메뉴 건너뛰기




Volumn 65, Issue 5, 2013, Pages 621-633

Intestinal absorption and bioavailability of traditional Chinese medicines: A review of recent experimental progress and implication for quality control

Author keywords

bioavailability; herbal interactions; intestinal absorption; quality control; traditional Chinese medicine

Indexed keywords

ACONITINE; AURANTIIN; BAICALEIN; BAICALIN; BORNEOL; CHINESE DRUG; CINNAMIC ACID; COUMARIN DERIVATIVE; CRYPTOTANSHINONE; CURCUMIN; FERULIC ACID; GASTRODIN; HESPERIDIN; HONOKIOL; HYPACONITINE; MESACONITINE; OROXYLIN A; PAEONIFLORIN; PEONOL; PIPERINE; SAIKOSAPONIN A; SAIKOSAPONIN D; SALVIANOLIC ACID B; SINOMENINE; TANSHINONE; TANSHINONE IIA; TETRAMETHYLPYRAZINE; TURMERONE; UNINDEXED DRUG; WOGONIN;

EID: 84876466708     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2012.01608.x     Document Type: Review
Times cited : (42)

References (102)
  • 1
    • 0022191565 scopus 로고
    • Medicinal plants in therapy
    • Farnsworth N, et al. Medicinal plants in therapy. Bull World Health Organ 1985; 63: 965-981.
    • (1985) Bull World Health Organ , vol.63 , pp. 965-981
    • Farnsworth, N.1
  • 2
    • 78650143251 scopus 로고    scopus 로고
    • Traditional Chinese medicine and oral diseases: Today and tomorrow
    • Zheng LW, et al. Traditional Chinese medicine and oral diseases: today and tomorrow. Oral Dis 2011; 17: 7-12.
    • (2011) Oral Dis , vol.17 , pp. 7-12
    • Zheng, L.W.1
  • 3
    • 9644284419 scopus 로고    scopus 로고
    • Chinese medicinal materials and their interface with Western medical concepts
    • Chan K,. Chinese medicinal materials and their interface with Western medical concepts. J Ethnopharmacol 2005; 96: 1-18.
    • (2005) J Ethnopharmacol , vol.96 , pp. 1-18
    • Chan, K.1
  • 4
    • 84876492793 scopus 로고    scopus 로고
    • Study on the application of intestinal absorption in vitro coupled with bioactivity assessment in Yuanhu Zhitong preparation
    • Zhang YC, et al. Study on the application of intestinal absorption in vitro coupled with bioactivity assessment in Yuanhu Zhitong preparation. J Med Plants Res 2012; 6: 1941-1947.
    • (2012) J Med Plants Res , vol.6 , pp. 1941-1947
    • Zhang, Y.C.1
  • 5
    • 0034775480 scopus 로고    scopus 로고
    • Synergy and other interactions in phytomedicines
    • Williamson EM,. Synergy and other interactions in phytomedicines. Phytomedicines 2001; 8: 401-409.
    • (2001) Phytomedicines , vol.8 , pp. 401-409
    • Williamson, E.M.1
  • 6
    • 79952012614 scopus 로고    scopus 로고
    • Isolation and analysis of ginseng: Advances and challenges
    • Qi LW, et al. Isolation and analysis of ginseng: advances and challenges. Nat Prod Rep 2011; 28: 467-495.
    • (2011) Nat Prod Rep , vol.28 , pp. 467-495
    • Qi, L.W.1
  • 7
    • 60349130373 scopus 로고    scopus 로고
    • Qualitative and quantitative analysis in quality control of traditional Chinese medicines
    • Liang XM, et al. Qualitative and quantitative analysis in quality control of traditional Chinese medicines. J Chromatogr A 2009; 1216: 2033-2044.
    • (2009) J Chromatogr A , vol.1216 , pp. 2033-2044
    • Liang, X.M.1
  • 8
    • 0025804183 scopus 로고
    • Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
    • Artursson P, Karlsson J,. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun 1991; 175: 880-885.
    • (1991) Biochem Biophys Res Commun , vol.175 , pp. 880-885
    • Artursson, P.1    Karlsson, J.2
  • 9
    • 84871282507 scopus 로고    scopus 로고
    • Assessment and modulation of forsythiaside absorption with MDCKII cells and validation with in situ intestinal experiment
    • Li YX, et al. Assessment and modulation of forsythiaside absorption with MDCKII cells and validation with in situ intestinal experiment. Eur J Drug Metab Pharmacokinet 2012; 37: 179-186.
