A ROS-mediated lysosomal-mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human Hela cervix carcinoma cells

Cancer Letters

Volumn 333, Issue 2, 2013, Pages 229-238

  Shen, Ke ^a   Sun, Liyun ^a   Zhang, Huanying ^a   Xu, Yufang ^a   Qian, Xuhong ^a   Lu, Yanhua ^a   Li, Qi ^b   Ni, Lei ^c   Liu, Jianwen ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

7c; Apoptosis; Lysosomes; Mitochondrion; Oxidative stress

Indexed keywords

2 [3 [2 (DIMETHYLAMINO)ETHYLAMINO]PROPYL] 6 (OCTYLAMINO) 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 7 C; AMONAFIDE; ANTINEOPLASTIC AGENT; CASPASE; CATHEPSIN B; CYTOCHROME C; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL METABOLISM; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LYSOSOME; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN MODIFICATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; UTERINE CERVIX CANCER;

ANTINEOPLASTIC AGENTS; APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; INTRACELLULAR MEMBRANES; LYSOSOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NAPHTHALIMIDES; PERMEABILITY; REACTIVE OXYGEN SPECIES;

EID: 84876720134     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2013.01.038     Document Type: Article

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