649208201 scopus 로고
    • Studies on enzymes involved in nucleic acid metabolism in foetal, young and regenerating rat liver
    • Stevens L., Stocken L.A. Studies on enzymes involved in nucleic acid metabolism in foetal, young and regenerating rat liver. Biochem J 1963, 87:12-15.
    • (1963) Biochem J , vol.87 , pp. 12-15
    • Stevens, L.1    Stocken, L.A.2
  • 29
    • 75549083222 scopus 로고    scopus 로고
    • Skin-resident T cells: the ups and downs of on site immunity
    • Clark R.A. Skin-resident T cells: the ups and downs of on site immunity. J Invest Dermatol 2010, 130:362-370.
    • (2010) J Invest Dermatol , vol.130 , pp. 362-370
    • Clark, R.A.1
  • 31
    • 1542313881 scopus 로고    scopus 로고
    • Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha
    • Boyman O., Hefti H.P., Conrad C., Nickoloff B.J., Suter M., Nestle F.O. Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha. J Exp Med 2004, 199:731-736.
    • (2004) J Exp Med , vol.199 , pp. 731-736
    • Boyman, O.1    Hefti, H.P.2    Conrad, C.3    Nickoloff, B.J.4    Suter, M.5    Nestle, F.O.6
  • 32
    • 0038824717 scopus 로고    scopus 로고
    • Alefacept therapy produces remission for patients with chronic plaque psoriasis
    • Krueger G.G., Ellis C.N. Alefacept therapy produces remission for patients with chronic plaque psoriasis. Br J Dermatol 2003, 148:784-788.
    • (2003) Br J Dermatol , vol.148 , pp. 784-788
    • Krueger, G.G.1    Ellis, C.N.2
  • 34
    • 61849168497 scopus 로고    scopus 로고
    • Serum levels of IL-17 and IL-22 are reduced by etanercept, but not by acitretin, in patients with psoriasis: a randomized-controlled trial
    • Caproni M., Antiga E., Melani L., Volpi W., Del Bianco E., Fabbri P. Serum levels of IL-17 and IL-22 are reduced by etanercept, but not by acitretin, in patients with psoriasis: a randomized-controlled trial. J Clin Immunol 2009, 29:210-214.
    • (2009) J Clin Immunol , vol.29 , pp. 210-214
    • Caproni, M.1    Antiga, E.2    Melani, L.3    Volpi, W.4    Del Bianco, E.5    Fabbri, P.6
  • 35
    • 34648836878 scopus 로고    scopus 로고
    • Modulation of CLA, IL-12R, CD40L, and IL-2Ralpha expression and inhibition of IL-12- and IL-23-induced cytokine secretion by CNTO 1275
    • Reddy M., Davis C., Wong J., Marsters P., Pendley C., Prabhakar U. Modulation of CLA, IL-12R, CD40L, and IL-2Ralpha expression and inhibition of IL-12- and IL-23-induced cytokine secretion by CNTO 1275. Cell Immunol 2007, 247:1-11.
    • (2007) Cell Immunol , vol.247 , pp. 1-11
    • Reddy, M.1    Davis, C.2    Wong, J.3    Marsters, P.4    Pendley, C.5    Prabhakar, U.6
  • 39
    • 82955236074 scopus 로고    scopus 로고
    • Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1
    • Van Hauwermeiren F., Vandenbroucke R.E., Libert C. Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1. Cytokine Growth Factor Rev 2011, 22:311-319.
    • (2011) Cytokine Growth Factor Rev , vol.22 , pp. 311-319
    • Van Hauwermeiren, F.1    Vandenbroucke, R.E.2    Libert, C.3
  • 40
    • 84862962823 scopus 로고    scopus 로고
    • Historical perspectives on tumor necrosis factor and its superfamily: 25years later, a golden journey
    • Aggarwal B.B., Gupta S.C., Kim J.H. Historical perspectives on tumor necrosis factor and its superfamily: 25years later, a golden journey. Blood 2012, 119:651-665.
    • (2012) Blood , vol.119 , pp. 651-665
    • Aggarwal, B.B.1    Gupta, S.C.2    Kim, J.H.3
  • 41
  • 42
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
    • Papp K.A., Langley R.G., Lebwohl M., Krueger G.G., Szapary P., Yeilding N., et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 2008, 371:1675-1684.
