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Volumn 78, Issue 6, 2013, Pages 576-582

Lessons from the dissection of the activation functions (AF-1 and AF-2) of the estrogen receptor alpha in vivo

Author keywords

Estrogen; Estrogen receptor; Menopause; Uterus

Indexed keywords

AF 1 PROTEIN; AF 2 PROTEIN; DNA BINDING PROTEIN; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; TAMOXIFEN CITRATE; UNCLASSIFIED DRUG;

EID: 84876665470     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.11.011     Document Type: Conference Paper
Times cited : (39)

References (85)
  • 1
    • 33747466839 scopus 로고    scopus 로고
    • Structure-function relationship of estrogen receptor alpha and beta: Impact on human health
    • P. Ascenzi, A. Bocedi, and M. Marino Structure-function relationship of estrogen receptor alpha and beta: impact on human health Mol Aspects Med 27 2006 299 402
    • (2006) Mol Aspects Med , vol.27 , pp. 299-402
    • Ascenzi, P.1    Bocedi, A.2    Marino, M.3
  • 2
    • 0141431993 scopus 로고    scopus 로고
    • Resurrecting the ancestral steroid receptor: Ancient origin of estrogen signaling
    • J.W. Thornton, E. Need, and D. Crews Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling Science 301 2003 1714 1717
    • (2003) Science , vol.301 , pp. 1714-1717
    • Thornton, J.W.1    Need, E.2    Crews, D.3
  • 3
    • 0022720813 scopus 로고
    • The chicken oestrogen receptor sequence. Homology with verba and the human oestrogen and glucocorticoid receptors
    • A. Krust, S. Green, P. Argos, V. Kumar, P. Walter, J.M. Bornert, and P. Chambon The chicken oestrogen receptor sequence. Homology with verba and the human oestrogen and glucocorticoid receptors EMBO J 5 1986 891 897
    • (1986) EMBO J , vol.5 , pp. 891-897
    • Krust, A.1    Green, S.2    Argos, P.3    Kumar, V.4    Walter, P.5    Bornert, J.M.6    Chambon, P.7
  • 4
    • 0024317270 scopus 로고
    • The human estrogen receptor has two independent nonacidic transcriptional activation functions
    • L. Tora, J. White, C. Brou, D. Tasset, N. Webster, E. Scheer, and P. Chambon The human estrogen receptor has two independent nonacidic transcriptional activation functions Cell 59 1989 477 487
    • (1989) Cell , vol.59 , pp. 477-487
    • Tora, L.1    White, J.2    Brou, C.3    Tasset, D.4    Webster, N.5    Scheer, E.6    Chambon, P.7
  • 5
    • 0037154974 scopus 로고    scopus 로고
    • Combinatorial control of gene expression by nuclear receptors and coregulators
    • N.J. McKenna, and B.W. O'Malley Combinatorial control of gene expression by nuclear receptors and coregulators Cell 108 2002 465 474
    • (2002) Cell , vol.108 , pp. 465-474
    • McKenna, N.J.1    O'Malley, B.W.2
  • 6
    • 0032472911 scopus 로고    scopus 로고
    • Different positioning of the ligand-binding domain helix 12 and the f domain of the estrogen receptor accounts for functional differences between agonists and antagonists
    • M. Nichols, J.M. Rientjes, and A.F. Stewart Different positioning of the ligand-binding domain helix 12 and the f domain of the estrogen receptor accounts for functional differences between agonists and antagonists EMBO J 17 1998 765 773
    • (1998) EMBO J , vol.17 , pp. 765-773
    • Nichols, M.1    Rientjes, J.M.2    Stewart, A.F.3
  • 7
    • 0029058152 scopus 로고
    • The carboxy-terminal f domain of the human estrogen receptor: Role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists
    • M.M. Montano, V. Muller, A. Trobaugh, and B.S. Katzenellenbogen The carboxy-terminal f domain of the human estrogen receptor: role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists Mol Endocrinol 9 1995 814 825
    • (1995) Mol Endocrinol , vol.9 , pp. 814-825
    • Montano, M.M.1    Muller, V.2    Trobaugh, A.3    Katzenellenbogen, B.S.4
  • 8
    • 34247889975 scopus 로고    scopus 로고
    • Identification of regions within the f domain of the human estrogen receptor alpha that are important for modulating transactivation and protein-protein interactions
    • A. Koide, C. Zhao, M. Naganuma, J. Abrams, S. Deighton-Collins, D.F. Skafar, and S. Koide Identification of regions within the f domain of the human estrogen receptor alpha that are important for modulating transactivation and protein-protein interactions Mol Endocrinol 21 2007 829 842
    • (2007) Mol Endocrinol , vol.21 , pp. 829-842
    • Koide, A.1    Zhao, C.2    Naganuma, M.3    Abrams, J.4    Deighton-Collins, S.5    Skafar, D.F.6    Koide, S.7
  • 9
    • 0033305438 scopus 로고    scopus 로고
    • Estrogen receptor null mice. What have we learned and where will they lead us?
