메뉴 건너뛰기




Volumn 72, Issue 5, 2013, Pages 396-403

Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice

Author keywords

Apolipoprotein E; Axon injury; Traumatic brain injury

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; PHOSPHOSERINE; TAU PROTEIN;

EID: 84876687723     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e31828e24ab     Document Type: Article
Times cited : (34)

References (53)
  • 1
    • 0029018224 scopus 로고
    • Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease
    • Mayeux R, Ottman R, Maestre G, et al. Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease. Neurology 1995;45:555-57
    • (1995) Neurology , vol.45 , pp. 555-557
    • Mayeux, R.1    Ottman, R.2    Maestre, G.3
  • 2
    • 0030770308 scopus 로고    scopus 로고
    • Association of apolipoprotein e polymorphism with outcome after head injury
    • Teasdale GM, Nicoll JA, Murray G, et al. Association of apolipoprotein E polymorphism with outcome after head injury. Lancet 1997;350:1069-71
    • (1997) Lancet , vol.350 , pp. 1069-1071
    • Teasdale, G.M.1    Nicoll, J.A.2    Murray, G.3
  • 3
    • 0033554880 scopus 로고    scopus 로고
    • Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury
    • Friedman G, Froom P, Sazbon L, et al. Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury. Neurology 1999;52:244-48
    • (1999) Neurology , vol.52 , pp. 244-248
    • Friedman, G.1    Froom, P.2    Sazbon, L.3
  • 4
    • 27644546646 scopus 로고    scopus 로고
    • The association between APOE epsilon4, age and outcome after head injury: A prospective cohort study
    • Teasdale GM, Murray GD, Nicoll JA. The association between APOE epsilon4, age and outcome after head injury: A prospective cohort study. Brain 2005;128:2556-61
    • (2005) Brain , vol.128 , pp. 2556-2561
    • Teasdale, G.M.1    Murray, G.D.2    Nicoll, J.A.3
  • 5
    • 0030612497 scopus 로고    scopus 로고
    • Apolipoprotein e epsilon4 associated with chronic traumatic brain injury in boxing
    • Jordan BD, Relkin NR, Ravdin LD, et al. Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing. JAMA 1997; 278:136-40
    • (1997) JAMA , vol.278 , pp. 136-140
    • Jordan, B.D.1    Relkin, N.R.2    Ravdin, L.D.3
  • 6
    • 0034521191 scopus 로고    scopus 로고
    • Lower cognitive performance of older football players possessing apolipoprotein e epsilon4
    • Kutner KC, Erlanger DM, Tsai J, et al. Lower cognitive performance of older football players possessing apolipoprotein E epsilon4. Neurosur-gery 2000;47:651-57
    • (2000) Neurosur-gery , vol.47 , pp. 651-657
    • Kutner, K.C.1    Erlanger, D.M.2    Tsai, J.3
  • 7
    • 0024299370 scopus 로고
    • Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
    • Mahley RW. Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science 1988;240:622-30
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 8
    • 79951713725 scopus 로고    scopus 로고
    • Apolipoprotein e in Alzheimer's disease and other neurological disorders
    • Verghese PB, Castellano JM, Holtzman DM. Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol 2011;10:241-52
    • (2011) Lancet Neurol , vol.10 , pp. 241-252
    • Verghese, P.B.1    Castellano, J.M.2    Holtzman, D.M.3
  • 9
    • 0027194791 scopus 로고
    • Gene dose of apolipo-protein e type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipo-protein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-23
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 10
    • 0027407565 scopus 로고
    • Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
    • Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993;90:1977-81
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1977-1981
    • Strittmatter, W.J.1    Saunders, A.M.2    Schmechel, D.3
  • 11
    • 10044250141 scopus 로고    scopus 로고
    • Head injury and dementia
    • Jellinger KA. Head injury and dementia. Curr Opin Neurol 2004;17: 719-23
    • (2004) Curr Opin Neurol , vol.17 , pp. 719-723
    • Jellinger, K.A.1
  • 12
    • 0034711173 scopus 로고    scopus 로고
    • Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias
    • Plassman BL, Havlik RJ, Steffens DC, et al. Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias. Neurology 2000;55:1158-66
    • (2000) Neurology , vol.55 , pp. 1158-1166
    • Plassman, B.L.1    Havlik, R.J.2    Steffens, D.C.3
  • 13
    • 67349270965 scopus 로고    scopus 로고
    • Apolipoprotein e and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy
    • Bu G. Apolipoprotein E and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy. Nat Rev Neurosci 2009;10:333-44
    • (2009) Nat Rev Neurosci , vol.10 , pp. 333-344
    • Bu, G.1
  • 14
    • 0036896994 scopus 로고    scopus 로고
    • Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease
    • Hartman RE, Laurer H, Longhi L, et al. Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. J Neurosci 2002;22:10083-87
    • (2002) J Neurosci , vol.22 , pp. 10083-10087
    • Hartman, R.E.1    Laurer, H.2    Longhi, L.3
  • 15
    • 0028986690 scopus 로고
    • Apolipoprotein e epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury
    • Nicoll JA, Roberts GW, Graham DI. Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury. Nat Med 1995;1:135-37
    • (1995) Nat Med , vol.1 , pp. 135-137
    • Nicoll, J.A.1    Roberts, G.W.2    Graham, D.I.3
  • 16
    • 33644554821 scopus 로고    scopus 로고
    • Association of APOE e4 and cerebrovascular pathology in traumatic brain injury
    • Smith C, Graham DI, Murray LS, et al. Association of APOE e4 and cerebrovascular pathology in traumatic brain injury. J Neurol Neurosurg Psychiatry 2006;77:363-66
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 363-366
    • Smith, C.1    Graham, D.I.2    Murray, L.S.3
  • 17
    • 0036119782 scopus 로고    scopus 로고
    • Effect of apolipoprotein e genotype on hematoma volume after trauma
    • Liaquat I, Dunn LT, Nicoll JA, et al. Effect of apolipoprotein E genotype on hematoma volume after trauma. J Neurosurg 2002;96:90-96
    • (2002) J Neurosurg , vol.96 , pp. 90-96
    • Liaquat, I.1    Dunn, L.T.2    Nicoll, J.A.3
  • 18
    • 0025840201 scopus 로고
    • Beta A4 amyloid protein deposition in brain after head trauma
    • Roberts GW, Gentleman SM, Lynch A, et al. Beta A4 amyloid protein deposition in brain after head trauma. Lancet 1991;338:1422-23
    • (1991) Lancet , vol.338 , pp. 1422-1423
    • Roberts, G.W.1    Gentleman, S.M.2    Lynch, A.3
  • 19
    • 0028174629 scopus 로고
    • Beta amyloid protein deposition in the brain after severe head injury: Implications for the path-ogenesis of Alzheimer's disease
    • Roberts GW, Gentleman SM, Lynch A, et al. Beta amyloid protein deposition in the brain after severe head injury: Implications for the path-ogenesis of Alzheimer's disease. J Neurol Neurosurg Psychiatry 1994;57: 419-25
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , pp. 419-425
    • Roberts, G.W.1    Gentleman, S.M.2    Lynch, A.3
  • 20
    • 0037404532 scopus 로고    scopus 로고
    • Amyloid beta accumulation in axons after traumatic brain injury in humans
    • Smith DH, Chen XH, Iwata A, et al. Amyloid beta accumulation in axons after traumatic brain injury in humans. J Neurosurg 2003;98:1072-77
    • (2003) J Neurosurg , vol.98 , pp. 1072-1077
    • Smith, D.H.1    Chen, X.H.2    Iwata, A.3
  • 21
    • 36049047066 scopus 로고    scopus 로고
    • Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans
    • Uryu K, Chen XH, Martinez D, et al. Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans. Exp Neurol 2007;208:185-92
    • (2007) Exp Neurol , vol.208 , pp. 185-192
    • Uryu, K.1    Chen, X.H.2    Martinez, D.3
  • 22
    • 5044237263 scopus 로고    scopus 로고
    • Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury
    • Ikonomovic MD, Uryu K, Abrahamson EE, et al. Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury. Exp Neurol 2004;190:192-203
    • (2004) Exp Neurol , vol.190 , pp. 192-203
    • Ikonomovic, M.D.1    Uryu, K.2    Abrahamson, E.E.3
  • 23
    • 0034736194 scopus 로고    scopus 로고
    • Susceptibility of transgenic mice expressing human apolipoprotein e to closed head injury: The allele E3 is neuroprotective whereas E4 increases fatalities