    • (2008) Lancet , vol.371 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3    Krueger, G.G.4    Szapary, P.5    Yeilding, N.6
  • 43
    • 34249039292 scopus 로고    scopus 로고
    • A phase 1, double-blind, placebo-controlled study evaluating single subcutaneous administrations of a human interleukin-12/23 monoclonal antibody in subjects with plaque psoriasis
    • Gottlieb A.B., Cooper K.D., McCormick T.S., Toichi E., Everitt D.E., Frederick B., et al. A phase 1, double-blind, placebo-controlled study evaluating single subcutaneous administrations of a human interleukin-12/23 monoclonal antibody in subjects with plaque psoriasis. Curr Med Res Opin 2007, 23:1081-1092.
    • (2007) Curr Med Res Opin , vol.23 , pp. 1081-1092
    • Gottlieb, A.B.1    Cooper, K.D.2    McCormick, T.S.3    Toichi, E.4    Everitt, D.E.5    Frederick, B.6
  • 44
    • 9744265704 scopus 로고    scopus 로고
    • A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis
    • Kauffman C.L., Aria N., Toichi E., McCormick T.S., Cooper K.D., Gottlieb A.B., et al. A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis. J Invest Dermatol 2004, 123:1037-1044.
    • (2004) J Invest Dermatol , vol.123 , pp. 1037-1044
    • Kauffman, C.L.1    Aria, N.2    Toichi, E.3    McCormick, T.S.4    Cooper, K.D.5    Gottlieb, A.B.6
  • 45
    • 36049052516 scopus 로고    scopus 로고
    • Interleukin-12, interleukin-23, and psoriasis: current prospects
    • Torti D.C., Feldman S.R. Interleukin-12, interleukin-23, and psoriasis: current prospects. J Am Acad Dermatol 2007, 57:1059-1068.
    • (2007) J Am Acad Dermatol , vol.57 , pp. 1059-1068
    • Torti, D.C.1    Feldman, S.R.2
  • 46
    • 34548835499 scopus 로고    scopus 로고
    • Sexy and 17: TH17 effector T cells and psoriasis
    • Brownell I. Sexy and 17: TH17 effector T cells and psoriasis. J Drugs Dermatol 2007, 6:853-856.
    • (2007) J Drugs Dermatol , vol.6 , pp. 853-856
    • Brownell, I.1
  • 48
    • 38849187386 scopus 로고    scopus 로고
    • IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation
    • Ma H.L., Liang S., Li J., Napierata L., Brown T., Benoit S., et al. IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest 2008, 118:597-607.
    • (2008) J Clin Invest , vol.118 , pp. 597-607
    • Ma, H.L.1    Liang, S.2    Li, J.3    Napierata, L.4    Brown, T.5    Benoit, S.6
  • 53
    • 0032729645 scopus 로고    scopus 로고
    • The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients
    • Austin L.M., Ozawa M., Kikuchi T., Walters I.B., Krueger J.G. The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J Invest Dermatol 1999, 113:752-759.
    • (1999) J Invest Dermatol , vol.113 , pp. 752-759
    • Austin, L.M.1    Ozawa, M.2    Kikuchi, T.3    Walters, I.B.4    Krueger, J.G.5
  • 54
    • 0027439191 scopus 로고
    • The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response
    • Uyemura K., Yamamura M., Fivenson D.F., Modlin R.L., Nickoloff B.J. The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response. J Invest Dermatol 1993, 101:701-705.
    • (1993) J Invest Dermatol , vol.101 , pp. 701-705
    • Uyemura, K.1    Yamamura, M.2    Fivenson, D.F.3    Modlin, R.L.4    Nickoloff, B.J.5
  • 55
    • 0035880456 scopus 로고    scopus 로고
    • Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies
    • Bowcock A.M., Shannon W., Du F., Duncan J., Cao K., Aftergut K., et al. Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum Mol Genet 2001, 10:1793-1805.
