Gβγ signaling promotes breast cancer cell migration and invasion

Journal of Pharmacology and Experimental Therapeutics

Volumn 333, Issue 2, 2010, Pages 393-403

  Kirui, Joseph K ^a   Xie, Yan ^a   Wolff, Dennis W ^a   Jiang, Haihong ^a   Abel, Peter W ^a   Tu, Yaping ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 (4,5,6 TRIHYDROXY 3 OXO 3H XANTHEN 9 YL) 1 NAPHTHALENE CARBOXYLIC ACID); ADENYLATE CYCLASE; ANTINEOPLASTIC AGENT; CARBOXYLIC ACID DERIVATIVE; CHEMOKINE RECEPTOR CXCR4; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; RAC PROTEIN; RAC1 PROTEIN; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; BARKCT PROTEIN, RECOMBINANT; CXCR4 PROTEIN, HUMAN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOHEXANE DERIVATIVE; G PROTEIN BETA GAMMA; G-PROTEIN BETA GAMMA; M119 COMPOUND; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; XANTHENE DERIVATIVE;

ARTICLE; BREAST CANCER; CANCER CELL; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; LAMELLIPODIUM; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; BREAST TUMOR; CANCER INVASION; CELL MOTION; DRUG EFFECT; FEMALE; FLUORESCENCE MICROSCOPY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSEUDOPODIUM; TUMOR CELL LINE;

ADENYLATE CYCLASE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLOHEXANES; FEMALE; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HUMANS; MICROSCOPY, FLUORESCENCE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PEPTIDE FRAGMENTS; PSEUDOPODIA; RAC GTP-BINDING PROTEINS; RECEPTORS, CXCR4; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; XANTHENES;

EID: 77951038932     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.164814     Document Type: Article

References (40)

