Modulatory effects of melatonin on genotoxic response of reference mutagens in the Ames test and the comet assay

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 417, Issue 2-3, 1998, Pages 75-84

  Musatov, S A ^a,b   Anisimov, V N ^b   Andre V ^c,d   Vigreux, C ^c,d   Godard, T ^c,d   Gauduchon, P ^c,d   Sichel, F ^c,d  

^a IP Pavlov St Petersburg State M ^*  (Russian Federation)

^b N N PETROV RESEARCH INSTITUTE OF ONCOLOGY   (Russian Federation)

^c UNIVERSITÉ DE CAEN   (France)

^d CENTRE FRANÇOIS BACLESSE   (France)

Author keywords

1,2 dimethylhydrazine; 2,4,7 trinitro 9 fluorenone; 2 aminofluorene; 4 nitroquinoline N oxide; 7,12 dimethylbenz(a)anthracene; 9 aminoacridine; Ames test; Antioxidant; Benzo(a)pyrene; Bleomycin; Chinese hamster ovary cell; COMET assay; Cyclophosphamide; DNA damage; Melatonin; Mitomycin C; N nitrosomethylurea; SCGE assay; Sodium azide

Indexed keywords

1,2 DIMETHYLHYDRAZINE; 2 FLUORENYLAMINE; 2,4,7 TRINITROFLUORENONE; 4 NITROQUINOLINE 1 OXIDE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; AMINOACRIDINE; BLEOMYCIN; CYCLOPHOSPHAMIDE; MELATONIN; METHYLNITROSOUREA; MITOMYCIN; MUTAGENIC AGENT; SODIUM AZIDE; UNCLASSIFIED DRUG;

AMES TEST; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DNA DAMAGE; GEL ELECTROPHORESIS; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; CHO CELLS; CRICETINAE; MELATONIN; MUTAGENICITY TESTS; MUTAGENS; SALMONELLA TYPHIMURIUM;

CRICETINAE; CRICETULUS GRISEUS; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0031714160     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(98)00094-1     Document Type: Article

References (22)

