Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice

NeuroToxicology

Volumn 37, Issue , 2013, Pages 1-14

  Breckenridge, Charles B ^a   Sturgess, Nicholas C ^b   Butt, Mark ^c   Wolf, Jeffrey C ^d   Zadory, Dan ^d   Beck, Melissa ^e   Mathews, James M ^f   Tisdel, Merrill O ^a   Minnema, Daniel ^a   Travis, Kim Z ^b   Cook, Andrew R ^b   Botham, Philip A ^b   Smith, Lewis L ^b,g  

^a SYNGENTA CROP PROTECTION   (United States)

^b JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^c LLC   (United States)

^d EXPERIMENTAL PATHOLOGY LABORATORIES INC   (United States)

^e WIL RESEARCH LABORATORIES   (United States)

^f RTI INTERNATIONAL   (United States)

^g UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Dopamine turnover; Glial activation; Neuropathology; Paraquat; Pharmacokinetics; Stereology; Substantia nigra pars compacta

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; CASPASE 3; CHROMOGENIC SUBSTRATE; DOPAMINE; ENZYME ANTIBODY; GLIAL FIBRILLARY ACIDIC PROTEIN; HOMOVANILLIC ACID; IONIZED CALCIUM BINDING ADAPTOR MOLECULE 1 PROTEIN; NERVE PROTEIN; PARAQUAT; TYROSINE HYDROXYLASE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL COUNT; CELL LOSS; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; ENZYME ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROCHEMISTRY; NEUROPATHOLOGY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; SILVER STAINING; STEREOLOGY; SUBSTANTIA NIGRA PARS COMPACTA; TOXICITY TESTING;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; ASTROCYTES; BASAL GANGLIA; CELL DEATH; DOPAMINE; DOPAMINERGIC NEURONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HALF-LIFE; HERBICIDES; HOMOVANILLIC ACID; INJECTIONS, INTRAPERITONEAL; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED C57BL; MICROGLIA; MPTP POISONING; NERVE DEGENERATION; PARAQUAT; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

MUS;

EID: 84876734751     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2013.03.005     Document Type: Article

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