    • Sabo T, Lomnitski L, Nyska A, et al. Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: The allele E3 is neuroprotective whereas E4 increases fatalities. Neuroscience 2000;101: 879-84
    • (2000) Neuroscience , vol.101 , pp. 879-884
    • Sabo, T.1    Lomnitski, L.2    Nyska, A.3
  • 24
    • 78649338449 scopus 로고    scopus 로고
    • Traumatic brain injury exacerbates neurodegenerative pathology: Improvement with an apolipoprotein EYbased therapeutic
    • Laskowitz DT, Song P, Wang H, et al. Traumatic brain injury exacerbates neurodegenerative pathology: Improvement with an apolipoprotein EYbased therapeutic. J Neurotrauma 2010;27:1983-95
    • (2010) J Neurotrauma , vol.27 , pp. 1983-1995
    • Laskowitz, D.T.1    Song, P.2    Wang, H.3
  • 25
    • 78650875250 scopus 로고    scopus 로고
    • Age-dependent effect of apolipopro-tein E4 on functional outcome after controlled cortical impact in mice
    • Mannix RC, Zhang J, Park J, et al. Age-dependent effect of apolipopro-tein E4 on functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab 2011;31:351-61
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 351-361
    • Mannix, R.C.1    Zhang, J.2    Park, J.3
  • 26
    • 79959941349 scopus 로고    scopus 로고
    • Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-beta accumulation and independently accelerates the development of tau abnormalities
    • Tran HT, LaFerla FM, Holtzman DM, et al. Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-beta accumulation and independently accelerates the development of tau abnormalities. J Neurosci 2011;31:9513-25
    • (2011) J Neurosci , vol.31 , pp. 9513-9525
    • Tran, H.T.1    Laferla, F.M.2    Holtzman, D.M.3
  • 27
    • 80053319251 scopus 로고    scopus 로고
    • Distinct temporal and anatomical distributions of amyloid-beta and tau abnormalities following controlled cortical impact in transgenic mice
    • Tran HT, Sanchez L, Esparza TJ, et al. Distinct temporal and anatomical distributions of amyloid-beta and tau abnormalities following controlled cortical impact in transgenic mice. PLoS One 2011;6:e25475
    • (2011) PLoS One , vol.6
    • Tran, H.T.1    Sanchez, L.2    Esparza, T.J.3
  • 28
    • 0030741533 scopus 로고    scopus 로고
    • Targeted replacement of the mouse apolipoprotein e gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    • Sullivan PM, Mezdour H, Aratani Y, et al. Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem 1997;272:17972-80
    • (1997) J Biol Chem , vol.272 , pp. 17972-17980
    • Sullivan, P.M.1    Mezdour, H.2    Aratani, Y.3
  • 29
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
    • Oddo S, Caccamo A, Shepherd JD, et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction. Neuron 2003;39:409-21
    • (2003) Neuron , vol.39 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3
  • 30
    • 34249846751 scopus 로고    scopus 로고
    • Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury
    • Brody DL, Mac Donald C, Kessens CC, et al. Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury. J Neurotrauma 2007;24:657-73
    • (2007) J Neurotrauma , vol.24 , pp. 657-673
    • Brody, D.L.1    Mac Donald, C.2    Kessens, C.C.3
  • 31
    • 34247368915 scopus 로고    scopus 로고
    • Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury
    • Mac Donald CL, Dikranian K, Song SK, et al. Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury. Exp Neurol 2007;205:116-31
    • (2007) Exp Neurol , vol.205 , pp. 116-131
    • Mac Donald, C.L.1    Dikranian, K.2    Song, S.K.3
  • 32
    • 84856216795 scopus 로고    scopus 로고
    • Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury
    • Tang-Schomer MD, Johnson VE, Baas PW, et al. Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury. Exp Neurol 2012; 233:364-72
    • (2012) Exp Neurol , vol.233 , pp. 364-372
    • Tang-Schomer, M.D.1    Johnson, V.E.2    Baas, P.W.3
  • 33
    • 0025056563 scopus 로고
    • Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport
    • Koo EH, Sisodia SS, Archer DR, et al. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci USA 1990;87:1561-65
