Modification of cyclophosphamide-induced clastogenesis and apoptosis in rats by α-lipoic acid

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 606, Issue 1-2, 2006, Pages 85-91

  Selvakumar, E ^a   Prahalathan, C ^a   Varalakshmi, P ^a   Kumarasamy, P ^b   Saravanan, R ^b  

^a UNIVERSITY OF MADRAS   (India)

^b MADRAS VETERINARY COLLEGE   (India)

Author keywords

Apoptosis; Bone marrow; Chromosomal aberrations; Cyclophosphamide; DNA strand breaks; Lipoic acid

Indexed keywords

CYCLOPHOSPHAMIDE; THIOCTIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW; BONE MARROW CELL; CELL DEATH; CELL PROTECTION; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DOSE RESPONSE; DRUG EFFICACY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; BONE MARROW CELLS; CHROMOSOME ABERRATIONS; CHROMOSOMES, MAMMALIAN; CYCLOPHOSPHAMIDE; DNA; FLOW CYTOMETRY; MALE; NECROSIS; RATS; RATS, WISTAR; THIOCTIC ACID;

RATTUS NORVEGICUS;

EID: 33646814054     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2006.03.005     Document Type: Article

References (35)

1. Dollery C. Therapeutic Drugs (1999), Churchill Livingstone, Edinburgh pp. C349-C354
2. Fraiser L.H., Kanekal S., and Kehrer J.P. Cyclophosphamide toxicity. Characterising and avoiding the problem. Drugs 42 (1991) 781-795
3. Monteith D.K., and Vanstone J. Comparison of the microgel electrophoresis assay and other assays for genotoxicity in the detection of DNA damage. Mutat. Res. 345 (1995) 97-103
4. Elhajouji A., Santos A.P., Van Hummelen P., and Kirsch-Volders M. Metabolic differences between whole blood and isolated lymphocyte cultures for micronucleus (MN) induction by cyclophosphamide and benzo[a]pyrene. Mutagenesis 9 (1994) 307-313
5. Madle E., Korte A., and Beek B. Species differences in mutagenicity testing. II. Sister-chromatid exchange and micronucleus induction in rats, mice and Chinese hamsters treated with cyclophosphamide. Mutagenesis 1 (1986) 419-422
6. Jenderny J., Walk R.A., Hackenberg U., and Rohrborn G. Chromosomal abnormalities and sister-chromatid exchange in bone marrow cells of mice and Chinese hamsters after inhalation and intraperitoneal administration. II. Cyclophosphamide. Mutat. Res. 203 (1988) 1-10
7. Moore F.R., Urda G.A., Krishna G., and Theiss J.C. An in vivo/in vitro method for assessing micronucleus and chromosome aberration induction in rat bone marrow and spleen. 1. Studies with cyclophosphamide. Mutat. Res. 335 (1995) 191-199
8. Hannun Y.A. Apoptosis and the dilemma of cancer chemotherapy. Blood 89 (1997) 1845-1853
9. Mazur L., Augustynek A., Deptala A., Halicka H.D., and Bedner E. Effects of WR-2721 and cyclophosphamide on the cell cycle phase specificity of apoptosis in mouse bone marrow. Anticancer Drugs 13 (2002) 751-758
10. Cai L., Hales B.F., and Robaire B. Induction of apoptosis in the germ cells of adult male rats after exposure to cyclophosphamide. Biol. Reprod. 56 (1997) 1490-1497
11. Bischoff P.L., Holl V., Coelho D., Dufour P., Weltin D., and Luu B. Apoptosis at the interface of immunosuppressive and anticancer activities: the examples of two classes of chemical inducers, oxysterols and alkylating agents. Curr. Med. Chem. 7 (2000) 693-713
12. Dorr R.T. Chemoprotectants for cancer chemotherapy. Semin. Oncol. 18 (1991) 48-58
13. Packer L., Witt E.H., and Tritschler H.J. α-Lipoic acid as a biological antioxidant. Free Radic. Biol. Med. 19 (1995) 227-250
14. Moini H., Packer L., and Saris N.E. Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic acid. Toxicol. Appl. Pharmacol. 182 (2002) 84-90
