메뉴 건너뛰기




Volumn 17, Issue 2, 2003, Pages 273-285

Melatonin: Clinical relevance

Author keywords

Cancer; Circadian rhythms; Jet lag; Light:dark cycle; Melatonin; Oxidative stress; Pineal gland; Sleep

Indexed keywords

ANTINEOPLASTIC AGENT; ERYTHROPOIETIN; FREE RADICAL; INDOLE; IRON; MELATONIN; MELATONIN RECEPTOR;

EID: 0037700244     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-690X(03)00016-2     Document Type: Review
Times cited : (321)

References (64)
  • 3
    • 0034901997 scopus 로고    scopus 로고
    • Biology of mammalian photoperiodism and the critical role of the pineal gland and melatonin
    • Malpaux B, Migaud M, Tricoire H & Chemineau P. Biology of mammalian photoperiodism and the critical role of the pineal gland and melatonin. Journal of Biological Rhythms 2001; 16: 336-347.
    • (2001) Journal of Biological Rhythms , vol.16 , pp. 336-347
    • Malpaux, B.1    Migaud, M.2    Tricoire, H.3    Chemineau, P.4
  • 4
    • 0027210003 scopus 로고
    • The melatonin rhythm: Both a clock and a calendar
    • Reiter RJ. The melatonin rhythm: Both a clock and a calendar. Experientia 1993; 49: 654-664.
    • (1993) Experientia , vol.49 , pp. 654-664
    • Reiter, R.J.1
  • 7
    • 0036479749 scopus 로고    scopus 로고
    • Melatonin as a chronobiotic/anti-cancer agent: Cellular, biochemical and molecular mechanisms of action and their implications for circadian-based cancer therapy
    • Blask DE, Sauer LA & Dauchy RT. Melatonin as a chronobiotic/anti-cancer agent: Cellular, biochemical and molecular mechanisms of action and their implications for circadian-based cancer therapy. Current Topics in Medicinal Chemistry 2002; 2: 113-132.
    • (2002) Current Topics in Medicinal Chemistry , vol.2 , pp. 113-132
    • Blask, D.E.1    Sauer, L.A.2    Dauchy, R.T.3
  • 8
    • 0036797512 scopus 로고    scopus 로고
    • Melatonin: Reducing the toxicity and increasing the efficacy of drugs
    • Reiter RJ, Tan DX, Sainz RM et al. Melatonin: Reducing the toxicity and increasing the efficacy of drugs. Journal of Pharmacy and Pharmacology 2002; 54: 1299-1321.
    • (2002) Journal of Pharmacy and Pharmacology , vol.54 , pp. 1299-1321
    • Reiter, R.J.1    Tan, D.X.2    Sainz, R.M.3
  • 9
    • 0036482282 scopus 로고    scopus 로고
    • Chemical and physical properties and potential mechanisms: Melatonin as a broad-spectrum antioxidant and free radical scavenger
    • Tan DX, Reiter RJ, Manchester LC et al. Chemical and physical properties and potential mechanisms: Melatonin as a broad-spectrum antioxidant and free radical scavenger. Current Topics in Medicinal Chemistry 2002; 2: 181-198.
    • (2002) Current Topics in Medicinal Chemistry , vol.2 , pp. 181-198
    • Tan, D.X.1    Reiter, R.J.2    Manchester, L.C.3
  • 10
    • 0002445286 scopus 로고
    • The mammalian pineal gland as an end organ of the visual system
    • In Wettenberg L (ed.); Oxford: Pergamon Press
    • Reiter RJ. The mammalian pineal gland as an end organ of the visual system. In Wettenberg L (ed.) Light and Biological Rhythms in Man. Oxford: Pergamon Press, 1993, pp 145-150.
    • (1993) Light and Biological Rhythms in Man , pp. 145-150
    • Reiter, R.J.1
  • 13
    • 0031304819 scopus 로고    scopus 로고
    • Time and time again: The phylogeny of melatonin as a transducer of biological time
    • Cassone VM & Nateson AK. Time and time again: The phylogeny of melatonin as a transducer of biological time. Journal of Biological Rhythms 1997; 12: 489-497.
    • (1997) Journal of Biological Rhythms , vol.12 , pp. 489-497
    • Cassone, V.M.1    Nateson, A.K.2
  • 14
    • 0025758136 scopus 로고
    • Pineal melatonin: Cell biology of its synthesis and of its physiological interactions
    • Reiter RJ. Pineal melatonin: Cell biology of its synthesis and of its physiological interactions. Endocrine Reviews 1991; 12: 151-180.