    • J.F. Couse, and K.S. Korach Estrogen receptor null mice. What have we learned and where will they lead us? Endocr Rev 20 1999 358 417
    • (1999) Endocr Rev , vol.20 , pp. 358-417
    • Couse, J.F.1    Korach, K.S.2
  • 11
    • 82355163442 scopus 로고    scopus 로고
    • Minireview: Recent advances in extranuclear steroid receptor actions
    • S.R. Hammes, and E.R. Levin Minireview: recent advances in extranuclear steroid receptor actions Endocrinology 152 2011 4489 4495
    • (2011) Endocrinology , vol.152 , pp. 4489-4495
    • Hammes, S.R.1    Levin, E.R.2
  • 12
    • 0035687170 scopus 로고    scopus 로고
    • The past, present, and future of selective estrogen receptor modulation
    • V.C. Jordan The past, present, and future of selective estrogen receptor modulation Ann N Y Acad Sci 949 2001 72 79
    • (2001) Ann N y Acad Sci , vol.949 , pp. 72-79
    • Jordan, V.C.1
  • 13
    • 0037364074 scopus 로고    scopus 로고
    • Tamoxifen: A most unlikely pioneering medicine
    • V.C. Jordan Tamoxifen: a most unlikely pioneering medicine Nat Rev Drug Discov 2 2003 205 213
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 205-213
    • Jordan, V.C.1
  • 14
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group
    • Early Breast Cancer Trialists' Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;365:1687-1717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 15
    • 34047237367 scopus 로고    scopus 로고
    • Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause
    • J.E. Rossouw, R.L. Prentice, J.E. Manson, L. Wu, D. Barad, and V.M. Barnabei Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause JAMA 297 2007 1465 1477
    • (2007) JAMA , vol.297 , pp. 1465-1477
    • Rossouw, J.E.1    Prentice, R.L.2    Manson, J.E.3    Wu, L.4    Barad, D.5    Barnabei, V.M.6
  • 16
    • 69949154440 scopus 로고    scopus 로고
    • Coronary heart disease and menopause management: The swinging pendulum of HRT
    • J.C. Stevenson, H.N. Hodis, J.H. Pickar, and R.A. Lobo Coronary heart disease and menopause management: the swinging pendulum of HRT Atherosclerosis 207 2009 336 340
    • (2009) Atherosclerosis , vol.207 , pp. 336-340
    • Stevenson, J.C.1    Hodis, H.N.2    Pickar, J.H.3    Lobo, R.A.4
  • 17
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the women's health initiative randomized controlled trial
    • J.E. Rossouw, G.L. Anderson, R.L. Prentice, A.Z. LaCroix, C. Kooperberg, and M.L. Stefanick Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial JAMA 288 2002 321 333
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1    Anderson, G.L.2    Prentice, R.L.3    Lacroix, A.Z.4    Kooperberg, C.5    Stefanick, M.L.6
  • 18
    • 1842867053 scopus 로고    scopus 로고
    • Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: The women's health initiative randomized controlled trial
    • G.L. Anderson, M. Limacher, A.R. Assaf, T. Bassford, S.A. Beresford, and H. Black Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the women's health initiative randomized controlled trial JAMA 291 2004 1701 1712
    • (2004) JAMA , vol.291 , pp. 1701-1712
    • Anderson, G.L.1    Limacher, M.2    Assaf, A.R.3    Bassford, T.4    Beresford, S.A.5    Black, H.6
  • 19
    • 33748119290 scopus 로고    scopus 로고
    • Prior hormone therapy and breast cancer risk in the women's health initiative randomized trial of estrogen plus progestin
    • G.L. Anderson, R.T. Chlebowski, J.E. Rossouw, R.J. Rodabough, A. McTiernan, and K.L. Margolis Prior hormone therapy and breast cancer risk in the women's health initiative randomized trial of estrogen plus progestin Maturitas 55 2006 103 115
    • (2006) Maturitas , vol.55 , pp. 103-115
    • Anderson, G.L.1    Chlebowski, R.T.2    Rossouw, J.E.3    Rodabough, R.J.4    McTiernan, A.5    Margolis, K.L.6
  • 21
    • 34547792318 scopus 로고    scopus 로고
    • The complex role of estrogens in inflammation
    • R.H. Straub The complex role of estrogens in inflammation Endocr Rev 28 2007 521 574
    • (2007) Endocr Rev , vol.28 , pp. 521-574
    • Straub, R.H.1
  • 22
    • 84855857588 scopus 로고    scopus 로고
    • The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor alpha-signaling