15. Selvakumar E., Prahalathan C., Sudharsan P.T., and Varalakshmi P. Protective effect of lipoic acid on micronuclei induction by cyclophosphamide. Arch. Toxicol. 80 (2006) 115-119
16. Preston R.J., Dean B.J., Galloway S., Holden H., McFee A.F., and Shelby M. Mammalian in vivo cytogenetic assays. Analysis of chromosome aberrations in bone marrow cells. Mutat. Res. 189 (1987) 157-165
17. Birnboim H.C. Fluorometric analysis of DNA unwinding to study strand breaks and repair in mammalian cells. Methods Enzymol. 186 (1990) 550-555
18. Vermes I., Haanen C., Steffens-Nakken H., and Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods 184 (1995) 39-51
19. Sorsa M., and Anderson D. Monitoring of occupational exposure to cytostatic anticancer agents. Mutat. Res. 355 (1996) 253-261
20. Anderson D., Bishop J.B., Garner R.C., Ostrosky-Wegman P., and Selby P.B. Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks. Mutat. Res. 330 (1995) 115-181
21. Chabner B.A., Ryan D.P., Paz-Ares L., Garcia-Carbonero R., and Calabresi P. Antineoplastic agents. Goodman and Gilman's The Pharmacological Basis of Therapeutics (2001), Mc Graw Hill, New York pp. 1389-1459
22. Boyd V.L., Robbins J.D., Egan W., and Ludeman S.M. 31P nuclear magnetic resonance spectroscopic observation of the intracellular transformations of oncostatic cyclophosphamide metabolites. J. Med. Chem. 29 (1986) 1206-1210
23. De A.K., Agarwal K., Mukherjee A., and Sengupta D. Inhibition by capsaicin against cyclophosphamide-induced clastogenicity and DNA damage in mice. Mutat. Res. 335 (1995) 253-258
24. Povirk L.F., and Shuker D.E. DNA damage and mutagenesis induced by nitrogen mustards. Mutat. Res. 318 (1994) 205-226
25. van Engeland M., Nieland L.J., Ramaekers F.C., Schutte B., and Reutelingsperger C.P. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31 (1998) 1-9
26. Mazur L., Augustynek A., and Bochenek M. Flow cytometric estimation of the plasma membrane diversity of bone marrow cells in mice treated with WR-2721 and cyclophosphamide. Toxicology 171 (2002) 63-72
27. Han D., Handelman G., Marcocci L., Sen C.K., Roy S., Kobuchi H., Tritschler H.J., Flohe L., and Packer L. Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors 6 (1997) 321-338
28. Suh J.H., Wang H., Liu R.M., Liu J., and Hagen T.M. (R)-α-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch. Biochem. Biophys. 423 (2004) 126-135
29. Suh J.H., Shenvi S.V., Dixon B.M., Liu H., Jaiswal A.K., Liu R.M., and Hagen T.M. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 3381-3386
30. Packer L., Tritschler H.J., and Wessel K. Neuroprotection by the metabolic antioxidant α-lipoic acid. Free Radic. Biol. Med. 22 (1997) 359-378
31. Chorvatovicova D., Horvathova E., and Slamenova D. Antimutagenic effects of stobadine: review of results. Life Sci. 65 (1999) 2015-2017
32. Salvadori D.M., Ribeiro L.R., Oliveira M.D., Pereira C.A., and Becak W. The protective effect of β-carotene on genotoxicity induced by cyclophosphamide. Mutat. Res. 265 (1992) 237-244
33. Shukla Y., Arora A., and Taneja P. Antigenotoxic potential of certain dietary constituents. Teratog. Carcinog. Mutagen. 23 Suppl. 1 (2003) 323-335
34. Bustamante J., Slater A.F., and Orrenius S. Antioxidant inhibition of thymocyte apoptosis by dihydrolipoic acid. Free Radic. Biol. Med. 19 (1995) 339-347
35. Sen C.K., Roy S., and Packer L. α-Lipoic acid: cell regulatory function and potential therapeutic implications. In: Packer L., Hiramatsu M., and Yoshikawa T. (Eds). Antioxidant Food Supplements in Human Health (1999), Academic Press, San Diego 111-120