Effects of melatonin on DNA damage induced by cyclophosphamide in rats

Brazilian Journal of Medical and Biological Research

Volumn 46, Issue 3, 2013, Pages 278-286

  Ferreira, S G ^a   Peliciari Garcia, R A ^a   Takahashi Hyodo, S A ^b   Rodrigues, A C ^a   Amaral, F G ^a   Berra, C M ^a   Bordin, S ^a   Curi, R ^a   Cipolla Neto, J ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Universidade Braz Cubas   (Brazil)

Author keywords

Chromosomal aberration; Comet assay; Cyclophosphamide; DNA fragmentation; Melatonin; Xpf expression

Indexed keywords

BETA 2 MICROGLOBULIN; CYCLOPHOSPHAMIDE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; HISTONE DEACETYLASE 1; MELATONIN; MESSENGER RNA; TRIZOL; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG EFFECT; EXCISION REPAIR; MALE; MITOSIS INDEX; NONHUMAN; NUCLEOTIDE SEQUENCE; PINEALECTOMY; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 84876466713     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20122230     Document Type: Article

References (39)

1. Ganguly S, Coon SL, Klein DC. Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation. Cell Tissue Res 2002; 309: 127-137, doi: 10.1007/s00441-002-0579-y.
2. Goldman BD. Mammalian photoperiodic system: formal properties and neuroendocrine mechanisms of photoperiodic time measurement. J Biol Rhythms 2001; 16: 283-301, doi: 10.1177/074873001129001980.
3. Hardeland R, Tan DX, Reiter RJ. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009; 47: 109-126, doi: 10.1111/j.1600-079X.2009.00701.x.
4. Reiter RJ, Tan DX, Sainz RM, Mayo JC, Lopez-Burillo S. Melatonin: reducing the toxicity and increasing the efficacy of drugs. J Pharm Pharmacol 2002; 54: 1299-1321, doi: 10.1211/002235702760345374.
5. Afeche SC, Amaral FG, Villela DCM, Abrahao MV, Peres R, Cipolla-Neto J. Melatonin and pineal gland. In: Romano E, De Luca S (Editors), New research on neurosecretory systems. Hauppauge: Nova Science Publishers; 2008. p 151-177.
6. Klein DC. Arylalkylamine N-acetyltransferase: "the Timezyme". J Biol Chem 2007; 282: 4233-4237, doi: 10.1074/jbc.R600036200.
7. Reiter RJ, Tan DX, Manchester LC, Tamura H. Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage. J Physiol Pharmacol 2007; 58 (Suppl 6): 5-22.
8. Rodriguez C, Mayo JC, Sainz RM, Antolin I, Herrera F, Martin V, et al. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004; 36: 1-9, doi: 10.1046/j.1600-079X.2003.00092.x.
9. Simonneaux V, Ribelayga C. Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 2003; 55: 325-395, doi: 10.1124/pr.55.2.2.
10. Tan D, Reiter RJ, Chen LD, Poeggeler B, Manchester LC, Barlow-Walden LR. Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole. Carcinogenesis 1994; 15: 215-218, doi: 10.1093/carcin/15.2.215.
11. Mahal HS, Sharma HS, Mukherjee T. Antioxidant properties of melatonin: a pulse radiolysis study. Free Radic Biol Med 1999; 26: 557-565, doi: 10.1016/S0891-5849(98)00226-3.
12. Vijayalaxmi, Meltz ML, Reiter RJ, Herman TS. Melatonin and protection from genetic damage in blood and bone marrow: whole-body irradiation studies in mice. J Pineal Res 1999; 27: 221-225, doi: 10.1111/j.1600-079X.1999. tb00618.x.
13. Oz E, Ilhan MN. Effects of melatonin in reducing the toxic effects of doxorubicin. Mol Cell Biochem 2006; 286: 11-15, doi: 10.1007/s11010-005-9003-8.
14. Blask DE. Melatonin, sleep disturbance and cancer risk. Sleep Med Rev 2009; 13: 257-264, doi: 10.1016/j.smrv. 2008.07.007.
15. Reiter RJ. Melatonin: clinical relevance. Best Pract Res Clin Endocrinol Metab 2003; 17: 273-285, doi: 10.1016/S1521-690X(03)00016-2.
16. Martins E Jr, Fernandes LC, Bartol I, Cipolla-Neto J, Costa Rosa LF. The effect of melatonin chronic treatment upon macrophage and lymphocyte metabolism and function in Walker-256 tumour-bearing rats. J Neuroimmunol 1998; 82: 81-89, doi: 10.1016/S0165-5728(97)00191-4.
17. Messina G, Lissoni P, Marchiori P, Bartolacelli E, Brivio F, Magotti L. Enhancement of the efficacy of cancer chemotherapy by the pineal hormone melatonin and its relation with the psychospiritual status of cancer patients. J Res Med Sci 2010; 15: 225-228.
18. Salvadori DM, Ribeiro LR, Oliveira MD, Pereira CA, Becak W. The protective effect of beta-carotene on genotoxicity induced by cyclophosphamide. Mutat Res 1992; 265: 237-244, doi: 10.1016/0027-5107(92)90052-4.
