Elevated circulating free fatty acids levels causing pancreatic islet cell dysfunction through oxidative stress

Journal of Endocrinological Investigation

Volumn 33, Issue 6, 2010, Pages 388-394

  Zhang, X ^a   Bao, Y ^a   Ke, L ^a   Yu, Y ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Free fatty acids; Insulin secretion; Oxidative stress; Pancreatic cell

Indexed keywords

ACETYLCYSTEINE; FATTY ACID; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEPARIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTRALIPID; MALONALDEHYDE; GLUCOSE; LIPID EMULSION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; EX VIVO STUDY; FATTY ACID BLOOD LEVEL; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; RAT; SCORING SYSTEM; SIGNAL TRANSDUCTION; TISSUE PERFUSION; ANIMAL; BLOOD; DRUG EFFECTS; GLUCOSE TOLERANCE TEST; METABOLISM; PANCREAS ISLET; SECRETION (PROCESS); SPRAGUE DAWLEY RAT;

ACETYLCYSTEINE; ANIMALS; FAT EMULSIONS, INTRAVENOUS; FATTY ACIDS, NONESTERIFIED; GLUCOSE; GLUCOSE TOLERANCE TEST; GLUTATHIONE; INSULIN; ISLETS OF LANGERHANS; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77955396230     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/6621     Document Type: Article

References (29)

1. Charles MA, Eschwège E, Thibult N, et al. The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subject: results of the Paris Prospective Study. Diabetologia 1997, 40: 1101-6.
2. Chen S, Ogawa A, Ohneda M, Unger RH, Foster DW, McGarry JD. More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling. Diabetes 1994, 43: 878-83.
3. Prentki M, Joly E, El Assaad W, Roduit R. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in β-cell adaptation and failure in the etiology of diabetes. Diabetes 2002, 51 (Suppl 3): S405-13.
4. Dobbins RL, Chester MW, Daniels MB, McGarry JD, Stein DT. Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans. Diabetes 1998, 47: 1613-8.
5. Paolisso G. Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects. Diabetologia 1995, 38: 1295-9.
6. Boden G, Chen X, Rosner J, Barton M. Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes 1995, 44: 1239-42.
7. Carlsson C, Borg LA, Welsh N. Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. Endocrinology 1999, 140: 3422-8.
8. Maestre I, Jordán J, Calvo S, et al. Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1. Endocrinology 2003, 144: 335-45.
9. Wang X, Li H, De Leo D, et al. Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic β-cell line MIN6. Diabetes 2004, 53: 129-40.
10. Oprescu AI, Bikopoulos G, Naassan A, et al. Free fatty acid-induced reduction in glucose-stimulated insulin secretion. Evidence for a role of oxidative stress in vitro and in vivo. Diabetes 2007, 56: 2927-37.
11. Xiao C, Giacca A, Lewis GF. Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men. Diabetologia 2008, 51: 139-46.
12. Moore PC, Ugas MA, Hagman DK, Parazzoli SD, Poitout V. Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion. Diabetes 2004, 53: 2610-6.
13. Giustarini D, Dalle-Donne I, Colombo R, Milzani A, Rossi R. An improved HPLC measurement for GSH and GSSG in human blood. Free Radic Biol Med 2003, 35: 1365-72.
14. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997, 46: 3-10.
15. Magnan C, Collins S, Berthault MF, et al. Lipid infusion lowers sympathetic nervous activity and leads to increased beta-cell responsiveness to glucose. J Clin Invest 1999, 103: 413-9.
16. Magnan C, Cruciani C, Clement L, et al. Glucose-induced insulin hypersecretion in lipid-infused healthy subjects is associated with a decrease in plasma norepinephrine concentration and urinary excretion. J Clin Endocrinol Metab 2001, 86: 4901-7.
17. Carpentier A, Mittelman SD, Lamarche B, Bergman RN, Giacca A, Lewis GF. Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. Am J Physiol 1999, 276: E1055-66.
18. Stefan N, Wahl HG, Fritsche A, Häring H, Stumvoll M. Effect of the pattern of elevated free fatty acids on insulin sensitivity and insulin secretion in healthy humans. Horm Metab Res 2001, 33: 432-8.
19. Leung N, Sakaue T, Carpentier A, Uffelman K, Giacca A, Lewis GF. Prolonged increase of plasma non-esterified fatty acids fully abolishes the stimulatory effect of 24 hours of moderate hyperglycaemia on insulin sensitivity and pancreatic beta-cell function in obese men. Diabetologia 2004, 47: 204-13.
20. Mason TM, Goh T, Tchipashvili V, et al. Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats. Diabetes 1999, 48: 524-30.
21. Kashyap S, Belfort R, Gastaldelli A, et al. A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes 2003, 52: 2461-74.
22. Paolisso G, Tagliamonte MR, Rizzo MR, et al. Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes. Diabetologia 1998, 41: 1127-32.
23. Goh TT, Mason TM, Gupta N, et al. Lipid-induced β-cell dysfunction in vivo in models of progressive β-cell failure. Am J Physiol Endocrinol Metab 2007, 292: E549-60.
24. Shimabukuro M, Zhou YT, Levi M, Unger RH. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U S A 1998, 95: 2498-502.
25. Lupi R, Dotta F, Marselli L, et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 2002, 51: 1437-42.
26. Grankvist K, Marklund SL, Taljedal IB. CuZn-superoxide dismutase, Mnsuperoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem J 1981, 199: 393-8.
27. Tiedge M, Lortz S, Munday R, Lenzen S. Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species. Diabetes 1998, 47: 1578-85.
28. Karin M, Ben Neriah Y. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 2000, 18: 621-63.
29. Karin M. How NF-κB is activated: the role of the IκB kinase (IKK) complex. Oncogene 1991, 18: 6867-74.