Allosteric inhibition of human porphobilinogen synthase

Journal of Biological Chemistry

Volumn 284, Issue 51, 2009, Pages 35807-35817

  Lawrence, Sarah H ^a   Ramirez, Ursula D ^a   Selwood, Trevor ^a   Stith, Linda ^a   Jaffe, Eileen K ^a,b  

^a FOX CHASE CANCER CENTER   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC ENZYMES; ALLOSTERIC INHIBITION; CHEMICAL PURITY; DATA SUPPORT; DIMER CONFIGURATION; DISEASE STATE; ENZYMATIC ACTIVITIES; HEXAMERS; HIGH ACTIVITY; IN-SILICO; IN-VITRO; LEAD POISONING; MOBILITY SHIFT ASSAYS; NATURALLY OCCURRING; OCTAMERS; PORPHOBILINOGEN; PRESCREENING; QUATERNARY STRUCTURE; SIDE EFFECT; SMALL MOLECULES; SPECIFIC SURFACE; SYNTHASES; TETRAPYRROLES;

BIOCHEMISTRY; CHLOROPHYLL; CRYSTAL STRUCTURE; DRUG INTERACTIONS; ENZYMES; PORPHYRINS; STOICHIOMETRY;

PHOTONICS;

1,6 DIHYDRO N (3 METHOXYPHENOL) 1 METHYL 6 OXO 2 [(2 PYRIDINYLMETHYL)THIO] 5 PYRIMIDINECARBOXAMIDE; 5 CHLORO 7 (DIETHYLAMINOMETHYL)QUINOLIN 8 OL; CLIOQUINOL; DIIODOHYDROXYQUIN; ENZYME INHIBITOR; ML 3A9; ML 3H2; PORPHOBILINOGEN SYNTHASE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; MOLECULAR DOCKING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; PROTEIN STABILITY; STRUCTURE ANALYSIS;

ALLOSTERIC REGULATION; HUMANS; LEAD POISONING; LIGANDS; PORPHOBILINOGEN SYNTHASE; PORPHYRIAS; PROTEIN STRUCTURE, QUATERNARY;

EID: 72149114873     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.026294     Document Type: Article

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