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1561-1565
    • Koo, E.H.1    Sisodia, S.S.2    Archer, D.R.3
  • 34
    • 0027482350 scopus 로고
    • Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury
    • Gentleman SM, Nash MJ, Sweeting CJ, et al. Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury. Neurosci Lett 1993;160:139-44
    • (1993) Neurosci Lett , vol.160 , pp. 139-144
    • Gentleman, S.M.1    Nash, M.J.2    Sweeting, C.J.3
  • 35
    • 63349110141 scopus 로고    scopus 로고
    • Apolipoprotein E-genotype dependent hippocampal and cortical responses to traumatic brain injury
    • Crawford F, Wood M, Ferguson S, et al. Apolipoprotein E-genotype dependent hippocampal and cortical responses to traumatic brain injury. Neuroscience 2009;159:1349-62
    • (2009) Neuroscience , vol.159 , pp. 1349-1362
    • Crawford, F.1    Wood, M.2    Ferguson, S.3
  • 36
    • 0033559412 scopus 로고    scopus 로고
    • Expression of human apolipo-protein e reduces amyloid-beta deposition in a mouse model of Alzheimer's disease
    • Holtzman DM, Bales KR, Wu S, et al. Expression of human apolipo-protein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. J Clin Invest 1999;103:R15-21
    • (1999) J Clin Invest , vol.103
    • Holtzman, D.M.1    Bales, K.R.2    Wu, S.3
  • 37
    • 0030751161 scopus 로고    scopus 로고
    • Motor and cognitive deficits in apolipoprotein EYdeficient mice after closed head injury
    • Chen Y, Lomnitski L, Michaelson DM, et al. Motor and cognitive deficits in apolipoprotein EYdeficient mice after closed head injury. Neuroscience 1997;80:1255-62
    • (1997) Neuroscience , vol.80 , pp. 1255-1262
    • Chen, Y.1    Lomnitski, L.2    Michaelson, D.M.3
  • 38
    • 0036135127 scopus 로고    scopus 로고
    • Apolipoprotein e affects the central nervous system response to injury and the development of cerebral edema
    • Lynch JR, Pineda JA, Morgan D, et al. Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol 2002;51:113-17
    • (2002) Ann Neurol , vol.51 , pp. 113-117
    • Lynch, J.R.1    Pineda, J.A.2    Morgan, D.3
  • 39
    • 84872564252 scopus 로고    scopus 로고
    • The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein e
    • Namjoshi DR, Martin G, Donkin J, et al. The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E. PLoS One 2013;8:e53529
    • (2013) PLoS One , vol.8
    • Namjoshi, D.R.1    Martin, G.2    Donkin, J.3
  • 40
    • 29444436680 scopus 로고    scopus 로고
    • Lipid-and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochon-drial dysfunction and neurotoxicity
    • Chang S, ran Ma T, Miranda RD, et al. Lipid-and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochon-drial dysfunction and neurotoxicity. Proc Natl Acad Sci USA 2005;102: 18694-99
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18694-18699
    • Chang, S.1    Ran Ma, T.2    Miranda, R.D.3
  • 41
    • 84858423000 scopus 로고    scopus 로고
    • Reducing human apolipo-protein e levels attenuates age-dependent Abeta accumulation in mutant human amyloid precursor protein transgenic mice
    • Bien-Ly N, Gillespie AK, Walker D, et al. Reducing human apolipo-protein E levels attenuates age-dependent Abeta accumulation in mutant human amyloid precursor protein transgenic mice. J Neurosci 2012;32: 4803-11
    • (2012) J Neurosci , vol.32 , pp. 4803-4811
    • Bien-Ly, N.1    Gillespie, A.K.2    Walker, D.3
  • 42
    • 84865645094 scopus 로고    scopus 로고
    • Administration of COG1410 reduces axonal amyloid precursor protein immunoreactivity and microglial activation after controlled cortical impact in mice
    • Jiang Y, Brody DL. Administration of COG1410 reduces axonal amyloid precursor protein immunoreactivity and microglial activation after controlled cortical impact in mice. J Neurotrauma 2012;29:2332-41
    • (2012) J Neurotrauma , vol.29 , pp. 2332-2341
    • Jiang, Y.1    Brody, D.L.2
  • 43
    • 29444460533 scopus 로고    scopus 로고
    • Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target
    • Ye S, Huang Y, Mullendorff K, et al. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target. Proc Natl Acad Sci USA 2005;102: 18700-5
