Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma

International Journal of Cancer

Volumn 123, Issue 5, 2008, Pages 1053-1059

  Kawase, Akikazu ^a   Ishii, Genichiro ^a   Nagai, Kanji ^a   Ito, Takeo ^a   Nagano, Tatsuya ^a   Murata, Yukinori ^a   Hishida, Tomoyuki ^a   Nishimura, Mitsuyo ^a   Yoshida, Junji ^a   Suzuki, Kazuya ^b   Ochiai, Atsushi ^a,c  

^a NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Research Center for Innovative Oncology   (Japan)

Author keywords

Cancer associated fibroblasts; Lung adenocarcinoma; Podoplanin

Indexed keywords

PODOPLANIN; MEMBRANE PROTEIN; PDPN PROTEIN, HUMAN; TUMOR MARKER;

ADOLESCENT; ADULT; AGED; APICAL MEMBRANE; ARTICLE; CANCER ASSOCIATED FIBROBLAST; CANCER CELL; CANCER SURVIVAL; CELL SURVIVAL; CHILD; CONTROLLED STUDY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; LOG RANK TEST; LUNG ADENOCARCINOMA; MAJOR CLINICAL STUDY; MALE; NEWBORN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STROMA CELL; SURVIVAL TIME; UNIVARIATE ANALYSIS; ADENOCARCINOMA; CANCER INVASION; CANCER STAGING; CHEMISTRY; CONFOCAL MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; LUNG TUMOR; LYMPH NODE METASTASIS; MIDDLE AGED; PATHOLOGY; PREDICTION AND FORECASTING; RETROSPECTIVE STUDY; SURVIVAL; WESTERN BLOTTING;

ADENOCARCINOMA; AGED; BLOTTING, WESTERN; FEMALE; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MEMBRANE GLYCOPROTEINS; MICROSCOPY, CONFOCAL; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RETROSPECTIVE STUDIES; STROMAL CELLS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 47249155697     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23611     Document Type: Article

References (25)

1. Goya T, Asamura H, Yoshimura H, Kato H, Shimokata K, Tsuchiya R, Sohara Y, Miya T, Miyaoka E. Prognosis of 6644 resected non-small cell lung cancers in Japan: a Japanese lung cancer registry study. Lung Cancer 2005;50:227-34.
2. Martin-Villar E, Scholl FG, Gamallo C, Yurrita MM, Munoz-Guerra M, Cruces J, Quintanilla M. Characterization of human PA2.26 antigen (T1α-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Int J Cancer 2005;113:899-910.
3. Wicki A, Christofori G. The potential role of podoplanin in tumour invasion. Br J Cancer 2007;96:1-5.
4. Dumoff KL, Chu CS, Harris EE, Holtz D, Xu X, Zhang PJ, ACS G. Low podoplanin expression in pretreatment biopsy material predicts poor prognosis in advanced-stage squamous cell carcinoma of the uterine cervix treated by primary radiation. Mod Pathol 2006;19:708-16.
5. Yu H, Gibson JA, Pinkus GS, Homick JL. Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors. Am J Clin Pathol 2007;128:776-82.
6. Muller AM, Franke FE, Muller KM. D2-40: a reliable marker in the diagnosis of pleural mesothelioma. Pathobiology 2006;73:50-4.
7. Kato Y, Kaneko M, Sata M, Fujita N, Tsuruo T, Osawa M. Enhanced expression of Aggrus (T1α/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma. Tumour Biol 2005;26:195-200.
8. Yuan P, Temam S, El-Naggar A, Zhou X, Liu DD, Lee JJ, Mao L. Overexpression of podoplanin in oral cancer and its association with poor clinical outcome. Cancer 2006;107:563-9.
9. Ordonez NG. D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma. Hum Pathol 2005;36:372-80.
10. Naito Y, Ishii G, Kawai O, Hasebe T, Nishiwaki Y, Nagai K, Ochiai A. D240-positive solitary fibrous tumors of the pleura: diagnostic pitfall of biopsy specimen. Pathol Int 2007;57:618-21.
11. Ishii G, Sangai T, Sugiyama K, Ito T, Hasebe T, Endoh Y, Magae J, Ochiai A. In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions. Stem Cells 2005;23:699-706.
12. Ishii G, Sangai T, Ito T, Hasebe T, Endoh Y, Sasaki H, Harigaya K, Ochiai A. In vivo and in vitro characterization of human fibroblasts recruited selectively into human cancer stroma. Int J Cancer 2005;117:212-20.
13. Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006;6:392-401.
14. Ito TK, Ishii G, Chiba H, Ochiai A. The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells. Oncogene 2007;26:7194-203.
15. Hasebe T, Sasaki S, Imoto S, Ochiai A. Proliferative activity of intratumoral fibroblasts is closely correlated with lymph node and distant organ metastases of invasive ductal carcinoma of the breast. Am J Pathol 2000;156:1701-10.
16. Cekanova M, Masi T, Plummer HK, III, Majidi M, Fedorocko P, Schuller HM. Pulmonary fibroblasts stimulate the proliferation of cell lines from human lung adenocarcinomas. Anticancer Drugs 2006;17:771-81.
17. Mahalingam M, Ugen KE, Kao KJ, Klein PA. Functional role of platelets in experimental metastasis studied with cloned murine fibrosarcoma cell variants. Cancer Res 1988;48:1460-4.
18. Honn KV, Tang DG, Crissman JD. Platelets and cancer metastasis: a causal relationship? Cancer Metastasis Rev 1992;11:325-51.
19. Gasic GJ. Role of plasma, platelets, and endothelial cells in tumor metastasis. Cancer Metastasis Rev 1984;3:99-114.
20. Crissman JD, Hatfield JS, Menter DG, Sloane B, Honn KV. Morphological study of the interaction of intravascular tumor cells with endothelial cells and subendothelial matrix. Cancer Res 1988;48:4065-72.
21. Suzuki K, Aiura K, Ueda M, Kitajima M. The influence of platelets on the promotion of invasion by tumor cells and inhibition by antiplatelet agents. Pancreas 2004;29:132-40.
22. Suzuki-Inoue K, Kato Y, Inoue O, Kaneko MK, Mishima K, Yatomi Y, Yamazaki Y, Narimatsu H, Ozaki Y. Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. J Biol Chem 2007;282:25993-6001.
23. Chu AY, Litzky LA, Pasha TL, ACS G, Zhang PJ. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol 2005;18:105-10.
24. Kimura N, Kimura I. Podoplanin as a marker for mesothelioma. Pathol Int 2005;55:83-6.
25. Noguchi M, Morikawa A, Kawasaki M, Matsuno Y, Yamada T, Hirohashi S, Kondo H, Shimosato Y. Small adenocarcinoma of the lung. Histologic characteristics and prognosis. Cancer 1995;75:2844-52.