    • C. Seillet, S. Laffont, F. Tremollieres, N. Rouquie, C. Ribot, and J.F. Arnal The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor alpha-signaling Blood 119 2012 454 464
    • (2012) Blood , vol.119 , pp. 454-464
    • Seillet, C.1    Laffont, S.2    Tremollieres, F.3    Rouquie, N.4    Ribot, C.5    Arnal, J.F.6
  • 24
    • 18844393948 scopus 로고    scopus 로고
    • Controversies about HRT-lessons from monkey models
    • T.B. Clarkson, and S.E. Appt Controversies about HRT-lessons from monkey models Maturitas 51 2005 64 74
    • (2005) Maturitas , vol.51 , pp. 64-74
    • Clarkson, T.B.1    Appt, S.E.2
  • 25
    • 0033584721 scopus 로고    scopus 로고
    • The direct antiatherogenic effect of estrogen is present, absent, or reversed, depending on the state of the arterial endothelium. A time course study in cholesterol-clamped rabbits
    • P. Holm, H.L. Andersen, M.R. Andersen, E. Erhardtsen, and S. Stender The direct antiatherogenic effect of estrogen is present, absent, or reversed, depending on the state of the arterial endothelium. A time course study in cholesterol-clamped rabbits Circulation 100 1999 1727 1733
    • (1999) Circulation , vol.100 , pp. 1727-1733
    • Holm, P.1    Andersen, H.L.2    Andersen, M.R.3    Erhardtsen, E.4    Stender, S.5
  • 27
    • 0031054234 scopus 로고    scopus 로고
    • Medroxyprogesterone interferes with ovarian steroid protection against coronary vasospasm
    • K. Miyagawa, J. Rosch, F. Stanczyk, and K. Hermsmeyer Medroxyprogesterone interferes with ovarian steroid protection against coronary vasospasm Nat Med 3 1997 324 327
    • (1997) Nat Med , vol.3 , pp. 324-327
    • Miyagawa, K.1    Rosch, J.2    Stanczyk, F.3    Hermsmeyer, K.4
  • 28
    • 34548023930 scopus 로고    scopus 로고
    • Hormones and heart disease in women: The timing hypothesis
    • E. Barrett-Connor Hormones and heart disease in women: the timing hypothesis Am J Epidemiol 166 2007 506 510
    • (2007) Am J Epidemiol , vol.166 , pp. 506-510
    • Barrett-Connor, E.1
  • 29
    • 78651387575 scopus 로고    scopus 로고
    • Timing of the vascular actions of estrogens in experimental and human studies: Why protective early, and not when delayed?
    • F. Lenfant, F. Tremollieres, P. Gourdy, and J.F. Arnal Timing of the vascular actions of estrogens in experimental and human studies: why protective early, and not when delayed? Maturitas 68 2011 165 173
    • (2011) Maturitas , vol.68 , pp. 165-173
    • Lenfant, F.1    Tremollieres, F.2    Gourdy, P.3    Arnal, J.F.4
  • 30
    • 0035656115 scopus 로고    scopus 로고
    • Invited review: Pharmacogenetics of estrogen replacement therapy
    • D.M. Herrington, and K.P. Klein Invited review: pharmacogenetics of estrogen replacement therapy J Appl Physiol 91 2001 2776 2784
    • (2001) J Appl Physiol , vol.91 , pp. 2776-2784
    • Herrington, D.M.1    Klein, K.P.2
  • 31
    • 33645084778 scopus 로고    scopus 로고
    • Controversies regarding hormone therapy: Insights from inflammation and hemostasis
    • K.K. Koh, and B.K. Yoon Controversies regarding hormone therapy: insights from inflammation and hemostasis Cardiovasc Res 70 2006 22 30
    • (2006) Cardiovasc Res , vol.70 , pp. 22-30
    • Koh, K.K.1    Yoon, B.K.2
  • 32
    • 38349165674 scopus 로고    scopus 로고
    • Smoking increases the risk of venous thrombosis and acts synergistically with oral contraceptive use
    • E.R. Pomp, F.R. Rosendaal, and C.J. Doggen Smoking increases the risk of venous thrombosis and acts synergistically with oral contraceptive use Am J Hematol 83 2008 97 102
    • (2008) Am J Hematol , vol.83 , pp. 97-102
    • Pomp, E.R.1    Rosendaal, F.R.2    Doggen, C.J.3
  • 33
    • 33847116637 scopus 로고    scopus 로고
    • Hormone therapy and venous thromboembolism among postmenopausal women: Impact of the route of estrogen administration and progestogens: The esther study
    • M. Canonico, E. Oger, G. Plu-Bureau, J. Conard, G. Meyer, and H. Levesque Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the esther study Circulation 115 2007 840 845
    • (2007) Circulation , vol.115 , pp. 840-845
    • Canonico, M.1    Oger, E.2    Plu-Bureau, G.3    Conard, J.4    Meyer, G.5    Levesque, H.6
  • 34