    • (2012) Eur J Drug Metab Pharmacokinet , vol.37 , pp. 179-186
    • Li, Y.X.1
  • 10
    • 34447337731 scopus 로고    scopus 로고
    • Prediction of human pharmacokinetics - Gastrointestinal absorption
    • Fagerholm U,. Prediction of human pharmacokinetics-gastrointestinal absorption. J Pharm Pharmacol 2007; 59: 905-916.
    • (2007) J Pharm Pharmacol , vol.59 , pp. 905-916
    • Fagerholm, U.1
  • 12
    • 0033739725 scopus 로고    scopus 로고
    • Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine
    • Suzuki H, Sugiyama Y,. Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine. Eur J Pharm Sci 2000; 12: 3-12.
    • (2000) Eur J Pharm Sci , vol.12 , pp. 3-12
    • Suzuki, H.1    Sugiyama, Y.2
  • 13
    • 0034534704 scopus 로고    scopus 로고
    • Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form
    • Akao T, et al. Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. J Pharm Pharmacol 2000; 52: 1563-1568.
    • (2000) J Pharm Pharmacol , vol.52 , pp. 1563-1568
    • Akao, T.1
  • 14
    • 61449114671 scopus 로고    scopus 로고
    • Improved absorption and bioactivity of active compounds from an anti-diabetic extract of Artemisia dracunculus L
    • Ribnicky DM, et al. Improved absorption and bioactivity of active compounds from an anti-diabetic extract of Artemisia dracunculus L. Int J Pharm 2009; 370: 87-92.
    • (2009) Int J Pharm , vol.370 , pp. 87-92
    • Ribnicky, D.M.1
  • 15
    • 79951581524 scopus 로고    scopus 로고
    • A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chinese medicines, application to Si Wu Tang
    • Wang L, et al. A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chinese medicines, application to Si Wu Tang. Int J Pharm 2011; 406: 99-105.
    • (2011) Int J Pharm , vol.406 , pp. 99-105
    • Wang, L.1
  • 17
    • 80054749162 scopus 로고    scopus 로고
    • Bioavailability of the glucuronide and sulfate conjugates of genistein and daidzein in breast cancer resistance protein 1 knockout mice
    • Alvarez AI, et al. Bioavailability of the glucuronide and sulfate conjugates of genistein and daidzein in breast cancer resistance protein 1 knockout mice. Drug Metab Dispos 2011; 39: 2008-2012.
    • (2011) Drug Metab Dispos , vol.39 , pp. 2008-2012
    • Alvarez, A.I.1
  • 18
    • 84857043007 scopus 로고    scopus 로고
    • Everted gut sac model as a tool in pharmaceutical research: Limitations and applications
    • Alam MA, et al. Everted gut sac model as a tool in pharmaceutical research: limitations and applications. J Pharm Pharmacol 2012; 64: 326-336.
    • (2012) J Pharm Pharmacol , vol.64 , pp. 326-336
    • Alam, M.A.1
  • 19
    • 78751702292 scopus 로고    scopus 로고
    • Sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide
    • Liu W, et al. Sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide. J Pharm Biomed Anal 2011; 54: 1157-1162.
    • (2011) J Pharm Biomed Anal , vol.54 , pp. 1157-1162
    • Liu, W.1
  • 20
    • 0025327910 scopus 로고
    • Species difference in metabolism of strychnine with liver microsomes of mice, rats, guinea pigs, rabbits and dogs
    • Tanimoto Y, et al. Species difference in metabolism of strychnine with liver microsomes of mice, rats, guinea pigs, rabbits and dogs. J Pharmacobiodyn 1990; 13: 136-141.
    • (1990) J Pharmacobiodyn , vol.13 , pp. 136-141
    • Tanimoto, Y.1
  • 21
    • 58949083752 scopus 로고    scopus 로고
    • A study of the pharmacokinetics of andrograpolide sodium bisulphite in beagle dogs
    • Jin J, et al. A study of the pharmacokinetics of andrograpolide sodium bisulphite in beagle dogs. Herald Med 2005; 24: 109-111.
