Diverse clinical compounds alter the quaternary structure and inhibit the activity of an essential enzyme

ChemMedChem

Volumn 6, Issue 6, 2011, Pages 1067-1073

  Lawrence, Sarah H ^a   Selwood, Trevor ^a   Jaffe, Eileen K ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

Allosterism; Inhibitors; Lyases; Morpheeins; Proteins

Indexed keywords

2,4 DINITROANISOLE; ARTHROTEC; BENDROFLUMETHIAZIDE; COPPER SULFATE; DIBROMOSALICYLALDEHYDE; DICLOFENAC; DICLOFENAC POTASSIUM; ENZYME INHIBITOR; ENZYME VARIANT; FLUFENAMIC ACID; MECLOFENAMIC ACID; NIFLUGEL; NIFLUMIC ACID; NITROFURAL; OXANTEL; PENNSAID; PORPHOBILINOGEN SYNTHASE; PORPHOBILINOGEN SYNTHASE INHIBITOR; PV 10; ROSE BENGAL; SOLARAZ; TOLFENAMIC ACID; UNCLASSIFIED DRUG; ZIPSOR;

ARTICLE; BREAST CANCER; BURN; CALCULATION; CLINICAL TRIAL (TOPIC); CONFORMATIONAL TRANSITION; DRUG FORMULATION; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STABILITY; ENZYME STRUCTURE; HEME SYNTHESIS; HUMAN; IC 50; IN VITRO STUDY; MELANOMA; PHOSPHORUS BURN; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; STOICHIOMETRY; STRUCTURE ANALYSIS;

HUMANS; PHARMACEUTICAL PREPARATIONS; PORPHOBILINOGEN SYNTHASE; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY;

EID: 79957607075     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100009     Document Type: Article

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