    • (2001) Hum Mol Genet , vol.10 , pp. 1793-1805
    • Bowcock, A.M.1    Shannon, W.2    Du, F.3    Duncan, J.4    Cao, K.5    Aftergut, K.6
  • 56
    • 77649235565 scopus 로고    scopus 로고
    • Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severity
    • Zhang L., Yang X.Q., Cheng J., Hui R.S., Gao T.W. Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severity. Clin Immunol 2010, 135:108-117.
    • (2010) Clin Immunol , vol.135 , pp. 108-117
    • Zhang, L.1    Yang, X.Q.2    Cheng, J.3    Hui, R.S.4    Gao, T.W.5
  • 57
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005, 6:1123-1132.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6
  • 58
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005, 6:1133-1141.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3    Chang, S.H.4    Nurieva, R.5    Wang, Y.H.6
  • 59
    • 44049100797 scopus 로고    scopus 로고
    • Th17 cells: a new fate for differentiating helper T cells
    • Chen Z., O'Shea J.J. Th17 cells: a new fate for differentiating helper T cells. Immunol Res 2008.
    • (2008) Immunol Res
    • Chen, Z.1    O'Shea, J.J.2
  • 62
    • 67651171182 scopus 로고    scopus 로고
    • Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells
    • Trifari S., Kaplan C.D., Tran E.H., Crellin N.K., Spits H. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat Immunol 2009, 10:864-871.
    • (2009) Nat Immunol , vol.10 , pp. 864-871
    • Trifari, S.1    Kaplan, C.D.2    Tran, E.H.3    Crellin, N.K.4    Spits, H.5
  • 63
    • 80555150814 scopus 로고    scopus 로고
    • Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis
    • Zhang L., Li J.M., Liu X.G., Ma D.X., Hu N.W., Li Y.G., et al. Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis. J Clin Immunol 2011, 31:606-614.
    • (2011) J Clin Immunol , vol.31 , pp. 606-614
    • Zhang, L.1    Li, J.M.2    Liu, X.G.3    Ma, D.X.4    Hu, N.W.5    Li, Y.G.6
  • 64
    • 67651154105 scopus 로고    scopus 로고
    • Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    • Duhen T., Geiger R., Jarrossay D., Lanzavecchia A., Sallusto F. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol 2009, 10:857-863.
    • (2009) Nat Immunol , vol.10 , pp. 857-863
    • Duhen, T.1    Geiger, R.2    Jarrossay, D.3    Lanzavecchia, A.4    Sallusto, F.5
  • 66
    • 70350547787 scopus 로고    scopus 로고
    • IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression
    • Tohyama M., Hanakawa Y., Shirakata Y., Dai X., Yang L., Hirakawa S., et al. IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. Eur J Immunol 2009, 39:2779-2788.
    • (2009) Eur J Immunol , vol.39 , pp. 2779-2788
    • Tohyama, M.1    Hanakawa, Y.2    Shirakata, Y.3    Dai, X.4    Yang, L.5    Hirakawa, S.6
  • 68
    • 67349230808 scopus 로고    scopus 로고
    • The IL-23/Th17 axis in the immunopathogenesis of psoriasis
    • Di Cesare A., Di Meglio P., Nestle F.O. The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol 2009, 129:1339-1350.
    • (2009) J Invest Dermatol , vol.129 , pp. 1339-1350
    • Di Cesare, A.1    Di Meglio, P.2    Nestle, F.O.3
  • 69
    • 34248572345 scopus 로고    scopus 로고
    • T(H)-17 cells in the circle of immunity and autoimmunity
    • Bettelli E., Oukka M., Kuchroo V.K. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007, 8:345-350.
    • (2007) Nat Immunol , vol.8 , pp. 345-350
    • Bettelli, E.1    Oukka, M.2    Kuchroo, V.K.3
  • 71
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou L., Ivanov I.I., Spolski R., Min R., Shenderov K., Egawa T., et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007, 8:967-974.
    • (2007) Nat Immunol , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5    Egawa, T.6
  • 75
    • 0347285359 scopus 로고    scopus 로고
    • Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
    • Lee E., Trepicchio W.L., Oestreicher J.L., Pittman D., Wang F., Chamian F., et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 2004, 199:125-130.
