Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact

American Journal of Pathology

Volumn 182, Issue 5, 2013, Pages 1800-1810

  Migita, Toshiro ^a,b   Okabe, Sachiko ^a   Ikeda, Kazutaka ^b,c   Igarashi, Saori ^c   Sugawara, Shoko ^c   Tomida, Akihiro ^a   Taguchi, Ryo ^b,d   Soga, Tomoyoshi ^c   Seimiya, Hiroyuki ^a  

^a CANCER CHEMOTHERAPY CENTER   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KEIO UNIVERSITY   (Japan)

^d CHUBU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE CITRATE LYASE; HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER TISSUE; CONTROLLED STUDY; DNA DAMAGE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS; APOPTOSIS; ATP CITRATE (PRO-S)-LYASE; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MITOCHONDRIA; MOLECULAR TARGETED THERAPY; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; TUMOR MARKERS, BIOLOGICAL;

EID: 84876539223     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.01.048     Document Type: Article

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