Nanosized insulin-complexes based on biodegradable amine-modified graft polyesters poly[vinyl-3-(diethylamino)-propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft-poly(l-lactic acid): Protection against enzymatic degradation, interaction with Caco-2 cell monolayers, peptide transport and cytotoxicity

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 66, Issue 2, 2007, Pages 165-172

  Simon, Michael ^a   Behrens, Isabel ^a   Dailey, Lea Anne ^a   Wittmar, Matthias ^a   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Caco 2 cells; Cytotoxicity; Enzymatic degradation; Insulin; Nanocomplexes; Protein delivery

Indexed keywords

AMINE; INSULIN; LACTATE DEHYDROGENASE; NANOPARTICLE; POLY[VINYL 3 (DIETHYLAMINO) PROPYLCARBAMATE CO (VINYL ACETATE) CO (VINYL ALCOHOL)] GRAFT POLY (LACTIC ACID); POLYESTER; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADABILITY; CELL STRAIN CACO 2; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; DRUG UPTAKE; ENZYME DEGRADATION; ENZYME RELEASE; HUMAN; HUMAN CELL; PROTEIN TRANSPORT;

CACO-2 CELLS; CELL MEMBRANE; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; ELECTRIC IMPEDANCE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; L-LACTATE DEHYDROGENASE; NANOPARTICLES; POLYESTERS; TIME FACTORS; TRYPSIN;

EID: 34247532336     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.10.009     Document Type: Article

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