    • (2004) J Exp Med , vol.199 , pp. 125-130
    • Lee, E.1    Trepicchio, W.L.2    Oestreicher, J.L.3    Pittman, D.4    Wang, F.5    Chamian, F.6
  • 76
    • 31144441631 scopus 로고    scopus 로고
    • In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin
    • Piskin G., Sylva-Steenland R.M., Bos J.D., Teunissen M.B. In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin. J Immunol 2006, 176:1908-1915.
    • (2006) J Immunol , vol.176 , pp. 1908-1915
    • Piskin, G.1    Sylva-Steenland, R.M.2    Bos, J.D.3    Teunissen, M.B.4
  • 77
    • 70349753261 scopus 로고    scopus 로고
    • Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis
    • Harper E.G., Guo C., Rizzo H., Lillis J.V., Kurtz S.E., Skorcheva I., et al. Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol 2009, 129:2175-2183.
    • (2009) J Invest Dermatol , vol.129 , pp. 2175-2183
    • Harper, E.G.1    Guo, C.2    Rizzo, H.3    Lillis, J.V.4    Kurtz, S.E.5    Skorcheva, I.6
  • 78
    • 78649666553 scopus 로고    scopus 로고
    • Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis
    • Res P.C., Piskin G., de Boer O.J., van der Loos C.M., Teeling P., Bos J.D., et al. Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis. PLoS One 2010, 5:e14108.
    • (2010) PLoS One , vol.5
    • Res, P.C.1    Piskin, G.2    de Boer, O.J.3    van der Loos, C.M.4    Teeling, P.5    Bos, J.D.6
  • 79
    • 79959584686 scopus 로고    scopus 로고
    • Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
    • Lin A.M., Rubin C.J., Khandpur R., Wang J.Y., Riblett M., Yalavarthi S., et al. Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J Immunol 2011, 187:490-500.
    • (2011) J Immunol , vol.187 , pp. 490-500
    • Lin, A.M.1    Rubin, C.J.2    Khandpur, R.3    Wang, J.Y.4    Riblett, M.5    Yalavarthi, S.6
  • 80
    • 80052661515 scopus 로고    scopus 로고
    • Identification of a novel proinflammatory human skin-homing Vgamma9Vdelta2 T cell subset with a potential role in psoriasis
    • Laggner U., Di Meglio P., Perera G.K., Hundhausen C., Lacy K.E., Ali N., et al. Identification of a novel proinflammatory human skin-homing Vgamma9Vdelta2 T cell subset with a potential role in psoriasis. J Immunol 2011, 187:2783-2793.
    • (2011) J Immunol , vol.187 , pp. 2783-2793
    • Laggner, U.1    Di Meglio, P.2    Perera, G.K.3    Hundhausen, C.4    Lacy, K.E.5    Ali, N.6
  • 81
    • 80755180843 scopus 로고    scopus 로고
    • Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation
    • Cai Y., Shen X., Ding C., Qi C., Li K., Li X., et al. Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation. Immunity 2011, 35:596-610.
    • (2011) Immunity , vol.35 , pp. 596-610
    • Cai, Y.1    Shen, X.2    Ding, C.3    Qi, C.4    Li, K.5    Li, X.6
  • 82
    • 84876784472 scopus 로고    scopus 로고
    • CD8(+) T Cells in the Lesional Skin of Atopic Dermatitis and Psoriasis Patients Are an Important Source of IFN-gamma, IL-13, IL-17, and IL-22
    • Hijnen D., Knol E.F., Gent Y.Y., Giovannone B., S J.P.B., Kupper T.S., et al. CD8(+) T Cells in the Lesional Skin of Atopic Dermatitis and Psoriasis Patients Are an Important Source of IFN-gamma, IL-13, IL-17, and IL-22. J Invest Dermatol 2012.
    • (2012) J Invest Dermatol
    • Hijnen, D.1    Knol, E.F.2    Gent, Y.Y.3    Giovannone, B.4    S, J.P.B.5    Kupper, T.S.6
  • 84
    • 14244250511 scopus 로고    scopus 로고
    • Psoriasis assessment tools in clinical trials
    • [ii65-8; discussion ii69-73]
    • Feldman S.R., Krueger G.G. Psoriasis assessment tools in clinical trials. Ann Rheum Dis 2005, 64(Suppl. 2). [ii65-8; discussion ii69-73].