    • (2005) Herald Med , vol.24 , pp. 109-111
    • Jin, J.1
  • 22
    • 84887262681 scopus 로고
    • Pharmacokinetics of andrograpolide in rabbits by chemiluminescence method
    • Wang B, et al. Pharmacokinetics of andrograpolide in rabbits by chemiluminescence method. J Shenyang Pharm Univ 1995; 1: 5-7.
    • (1995) J Shenyang Pharm Univ , vol.1 , pp. 5-7
    • Wang, B.1
  • 23
    • 36549063536 scopus 로고    scopus 로고
    • Establishment of Caco-2 cell monolayer model and standard operation procedure for assessing intestinal absorption of chemical components of traditional Chinese medicine
    • Yang X, et al. Establishment of Caco-2 cell monolayer model and standard operation procedure for assessing intestinal absorption of chemical components of traditional Chinese medicine. Zhong Xi Yi Jie He Xue Bao 2007; 5: 634-641.
    • (2007) Zhong Xi Yi Jie He Xue Bao , vol.5 , pp. 634-641
    • Yang, X.1
  • 24
    • 85027907072 scopus 로고    scopus 로고
    • The absorption and transport of magnolol in Caco-2 cell model
    • (epub ahead of print).
    • Wu AG, et al. The absorption and transport of magnolol in Caco-2 cell model. Chin J Integr Med 2012; (epub ahead of print).
    • (2012) Chin J Integr Med
    • Wu, A.G.1
  • 25
    • 33748887871 scopus 로고    scopus 로고
    • Caco-2 cell permeability assays to measure drug absorption
    • van Breemen RB, Li Y,. Caco-2 cell permeability assays to measure drug absorption. Expert Opin Drug Metab Toxicol 2005; 1: 175-185.
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , pp. 175-185
    • Van Breemen, R.B.1    Li, Y.2
  • 26
    • 60149111908 scopus 로고    scopus 로고
    • Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
    • Lai SK, et al. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev 2009; 61: 158-171.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 158-171
    • Lai, S.K.1
  • 27
    • 83555163718 scopus 로고    scopus 로고
    • The absorption characterization effects and mechanism of Radix Angelicae dahuricae extracts on baicalin in Radix Scutellariae using in vivo and in vitro absorption models
    • Liang XL, et al. The absorption characterization effects and mechanism of Radix Angelicae dahuricae extracts on baicalin in Radix Scutellariae using in vivo and in vitro absorption models. J Ethnopharmacol 2012; 139: 52-57.
    • (2012) J Ethnopharmacol , vol.139 , pp. 52-57
    • Liang, X.L.1
  • 28
    • 84864644022 scopus 로고    scopus 로고
    • Intestinal absorption of forsythoside A in in situ single-pass intestinal perfusion and in vitro Caco-2 cell models
    • Zhou W, et al. Intestinal absorption of forsythoside A in in situ single-pass intestinal perfusion and in vitro Caco-2 cell models. Acta Pharmacol Sin 2012; 33: 1069-1079.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 1069-1079
    • Zhou, W.1
  • 29
    • 81855206518 scopus 로고    scopus 로고
    • Drug-permeability and transporter assays in Caco-2 and MDCK cell lines
    • Volpe DA,. Drug-permeability and transporter assays in Caco-2 and MDCK cell lines. Future Med Chem 2011; 3: 2063-2077.
    • (2011) Future Med Chem , vol.3 , pp. 2063-2077
    • Volpe, D.A.1
  • 30
    • 77949816283 scopus 로고    scopus 로고
    • Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models
    • Linnankoski J, et al. Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models. J Pharm Sci 2010; 99: 2166-2175.
    • (2010) J Pharm Sci , vol.99 , pp. 2166-2175
    • Linnankoski, J.1
  • 31
    • 34548105910 scopus 로고    scopus 로고
    • Predicting human drug pharmacokinetics from in vitro permeability using an absorption-disposition model
    • Fliszar KA, et al. Predicting human drug pharmacokinetics from in vitro permeability using an absorption-disposition model. J Pharm Sci 2007; 96: 2161-2170.
    • (2007) J Pharm Sci , vol.96 , pp. 2161-2170
    • Fliszar, K.A.1
  • 32
    • 12344274316 scopus 로고    scopus 로고
    • Exploring the role of different drug transport routes in permeability screening
    • Matsson P, et al. Exploring the role of different drug transport routes in permeability screening. J Med Chem 2005; 48: 604-613.
