Targeting doxorubicin to epidermal growth factor receptors by site-specific conjugation of C225 to poly(L-glutamic acid) through a polyethylene glycol spacer

Pharmaceutical Research

Volumn 20, Issue 5, 2003, Pages 826-832

  Vega, Javier ^a   Ke, Shi ^a   Fan, Zhen ^a   Wallace, Sidney ^a   Charsangavej, Chusilp ^a   Li, Chun ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Doxorubicin; Epidermal growth factor receptors; Poly(L glutamic acid); Targeting

Indexed keywords

ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; CETUXIMAB; COPOLYMER; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY; POLYGLUTAMIC ACID; POLYGLUTAMIC ACID CO POLYETHYLENE GLYCOL; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; CONFOCAL LASER MICROSCOPY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG TARGETING; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SQUAMOUS CELL CARCINOMA; SYNTHESIS; ULTRAVIOLET SPECTROPHOTOMETRY; VULVA CARCINOMA;

ANTIBODIES, MONOCLONAL; BINDING SITES; CELL LINE, TUMOR; DOXORUBICIN; DRUG DELIVERY SYSTEMS; HUMANS; POLYETHYLENE GLYCOLS; POLYGLUTAMIC ACID; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 0037407394     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023454107190     Document Type: Article

References (18)

1. D. Putnam and J. Kopecek. Polymer conjugates with anticancer activity. Adv. Polym. Sci. 122:55-123 (1995).
2. L. B. Shih, D. M. Goldenberg, H. Xuan, H. Lu, R. M. Sharkey, and T. C. Hall. Anthracycline immunoconjugates prepared by a site-specific linkage via an amino-dextran intermediate carrier. Cancer Res. 51:4192-4198 (1991).
3. C. Li. Poly(L-glutamic acid)-anticancer drug conjugates. Adv. Drug Deliv. Rev. 54:695-713 (2002).
4. G. F. Rowland, G. J. O'Neill, and D. A. L. Davies. Suppression of tumor growth in mice by drug-antibody conjugate using a novel approach to linkage. Nature 255:487-488 (1975).
5. J. S. Mann, J. C. Huang, and J. F. W. Keana. Molecular amplifiers: Synthesis and functionalization of a poly(aminopropyl)dextran bearing a uniquely reactive terminus for univalent attachment to biomolecules. Bioconjug. Chem. 3:154-159 (1992).
6. Y. Kato, N. Umemoto, Y. Kayama, H. Fukushima, Y. Takeda, T. Hara, and Y. Tsukada. A novel method of conjugation of daunomycin with antibody with a poly-L-glutamic acid derivative as intermediate drug carrier: An anti-α-fetoprotein antibody-daunomycin conjugate. J. Med. Chem. 27:1602-1607 (1984).
7. A. P. Chapman, P. Antoniw, M. Spitali, S. West, S. Stephens, and D. J. King. Therapeutic antibody fragments with prolonged in vivo half-lives. Nat. Biotech. 17:780-783 (1999).
8. A. Gabizon. Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes. Cancer Res. 52:891-896 (1992).
9. K. Kitamura, T. Takahashi, T. Yamaguchi, A. Noguchi, A. Nogichu, K.-I. Takashina, H. Tsurumi, M. Inagake, T. Toyokuni, and S.-I. Hakomori. Chemical engineering of the monoclonal antibody A7 by polyethylene glycol for targeting cancer chemotherapy. Cancer Res. 51:4310-4315 (1991).
10. X.-X. Wen, Q.-P. Wu, Y. Lu, Z. Fan, C. Charnsangavej, S. Wallace, D. Chow, and C. Li. Poly(ethylene glycol) conjugated anti-EGF receptor antibody C225 with radiometal chelator attached to the termini of polymer chains. Bioconjug. Chem. 12:545-553 (2001).
11. 111In-DTPA-poly(ethylene glycol) conjugated anti-EGF receptor antibody C225. J. Nucl. Med. 42:1530-1537 (2001).
12. H. Modjahedi and C. Dean. The receptor for EGF and its ligands: expression, prognostic value and target for therapy in cancer (review). Int. J. Oncol. 4:277-296 (1994).
13. J. Mendelsohn. Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy. Clin. Cancer Res. 3:2703-2707 (1997).
14. M. Yokoyama, M. Miyauchi, N. Yamada, T. Okano, Y. Sakurai, K. Kataoka, and S. Inoue. Polymer micelles as novel drug carrier: adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. J. Control. Release 11:269-278 (1990).
15. C. Jeppesen, J. Y. Wong, T. Kuhl, J. N. Israelachvili, N. Mullah, S. Zalipsky, and C. M. Marques. Impact of polymer tether length on multiple ligand-receptor bond formation. Science 293:465-468 (2001).
16. Y. Deguchi, A. Kurihara, and W. M. Pardridge. Retention of biological activity of human epidermal growth factor following conjugation to a blood-barrier drug delivery vector via an extended poly(ethylene glycol) linker. Bioconjug. Chem. 10:32-37 (1999).
17. G. T. Hermanson. Bioconjugate Techniques, Academic Press, San Diego, California, 1996.
18. M. Yokoyama, M. Miyauchi, N. Yamada, T. Okano, Y. Sakurai, K. Kataoka, and S. Inoue. Polymer micelles as novel drug carrier: adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. J. Control. Release 11:269-278 (1990).