    • (1991) Endocrine Reviews , vol.12 , pp. 151-180
    • Reiter, R.J.1
  • 15
    • 0030626244 scopus 로고    scopus 로고
    • The melatonin rhythm-generating enzyme: Molecular regulation of serotonin N-acetyltransferase in the pineal gland
    • Klein DC, Coon SL, Rosenboom PH et al. The melatonin rhythm-generating enzyme: Molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent Progress in Hormone Research 1997; 52: 307-358.
    • (1997) Recent Progress in Hormone Research , vol.52 , pp. 307-358
    • Klein, D.C.1    Coon, S.L.2    Rosenboom, P.H.3
  • 16
    • 0034642083 scopus 로고    scopus 로고
    • Melatonin, circadian rhythms and sleep
    • Arendt J. Melatonin, circadian rhythms and sleep. New England Journal of Medicine 2000; 343: 1114-1116.
    • (2000) New England Journal of Medicine , vol.343 , pp. 1114-1116
    • Arendt, J.1
  • 17
    • 0036142587 scopus 로고    scopus 로고
    • Melatonin enters the cerebrospinal fluid through the pineal recess
    • Tricoire H, Lacotelli A,Chemineau P & Malpaux B. Melatonin enters the cerebrospinal fluid through the pineal recess. Endocrinology 2002; 143: 84-90.
    • (2002) Endocrinology , vol.143 , pp. 84-90
    • Tricoire, H.1    Lacotelli, A.2    Chemineau, P.3    Malpaux, B.4
  • 18
    • 0034906321 scopus 로고    scopus 로고
    • Photoperiodism in humans and other primates: Evidence and implications
    • Wehr TA. Photoperiodism in humans and other primates: Evidence and implications. Journal of Biological Rhythms 2001; 16: 348-364.
    • (2001) Journal of Biological Rhythms , vol.16 , pp. 348-364
    • Wehr, T.A.1
  • 19
    • 0038008019 scopus 로고    scopus 로고
    • Good light and bad: Some physiological consequences of the electromagnetic spectrum
    • In Hocevar A, Crepinsek Z & Kaifez-Bogataj L (eds); Ljublijiana: CIP Press
    • Reiter RJ. Good light and bad: Some physiological consequences of the electromagnetic spectrum. In Hocevar A, Crepinsek Z & Kaifez-Bogataj L (eds) Biometerology, vol. 2, pt. 2. Ljublijiana: CIP Press, 1997, pp 112-123.
    • (1997) Biometerology , vol.2 , Issue.PART 2 , pp. 112-123
    • Reiter, R.J.1
  • 20
    • 0026830761 scopus 로고
    • The aging pineal gland and its physiological consequences
    • Reiter RJ. The aging pineal gland and its physiological consequences. BioEssays 1992; 14: 169-175.
    • (1992) BioEssays , vol.14 , pp. 169-175
    • Reiter, R.J.1
  • 22
    • 0032583461 scopus 로고    scopus 로고
    • A novel melatonin metabolite, cyclic 3-hydroxymelatonin: A biomarker of melatonin interaction with hydroxyl radicals
    • Tan DX, Manchester LC, Reiter RJ et al. A novel melatonin metabolite, cyclic 3-hydroxymelatonin: A biomarker of melatonin interaction with hydroxyl radicals. Biochemical and Biophysical Research Communications 1998; 253: 614-620.
    • (1998) Biochemical and Biophysical Research Communications , vol.253 , pp. 614-620
    • Tan, D.X.1    Manchester, L.C.2    Reiter, R.J.3
  • 23
    • 0037246752 scopus 로고    scopus 로고
    • Melatonin: A hormone, a tissue factor, an autocoid, a paracoid and a antioxidant vitamin
    • Tan DX, Manchester LC, Hardeland R et al. Melatonin: A hormone, a tissue factor, an autocoid, a paracoid and a antioxidant vitamin. Journal of Pineal Research 2003; 34: 75-78.
    • (2003) Journal of Pineal Research , vol.34 , pp. 75-78
    • Tan, D.X.1    Manchester, L.C.2    Hardeland, R.3
  • 24
    • 0031297742 scopus 로고    scopus 로고
    • Melatonin receptors: Molecular biology of a new family of G protein-coupled receptors
    • Reppert SM. Melatonin receptors: Molecular biology of a new family of G protein-coupled receptors. Journal of Biological Rhythms 1997; 12: 528-531.