    • (2005) J Med Chem , vol.48 , pp. 604-613
    • Matsson, P.1
  • 33
    • 0037336533 scopus 로고    scopus 로고
    • Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers
    • Tavelin S, et al. Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers. Pharm Res 2003; 20: 397-405.
    • (2003) Pharm Res , vol.20 , pp. 397-405
    • Tavelin, S.1
  • 34
    • 84862962484 scopus 로고    scopus 로고
    • Increased systemic exposure to rhizoma coptidis alkaloids in lipopolysaccharide-pretreated rats attributable to enhanced intestinal absorption
    • Ma BL, et al. Increased systemic exposure to rhizoma coptidis alkaloids in lipopolysaccharide-pretreated rats attributable to enhanced intestinal absorption. Drug Metab Dispos 2012; 40: 381-388.
    • (2012) Drug Metab Dispos , vol.40 , pp. 381-388
    • Ma, B.L.1
  • 35
    • 84859440002 scopus 로고    scopus 로고
    • Consensus hologram QSAR modeling for the prediction of human intestinal absorption
    • Moda TL, Andricopulo AD,. Consensus hologram QSAR modeling for the prediction of human intestinal absorption. Bioorg Med Chem Lett 2012; 22: 2889-2893.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 2889-2893
    • Moda, T.L.1    Andricopulo, A.D.2
  • 36
    • 72449191263 scopus 로고    scopus 로고
    • In silico prediction of human oral absorption based on QSAR analyses of PAMPA permeability
    • Akamatsu M, et al. In silico prediction of human oral absorption based on QSAR analyses of PAMPA permeability. Chem Biodivers 2009; 6: 1845-1866.
    • (2009) Chem Biodivers , vol.6 , pp. 1845-1866
    • Akamatsu, M.1
  • 37
    • 66849113847 scopus 로고    scopus 로고
    • Recent developments of in silico predictions of intestinal absorption and oral bioavailability
    • Hou T, et al. Recent developments of in silico predictions of intestinal absorption and oral bioavailability. Comb Chem High Throughput Screen 2009; 12: 497-506.
    • (2009) Comb Chem High Throughput Screen , vol.12 , pp. 497-506
    • Hou, T.1
  • 38
    • 0036803219 scopus 로고    scopus 로고
    • Prediction of intestinal absorption: Comparative assessment of GASTROPLUS and IDEA
    • Parrott N, Lave T,. Prediction of intestinal absorption: comparative assessment of GASTROPLUS and IDEA. Eur J Pharm Sci 2002; 17: 51-61.
    • (2002) Eur J Pharm Sci , vol.17 , pp. 51-61
    • Parrott, N.1    Lave, T.2
  • 39
    • 33646823279 scopus 로고    scopus 로고
    • Absorption and metabolism of Astragali radix decoction: In silico, in vitro, and a case study in vivo
    • Xu F, et al. Absorption and metabolism of Astragali radix decoction: in silico, in vitro, and a case study in vivo. Drug Metab Dispos 2006; 34: 913-924.
    • (2006) Drug Metab Dispos , vol.34 , pp. 913-924
    • Xu, F.1
  • 40
    • 33750683906 scopus 로고    scopus 로고
    • An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) through Caco-2 monolayers
    • Schutte ME, et al. An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6- phenylimidazo [4,5-b]pyridine (PhIP) through Caco-2 monolayers. Toxicol Appl Pharmacol 2006; 217: 204-215.
    • (2006) Toxicol Appl Pharmacol , vol.217 , pp. 204-215
    • Schutte, M.E.1
  • 41
    • 84862796600 scopus 로고    scopus 로고
    • Intestinal permeability of forskolin by in situ single pass perfusion in rats
    • Liu ZJ, et al. Intestinal permeability of forskolin by in situ single pass perfusion in rats. Planta Med 2012; 78: 698-702.
    • (2012) Planta Med , vol.78 , pp. 698-702
    • Liu, Z.J.1
  • 42
    • 41849108414 scopus 로고    scopus 로고
    • In vitro stability of gentiamarin
    • Chen G, et al. In vitro stability of gentiamarin. Fudan Univ J Med Sci 2008; 35: 220-223.
