Beneficial properties for insulin absorption using superporous hydrogel containing interpenetrating polymer network as oral delivery vehicles

International Journal of Pharmaceutics

Volumn 350, Issue 1-2, 2008, Pages 220-229

  Yin, Lichen ^a   Ding, JieYing ^a   Fei, Likun ^a   He, Miao ^a   Cui, Fuying ^a   Tang, Cui ^a   Yin, Chunhua ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Enzymatic inhibition; Insulin; Muco adhesion; Oral administration; Superporous hydrogels containing full interpenetrating polymer networks; Transport enhancement

Indexed keywords

ACRYLAMIDE; CALCIUM; CARBOMER; CARBOPOL 934; CHITOSAN; CHYMOTRYPSIN A; INSULIN; O CARBOXYMETHYLCHITOSAN; POLYACRYLIC ACID; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM BINDING; CIRCULAR DICHROISM; COLON; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; DRUG RELEASE; DRUG STABILITY; DRUG TRANSPORT; DUODENUM; EX VIVO STUDY; HYDROGEL; HYPOGLYCEMIA; ILEUM; INSULIN RELEASE; INTESTINE WALL; IONIC STRENGTH; JEJUNUM; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; CALCIUM; CHITOSAN; CHYMOTRYPSIN; COPPER; DRUG STABILITY; HYDROGEL; HYDROGEN-ION CONCENTRATION; INSULIN; INTESTINAL ABSORPTION; MALE; OSMOLAR CONCENTRATION; POROSITY; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; TRYPSIN INHIBITORS; VEHICLES;

EID: 38349171756     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.08.051     Document Type: Article

References (37)