    • (2005) Ann Rheum Dis , vol.64 , Issue.SUPPL. 2
    • Feldman, S.R.1    Krueger, G.G.2
  • 85
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signalling in the IL-17 receptor family
    • Gaffen S.L. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol 2009, 9:556-567.
    • (2009) Nat Rev Immunol , vol.9 , pp. 556-567
    • Gaffen, S.L.1
  • 86
    • 80053600391 scopus 로고    scopus 로고
    • Recent advances in the IL-17 cytokine family
    • Gaffen S.L. Recent advances in the IL-17 cytokine family. Curr Opin Immunol 2011, 23:613-619.
    • (2011) Curr Opin Immunol , vol.23 , pp. 613-619
    • Gaffen, S.L.1
  • 87
    • 1842663219 scopus 로고    scopus 로고
    • Increased risk for cardiovascular mortality in psoriasis inpatients but not in outpatients
    • Mallbris L., Akre O., Granath F., Yin L., Lindelof B., Ekbom A., et al. Increased risk for cardiovascular mortality in psoriasis inpatients but not in outpatients. Eur J Epidemiol 2004, 19:225-230.
    • (2004) Eur J Epidemiol , vol.19 , pp. 225-230
    • Mallbris, L.1    Akre, O.2    Granath, F.3    Yin, L.4    Lindelof, B.5    Ekbom, A.6
  • 88
    • 33645016350 scopus 로고    scopus 로고
    • Psoriasis is associated with lipid abnormalities at the onset of skin disease
    • Mallbris L., Granath F., Hamsten A., Stahle M. Psoriasis is associated with lipid abnormalities at the onset of skin disease. J Am Acad Dermatol 2006, 54:614-621.
    • (2006) J Am Acad Dermatol , vol.54 , pp. 614-621
    • Mallbris, L.1    Granath, F.2    Hamsten, A.3    Stahle, M.4
  • 89
    • 77955898585 scopus 로고    scopus 로고
    • Cause-specific mortality in patients with severe psoriasis: a population-based cohort study in the UK
    • Abuabara K., Azfar R.S., Shin D.B., Neimann A.L., Troxel A.B., Gelfand J.M. Cause-specific mortality in patients with severe psoriasis: a population-based cohort study in the UK. Br J Dermatol 2010, 163:586-592.
    • (2010) Br J Dermatol , vol.163 , pp. 586-592
    • Abuabara, K.1    Azfar, R.S.2    Shin, D.B.3    Neimann, A.L.4    Troxel, A.B.5    Gelfand, J.M.6
  • 90
    • 84870795212 scopus 로고    scopus 로고
    • Psoriasis comorbidities: results from the national psoriasis foundation surveys 2003 to 2011
    • Armstrong A.W., Schupp C., Bebo B. Psoriasis comorbidities: results from the national psoriasis foundation surveys 2003 to 2011. Dermatology 2012, 225:121-126.
    • (2012) Dermatology , vol.225 , pp. 121-126
    • Armstrong, A.W.1    Schupp, C.2    Bebo, B.3
  • 91
    • 79960775900 scopus 로고    scopus 로고
    • Attributable risk estimate of severe psoriasis on major cardiovascular events
    • 775 e1-6
    • Mehta N.N., Yu Y., Pinnelas R., Krishnamoorthy P., Shin D.B., Troxel A.B., et al. Attributable risk estimate of severe psoriasis on major cardiovascular events. Am J Med 2011, 124. 775 e1-6.
    • (2011) Am J Med , vol.124
    • Mehta, N.N.1    Yu, Y.2    Pinnelas, R.3    Krishnamoorthy, P.4    Shin, D.B.5    Troxel, A.B.6
  • 92
    • 84875442130 scopus 로고    scopus 로고
    • Psoriasis and metabolic syndrome: a systematic review and meta-analysis of observational studies
    • Armstrong A.W., Harskamp C.T., Armstrong E.J. Psoriasis and metabolic syndrome: a systematic review and meta-analysis of observational studies. J Am Acad Dermatol 2013.