    • (2008) Fudan Univ J Med Sci , vol.35 , pp. 220-223
    • Chen, G.1
  • 43
    • 17444421115 scopus 로고    scopus 로고
    • Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics
    • Wright S,. Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics. Toxicol Appl Pharmacol 2005; 204: 309-319.
    • (2005) Toxicol Appl Pharmacol , vol.204 , pp. 309-319
    • Wright, S.1
  • 44
    • 34249943356 scopus 로고    scopus 로고
    • Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications
    • Koepsell H, et al. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 2007; 24: 1227-1251.
    • (2007) Pharm Res , vol.24 , pp. 1227-1251
    • Koepsell, H.1
  • 45
    • 77749343660 scopus 로고    scopus 로고
    • Intestinal permeability of sesquiterpenes in the caco-2 cell monolayer model
    • Wu Q, et al. Intestinal permeability of sesquiterpenes in the caco-2 cell monolayer model. Planta Med 2010; 76: 319-324.
    • (2010) Planta Med , vol.76 , pp. 319-324
    • Wu, Q.1
  • 46
    • 34047162392 scopus 로고    scopus 로고
    • Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra
    • Cao J, et al. Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra. Drug Metab Dispos 2007; 35: 539-553.
    • (2007) Drug Metab Dispos , vol.35 , pp. 539-553
    • Cao, J.1
  • 47
    • 34249093067 scopus 로고    scopus 로고
    • Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge
    • Yu XY, et al. Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge. Curr Drug Metab 2007; 8: 325-340.
    • (2007) Curr Drug Metab , vol.8 , pp. 325-340
    • Yu, X.Y.1
  • 48
    • 79952952269 scopus 로고    scopus 로고
    • Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: Involvement of P-glycoprotein
    • Zhang X, et al. Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein. Xenobiotica 2011; 41: 290-296.
    • (2011) Xenobiotica , vol.41 , pp. 290-296
    • Zhang, X.1
  • 49
    • 0033708071 scopus 로고    scopus 로고
    • Modulation of oral bioavailability of anticancer drugs: From mouse to man
    • Schellens JH, et al. Modulation of oral bioavailability of anticancer drugs: from mouse to man. Eur J Pharm Sci 2000; 12: 103-110.
    • (2000) Eur J Pharm Sci , vol.12 , pp. 103-110
    • Schellens, J.H.1
  • 50
    • 0033847137 scopus 로고    scopus 로고
    • Efflux of dietary flavonoid quercetin 4′-β-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance- associated protein-2
    • Richard A, et al. Efflux of dietary flavonoid quercetin 4′-β-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2. J Pharmacol Exp Ther 2000; 294: 830-836.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 830-836
    • Richard, A.1
  • 51
    • 33847389701 scopus 로고    scopus 로고
    • Effects of drug transporters on intestinal absorption of breviscapine
    • Zhang H, Ping Q,. Effects of drug transporters on intestinal absorption of breviscapine. J Chin Pharm Univ 2007; 38: 60-64.
    • (2007) J Chin Pharm Univ , vol.38 , pp. 60-64
    • Zhang, H.1    Ping, Q.2
  • 52
    • 58549098231 scopus 로고    scopus 로고
    • Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice
    • Shukla S, et al. Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res 2009; 26: 480-487.
    • (2009) Pharm Res , vol.26 , pp. 480-487
    • Shukla, S.1
  • 53
    • 22144481699 scopus 로고    scopus 로고
    • Structure activity relationships and quantitative structure activity relationships for the flavonoid-meditaed by breast cancer resistance protein
    • Zhang S, et al. Structure activity relationships and quantitative structure activity relationships for the flavonoid-meditaed by breast cancer resistance protein. Biochem Pharmacol 2005; 70: 627-639.
    • (2005) Biochem Pharmacol , vol.70 , pp. 627-639
    • Zhang, S.1
  • 54
    • 84876478132 scopus 로고    scopus 로고
    • Drug permeability studies in regulatory biowaver applications
    • A.V. D. Ehrhardt C. Kim K.J. eds. Dublin: New York, NY: Springer Science+Business Media.
    • A.V. D. Drug permeability studies in regulatory biowaver applications. In:, Ehrhardt C, Kim KJ, eds. Drug Absorption Studies. Dublin: New York, NY: Springer Science+Business Media, 2008: 666.
