Structural basis for morpheein-type allosteric regulation of Escherichia coli glucosamine-6-phosphate synthase: Equilibrium between inactive hexamer and active dimer

Journal of Biological Chemistry

Volumn 287, Issue 41, 2012, Pages 34533-34546

  Mouilleron, Stéphane ^a,b,c   Badet Denisot, Marie Ange ^b   Pecqueur, Ludovic ^a   Madiona, Karine ^a   Assrir, Nadine ^b   Badet, Bernard ^b   Golinelli Pimpaneau, Béatrice ^a,b  

^a LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

^b CNRS   (France)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALLOSTERIC REGULATION; ANTIBACTERIAL INHIBITORS; E. COLI; ENZYME CONCENTRATIONS; GLUCOSAMINE 6-PHOSPHATE; GLUCOSAMINE-6-PHOSPHATE SYNTHASE; GLUTAMINASE; HEXAMERS; IN-VITRO; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRODUCT INHIBITION; QUASI-ELASTIC LIGHT SCATTERING; SPECIFIC ACTIVITY; STABLE FORM; STRUCTURAL BASIS; ULTRACENTRIFUGATION; WILD-TYPE ENZYMES;

AMINO ACIDS; AMMONIA; CENTRIFUGATION; ELECTROPHORESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; GLUCOSAMINE; GLUCOSE;

ENZYME INHIBITION;

AMMONIA; DIMER; FRUCTOSE 6 PHOSPHATE; GLUTAMINASE; GLUTAMINE; GLUTAMINE FRUCTOSE 6 PHOSPHATE AMINOTRANSFERASE; NUCLEOPHILE;

ALLOSTERISM; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIMERIZATION; ENZYME STRUCTURE; ESCHERICHIA COLI; GEL PERMEATION CHROMATOGRAPHY; LIGHT SCATTERING; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; ULTRACENTRIFUGATION;

ALLOSTERIC REGULATION; ENZYME STABILITY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLUTAMINE-FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867247853     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.380378     Document Type: Article

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