    • (1997) Journal of Biological Rhythms , vol.12 , pp. 528-531
    • Reppert, S.M.1
  • 26
    • 0031054011 scopus 로고    scopus 로고
    • Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: Activation of protein kinase C at dusk and dawn
    • McArthur AJ, Hunt AE & Gillette MV. Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: Activation of protein kinase C at dusk and dawn. Endocrinology 1997; 138: 627-634.
    • (1997) Endocrinology , vol.138 , pp. 627-634
    • McArthur, A.J.1    Hunt, A.E.2    Gillette, M.V.3
  • 27
    • 0034100724 scopus 로고    scopus 로고
    • The pars luberalis: The missing link in the photopliodic regulation of prolactin secretion?
    • Morgan PJ. The pars luberalis: The missing link in the photopliodic regulation of prolactin secretion? Journal of Neuroendocrinology 2000; 12: 287-295.
    • (2000) Journal of Neuroendocrinology , vol.12 , pp. 287-295
    • Morgan, P.J.1
  • 28
    • 0030930937 scopus 로고    scopus 로고
    • Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin
    • Pozo D, Reiter RJ, Calvo JR & Guerrero JM. Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin. Journal of Cellular Biochemistry 1997; 65: 430-442.
    • (1997) Journal of Cellular Biochemistry , vol.65 , pp. 430-442
    • Pozo, D.1    Reiter, R.J.2    Calvo, J.R.3    Guerrero, J.M.4
  • 29
    • 0033809810 scopus 로고    scopus 로고
    • Correlation between nuclear melatonin reception expression and enhanced cytokine production in human lymphocytic and monocytic cell lines
    • Garcia-Maurino S, Pozo D, Calvo JR & Guerrero JM. Correlation between nuclear melatonin reception expression and enhanced cytokine production in human lymphocytic and monocytic cell lines. Journal of Pineal Research 2000; 29: 129-137.
    • (2000) Journal of Pineal Research , vol.29 , pp. 129-137
    • Garcia-Maurino, S.1    Pozo, D.2    Calvo, J.R.3    Guerrero, J.M.4
  • 31
    • 12244304145 scopus 로고    scopus 로고
    • The chemistry of melatonin's interaction with reactive species
    • Allegra M, Reiter RJ, Tan DX et al. The chemistry of melatonin's interaction with reactive species. Journal of Pineal Research 2003; 34: 1-10.
    • (2003) Journal of Pineal Research , vol.34 , pp. 1-10
    • Allegra, M.1    Reiter, R.J.2    Tan, D.X.3
  • 33
    • 0036755069 scopus 로고    scopus 로고
    • Jet lag: Minimizing its effects with critically timed bright light and melatonin administration
    • Parry BL. Jet lag: Minimizing its effects with critically timed bright light and melatonin administration. Journal of Molecular Microbiology and Biotechnology 2002; 4: 463-466.
    • (2002) Journal of Molecular Microbiology and Biotechnology , vol.4 , pp. 463-466
    • Parry, B.L.1
  • 34
    • 0031304820 scopus 로고    scopus 로고
    • Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep, EEG
    • Dijk DJ & Cajochen C. Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep, EEG. Journal of Biological Rhythms 1997; 12: 636-643.
    • (1997) Journal of Biological Rhythms , vol.12 , pp. 636-643
    • Dijk, D.J.1    Cajochen, C.2
  • 36
    • 0033082096 scopus 로고    scopus 로고
    • Daytime melatonin and temazepam in young adult humans: Equivalent effects on sleep latency and body temperature
    • Gilbert SS, Van Den Heuvel CJ & Dawson D. Daytime melatonin and temazepam in young adult humans: Equivalent effects on sleep latency and body temperature. Journal of Physiology (London) 1999; 514: 903-914.
    • (1999) Journal of Physiology (London) , vol.514 , pp. 903-914
    • Gilbert, S.S.1    Van Den Heuvel, C.J.2    Dawson, D.3
  • 38
    • 0035876962 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids, melatonin and cancer progression
    • Sauer LA, Dauchy RT & Blask DE. Polyunsaturated fatty acids, melatonin and cancer progression. Biochemical Pharmacology 2001; 61: 1455-1462.