    • (2008) Drug Absorption Studies , pp. 666
  • 55
    • 84861891478 scopus 로고    scopus 로고
    • Absorption, disposition, and pharmacokinetics of saponins from chinese medicinal herbs: What do we know and what do we need to know more?
    • Yu K, et al. Absorption, disposition, and pharmacokinetics of saponins from chinese medicinal herbs: what do we know and what do we need to know more? Curr Drug Metab 2012; 13: 577-598.
    • (2012) Curr Drug Metab , vol.13 , pp. 577-598
    • Yu, K.1
  • 56
    • 33746646760 scopus 로고    scopus 로고
    • The relationship between the intestinal absorption and in vivo activity of genistein
    • Ruan L, et al. The relationship between the intestinal absorption and in vivo activity of genistein. Chin J Nat Med 2006; 4: 278-282.
    • (2006) Chin J Nat Med , vol.4 , pp. 278-282
    • Ruan, L.1
  • 57
    • 69249218546 scopus 로고    scopus 로고
    • Study on the preparation and dissolution of the sustained release solid dispersions of Artemisinin
    • Li GD, et al. Study on the preparation and dissolution of the sustained release solid dispersions of Artemisinin. Pharm J Chin People's Liberation Army 2000; 16: 15-17.
    • (2000) Pharm J Chin People's Liberation Army , vol.16 , pp. 15-17
    • Li, G.D.1
  • 58
    • 3042704261 scopus 로고    scopus 로고
    • Advances in the study of Chinese herbal drug dripping pills
    • Zheng X, et al. Advances in the study of Chinese herbal drug dripping pills. Zhongguo Zhong Yao Za Zhi 2003; 28: 292-295.
    • (2003) Zhongguo Zhong Yao Za Zhi , vol.28 , pp. 292-295
    • Zheng, X.1
  • 59
    • 84887262619 scopus 로고    scopus 로고
    • Study on dry granulation technique for shuanghuanglian effervescent tablets
    • Wei X, et al. Study on dry granulation technique for shuanghuanglian effervescent tablets. Chin J Exp Traditional Med Formulae 2010; 11: 1-5.
    • (2010) Chin J Exp Traditional Med Formulae , vol.11 , pp. 1-5
    • Wei, X.1
  • 60
    • 0042913501 scopus 로고    scopus 로고
    • Studies on the preparation of camptothecin niosomes
    • Luan L, et al. Studies on the preparation of camptothecin niosomes. Acta Pharm Sin 2002; 1: 59-62.
    • (2002) Acta Pharm Sin , vol.1 , pp. 59-62
    • Luan, L.1
  • 62
    • 39449096599 scopus 로고    scopus 로고
    • Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration
    • Cai Z, et al. Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration. J Drug Target 2008; 16: 178-184.
    • (2008) J Drug Target , vol.16 , pp. 178-184
    • Cai, Z.1
  • 64
    • 33646262057 scopus 로고    scopus 로고
    • Absorption mechanism of liposoluble components of Salvia miltiorrhiza with Caco-2 cell model
    • [in Chinese].
    • Li L, et al. Absorption mechanism of liposoluble components of Salvia miltiorrhiza with Caco-2 cell model. Chin Pharma J 2006; 41: 108-111 [in Chinese].
    • (2006) Chin Pharma J , vol.41 , pp. 108-111
    • Li, L.1
  • 66
    • 84862778921 scopus 로고    scopus 로고
    • Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model
    • Li N, et al. Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model. Planta Med 2012; 78: 692-697.
    • (2012) Planta Med , vol.78 , pp. 692-697
    • Li, N.1
  • 67
    • 84863262829 scopus 로고    scopus 로고
    • The role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal Caco-2 cells
    • Yue GG, et al. The role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal Caco-2 cells. J Med Food 2012; 15: 242-252.
    • (2012) J Med Food , vol.15 , pp. 242-252
    • Yue, G.G.1
  • 68
    • 33947164202 scopus 로고    scopus 로고
    • Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats
    • Kim Y, et al. Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats. Arch Pharm Res 2007; 30: 260-265.
    • (2007) Arch Pharm Res , vol.30 , pp. 260-265
    • Kim, Y.1
  • 69
    • 84871032395 scopus 로고    scopus 로고
    • Pharmacokinetic interactions among major bioactive components in radix scutellariae via metabolic competition
    • (epub ahead of print).