1. Albini A and Benelli R (2007) The chemoinvasion assay: a method to assess tumor and endothelial cell invasion and its modulation. Nat Protoc 2:504-511. (Pubitemid 47040014)
2. Baugher PJ, Krishnamoorthy L, Price JE, and Dharmawardhane SF (2005) Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells. Breast Cancer Res 7:965-974.
3. Boire A, Covic L, Agarwal A, Jacques S, Sherifi S, and Kuliopulos A (2005) PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120:303-313. (Pubitemid 40222426)
4. Bonacci TM, Mathews JL, Yuan C, Lehmann DM, Malik S, Wu D, Font JL, Bidlack JM, and Smrcka AV (2006) Differential targeting of Gβγ- subunit signaling with small molecules. Science 312:443-446.
5. Bookout AL, Finney AE, Guo R, Peppel K, and Koch WJ (2003) Targeting Gβγ signaling to inhibit prostate tumor formation and growth. J Biol Chem 278:37569-37573. (Pubitemid 37175279)
6. Burger JA and Kipps TJ (2006) CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107:1761-1767.
7. Ching YP, Leong VY, Lee MF, Xu HT, Jin DY, and Ng IO (2007) P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation. Cancer Res 67:3601-3608.
8. Condeelis JS, Wyckoff JB, Bailly M, Pestell R, Lawrence D, Backer J, and Segall JE (2001) Lamellipodia in invasion. Semin Cancer Biol 11:119-128.
9. Daaka Y (2004) G proteins in cancer: the prostate cancer paradigm. Sci STKE 2004:re2.
10. Dorsam RT and Gutkind JS (2007) G protein-coupled receptors and cancer. Nat Rev Cancer 7:79-94.
11. Doupnik CA, Davidson N, Lester HA, and Kofuji P (1997) RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K+ channels. Proc Natl Acad Sci USA 94:10461-10466. (Pubitemid 27407064)
12. Faivre S, Régnauld K, Bruyneel E, Nguyen QD, Mareel M, Emami S, and Gespach C (2001) Suppression of cellular invasion by activated G-protein subunits Gαo, Gαi1, Gαi2, and Gαi3 and sequestration of Gβγ. Mol Pharmacol 60:363-372. (Pubitemid 32678302)
13. Gilman AG (1987) G proteins: transducers of receptor-generated signals. Annu Rev Biochem 56:615-649.
14. Gutkind, JS (2000) Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors. Sci STKE 2000: re1.
15. Hatse S, Princen K, Bridger G, De Clercq E, and Schols D (2002) Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Lett 527:255-262. (Pubitemid 35253875)
16. Hawes BE, van Biesen T, Koch WJ, Luttrell LM, and Lefkowitz RJ (1995) Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. J Biol Chem. 270:17148-17153.
17. He H, Levitzki A, Zhu HJ, Walker F, Burgess A, and Maruta H (2001) Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases. J Biol Chem 276:26741-26744. (Pubitemid 37410570)
18. Huang C, Hepler JR, Gilman AG, and Mumby SM (1997) Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells. Proc Natl Acad Sci USA 94:6159-6163. (Pubitemid 27270654)
19. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, and Thun MJ (2008) Cancer statistics. CA Cancer J Clin 58:71-96.
20. Kelly P, Moeller BJ, Juneja J, Booden MA, Der CJ, Daaka Y, Dewhirst MW, Fields TA, and Casey PJ (2006) The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci USA 103:8173-8178. (Pubitemid 43801071)
21. Lehmann DM, Seneviratne AM, and Smrcka AV (2008) Small-molecule distruption of G protein subunit signaling inhibits neutrophil chemotaxis and inflammation. Mol Pharmacol 73:410-418.
22. Li X, Ikezu T, and Hexum TD (2004) βγ Subunits mediate the NPY enhancement of ATP-stimulated inositol phosphate formation. Peptides 25:267-274. (Pubitemid 38520057)
23. Li Z, Hannigan M, Mo Z, Liu B, Lu W, Wu Y, Smrcka AV, Wu G, Li L, Liu M, et al. (2003) Directional sensing requires Gβγ-mediated PAK1 and PIX α-dependent activation of Cdc42. Cell 114:215-227. (Pubitemid 36936915)
24. Luker KE and Luker GD (2006) Functions of CXCL12 and CXCR4 in breast cancer. Cancer Lett 238:30-41.
25. Neptune ER and Bourne HR (1997) Receptors induce chemotaxis by releasing the βγ subunit of Gi, not by activating Gq or Gs. Proc Natl Acad Sci USA 94:14489-14494.
26. Neptune ER, Iiri T, and Bourne HR (1999) Gαi is not required for chemotaxis mediated by Gi-coupled receptors. J Biol Chem 274:2824-2828. (Pubitemid 29075365)
27. Prévost GP, Lonchampt MO, Holbeck S, Attoub S, Zaharevitz D, Alley M, Wright J, Brezak MC, Coulomb H, Savola A, et al. (2006) Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Gα/Gβγ protein complex. Cancer Res 66:9227-9234. (Pubitemid 44521144)
28. Qin J, Xie Y, Wang B, Hoshino M, Wolff DW, Zhao J, Scofield MA, Dowd FJ, Lin MF, and Tu Y (2009) Up-regulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. Oncogene 28:1853-1863.
29. Smrcka AV (2008) G protein βγ subunits: central mediators of G protein-coupled receptor signaling. Cell Mol Life Sci 65:2191-2214.
30. Sternweis PC (1994) The active role of βγ in signal transduction. Curr Opin Cell Biol 6:198-203.
31. Stetler-Stevenson WG and Kleiner DE Jr (2001) Molecular biology of cancer: invasion and metastases, in Cancer: Principles and Practice of Oncology, 6th ed (DeVita VT Jr., Hellmann S, and Rosenberg SA, eds), pp 123-136, Lippincott Williams & Wilkins, Philadelphia.
32. Van Haastert PJ, and Devreotes PN (2004) Chemotaxis: signaling the way forward. Nat Rev Mol Cell Biol 5:626-634.
33. 3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac. Cell 108:809-821.
34. Weed SA and Parsons JT (2001) Cortactin: coupling membrane dynamics to cortical actin assembly. Oncogene 20:6418-6434.
35. Xie Y, Wolff DW, Lin MF, and Tu Y (2007) Vasoactive intestinal peptides transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells. Mol Pharmacol 72:73-85. (Pubitemid 46998526)
36. Xie Y, Wolff DW, Wang B, Deng C, Kirui JK, Jiang H, Qin J, Abel PW, and Tu Y (2009) Breast cancer migration and invasion depends on proteasome degradation of regulator of G protein signaling 4. Cancer Res 69:5743-5751.
37. Yamazaki D, Kurisu S, and Takenawa T (2005) Regulation of cancer cell motility through actin reorganization. Cancer Sci 96:379-386. (Pubitemid 41179738)
38. Yoshizawa M, Kawauchi T, Sone M, Nishimura YV, Terao M, Chihama K, Nabeshima Y, and Hoshino M (2005) Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration. J Neurosci 25:4406-4419. (Pubitemid 40628785)
39. Ye RD (2001) Regulation of nuclear factor κB activation by G protein-coupled receptors. J Leukocyte Biol 70:839-848. (Pubitemid 33151122)
40. Zhao T, Nalbant P, Hoshino M, Dong X, Wu D, and Bokoch GM (2007) Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function. J Leukocyte Biol 81:1127-1136. (Pubitemid 46495662)