IL-27 Receptor Signalling Restricts the Formation of Pathogenic, Terminally Differentiated Th1 Cells during Malaria Infection by Repressing IL-12 Dependent Signals

PLoS Pathogens

Volumn 9, Issue 4, 2013, Pages

  Villegas Mendez, Ana ^a,f   de Souza, J Brian ^a,b   Lavelle, Seen Wai ^a   Gwyer Findlay, Emily ^a,g   Shaw, Tovah N ^a,f   van Rooijen, Nico ^c   Saris, Christiaan J ^d   Hunter, Christopher A ^e   Riley, Eleanor M ^a   Couper, Kevin N ^a,f  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d AMGEN INC   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

^g UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 27; INTERLEUKIN 27 RECEPTOR; INTERLEUKIN RECEPTOR; STAT4 PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FLOW CYTOMETRY; HISTOPATHOLOGY; MALARIA; MOUSE; NONHUMAN; PHENOTYPE; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAINING; T CELL DEPLETION; TH1 CELL;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; FORKHEAD TRANSCRIPTION FACTORS; INTERFERON-GAMMA; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-10 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-12; INTERLEUKIN-2; INTERLEUKIN-27; MALARIA, FALCIPARUM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLASMODIUM FALCIPARUM; RECEPTORS, CYTOKINE; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; TH1 CELLS;

MUS;

EID: 84876793137     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003293     Document Type: Article

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