    • 79953120230 scopus 로고    scopus 로고
    • Transdermal and oral hormone replacement therapy and the risk of stroke: A nested case-control study
    • C. Renoux, S. Dell'aniello, E. Garbe, and S. Suissa Transdermal and oral hormone replacement therapy and the risk of stroke: a nested case-control study BMJ 340 2010 c2519
    • (2010) BMJ , vol.340 , pp. 2519
    • Renoux, C.1    Dell'Aniello, S.2    Garbe, E.3    Suissa, S.4
  • 35
    • 84865428859 scopus 로고    scopus 로고
    • Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the haematopoietic estrogen receptor alpha
    • M.C. Valera, M.P. Gratacap, P. Gourdy, F. Lenfant, C. Cabou, and C.E. Toutain Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the haematopoietic estrogen receptor alpha Blood 2012
    • (2012) Blood
    • Valera, M.C.1    Gratacap, M.P.2    Gourdy, P.3    Lenfant, F.4    Cabou, C.5    Toutain, C.E.6
  • 36
    • 15744393640 scopus 로고    scopus 로고
    • Regulation of signal transduction pathways by estrogen and progesterone
    • D.P. Edwards Regulation of signal transduction pathways by estrogen and progesterone Annu Rev Physiol 67 2005 335 376
    • (2005) Annu Rev Physiol , vol.67 , pp. 335-376
    • Edwards, D.P.1
  • 37
    • 2642544592 scopus 로고    scopus 로고
    • Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter
    • R. Metivier, G. Penot, M.R. Hubner, G. Reid, H. Brand, and M. Kos Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter Cell 115 2003 751 763
    • (2003) Cell , vol.115 , pp. 751-763
    • Metivier, R.1    Penot, G.2    Hubner, M.R.3    Reid, G.4    Brand, H.5    Kos, M.6
  • 38
    • 84995870933 scopus 로고
    • Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions
    • M.T. Tzukerman, A. Esty, D. Santiso-Mere, P. Danielian, M.G. Parker, and R.B. Stein Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions Mol Endocrinol 8 1994 21 30
    • (1994) Mol Endocrinol , vol.8 , pp. 21-30
    • Tzukerman, M.T.1    Esty, A.2    Santiso-Mere, D.3    Danielian, P.4    Parker, M.G.5    Stein, R.B.6
  • 39
    • 0025062215 scopus 로고
    • Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen
    • M. Berry, D. Metzger, and P. Chambon Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen EMBO J 9 1990 2811 2818
    • (1990) EMBO J , vol.9 , pp. 2811-2818
    • Berry, M.1    Metzger, D.2    Chambon, P.3
  • 40
    • 1442351143 scopus 로고    scopus 로고
    • Coregulator function: A key to understanding tissue specificity of selective receptor modulators
    • C.L. Smith, and B.W. O'Malley Coregulator function: a key to understanding tissue specificity of selective receptor modulators Endocr Rev 25 2004 45 71
    • (2004) Endocr Rev , vol.25 , pp. 45-71
    • Smith, C.L.1    O'Malley, B.W.2
  • 41
    • 0034116143 scopus 로고    scopus 로고
    • A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen
    • D. Knutti, A. Kaul, and A. Kralli A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen Mol Cell Biol 20 2000 2411 2422
    • (2000) Mol Cell Biol , vol.20 , pp. 2411-2422
    • Knutti, D.1    Kaul, A.2    Kralli, A.3
  • 42
    • 0032814142 scopus 로고    scopus 로고
    • Purification and identification of p68 rna helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha
    • H. Endoh, K. Maruyama, Y. Masuhiro, Y. Kobayashi, M. Goto, and H. Tai Purification and identification of p68 rna helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha Mol Cell Biol 19 1999 5363 5372
    • (1999) Mol Cell Biol , vol.19 , pp. 5363-5372
    • Endoh, H.1    Maruyama, K.2    Masuhiro, Y.3    Kobayashi, Y.4    Goto, M.5    Tai, H.6
  • 43
    • 0035968284 scopus 로고    scopus 로고
    • The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor
    • X. Wu, H. Li, and J.D. Chen The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor J Biol Chem 276 2001 23962 23968
    • (2001) J Biol Chem , vol.276 , pp. 23962-23968
    • Wu, X.1    Li, H.2    Chen, J.D.3
  • 44
    • 0034717277 scopus 로고    scopus 로고
    • P300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the n-terminal a/b domains
    • Y. Kobayashi, T. Kitamoto, Y. Masuhiro, M. Watanabe, T. Kase, and D. Metzger P300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the n-terminal a/b domains J Biol Chem 275 2000 15645 15651