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18700-18705
    • Ye, S.1    Huang, Y.2    Mullendorff, K.3
  • 44
    • 0035902514 scopus 로고    scopus 로고
    • Apolipoprotein e fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons
    • Huang Y, Liu XQ, Wyss-Coray T, et al. Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc Natl Acad Sci USA 2001;98:8838-43
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8838-8843
    • Huang, Y.1    Liu, X.Q.2    Wyss-Coray, T.3
  • 45
    • 12144290271 scopus 로고    scopus 로고
    • Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice
    • Brecht WJ, Harris FM, Chang S, et al. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci 2004;24:2527-34
    • (2004) J Neurosci , vol.24 , pp. 2527-2534
    • Brecht, W.J.1    Harris, F.M.2    Chang, S.3
  • 46
    • 0037313587 scopus 로고    scopus 로고
    • Apolipoprotein e and Reelin ligands modulate tau phosphorylation through an apolipoprotein e receptor/disabled-1/glycogen synthase kinase-3beta cascade
    • Ohkubo N, Lee YD, Morishima A, et al. Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/ glycogen synthase kinase-3beta cascade. FASEB J 2003;17:295-97
    • (2003) FASEB J , vol.17 , pp. 295-297
    • Ohkubo, N.1    Lee, Y.D.2    Morishima, A.3
  • 47
    • 0033889344 scopus 로고    scopus 로고
    • Expression of human apoli-poprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice
    • Tesseur I, Van Dorpe J, Spittaels K, et al. Expression of human apoli-poprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. Am J Pathol 2000;156:951-64
    • (2000) Am J Pathol , vol.156 , pp. 951-964
    • Tesseur, I.1    Van Dorpe, J.2    Spittaels, K.3
  • 48
    • 0033694470 scopus 로고    scopus 로고
    • Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord
    • Tesseur I, Van Dorpe J, Bruynseels K, et al. Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord. Am J Pathol 2000; 157:1495-510
    • (2000) Am J Pathol , vol.157 , pp. 1495-1510
    • Tesseur, I.1    Van Dorpe, J.2    Bruynseels, K.3
  • 49
    • 0029782194 scopus 로고    scopus 로고
    • Selective alterations in the cellular distribution of apolipoprotein e immunoreactivity following transient cerebral is-chaemia in the rat
    • Horsburgh K, Nicoll JA. Selective alterations in the cellular distribution of apolipoprotein E immunoreactivity following transient cerebral is-chaemia in the rat. Neuropathol Appl Neurobiol 1996;22:342-49
    • (1996) Neuropathol Appl Neurobiol , vol.22 , pp. 342-349
    • Horsburgh, K.1    Nicoll, J.A.2
  • 50
    • 0028035306 scopus 로고
    • Isoform-specific interactions of apolipoprotein e with microtubule-associated protein tau: Implications for Alzheimer disease
    • Strittmatter WJ, Saunders AM, Goedert M, et al. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: Implications for Alzheimer disease. Proc Natl Acad Sci USA 1994;91: 11183-86
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11183-11186
    • Strittmatter, W.J.1    Saunders, A.M.2    Goedert, M.3
  • 51
    • 84855483701 scopus 로고    scopus 로고
    • APP physiological and pathophysiological functions: Insights from animal models
    • Guo Q, Wang Z, Li H, et al. APP physiological and pathophysiological functions: Insights from animal models. Cell Res 2012;22:78-89
    • (2012) Cell Res , vol.22 , pp. 78-89
    • Guo, Q.1    Wang, Z.2    Li, H.3
  • 52
    • 0041803006 scopus 로고    scopus 로고
    • Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
    • Andorfer C, Kress Y, Espinoza M, et al. Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 2003;86:582-90
    • (2003) J Neurochem , vol.86 , pp. 582-590
    • Andorfer, C.1    Kress, Y.2    Espinoza, M.3
  • 53
    • 79959526865 scopus 로고    scopus 로고
    • Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivity
    • Shitaka Y, Tran HT, Bennett RE, et al. Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivity. J Neuropathol Exp Neurol 2012;70:551-67
    • (2012) J Neuropathol Exp Neurol , vol.70 , pp. 551-567
    • Shitaka, Y.1    Tran, H.T.2    Bennett, R.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.