The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes a meta-analysis

Diabetes Care

Volumn 26, Issue 6, 2003, Pages 1895-1901

  Maser, Raelene E ^a   Mitchell, Braxton D ^b   Vinik, Aaron I ^c   Freeman, Roy ^d  

^a UNIVERSITY OF DELAWARE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTONOMIC NEUROPATHY; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; COMORBIDITY; DIABETES MELLITUS; DIABETIC NEUROPATHY; FOLLOW UP; HAND GRIP; HEART RATE VARIABILITY; HUMAN; MANTEL HAENSZEL TEST; MEDLINE; META ANALYSIS; MORTALITY; RISK ASSESSMENT; VALSALVA MANEUVER;

AUTONOMIC NERVOUS SYSTEM DISEASES; CARDIOVASCULAR DISEASES; DIABETES MELLITUS; DIABETIC ANGIOPATHIES; HUMANS; MEDLINE; RISK;

EID: 0041668049     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.26.6.1895     Document Type: Article

References (33)

1. Maser RE, Lenhard MJ, DeChemey GS: Cardiovascular autonomic neuropathy: the clinical significance of its determination. Endocrinologist 10:27-33, 2000
2. Freeman R: Cardiovascular autonomic neuropathy. In Diabetic Neuropathy. 2nd ed. Dyck PJ, Thomas PK, Eds. Philadelphia, W.B. Saunders, 1999, p. 541-554
3. Hilsted J, Low PA: Diabetic autonomic neuropathy. In Clinical Autonomic Disorders. 2nd ed. Low PA, Ed. Philadelphia, Lippincott-Raven, 1997, p. 487-508
4. Ziegler D: Cardiovascular autonomic neuropathy: clinical manifestations and measurement. Diabetes Rev 7:300-315, 1999
5. Ewing DJ, Campbell IW, Clarke BF: The natural history of diabetic autonomic neuropathy. Q J Med 49:95-108, 1980
6. Orchard TJ, Lloyd CE, Maser RE, Kuller LH: Why does diabetic autonomic neuropathy predict IDDM mortality? An analysis from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes Res Clin Pract 34 (Suppl.):S165-S171, 1996
7. Ewing DJ, Martyn CN, Young RJ, Clarke BF: The value of cardiovascular autonomic function tests: 10 years' experience in diabetes. Diabetes Care 8:491-498, 1985
8. Mantel N, Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719-748, 1959
9. Sampson MJ, Wilson S, Karagiannis P, Edmonds M, Watkins PJ: Progression of diabetic autonomic neuropathy over a decade in insulin-dependent diabetics. Q J Med 75:635-646, 1990
10. O'Brien IA, McFadden JP, Corrall RJM: The influence of autonomic neuropathy on mortality in insulin-dependent diabetes. Q J Med 79:495-502, 1991
11. Ewing DJ, Boland O, Neilson JMM, Cho CG, Clarke BF: Autonomic neuropathy, QT interval lengthening, and unexpected deaths in male diabetic patients. Diabetologia 34:182-185, 1991
12. Jermend G, Toth L, Voros P, Koltai MZ, Pogatsa G: Cardiac autonomic neuropathy and QT interval length: a follow-up study in diabetic patients. Acta Cardiol 46:189-200, 1991
13. Rathmann W, Ziegler D, Jahnke M, Haastert B, Gries FA: Mortality in diabetic patients with cardiovascular autonomic neuropathy. Diabet Med 10:820-824, 1993
14. Hathaway DK, El-Gebely S, Cardoso SS, Elmer DS, Gaber AO: Autonomic cardiac dysfunction in diabetic transplant recipients succumbing to sudden cardiac death. Transplantation 59:634-637, 1995
15. Navarro X, Kennedy WR, Aeppli D, Sutherland DER: Neuropathy and mortality in diabetes: influence of pancreas transplantation. Muscle Nerve 19:1009-1016, 1996
16. Veglio M, Sivieri R, Chinaglia A, Scaglione L, Cavallo-Perin P for the Neuropathy Study Group of the Italian Society of the Study of Diabetes, Piemonte Affiliate: QT interval prolongation and mortality in type 1 diabetic patients: a 5-year cohort prospective study. Diabetes Care 23:1381-1383, 2000