    • (2000) J Biol Chem , vol.275 , pp. 15645-15651
    • Kobayashi, Y.1    Kitamoto, T.2    Masuhiro, Y.3    Watanabe, M.4    Kase, T.5    Metzger, D.6
  • 45
    • 0034740164 scopus 로고    scopus 로고
    • Synergism between eralpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: Requirement for the AF-1 alpha-helical core and for a direct interaction between the n- and c-terminal domains
    • R. Metivier, G. Penot, G. Flouriot, and F. Pakdel Synergism between eralpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the n- and c-terminal domains Mol Endocrinol 15 2001 1953 1970
    • (2001) Mol Endocrinol , vol.15 , pp. 1953-1970
    • Metivier, R.1    Penot, G.2    Flouriot, G.3    Pakdel, F.4
  • 46
    • 67449141657 scopus 로고    scopus 로고
    • Membrane-initiated actions of estrogen on the endothelium
    • K.H. Kim, and J.R. Bender Membrane-initiated actions of estrogen on the endothelium Mol Cell Endocrinol 308 2009 3 8
    • (2009) Mol Cell Endocrinol , vol.308 , pp. 3-8
    • Kim, K.H.1    Bender, J.R.2
  • 47
    • 23744447497 scopus 로고    scopus 로고
    • Integration of the extranuclear and nuclear actions of estrogen
    • E.R. Levin Integration of the extranuclear and nuclear actions of estrogen Mol Endocrinol 19 2005 1951 1959
    • (2005) Mol Endocrinol , vol.19 , pp. 1951-1959
    • Levin, E.R.1
  • 48
    • 0035831020 scopus 로고    scopus 로고
    • Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity
    • S. Kousteni, T. Bellido, L.I. Plotkin, C.A. O'Brien, D.L. Bodenner, and L. Han Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity Cell 104 2001 719 730
    • (2001) Cell , vol.104 , pp. 719-730
    • Kousteni, S.1    Bellido, T.2    Plotkin, L.I.3    O'Brien, C.A.4    Bodenner, D.L.5    Han, L.6
  • 50
    • 0037462733 scopus 로고    scopus 로고
    • Proximal events in signaling by plasma membrane estrogen receptors
    • M. Razandi, A. Pedram, S.T. Park, and E.R. Levin Proximal events in signaling by plasma membrane estrogen receptors J Biol Chem 278 2003 2701 2712
    • (2003) J Biol Chem , vol.278 , pp. 2701-2712
    • Razandi, M.1    Pedram, A.2    Park, S.T.3    Levin, E.R.4
  • 51
    • 11144332004 scopus 로고    scopus 로고
    • Palmitoylation-dependent estrogen receptor alpha membrane localization: Regulation by 17beta-estradiol
    • F. Acconcia, P. Ascenzi, A. Bocedi, E. Spisni, V. Tomasi, and A. Trentalance Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol Mol Biol Cell 16 2005 231 237
    • (2005) Mol Biol Cell , vol.16 , pp. 231-237
    • Acconcia, F.1    Ascenzi, P.2    Bocedi, A.3    Spisni, E.4    Tomasi, V.5    Trentalance, A.6
  • 52
    • 0037069418 scopus 로고    scopus 로고
    • Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade
    • C.W. Wong, C. McNally, E. Nickbarg, B.S. Komm, and B.J. Cheskis Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade Proc Natl Acad Sci U S A 99 2002 14783 14788
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 14783-14788
    • Wong, C.W.1    McNally, C.2    Nickbarg, E.3    Komm, B.S.4    Cheskis, B.J.5
  • 53
    • 10344237581 scopus 로고    scopus 로고
    • Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial no synthase by estrogen receptor alpha
    • Q. Lu, D.C. Pallas, H.K. Surks, W.E. Baur, M.E. Mendelsohn, and R.H. Karas Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial no synthase by estrogen receptor alpha Proc Natl Acad Sci U S A 101 2004 17126 17131
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 17126-17131
    • Lu, Q.1    Pallas, D.C.2    Surks, H.K.3    Baur, W.E.4    Mendelsohn, M.E.5    Karas, R.H.6
  • 54
    • 20444398494 scopus 로고    scopus 로고
    • Molecular and cellular basis of cardiovascular gender differences
    • M.E. Mendelsohn, and R.H. Karas Molecular and cellular basis of cardiovascular gender differences Science 308 2005 1583 1587
    • (2005) Science , vol.308 , pp. 1583-1587
    • Mendelsohn, M.E.1    Karas, R.H.2
  • 55
    • 73949087372 scopus 로고    scopus 로고
    • Mechanisms of action of estrogen receptors in vascular cells: Relevance for menopause and aging
    • T. Simoncini Mechanisms of action of estrogen receptors in vascular cells: relevance for menopause and aging Climacteric 12 Suppl. 1 2009 6 11
