The Diflunisal Trial: Study accrual and drug tolerance

Amyloid

Volumn 19, Issue SUPPL. 1, 2012, Pages 37-38

  Berk, John L ^a   Suhr, Ole B ^b   Sekijima, Yoshiki ^c   Yamashita, Taro ^d   Heneghan, Michael ^e   Zeldenrust, Steven R ^f   Ando, Yukio ^d   Ikeda, Shu Ichi ^c   Gorevic, Peter ^g   Merlini, Giampaolo ^h   Kelly, Jeffrey W ⁱ   Skinner, Martha ^a   Bisbee, Alice B ^a   Dyck, Peter J ^f   Obici, Laura ⁱ  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b UMEÅ UNIVERSITY   (Sweden)

^c SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

^e KING S COLLEGE HOSPITAL   (United Kingdom)

^f MAYO CLINIC ROCHESTER   (United States)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF PAVIA   (Italy)

ⁱ SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Clinical trials; Diflunisal; FAP; Neuropathy; transthyretin

Indexed keywords

DIFLUNISAL;

ADULT; AGED; CONFERENCE PAPER; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG TOLERANCE; EDEMA; FAMILIAL AMYLOID POLYNEUROPATHY; FEMALE; GASTROINTESTINAL DISEASE; HEART ARREST; HEART ARRHYTHMIA; HUMAN; HYPERTENSION; INFORMATION PROCESSING; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MUTATION; NEUROLOGIC DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTOPENIA;

ADULT; AGED; AMYLOID NEUROPATHIES, FAMILIAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DIFLUNISAL; FEMALE; HUMANS; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84861438796     PISSN: 13506129     EISSN: 17442818     Source Type: Journal    
DOI: 10.3109/13506129.2012.678509     Document Type: Conference Paper

References (7)

1. Benson MD, Kincaid JC. The molecular biology and clinical features of amyloid neuropathy. Muscle Nerve 2007;36:411-423. (Pubitemid 47512065)
2. Dubrey SW, Davidoff R, Skinner M, Bergethon P, Lewis D, Falk RH. Progression of ventricular wall thickening after liver transplantation for familial amyloidosis. Transplantation 1997;64:74-80. (Pubitemid 27327203)
3. Stangou AJ, Hawkins PN, Heaton ND, Rela M, Monaghan M, Nihoyannopoulos P, O'Grady J, et al. Progressive cardiac amyloidosis following liver transplantation for familial amyloid polyneuropathy: implications for amyloid fibrillogenesis. Transplantation 1998;66:229-233. (Pubitemid 28370006)
4. Sekijima Y, Dendle MA, Kelly JW. Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis. Amyloid 2006;13:236-249. (Pubitemid 44764463)
5. Miller SR, Sekijima Y, Kelly JW. Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants. Lab Invest 2004;84:545-552. (Pubitemid 38858463)
6. Peripheral Nerve Society. Diabetic polyneuropathy in controlled clinical trials: concensus report of the Peripheral Nerve Society. Ann Neurol 1995;38:478-482.
7. Dyck PJ, Davies JL, Litchy WJ, O'Brien PC. Longitudinal assessment of diabetic polyneuropathy using a composite score in the Rochester Diabetic Neuropathy Study cohort. Neurology 1997; 49:229-239. (Pubitemid 27328707)