Probing the solution structure of tumor necrosis factor-α homotrimer and heterotrimer after complex perturbation using electrospray ionization mass spectrometry

Journal of Molecular Recognition

Volumn 25, Issue 3, 2012, Pages 174-183

  Beil, Eric J ^a   Heavner, George A ^a   Wu, Sheng Jiun ^a   Nemeth, Jennifer F ^a  

^a CENTOCOR INC   (United States)

Author keywords

complex; mass spectrometry; non covalent interactions; trimer; Tumor necrosis factor

Indexed keywords

DIMETHYL SULFOXIDE; SOLVENT; TUMOR NECROSIS FACTOR ALPHA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; GENETICS; HUMAN; MOLECULAR GENETICS; MOLECULAR WEIGHT; PH; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN REFOLDING; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; DIMETHYL SULFOXIDE; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN MULTIMERIZATION; PROTEIN REFOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SOLVENTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863275895     PISSN: 09523499     EISSN: 10991352     Source Type: Journal    
DOI: 10.1002/jmr.1170     Document Type: Article

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