1. R.J. Reiter, D. Melchiorri, E. Sewerinek, B. Poegeller, L. Barlow-Walden, J. Chuang, G.G. Ortiz, D. Acuna-Castroviejo, A review of the evidence supporting melatonin's role as an antioxidant, J. Pineal Res. 18 (1995) 1-11.
2. D.X. Tan, R.J. Reiter, L.D. Chen, B. Poeggeler, L.C. Manchester, L.R. Barlow-Walden, Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole, Carcinogenesis 15 (2) (1994) 215-218.
3. Vijayalaxmi, R.J. Reiter, M.L. Meltz, Melatonin protects human blood lymphocytes from radiation-induced chromosome damage, Mutat. Res. 346 (2) (1995) 23-31.
4. R. Koratkar, A. Vasudha, G. Ramesh, M. Padma, U.N. Das, Effect of melatonin on cis-platinum induced genetic damage to the bone marrow cells of mice, Med. Sci. Res. 20 (1992) 179-180.
5. N. Susa, S. Ueno, Y. Furukawa, J. Ueda, M. Sugiyama, Potent protective effect of melatonin on chromium(VI)-induced DNA single-strand breaks, cytotoxicity, and lipid peroxidation in primary cultures of rat hepatocytes, Toxicol. Appl. Pharmacol. 144 (2) (1997) 377-384.
6. S.A. Musatov, S.V. Rosenfeld, E.F. Togo, V.S. Mikheev, V.N. Anisimov, The influence of melatonin on mutagenicity and antitumor action of cytostatic drugs in mice, Vopr. Onkol. 43 (6) (1997) 623-627.
7. M.P. DeMéo, S. Mérono, A.D. DeBaille, A. Botta, M. Laget, H. Guiraud, G. Duménil, Monitoring exposure of hospital personnel handling cytostatic drugs and contaminated materials, Int. Arch. Occup. Environ. Health 66 (1995) 363-368.
8. H. Matsushita Jr., O. Endo, H. Matsushita, M. Yamamoto, M. Mochizuki, Mutagenicity of alkyl hydrazine oxalates in Salmonella typhimurium TA 100 and TA 102 demonstrated by modifying the growth conditions of the bacteria, Mutat. Res. 301 (4) (1993) 213-222.
9. S.A. Laidlaw, M.F. Dietrich, M.P. Lamtenzan, H.I. Vargas, J.B. Block, J.D. Kopple, Antimutagenic effects of taurine in a bacterial assay system, Cancer Res. 49 (1989) 6600-6604.
10. V.J. McKelvey-Martin, M.H.L. Green, P. Schmezer, B.L. Pool-Zobel, M.P. De Méo, A. Collins, The single cell gel electrophoresis assay (comet assay): a European review, Mutat. Res. 288 (1993) 47-63.
11. D.X. Tan, L.D. Chen, B. Poeggeler, L.C. Manchester, R.J. Reiter, Melatonin: a potent, endogenous hydroxyl radical scavanger, Endocr. J. 1 (1993) 57-60.
12. L. Kothari, A.A. Subramanian, A possible modulatory influence of melatonin on representative phase I and II drug metabolizing enzymes in 9,10-dimethyl-1,2-benzanthracene induced rat mammary tumorigenesis, Anti-Cancer Drugs 3 (1992) 623-628.
13. D.E. Levin, M. Hollstein, M.F. Christman, A. Schwiers, B.N. Ames, Salmonella tester strain (TA 102) with A-T base pairs at the site of mutation detects oxidative mutagens, Proc. Natl. Acad. Sci. U.S.A. 79 (1982) 7445-7449.
14. D.M. Maron, B.N. Ames, Revised methods for the Salmonella mutagenicity test, in: B.J. Kilbey, M.S. Legator, W. Nochols, C. Ramel (Eds.), Handbook of Mutagenicity Test Procedures, Elsevier, Amsterdam, 1984, pp. 93-140.
15. J.B. Block, M.F. Dietrich, R. Tsunokai, Inhibition of adriamycin and mitomycin C mutagenesis by menadione, Proc. Am. Assoc. Cancer Res. 27 (1986) 307.
16. I. Mahmutoglu, H. Kappus, Redox cycling of bleomycin-Fe(III) by an NADP-dependent enzyme, and DNA damage in isolated rat liver nuclei, Biochem. Pharmacol. 36 (1987) 3667-3671.
17. A. Tomasi, E. Abano, B. Botti, V. Vannini, Detection of free radicals intermediates in the oxidative metabolism of carcinogenic hydrazine derivatives, Toxicol. Pathol. 15 (2) (1987) 178-183.
18. J. Cummings, V.J. Spanswick, J.F. Smyth, Re-evaluation of the molecular pharmacology of mitomycin C, Eur. J. Cancer 31A (1995) 1928-1933.
19. G. Pierrefiche, G. Topall, G. Courboin, I. Henriet, H. Laborit, Antioxidant activity of melatonin in mice, Res. Commun. Chem. Pathol. Pharmacol. 80 (1993) 211-223.
20. L.R. Barlow-Walden, R.J. Reiter, M. Abe, M. Pablos, A. Menendez-Pelaez, L.-D. Chen, B. Poeggeler, Melatonin stimulates brain glutathione peroxidase activity, Eurochem. Int. 26 (5) (1995) 497-502.
21. S.T. Zakhidov, T.L. Marshak, O.S. Smirnova, L.P. Paranyushkina, Modifying cytogenetic effects of gossypol and some derivatives, Proc. Russ. Acad. Sci. 4 (1994) 694-700.
22. C. Pieri, M. Marra, F. Moroni, R. Decchioni, F. Marcheselli, Melatonin: a peroxyl radical scavenger more effective than vitamin E, Life Sci. 55 (1994) 271-276.