Impact of quaternary structure dynamics on allosteric drug discovery

Current Topics in Medicinal Chemistry

Volumn 13, Issue 1, 2013, Pages 55-63

  Jaffe, Eileen K ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

HIV integrase; Morpheein; Phenylalanine hydroxylase; Porphobilinogen synthase; Protein dynamics; Pyruvate kinase; Transthyretin; Tumor necrosis factor alpha

Indexed keywords

ADENYLOSUCCINATE LYASE; DICLOFENAC; DIFLUNISAL; INTEGRASE; LENS EPITHELIUM DERIVED GROWTH FACTOR; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; PORPHOBILINOGEN SYNTHASE; PREALBUMIN; PYRUVATE KINASE; TUMOR NECROSIS FACTOR ALPHA;

ALLOSTERISM; ARTICLE; CLINICAL TRIAL (TOPIC); DRUG DESIGN; DYNAMICS; ENERGY METABOLISM; HUMAN; INBORN ERROR OF METABOLISM; PHENYLKETONURIA; PHYLOGENY; PORPHYRIA; PROTEIN QUATERNARY STRUCTURE; RADIATION SCATTERING; UNSPECIFIED SIDE EFFECT;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; DRUG DISCOVERY; DRUGS, INVESTIGATIONAL; HIV INTEGRASE; HUMANS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; PHENYLALANINE HYDROXYLASE; PORPHOBILINOGEN SYNTHASE; PREALBUMIN; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PYRUVATE KINASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84876732401     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026611313010006     Document Type: Article

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