17. Chen HS, Hwu CM, Kuo BI, Chiang SC, Kwok CF, Lee SH, Lee YS, Weih MJ, Hsiao LC, Lin SH, Ho LT: Abnormal cardiovascular reflex tests are predictors of mortality in type 2 diabetes mellitus. Diabet Med 18:268-273, 2001
18. Sawicki PT, Dahne R, Bender R, Berger M: Prolonged QT interval as a predictor of mortality in diabetic nephropathy. Diabetologia 39:77-81, 1996
19. Toyry JP, Niskanen LK, Mantysaari MJ, Lansimies EA, Uusitupa MIJ: Occurrence, predictors, and clinical significance of autonomic neuropathy in NIDDM: ten-year follow-up from the diagnosis. Diabetes 45:308-315, 1996
20. Sawicki PT, Kiwitt S, Bender R, Berger M: The value of QT interval dispersion for identification of total mortality risk in non-insulin-dependent diabetes mellitus. J Intern Med 243:49-56, 1998
21. Gerritsen J, Dekker JM, TenVoorde BJ, Kostense PJ, Heine RJ, Bouter LM, Heethaar RM, Stehouwer CDA: Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study. Diabetes Care 24:1793-1798, 2001
22. Wirta O, Pasternack A, Mustonen J, Laippala P: Renal and cardiovascular predictors of 9-year total and sudden cardiac mortality in non-insulin-dependent diabetic subjects. Nephrol Dial Transplant 12:2612-2617, 1997
23. Levitt NS, Stansberry KB, Wynchank S, Vinik AI: The natural progression of autonomic neuropathy and autonomic function tests in a cohort of people with IDDM. Diabetes Care 19:751-754, 1996
24. Reichard P, Pihl M: Mortality and treatment side-effects during long-term intensified conventional insulin treatment in the Stockholm Diabetes Intervention Study. Diabetes 43:313-317, 1994
25. Charlson ME, MacKenzie CR, Gold JP: Preoperative autonomic function abnormalities in patients with diabetes mellitus and patients with hypertension. J Am Coll Surg 179:1-10, 1994
26. The Diabetes Control and Complications Trial Research Group: The effect of intensive diabetes therapy on measures of autonomic nervous system function in the Diabetes Control and Complications Trial (DCCT). Diabetologia 41:416-423, 1998
27. Gaede P, Vedel P, Parving HH, Pedersen O: Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomized study. Lancet 353:617-622, 1999
28. Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S, Kojima Y, Furuyoshi N, Shichiri M: Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Prac 28:103-117, 1995
29. Ebbehoj E, Poulsen PL, Hansen KW, Knudsen ST, Molgaard H, Mogensen CE: Effects on heart rate variability of metoprolol supplementary to ongoing ACE-inhibitor treatment in type 1 diabetic patients with abnormal albuminuria. Diabeteologia 45:965-975, 2002
30. Malik RA, Williamson S, Abbott C, Carrington AL, Iqbal J, Schady W, Boulton AJM: Effect of angiotensin-converting-enzyme (ACE) inhibitor trandolapril on human diabetic neuropathy: randomized double-blind controlled trial. Lancet 352:1978-1981, 1998
31. Kontopoulos AG, Athyros VG, Didangelos TP, Papageorgiou AA, Avramidis MJ, Mayroudi MC, Karamitsos DT: Effect of chronic quinapril administration on heart rate variability in patients with diabetic autonomic neuropathy. Diabetes Care 20:355-361, 1997
32. Ziegler D, Schatz H, Conrad F, Gries FA, Ulrich H, DEKAN Study Group, Reichel G: Effects of treatment with the antioxidant α-lipoic acid on cardiac autonomic neuropathy in NIDDM patients: a 4-month randomized controlled multicenter trial (DEKAN Study). Diabetes Care 20:369-373, 1997
33. Vinik AI, Erbas T: Recognizing and treating diabetic autonomic neuropathy. Cleveland Clinic J Med 68:928-944, 2001