    • Li CR, et al. Pharmacokinetic interactions among major bioactive components in radix scutellariae via metabolic competition. Biopharm Drug Dispos 2012; (epub ahead of print).
    • (2012) Biopharm Drug Dispos
    • Li, C.R.1
  • 70
    • 35748982105 scopus 로고    scopus 로고
    • Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat
    • Song M, et al. Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat. Eur J Pharm Sci 2007; 32: 247-253.
    • (2007) Eur J Pharm Sci , vol.32 , pp. 247-253
    • Song, M.1
  • 71
    • 79960105959 scopus 로고    scopus 로고
    • Comparative pharmacokinetic and bioavailability studies of three salvianolic acids after the administration of Salviae miltiorrhizae alone or with synthetical borneol in rats
    • Lai XJ, et al. Comparative pharmacokinetic and bioavailability studies of three salvianolic acids after the administration of Salviae miltiorrhizae alone or with synthetical borneol in rats. Fitoterapia 2011; 82: 883-888.
    • (2011) Fitoterapia , vol.82 , pp. 883-888
    • Lai, X.J.1
  • 72
    • 82255184186 scopus 로고    scopus 로고
    • Interaction of the main components from the traditional Chinese drug pair Chaihu-Shaoyao based on rat intestinal absorption
    • Chen Y, et al. Interaction of the main components from the traditional Chinese drug pair Chaihu-Shaoyao based on rat intestinal absorption. Molecules 2011; 16: 9600-9610.
    • (2011) Molecules , vol.16 , pp. 9600-9610
    • Chen, Y.1
  • 73
    • 65649117769 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability of cinnamic acid after oral administration of Ramulus Cinnamomi in rats
    • Chen Y, et al. Pharmacokinetics and bioavailability of cinnamic acid after oral administration of Ramulus Cinnamomi in rats. Eur J Drug Metab Pharmacokinet 2009; 34: 51-56.
    • (2009) Eur J Drug Metab Pharmacokinet , vol.34 , pp. 51-56
    • Chen, Y.1
  • 75
    • 84876463691 scopus 로고    scopus 로고
    • Study on relative bioavailability of ferulic acid of combination Radix Angelicae Sinensis and Cortex Cinnamonmi in mice
    • [in Chinese].
    • Yang ZY, et al. Study on relative bioavailability of ferulic acid of combination Radix Angelicae Sinensis and Cortex Cinnamonmi in mice. Chin J Chin Mater Med 2006; 32: 1012-1015 [in Chinese].
    • (2006) Chin J Chin Mater Med , vol.32 , pp. 1012-1015
    • Yang, Z.Y.1
  • 76
    • 31344441408 scopus 로고    scopus 로고
    • The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model
    • Chan K, et al. The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model. J Ethnopharmacol 2006; 103: 425-432.
    • (2006) J Ethnopharmacol , vol.103 , pp. 425-432
    • Chan, K.1
  • 77
    • 0031860081 scopus 로고    scopus 로고
    • Influence of piperine on the pharmacokinetcs of curcumin in animals and human volunteers
    • Shoba G, et al. Influence of piperine on the pharmacokinetcs of curcumin in animals and human volunteers. Planta Med 1998; 64: 353-356.
    • (1998) Planta Med , vol.64 , pp. 353-356
    • Shoba, G.1
  • 78
    • 29844436827 scopus 로고
    • The comparion study on the absorption and metabolism of paeonol in Cortex moutan and Cynanchum
    • [in Chinese].
    • Wang B, et al. The comparion study on the absorption and metabolism of paeonol in Cortex moutan and Cynanchum. J Xi'an Med Univ 1995; 16: 47-49 [in Chinese].
    • (1995) J xi'An Med Univ , vol.16 , pp. 47-49
    • Wang, B.1
  • 79
    • 84867316656 scopus 로고    scopus 로고
    • Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction in rats
    • Gong HL, et al. Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction in rats. Chin J Integr Med 2012; 18: 708-713.