    • (2013) J Am Acad Dermatol
    • Armstrong, A.W.1    Harskamp, C.T.2    Armstrong, E.J.3
  • 93
    • 84864411560 scopus 로고    scopus 로고
    • Metabolic syndrome in patients with psoriatic disease
    • Gelfand J.M., Yeung H. Metabolic syndrome in patients with psoriatic disease. J Rheumatol Suppl 2012, 89:24-28.
    • (2012) J Rheumatol Suppl , vol.89 , pp. 24-28
    • Gelfand, J.M.1    Yeung, H.2
  • 94
    • 84857061326 scopus 로고    scopus 로고
    • Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom
    • Langan S.M., Seminara N.M., Shin D.B., Troxel A.B., Kimmel S.E., Mehta N.N., et al. Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom. J Invest Dermatol 2012, 132:556-562.
    • (2012) J Invest Dermatol , vol.132 , pp. 556-562
    • Langan, S.M.1    Seminara, N.M.2    Shin, D.B.3    Troxel, A.B.4    Kimmel, S.E.5    Mehta, N.N.6
  • 96
    • 84884289535 scopus 로고    scopus 로고
    • The association between psoriasis and hypertension: a systematic review and meta-analysis of observational studies
    • Armstrong A.W., Harskamp C.T., Armstrong E.J. The association between psoriasis and hypertension: a systematic review and meta-analysis of observational studies. J Hypertens 2012.
    • (2012) J Hypertens
    • Armstrong, A.W.1    Harskamp, C.T.2    Armstrong, E.J.3
  • 98
    • 84865237108 scopus 로고    scopus 로고
    • Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish nationwide cohort study
    • Ahlehoff O., Gislason G.H., Jorgensen C.H., Lindhardsen J., Charlot M., Olesen J.B., et al. Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish nationwide cohort study. Eur Heart J 2012, 33:2054-2064.
    • (2012) Eur Heart J , vol.33 , pp. 2054-2064
    • Ahlehoff, O.1    Gislason, G.H.2    Jorgensen, C.H.3    Lindhardsen, J.4    Charlot, M.5    Olesen, J.B.6
  • 99
    • 84858750389 scopus 로고    scopus 로고
    • Coronary artery disease in patients with psoriasis referred for coronary angiography
    • Armstrong A.W., Harskamp C.T., Ledo L., Rogers J.H., Armstrong E.J. Coronary artery disease in patients with psoriasis referred for coronary angiography. Am J Cardiol 2012, 109:976-980.
    • (2012) Am J Cardiol , vol.109 , pp. 976-980
    • Armstrong, A.W.1    Harskamp, C.T.2    Ledo, L.3    Rogers, J.H.4    Armstrong, E.J.5
  • 101
    • 84864856106 scopus 로고    scopus 로고
    • Cardiovascular mortality in psoriasis and psoriatic arthritis: epidemiology, pathomechanisms, therapeutic implications, and perspectives
    • Boehncke W.H., Boehncke S. Cardiovascular mortality in psoriasis and psoriatic arthritis: epidemiology, pathomechanisms, therapeutic implications, and perspectives. Curr Rheumatol Rep 2012, 14:343-348.
    • (2012) Curr Rheumatol Rep , vol.14 , pp. 343-348
    • Boehncke, W.H.1    Boehncke, S.2
  • 102
    • 79952729906 scopus 로고    scopus 로고
    • The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity
    • Boehncke W.H., Boehncke S., Tobin A.M., Kirby B. The 'psoriatic march': a concept of how severe psoriasis may drive cardiovascular comorbidity. Exp Dermatol 2011, 20:303-307.
    • (2011) Exp Dermatol , vol.20 , pp. 303-307
    • Boehncke, W.H.1    Boehncke, S.2    Tobin, A.M.3    Kirby, B.4
  • 103
    • 65349129341 scopus 로고    scopus 로고
    • Keratinocyte but not endothelial cell-specific overexpression of Tie2 leads to the development of psoriasis
    • Wolfram J.A., Diaconu D., Hatala D.A., Rastegar J., Knutsen D.A., Lowther A., et al. Keratinocyte but not endothelial cell-specific overexpression of Tie2 leads to the development of psoriasis. Am J Pathol 2009, 174:1443-1458.