    • (2009) Climacteric , vol.12 , Issue.SUPPL. 1 , pp. 6-11
    • Simoncini, T.1
  • 56
    • 0027429548 scopus 로고
    • Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
    • D.B. Lubahn, J.S. Moyer, T.S. Golding, J.F. Couse, K.S. Korach, and O. Smithies Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene Proc Natl Acad Sci U S A 90 1993 11162 11166
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11162-11166
    • Lubahn, D.B.1    Moyer, J.S.2    Golding, T.S.3    Couse, J.F.4    Korach, K.S.5    Smithies, O.6
  • 57
    • 0030914164 scopus 로고    scopus 로고
    • Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice
    • M.D. Iafrati, R.H. Karas, M. Aronovitz, S. Kim, T.R. Sullivan Jr., and D.B. Lubahn Estrogen inhibits the vascular injury response in estrogen receptor alpha-deficient mice Nat Med 3 1997 545 548
    • (1997) Nat Med , vol.3 , pp. 545-548
    • Iafrati, M.D.1    Karas, R.H.2    Aronovitz, M.3    Kim, S.4    Sullivan Jr., T.R.5    Lubahn, D.B.6
  • 58
    • 0033592986 scopus 로고    scopus 로고
    • Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice
    • R.H. Karas, J.B. Hodgin, M. Kwoun, J.H. Krege, M. Aronovitz, and W. Mackey Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice Proc Natl Acad Sci U S A 96 1999 15133 15136
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 15133-15136
    • Karas, R.H.1    Hodgin, J.B.2    Kwoun, M.3    Krege, J.H.4    Aronovitz, M.5    Mackey, W.6
  • 59
    • 0035860836 scopus 로고    scopus 로고
    • Effects of estrogen on the vascular injury response in estrogen receptor alpha, beta (double) knockout mice
    • R.H. Karas, H. Schulten, G. Pare, M.J. Aronovitz, C. Ohlsson, and J.A. Gustafsson Effects of estrogen on the vascular injury response in estrogen receptor alpha, beta (double) knockout mice Circ Res 89 2001 534 539
    • (2001) Circ Res , vol.89 , pp. 534-539
    • Karas, R.H.1    Schulten, H.2    Pare, G.3    Aronovitz, M.J.4    Ohlsson, C.5    Gustafsson, J.A.6
  • 60
    • 0033767836 scopus 로고    scopus 로고
    • Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes
    • S. Dupont, A. Krust, A. Gansmuller, A. Dierich, P. Chambon, and M. Mark Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes Development 127 2000 4277 4291
    • (2000) Development , vol.127 , pp. 4277-4291
    • Dupont, S.1    Krust, A.2    Gansmuller, A.3    Dierich, A.4    Chambon, P.5    Mark, M.6
  • 61
    • 0035936528 scopus 로고    scopus 로고
    • Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-beta
    • L. Brouchet, A. Krust, S. Dupont, P. Chambon, F. Bayard, and J.F. Arnal Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-beta Circulation 103 2001 423 428
    • (2001) Circulation , vol.103 , pp. 423-428
    • Brouchet, L.1    Krust, A.2    Dupont, S.3    Chambon, P.4    Bayard, F.5    Arnal, J.F.6
  • 62
    • 0037040830 scopus 로고    scopus 로고
    • Estradiol alters nitric oxide production in the mouse aorta through the alpha-, but not beta-, estrogen receptor
    • B. Darblade, C. Pendaries, A. Krust, S. Dupont, M.J. Fouque, and J. Rami Estradiol alters nitric oxide production in the mouse aorta through the alpha-, but not beta-, estrogen receptor Circ Res 90 2002 413 419
    • (2002) Circ Res , vol.90 , pp. 413-419
    • Darblade, B.1    Pendaries, C.2    Krust, A.3    Dupont, S.4    Fouque, M.J.5    Rami, J.6
  • 63
    • 0037205290 scopus 로고    scopus 로고
    • Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury
    • G. Pare, A. Krust, R.H. Karas, S. Dupont, M. Aronovitz, and P. Chambon Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury Circ Res 90 2002 1087 1092
    • (2002) Circ Res , vol.90 , pp. 1087-1092
    • Pare, G.1    Krust, A.2    Karas, R.H.3    Dupont, S.4    Aronovitz, M.5    Chambon, P.6
  • 64
    • 73949135461 scopus 로고    scopus 로고
    • Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice
    • A. Billon-Gales, C. Fontaine, V. Douin-Echinard, L. Delpy, H. Berges, and B. Calippe Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice Circulation 120 2009 2567 2576
    • (2009) Circulation , vol.120 , pp. 2567-2576