1. Aboubakar M., Couvreur P., Pinto-Alphandary H., Gouritin B., Lacour B., Farinotti R., Puisieux F., and Vauthier C. Insulin-loaded nanocapsules for oral administration: in vitro and in vivo investigation. Drug Dev. Res. 49 (2000) 109-117
2. Ameye D., Voorspoels J., Foreman P., Tsai J., Richardson P., Geresh S., and Remon J.P. Trypsin inhibition, calcium and zinc ion binding of starch-g-poly(acrylic acid) copolymers and starch/poly(acrylic acid) mixtures for peroral peptide drug delivery. J. Control. Release 75 (2001) 357-364
3. Aoki Y., Morishita M., Asai K., Akikusa B., Hosoda S., and Takayama K. Regional dependent role of the mucous/glycocalyx layers in insulin permeation across rat small intestinal membrane. Pharm. Res. 22 (2005) 1854-1862
4. Asada H., Douen T., Waki M., Adachi S., Fujita T., Yamamoto A., and Muranishi S. Absorption characteristics of chemically modified-insulin derivatives with various fatty acids in the small and large intestine. J. Pharm. Sci. 84 (1995) 682-687
5. Bai J.P.F., Chang L.L., and Guo J.H. Effects of polyacrylic polymers on the degradation of insulin and peptide drugs by chymotrypsin and trypsin. J. Pharm. Pharmacol. 48 (1996) 17-21
6. Chinese Pharmacopoeia, vol. 2, 2000. Chinese Pharmacopeial Convention, China, pp. 439.
7. Citi S. Protein kinase inhibitors prevent junction dissociation by low extracellular calcium in MDCK epithelial cells. J. Cell Biol. 117 (1992) 169-178
8. Derwenda U., Derwenda Z., Dodson G.G., Hubbard R.E., and Korber F. Molecular structure of insulin: the insulin monomer and its assembly. Br. Med. Bull. 45 (1989) 4-18
9. Dorkoosh F.A., Borchard G., Rafiee-Tehrani M., Verhoef J.C., and Junginger H.E. Evaluation of superporous hydrogel (SPH) and SPH composites in porcine intestine ex vivo: assessment of drug transport, morphology effect, and mechanical fixation to intestinal wall. Eur. J. Pharm. Biopharm. 53 (2002) 161-166
10. Dorkoosh F.A., Verhoef J.C., Borchard G., Rafiee-Tehrani M., and Junginger H.E. Development and characterization of a novel peroral peptide drug delivery system. J. Control. Release 71 (2001) 307-318
11. Dorkoosh F.A., Setyaningsih D., Borchard G., Rafiee-Tehrani M., Verhoef J.C., and Junginger H.E. Effects of superporous hydrogels on paracellular drug permeability and cytotoxicity studies in Caco-2 cell monolayers. Int. J. Pharm. 241 (2002) 35-45
12. Dorkoosh F.A., Verhoef J.C., Ambagts M.H.C., Rafiee-Tehrani M., Borchard G., and Junginger H.E. Peroral delivery system based on superporous hydrogel polymers: release characteristics of the peptide drugs buserelin, octreotide and insulin. Eur. J. Pharm. Sci. 15 (2002) 433-439
13. Goldman J., and Carpenter F.H. Zinc binding, circular dichroism, and equilibrium sedimentation studies in insulin (bovine) and several of its derivatives. Biochemistry 13 (1974) 4566-4574
14. Haas J., and Lehr C.M. Developments in the area of bioadhesive drug delivery systems. Expert Opin. Biol. Ther. 2 (2002) 287-298
15. Hejazi R., and Amiji M. Chitosan-based gastrointestinal delivery systems. J. Control. Release 89 (2003) 151-165
16. Hind K., Koh J.J., Joss L., Liu F., Baudys M., and Kim S.W. Synthesis and characterization of poly(ethylene glycol)-insulin conjugates. Bioconjug. Chem. 11 (2000) 195-201
17. Kriwet B., and Kissel T. Interactions between bioadhesive poly(acrylic acid) and calcium ions. Int. J. Pharm. 127 (1996) 135-145
18. Liang P., Zhao Y., Shen Q., Wang D., and Xu D. The effect of carboxymethyl chitosan on the precipitation of calcium carbonate. J. Cryst. Growth 261 (2004) 571-576
19. Lueβen H.L., Borchard G., Verhoef J.C., Lehr C.-M., Boer A.G., and Junginger H.E. Mucoadhesive polymers in peroral peptide drug delivery. II. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin. Pharm. Res. 12 (1995) 1293-1298
20. Lueβen H.L., Bohner V., Perard D., Langguth P., Verhoef J.C., Boer A.G., Merkle H.P., and Junginger H.E. Mucoadhesive polymers in peroral peptide drug delivery. V. Effect of poly(acrylates) on the enzymatic degradation of peptide drugs by intestinal brush border membrane vesicles. Int. J. Pharm. 141 (1996) 39-52
21. Mark A.E., and Jeffrey P.D. The self-association of zinc-free bovine insulin-4 model patterns and their significance. Biol. Chem. Hoppe-Seyler 371 (1990) 1165-1174
22. Marschutz M.K., Caliceti P., and Bernkop-Schnurch A. Design and in vivo evaluation of an oral delivery system for insulin. Pharm. Res. 17 (2000) 1468-1474
23. Mercola D.A., Morris J.W.S., Arquilla E.R., and Bromer W.W. The ultraviolet circular dichroism of bovine insulin and desoctapeptide insulin. Biochim. Biophys. Acta 133 (1967) 224-232
24. Mesiha M., Plakogiannis F., and Vejosoth S. Enhanced oral absorption of insulin from desolvated fatty acid-sodium glycocholate emulsions. Int. J. Pharm. 111 (1994) 213-216
25. Morishita M., Aoki Y., Sakagami M., Nagai T., and Takayama K. In situ ileal absorption of insulin in rats: effects of hyaluronidase pretreatment diminishing the mucous/glycocalyx layers. Pharm. Res. 21 (2004) 309-316
26. Pocker Y., and Biswas S.B. Conformational dynamics of insulin in solution. Circular dichroic studies. Biochemistry 19 (1980) 5043-5049
27. Polnok A., Verhoef J.C., Borchard G., Sarisuta N., and Junginger H.E. In vitro evaluation of intestinal absorption of desmopressin using drug-delivery systems based on superporous hydrogels. Int. J. Pharm. 269 (2004) 303-310
28. Radwant M.A., and Aboul-Enein H.Y. The effect of oral absorption enhancers on the in vivo performance of insulin-loaded poly(ethylcyanoacrylate) nanospheres in diabetic rats. J. Microencapsul. 19 (2002) 225-235
29. Saffran M., Pansky B., Budd G.C., and Williams F.E. Insulin and the gastrointestinal tract. J. Control. Release 46 (1997) 89-98
30. Sun S., and Wang A. Adsorption kinetics of Cu(II) ions using N,O-carboxymethyl-chitosan. J. Hazard. Mater. B 131 (2006) 103-111
31. Sun S., and Wang A. Adsorption properties and mechanism of cross-linked carboxymethyl-chitosan resin with Zn(II) as template ion. React. Func. Polym. 66 (2006) 819-826
32. Sun S., Wang L., and Wang A. Adsorption properties of crosslinked carboxymethyl-chitosan resin with Pb(II) as template ions. J. Hazard. Mater. 136 (2006) 930-937
33. Takeuchi H., Yamamoto H., Niwa T., Hino T., and Kawashima Y. Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes. Pharm. Res. 13 (1996) 896-901
34. Walker G.F., Ledger R., and Tucker I.G. Carbomer inhibits tryptic proteolysis of luteinizing hormone-releasing hormone and N-a-benzoyl-l-arginine ethyl ester by binding the enzyme. Pharm. Res. 16 (1999) 1074-1080
35. Yin L., Fei L., Cui F., Tang C., and Yin C. Superporous hydrogels containing poly(acrylic acid-co-acrylamide)/O-carboxymethyl chitosan interpenetrating polymer networks. Biomaterials 28 (2007) 1258-1266
36. Zhao X., Kato K., Fukumoto Y., and Nakamae K. Synthesis of bioadhesive hydrogels from chitin derivatives. Int. J. Adhes. Adhes. 21 (2001) 227-232
37. Ziv E., Kidron M., Raz I., Krausz M., Blatt Y., Rotman A., and Bar-On H. Oral administration of insulin in solid form to nondiabetic and diabetic dogs. J. Pharm. Sci. 83 (1994) 792-794