    • (2009) Am J Pathol , vol.174 , pp. 1443-1458
    • Wolfram, J.A.1    Diaconu, D.2    Hatala, D.A.3    Rastegar, J.4    Knutsen, D.A.5    Lowther, A.6
  • 104
    • 84863981183 scopus 로고    scopus 로고
    • Chronic skin-specific inflammation promotes vascular inflammation and thrombosis
    • Wang Y., Gao H., Loyd C.M., Fu W., Diaconu D., Liu S., et al. Chronic skin-specific inflammation promotes vascular inflammation and thrombosis. J Invest Dermatol 2012, 132:2067-2075.
    • (2012) J Invest Dermatol , vol.132 , pp. 2067-2075
    • Wang, Y.1    Gao, H.2    Loyd, C.M.3    Fu, W.4    Diaconu, D.5    Liu, S.6
  • 105
    • 79953726733 scopus 로고    scopus 로고
    • Depletion of antigen-presenting cells by clodronate liposomes reverses the psoriatic skin phenotype in KC-Tie2 mice
    • Ward N.L., Loyd C.M., Wolfram J.A., Diaconu D., Michaels C.M., McCormick T.S. Depletion of antigen-presenting cells by clodronate liposomes reverses the psoriatic skin phenotype in KC-Tie2 mice. Br J Dermatol 2011, 164:750-758.
    • (2011) Br J Dermatol , vol.164 , pp. 750-758
    • Ward, N.L.1    Loyd, C.M.2    Wolfram, J.A.3    Diaconu, D.4    Michaels, C.M.5    McCormick, T.S.6
  • 106
    • 84862323012 scopus 로고    scopus 로고
    • Botulinum neurotoxin A decreases infiltrating cutaneous lymphocytes and improves acanthosis in the KC-Tie2 mouse model
    • Ward N.L., Kavlick K.D., Diaconu D., Dawes S.M., Michaels K.A., Gilbert E. Botulinum neurotoxin A decreases infiltrating cutaneous lymphocytes and improves acanthosis in the KC-Tie2 mouse model. J Invest Dermatol 2012, 132:1927-1930.
    • (2012) J Invest Dermatol , vol.132 , pp. 1927-1930
    • Ward, N.L.1    Kavlick, K.D.2    Diaconu, D.3    Dawes, S.M.4    Michaels, K.A.5    Gilbert, E.6
  • 107
    • 79958783026 scopus 로고    scopus 로고
    • Cutaneous denervation of psoriasiform mouse skin improves acanthosis and inflammation in a sensory neuropeptide-dependent manner
    • Ostrowski S.M., Belkadi A., Loyd C.M., Diaconu D., Ward N.L. Cutaneous denervation of psoriasiform mouse skin improves acanthosis and inflammation in a sensory neuropeptide-dependent manner. J Invest Dermatol 2011, 131:1530-1538.
    • (2011) J Invest Dermatol , vol.131 , pp. 1530-1538
    • Ostrowski, S.M.1    Belkadi, A.2    Loyd, C.M.3    Diaconu, D.4    Ward, N.L.5
  • 108
    • 84876783157 scopus 로고    scopus 로고
    • Cardiovascular disease event rates in patients with severe psoriasis treated with systemic anti-inflammatory drugs: a Danish real-world cohort study
    • Ahlehoff O., Skov L., Gislason G., Lindhardsen J., Kristensen S.L., Iversen L., et al. Cardiovascular disease event rates in patients with severe psoriasis treated with systemic anti-inflammatory drugs: a Danish real-world cohort study. J Intern Med 2012.
    • (2012) J Intern Med
    • Ahlehoff, O.1    Skov, L.2    Gislason, G.3    Lindhardsen, J.4    Kristensen, S.L.5    Iversen, L.6
  • 109
    • 76749088486 scopus 로고    scopus 로고
    • Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques
    • de Boer O.J., van der Meer J.J., Teeling P., van der Loos C.M., Idu M.M., van Maldegem F., et al. Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques. J Pathol 2010, 220:499-508.