    • (2001) Biochemical Pharmacology , vol.61 , pp. 1455-1462
    • Sauer, L.A.1    Dauchy, R.T.2    Blask, D.E.3
  • 39
    • 0036936925 scopus 로고    scopus 로고
    • Is there a role for melatonin in supportive care?
    • Lissoni P. Is there a role for melatonin in supportive care? Supportive Cancer Care 2002; 10: 110-116.
    • (2002) Supportive Cancer Care , vol.10 , pp. 110-116
    • Lissoni, P.1
  • 40
    • 0028572548 scopus 로고
    • Modulation of oestrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells
    • Molis TM, Spriggs LL & Hill SM. Modulation of oestrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells. Molecular Endocrinology 1994; 8: 1681-1690.
    • (1994) Molecular Endocrinology , vol.8 , pp. 1681-1690
    • Molis, T.M.1    Spriggs, L.L.2    Hill, S.M.3
  • 41
  • 42
    • 0027196665 scopus 로고
    • The immunoneuroendocrine role of melatonin
    • Maestroni CJM. The immunoneuroendocrine role of melatonin. Journal of Pineal Research 1993; 14: 1-10.
    • (1993) Journal of Pineal Research , vol.14 , pp. 1-10
    • Maestroni, C.J.M.1
  • 43
    • 0034896128 scopus 로고    scopus 로고
    • Pineal indoles stimulate the gene expression of immunomodulating cytokines
    • Liu F, Ng TB & Fung MC. Pineal indoles stimulate the gene expression of immunomodulating cytokines. Journal of Neural Transmission 2001; 108: 397-405.
    • (2001) Journal of Neural Transmission , vol.108 , pp. 397-405
    • Liu, F.1    Ng, T.B.2    Fung, M.C.3
  • 45
    • 0032845245 scopus 로고    scopus 로고
    • Melatonin regulates glucocorticoid receptor: An answer to its antiapoptic action in thymus
    • Sainz RM, Mayo JC, Reiter RJ et al. Melatonin regulates glucocorticoid receptor: An answer to its antiapoptic action in thymus. FASEB J 2000; 13: 1547-1556.
    • (2000) FASEB J , vol.13 , pp. 1547-1556
    • Sainz, R.M.1    Mayo, J.C.2    Reiter, R.J.3
  • 46
    • 0032444559 scopus 로고    scopus 로고
    • Involvement of molecular binding sites for melatonin in the regulation of, IL-2 and, IL-6 production by human blood mononuclear cells
    • Garcia-Maurino, S., Gonzalez-Haba, MG, Calvo, JR, et al. Involvement of molecular binding sites for melatonin in the regulation of, IL-2 and, IL-6 production by human blood mononuclear cells. Journal of Neuroimmunology 1998; 92: 76-84.
    • (1998) Journal of Neuroimmunology , vol.92 , pp. 76-84
    • Garcia-Maurino, S.1    Gonzalez-Haba, M.G.2    Calvo, J.R.3
  • 48
    • 0002979059 scopus 로고
    • Melatonin: A patent, endogenous hydroxyl radical scavenger
    • Tan DX, Chen LD, Poeggeler B et al. Melatonin: A patent, endogenous hydroxyl radical scavenger. Endocrine Journal 1993; 1: 57-63.
    • (1993) Endocrine Journal , vol.1 , pp. 57-63
    • Tan, D.X.1    Chen, L.D.2    Poeggeler, B.3
  • 50
    • 0032878234 scopus 로고    scopus 로고
    • Melatonin induces gamma-glutymlcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells
    • Urata Y, Honma S, Goto S et al. Melatonin induces gamma-glutymlcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells. Free Radical Biology and Medicine 1999; 27: 838-847.
    • (1999) Free Radical Biology and Medicine , vol.27 , pp. 838-847
    • Urata, Y.1    Honma, S.2    Goto, S.3
  • 52
    • 0031845040 scopus 로고    scopus 로고
    • Oxidative damage in the central nervous system: Protection by melatonin
    • Reiter RJ. Oxidative damage in the central nervous system: Protection by melatonin. Progress in Neurobiology 1998; 56: 359-384.