    • Billon-Gales, A.1    Fontaine, C.2    Douin-Echinard, V.3    Delpy, L.4    Berges, H.5    Calippe, B.6
  • 65
    • 0028866648 scopus 로고
    • Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene
    • J.F. Couse, S.W. Curtis, T.F. Washburn, J. Lindzey, T.S. Golding, and D.B. Lubahn Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene Mol Endocrinol 9 1995 1441 1454
    • (1995) Mol Endocrinol , vol.9 , pp. 1441-1454
    • Couse, J.F.1    Curtis, S.W.2    Washburn, T.F.3    Lindzey, J.4    Golding, T.S.5    Lubahn, D.B.6
  • 66
    • 0037133190 scopus 로고    scopus 로고
    • The AF-1 activation-function of eralpha may be dispensable to mediate the effect of estradiol on endothelial no production in mice
    • C. Pendaries, B. Darblade, P. Rochaix, A. Krust, P. Chambon, and K.S. Korach The AF-1 activation-function of eralpha may be dispensable to mediate the effect of estradiol on endothelial no production in mice Proc Natl Acad Sci U S A 99 2002 2205 2210
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 2205-2210
    • Pendaries, C.1    Darblade, B.2    Rochaix, P.3    Krust, A.4    Chambon, P.5    Korach, K.S.6
  • 67
    • 77955006975 scopus 로고    scopus 로고
    • Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice
    • K.L. Chambliss, Q. Wu, S. Oltmann, E.S. Konaniah, M. Umetani, and K.S. Korach Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice J Clin Invest 120 2010 2319 2330
    • (2010) J Clin Invest , vol.120 , pp. 2319-2330
    • Chambliss, K.L.1    Wu, Q.2    Oltmann, S.3    Konaniah, E.S.4    Umetani, M.5    Korach, K.S.6
  • 68
    • 19444386784 scopus 로고    scopus 로고
    • The acute estrogenic dilation of rat aorta is mediated solely by selective estrogen receptor-alpha agonists and is abolished by estrogen deprivation
    • C. Bolego, A. Cignarella, P. Sanvito, V. Pelosi, F. Pellegatta, and L. Puglisi The acute estrogenic dilation of rat aorta is mediated solely by selective estrogen receptor-alpha agonists and is abolished by estrogen deprivation J Pharmacol Exp Ther 313 2005 1203 1208
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 1203-1208
    • Bolego, C.1    Cignarella, A.2    Sanvito, P.3    Pelosi, V.4    Pellegatta, F.5    Puglisi, L.6
  • 70
    • 0029796605 scopus 로고    scopus 로고
    • Different regions in activation function-1 of the human estrogen receptor required for antiestrogen- and estradiol-dependent transcription activation
    • E.M. McInerney, and B.S. Katzenellenbogen Different regions in activation function-1 of the human estrogen receptor required for antiestrogen- and estradiol-dependent transcription activation J Biol Chem 271 1996 24172 24178
    • (1996) J Biol Chem , vol.271 , pp. 24172-24178
    • McInerney, E.M.1    Katzenellenbogen, B.S.2
  • 71
    • 0028901040 scopus 로고
    • Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells
    • D. Metzger, S. Ali, J.M. Bornert, and P. Chambon Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells J Biol Chem 270 1995 9535 9542
    • (1995) J Biol Chem , vol.270 , pp. 9535-9542
    • Metzger, D.1    Ali, S.2    Bornert, J.M.3    Chambon, P.4
  • 72
    • 60549099919 scopus 로고    scopus 로고
    • The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17{beta}-estradiol
    • A. Billon-Gales, C. Fontaine, C. Filipe, V. Douin-Echinard, M.J. Fouque, and G. Flouriot The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17{beta}-estradiol Proc Natl Acad Sci U S A 106 2009 2053 2058
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 2053-2058
    • Billon-Gales, A.1    Fontaine, C.2    Filipe, C.3    Douin-Echinard, V.4    Fouque, M.J.5    Flouriot, G.6
  • 73
    • 0036919257 scopus 로고    scopus 로고
    • Down but not out? A novel protein isoform of the estrogen receptor alpha is expressed in the estrogen receptor alpha knockout mouse
    • M. Kos, S. Denger, G. Reid, K.S. Korach, and F. Gannon Down but not out? A novel protein isoform of the estrogen receptor alpha is expressed in the estrogen receptor alpha knockout mouse J Mol Endocrinol 29 2002 281 286
    • (2002) J Mol Endocrinol , vol.29 , pp. 281-286
    • Kos, M.1    Denger, S.2    Reid, G.3    Korach, K.S.4    Gannon, F.5
  • 74
    • 80051954941 scopus 로고    scopus 로고