    • (2010) J Pathol , vol.220 , pp. 499-508
    • de Boer, O.J.1    van der Meer, J.J.2    Teeling, P.3    van der Loos, C.M.4    Idu, M.M.5    van Maldegem, F.6
  • 110
    • 64549126102 scopus 로고    scopus 로고
    • Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells
    • Eid R.E., Rao D.A., Zhou J., Lo S.F., Ranjbaran H., Gallo A., et al. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation 2009, 119:1424-1432.
    • (2009) Circulation , vol.119 , pp. 1424-1432
    • Eid, R.E.1    Rao, D.A.2    Zhou, J.3    Lo, S.F.4    Ranjbaran, H.5    Gallo, A.6
  • 111
    • 40849130955 scopus 로고    scopus 로고
    • The Th17/Treg imbalance in patients with acute coronary syndrome
    • Cheng X., Yu X., Ding Y.J., Fu Q.Q., Xie J.J., Tang T.T., et al. The Th17/Treg imbalance in patients with acute coronary syndrome. Clin Immunol 2008, 127:89-97.
    • (2008) Clin Immunol , vol.127 , pp. 89-97
    • Cheng, X.1    Yu, X.2    Ding, Y.J.3    Fu, Q.Q.4    Xie, J.J.5    Tang, T.T.6
  • 112
    • 10844222790 scopus 로고    scopus 로고
    • Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation
    • Sugiyama H., Gyulai R., Toichi E., Garaczi E., Shimada S., Stevens S.R., et al. Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. J Immunol 2005, 174:164-173.
    • (2005) J Immunol , vol.174 , pp. 164-173
    • Sugiyama, H.1    Gyulai, R.2    Toichi, E.3    Garaczi, E.4    Shimada, S.5    Stevens, S.R.6
  • 113
    • 78650637747 scopus 로고    scopus 로고
    • A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice
    • Gao Q., Jiang Y., Ma T., Zhu F., Gao F., Zhang P., et al. A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice. J Immunol 2010, 185:5820-5827.
    • (2010) J Immunol , vol.185 , pp. 5820-5827
    • Gao, Q.1    Jiang, Y.2    Ma, T.3    Zhu, F.4    Gao, F.5    Zhang, P.6
  • 114
    • 77951485998 scopus 로고    scopus 로고
    • Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice
    • Smith E., Prasad K.M., Butcher M., Dobrian A., Kolls J.K., Ley K., et al. Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice. Circulation 2010, 121:1746-1755.
    • (2010) Circulation , vol.121 , pp. 1746-1755
    • Smith, E.1    Prasad, K.M.2    Butcher, M.3    Dobrian, A.4    Kolls, J.K.5    Ley, K.6
  • 115
    • 73849097617 scopus 로고    scopus 로고
    • The Th17/Treg functional imbalance during atherogenesis in apoE(-/-) mice
    • Xie J.J., Wang J., Tang T.T., Chen J., Gao X.L., Yuan J., et al. The Th17/Treg functional imbalance during atherogenesis in apoE(-/-) mice. Cytokine 2010, 49:185-193.
    • (2010) Cytokine , vol.49 , pp. 185-193
    • Xie, J.J.1    Wang, J.2    Tang, T.T.3    Chen, J.4    Gao, X.L.5    Yuan, J.6
  • 116
    • 84859102455 scopus 로고    scopus 로고
    • Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in western diet-induced apoE-deficient mice
    • Usui F., Kimura H., Ohshiro T., Tatsumi K., Kawashima A., Nishiyama A., et al. Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in western diet-induced apoE-deficient mice. Biochem Biophys Res Commun 2012, 420:72-77.
    • (2012) Biochem Biophys Res Commun , vol.420 , pp. 72-77
    • Usui, F.1    Kimura, H.2    Ohshiro, T.3    Tatsumi, K.4    Kawashima, A.5    Nishiyama, A.6
  • 117
    • 76249103398 scopus 로고    scopus 로고
    • Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient mice
    • Erbel C., Chen L., Bea F., Wangler S., Celik S., Lasitschka F., et al. Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient mice. J Immunol 2009, 183:8167-8175.
    • (2009) J Immunol , vol.183 , pp. 8167-8175
    • Erbel, C.1    Chen, L.2    Bea, F.3    Wangler, S.4    Celik, S.5    Lasitschka, F.6


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