    • (1998) Progress in Neurobiology , vol.56 , pp. 359-384
    • Reiter, R.J.1
  • 54
    • 0033968704 scopus 로고    scopus 로고
    • An assessment of the antioxidant and antiamyloidogenic properties of melatonin: Implications for Alzheimer's disease
    • Pappolla MA, Chyan YJ, Poeggeler B et al. An assessment of the antioxidant and antiamyloidogenic properties of melatonin: Implications for Alzheimer's disease. Journal of Neural Transmission 2000; 107: 203-231
    • (2000) Journal of Neural Transmission , vol.107 , pp. 203-231
    • Pappolla, M.A.1    Chyan, Y.J.2    Poeggeler, B.3
  • 55
    • 0037067791 scopus 로고    scopus 로고
    • Protective effect of melatonin in a chronic experimental model of Parkinson's disease
    • Antolin I, Mayo JC, Sainz RM et al. Protective effect of melatonin in a chronic experimental model of Parkinson's disease. Brain Research 2002; 943: 163-173.
    • (2002) Brain Research , vol.943 , pp. 163-173
    • Antolin, I.1    Mayo, J.C.2    Sainz, R.M.3
  • 56
    • 0344492689 scopus 로고    scopus 로고
    • Monozygotic twins in Alzheimer's disease treated with melatonin: Case report
    • Brusco LI, Marquez M & Cardinali DP. Monozygotic twins in Alzheimer's disease treated with melatonin: Case report. Journal of Pineal Research 1998; 25: 260-263.
    • (1998) Journal of Pineal Research , vol.25 , pp. 260-263
    • Brusco, L.I.1    Marquez, M.2    Cardinali, D.P.3
  • 57
    • 0033994649 scopus 로고    scopus 로고
    • Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease
    • Brusco LI, Marquez M & Cardinali DP. Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease. Neuroendocrinology Letters 2000; 21: 39-42.
    • (2000) Neuroendocrinology Letters , vol.21 , pp. 39-42
    • Brusco, L.I.1    Marquez, M.2    Cardinali, D.P.3
  • 58
    • 0033832475 scopus 로고    scopus 로고
    • Melatonin for treatment of sundowning in elderly persons with dementia-a preliminary study
    • Cohen-Mansfield J, Garfinkel D & Lipson S. Melatonin for treatment of sundowning in elderly persons with dementia-a preliminary study. Archives of Gerontology and Geriatrics 2000; 31: 65-76.
    • (2000) Archives of Gerontology and Geriatrics , vol.31 , pp. 65-76
    • Cohen-Mansfield, J.1    Garfinkel, D.2    Lipson, S.3
  • 59
    • 0035204767 scopus 로고    scopus 로고
    • Effects of melatonin treatment in septic newborns
    • Gitto E, Karbownik M, Reiter RJ et al. Effects of melatonin treatment in septic newborns. Pediatric Research 2001; 50: 756-760.
    • (2001) Pediatric Research , vol.50 , pp. 756-760
    • Gitto, E.1    Karbownik, M.2    Reiter, R.J.3
  • 60
    • 0034755034 scopus 로고    scopus 로고
    • Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: Reduction by melatonin
    • Fulia F, Gitto E, Cuzzocrea S et al. Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: Reduction by melatonin. Journal of Pineal Research 2001; 31: 343-349.
    • (2001) Journal of Pineal Research , vol.31 , pp. 343-349
    • Fulia, F.1    Gitto, E.2    Cuzzocrea, S.3
  • 61
    • 0029762091 scopus 로고    scopus 로고
    • Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). A dose response study
    • Bangha E, Elsner P & Kistler GS. Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). A dose response study. Archives of Dermatological Research 1996; 288: 522-526.
    • (1996) Archives of Dermatological Research , vol.288 , pp. 522-526
    • Bangha, E.1    Elsner, P.2    Kistler, G.S.3
  • 62
    • 0035158194 scopus 로고    scopus 로고
    • Melatonin treatment for tardive dyskinesia: A double-blind, placebo-controlled, cross-over study
    • Shamir E, Barak Y, Shalman I et al. Melatonin treatment for tardive dyskinesia: A double-blind, placebo-controlled, cross-over study. Archives of General Psychiatry 2001; 58: 1049-1052.
    • (2001) Archives of General Psychiatry , vol.58 , pp. 1049-1052
    • Shamir, E.1    Barak, Y.2    Shalman, I.3
  • 64
    • 0032773594 scopus 로고    scopus 로고
    • Physiological levels of melatonin contribute to the antioxidant capacity of human serum
    • Benot S, Goberna R, Reiter RJ et al. Physiological levels of melatonin contribute to the antioxidant capacity of human serum. Journal of Pineal Research 1999; 27: 59-64.
    • (1999) Journal of Pineal Research , vol.27 , pp. 59-64
    • Benot, S.1    Goberna, R.2    Reiter, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.