    • Activation function 2 (AF2) of estrogen receptor-{alpha} is required for the atheroprotective action of estradiol but not to accelerate endothelial healing
    • A. Billon-Gales, A. Krust, C. Fontaine, A. Abot, G. Flouriot, and C. Toutain Activation function 2 (AF2) of estrogen receptor-{alpha} is required for the atheroprotective action of estradiol but not to accelerate endothelial healing Proc Natl Acad Sci U S A 108 2011 13311 13316
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 13311-13316
    • Billon-Gales, A.1    Krust, A.2    Fontaine, C.3    Abot, A.4    Flouriot, G.5    Toutain, C.6
  • 75
    • 80052567302 scopus 로고    scopus 로고
    • Estrogen receptor alpha AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators
    • Y. Arao, K.J. Hamilton, M.K. Ray, G. Scott, Y. Mishina, and K.S. Korach Estrogen receptor alpha AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators Proc Natl Acad Sci U S A 108 2011 14986 14991
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 14986-14991
    • Arao, Y.1    Hamilton, K.J.2    Ray, M.K.3    Scott, G.4    Mishina, Y.5    Korach, K.S.6
  • 77
    • 63649148223 scopus 로고    scopus 로고
    • Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse
    • A. Pedram, M. Razandi, J.K. Kim, F. O'Mahony, E.Y. Lee, and U. Luderer Developmental phenotype of a membrane only estrogen receptor alpha (MOER) mouse J Biol Chem 284 2009 3488 3495
    • (2009) J Biol Chem , vol.284 , pp. 3488-3495
    • Pedram, A.1    Razandi, M.2    Kim, J.K.3    O'Mahony, F.4    Lee, E.Y.5    Luderer, U.6
  • 78
    • 41449090802 scopus 로고    scopus 로고
    • Genetic and pharmacologic strategies to determine the function of estrogen receptor alpha and estrogen receptor beta in cardiovascular system
    • P.A. Arias-Loza, V. Jazbutyte, and T. Pelzer Genetic and pharmacologic strategies to determine the function of estrogen receptor alpha and estrogen receptor beta in cardiovascular system Gend Med 5 Suppl. A 2008 S34 S45
    • (2008) Gend Med , vol.5 , Issue.SUPPL. A
    • Arias-Loza, P.A.1    Jazbutyte, V.2    Pelzer, T.3
  • 80
    • 40649084350 scopus 로고    scopus 로고
    • Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERbeta-null mutant
    • M.C. Antal, A. Krust, P. Chambon, and M. Mark Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERbeta-null mutant Proc Natl Acad Sci U S A 105 2008 2433 2438
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2433-2438
    • Antal, M.C.1    Krust, A.2    Chambon, P.3    Mark, M.4
  • 81
    • 84055197915 scopus 로고    scopus 로고
    • Roles for oestrogen receptor beta in adult brain function
    • R.J. Handa, S. Ogawa, J.M. Wang, and A.E. Herbison Roles for oestrogen receptor beta in adult brain function J Neuroendocrinol 24 2012 160 173
    • (2012) J Neuroendocrinol , vol.24 , pp. 160-173
    • Handa, R.J.1    Ogawa, S.2    Wang, J.M.3    Herbison, A.E.4
  • 83
    • 34250191787 scopus 로고    scopus 로고
    • Oestrogen receptors pathways to oestrogen responsive elements: The transactivation function-1 acts as the keystone of oestrogen receptor (ER)beta-mediated transcriptional repression of ER alpha
    • A. Gougelet, S.O. Mueller, K.S. Korach, and J.M. Renoir Oestrogen receptors pathways to oestrogen responsive elements: the transactivation function-1 acts as the keystone of oestrogen receptor (ER)beta-mediated transcriptional repression of ER alpha J Steroid Biochem Mol Biol 104 2007 110 122
    • (2007) J Steroid Biochem Mol Biol , vol.104 , pp. 110-122
    • Gougelet, A.1    Mueller, S.O.2    Korach, K.S.3    Renoir, J.M.4
  • 84
    • 73549104043 scopus 로고    scopus 로고
    • Genome-wide dynamics of chromatin binding of estrogen receptors alpha and beta: Mutual restriction and competitive site selection
    • T.H. Charn, E.T. Liu, E.C. Chang, Y.K. Lee, J.A. Katzenellenbogen, and B.S. Katzenellenbogen Genome-wide dynamics of chromatin binding of estrogen receptors alpha and beta: mutual restriction and competitive site selection Mol Endocrinol 24 2010 47 59
    • (2010) Mol Endocrinol , vol.24 , pp. 47-59
    • Charn, T.H.1    Liu, E.T.2    Chang, E.C.3    Lee, Y.K.4    Katzenellenbogen, J.A.5    Katzenellenbogen, B.S.6


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