19. Hengstler JG, Hengst A, Fuchs J, Tanner B, Pohl J, Oesch F. Induction of DNA crosslinks and DNA strand lesions by cyclophosphamide after activation by cytochrome P450 2B1. Mutat Res 1997; 373: 215-223, doi: 10.1016/S0027-5107(96)00200-X.
20. Selvakumar E, Prahalathan C, Varalakshmi P, Kumarasamy P, Saravanan R. Modification of cyclophosphamide-induced clastogenesis and apoptosis in rats by alpha-lipoic acid. Mutat Res 2006; 606: 85-91, doi: 10.1016/ j.mrgentox.2006.03.005.
21. Franke SI, Pra D, Erdtmann B, Henriques JA, da Silva J. Influence of orange juice over the genotoxicity induced by alkylating agents: an in vivo analysis. Mutagenesis 2005; 20: 279-283, doi: 10.1093/mutage/gei034.
22. Hoffman RA, Reiter RJ. Rapid pinealectomy in hamsters and other small rodents. Anat Rec 1965; 153: 19-21, doi: 10.1002/ar.1091530103.
23. Anderson D, Bishop JB, Garner RC, Ostrosky-Wegman P, Selby PB. Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks. Mutat Res 1995; 330: 115-181, doi: 10.1016/0027-5107(95)00039-L.
24. Ford CE, Hamerton JL. A colchicine, hypotonic citrate, squash sequence for mammalian chromosomes. Stain Technol 1956; 31: 247-251.
25. Preston RJ, Dean BJ, Galloway S, Holden H, McFee AF, Shelby M. Mammalian in vivo cytogenetic assays. Analysis of chromosome aberrations in bone marrow cells. Mutat Res 1987; 189: 157-165, doi: 10.1016/0165-1218(87) 90021-8.
26. Savage JR. Classification and relationships of induced chromosomal structual changes. J Med Genet 1976; 13: 103-122, doi: 10.1136/jmg.13.2.103.
27. Krishna G, Kropko ML, Ciaravino V, Theiss JC. Simultaneous micronucleus and chromosome aberration assessment in the rat. Mutat Res 1991; 264: 29-35, doi: 10.1016/0165-7992(91)90042-3.
28. Swierenga SH, Heddle JA, Sigal EA, Gilman JP, Brillinger RL, Douglas GR, et al. Recommended protocols based on a survey of current practice in genotoxicity testing laboratories, IV. Chromosome aberration and sister-chromatid exchange in Chinese hamster ovary, V79 Chinese hamster lung and human lymphocyte cultures. Mutat Res 1991; 246: 301-322, doi: 10.1016/0027-5107(91)90050-X.
29. Hartmann A, Herkommer K, Gluck M, Speit G. DNAdamaging effect of cyclophosphamide on human blood cells in vivo and in vitro studied with the single-cell gel test (comet assay). Environ Mol Mutagen 1995; 25: 180-187, doi: 10.1002/em.2850250303.
30. Collins AR. Investigating oxidative DNA damage and its repair using the comet assay. Mutat Res 2009; 681: 24-32, doi: 10.1016/j.mrrev.2007.10.002.
31. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) Method. Methods 2001; 25: 402-408, doi: 10.1006/meth.2001.1262.
32. Agez L, Laurent V, Guerrero HY, Pevet P, Masson-Pevet M, Gauer F. Endogenous melatonin provides an effective circadian message to both the suprachiasmatic nuclei and the pars tuberalis of the rat. J Pineal Res 2009; 46: 95-105, doi: 10.1111/j.1600-079X.2008.00636.x.
33. Fisher SP, Sugden D. Endogenous melatonin is not obligatory for the regulation of the rat sleep-wake cycle. Sleep 2010; 33: 833-840.
34. 2-and cyclophosphamide-induced DNA damage. Mutagenesis 1999; 14: 107-112, doi: 10.1093/mutage/14.1.107.
35. Vijayalaxmi, Reiter RJ, Meltz ML, Herman TS. Melatonin: possible mechanisms involved in its 'radioprotective' effect. Mutat Res 1998; 404: 187-189, doi: 10.1016/S0027-5107(98)00112-2.
36. Maestroni GJ. The immunoneuroendocrine role of melatonin. J Pineal Res 1993; 14: 1-10, doi: 10.1111/j.1600-079X. 1993.tb00478.x.
37. Lissoni P, PittalisS, Brivio F, Tisi E, Rovelli F, Ardizzoia A, et al. In vitro modulatory effects of interleukin-3 on macrophage activation induced by interleukin-2. Cancer 1993; 71: 2076-2081, doi: 10.1002/1097-0142(19930315)71:6,2076::AIDCNCR2820710624.3.0. CO;2-I.
38. Musatov SA, Anisimov VN, Andre V, Vigreux C, Godard T, Gauduchon P, et al. Modulatory effects of melatonin on genotoxic response of reference mutagens in the Ames test and the comet assay. Mutat Res 1998; 417: 75-84, doi: 10.1016/S1383-5718(98)00094-1.
39. Sliwinski T, Rozej W, Morawiec-Bajda A, Morawiec Z, Reiter R, Blasiak J. Protective action of melatonin against oxidative DNA damage: chemical inactivation versus base-excision repair. Mutat Res 2007; 634: 220-227, doi: 10.1016/ j.mrgentox.2007.07.013.