    • (2012) Chin J Integr Med , vol.18 , pp. 708-713
    • Gong, H.L.1
  • 80
    • 79951675974 scopus 로고    scopus 로고
    • Comparative pharmacokinetics of paeoniflorin in plasma of vascular dementia and normal rats orally administrated with Danggui-Shaoyao-San or pure paeoniflorin
    • Liu J, et al. Comparative pharmacokinetics of paeoniflorin in plasma of vascular dementia and normal rats orally administrated with Danggui-Shaoyao-San or pure paeoniflorin. Fitoterapia 2011; 82: 466-473.
    • (2011) Fitoterapia , vol.82 , pp. 466-473
    • Liu, J.1
  • 81
    • 77956268940 scopus 로고    scopus 로고
    • The effect of Acorus gramineus on the bioavailabilities and brain concentrations of ginsenosides Rg1, Re and Rb1 after oral administration of Kai-Xin-San preparations in rats
    • Wang W, et al. The effect of Acorus gramineus on the bioavailabilities and brain concentrations of ginsenosides Rg1, Re and Rb1 after oral administration of Kai-Xin-San preparations in rats. J Ethnopharmacol 2010; 131: 313-320.
    • (2010) J Ethnopharmacol , vol.131 , pp. 313-320
    • Wang, W.1
  • 82
    • 69949094176 scopus 로고    scopus 로고
    • Comparative pharmacokinetic study of paeoniflorin after oral administration of pure paeoniflorin, extract of Cortex Moutan and Shuang-Dan prescription to rats
    • Wu H, et al. Comparative pharmacokinetic study of paeoniflorin after oral administration of pure paeoniflorin, extract of Cortex Moutan and Shuang-Dan prescription to rats. J Ethnopharmacol 2009; 125: 444-449.
    • (2009) J Ethnopharmacol , vol.125 , pp. 444-449
    • Wu, H.1
  • 83
    • 84876501584 scopus 로고    scopus 로고
    • Comparison of pharmacokinetics of honokiol in Magnolia officinalis and Houpu Sanwu Tang after intragastric administration in rats
    • [in Chinese].
    • Su WJ, et al. Comparison of pharmacokinetics of honokiol in Magnolia officinalis and Houpu Sanwu Tang after intragastric administration in rats. J Chin Med Mater 2008; 59: 115-121 [in Chinese].
    • (2008) J Chin Med Mater , vol.59 , pp. 115-121
    • Su, W.J.1
  • 84
    • 37349022457 scopus 로고    scopus 로고
    • Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus Schisandrae aqueous extract and Sheng-Mai-San to rats
    • Xu M, et al. Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus Schisandrae aqueous extract and Sheng-Mai-San to rats. J Ethnopharmacol 2008; 115: 483-488.
    • (2008) J Ethnopharmacol , vol.115 , pp. 483-488
    • Xu, M.1
  • 85
    • 84876468617 scopus 로고    scopus 로고
    • A comparative study of the pharmacokinetics of aristolochic acid a in Longdanxiegan Pills and Caulis Aristolochiae manshuriensis in rats
    • [in Chinese].
    • Su X, et al. A comparative study of the pharmacokinetics of aristolochic acid a in Longdanxiegan Pills and Caulis Aristolochiae manshuriensis in rats. Herald Med 2005; 2: 116-118 [in Chinese].
    • (2005) Herald Med , vol.2 , pp. 116-118
    • Su, X.1
  • 86
    • 32344452108 scopus 로고    scopus 로고
    • Determination of astragaloside ? in rat plasma after the treatment Buyang Huanwu decoction by RP-HPLC and its harmacokinetics
    • [in Chinese].
    • He FY, et al. Determination of astragaloside ? in rat plasma after the treatment Buyang Huanwu decoction by RP-HPLC and its harmacokinetics. Chin Pharm J 2005; 40: 1647-1649 [in Chinese].
    • (2005) Chin Pharm J , vol.40 , pp. 1647-1649
    • He, F.Y.1
  • 87
    • 17944373017 scopus 로고    scopus 로고
    • Pharmacokinetics of emodin in Polygonum cuspidatum and its prescription in rats
    • [in Chinese].
    • Yao SK, et al. Pharmacokinetics of emodin in Polygonum cuspidatum and its prescription in rats. Chin J Chin Mater Med 2005; 30: 463-465 [in Chinese].
    • (2005) Chin J Chin Mater Med , vol.30 , pp. 463-465
    • Yao, S.K.1
  • 88
    • 33645486527 scopus 로고    scopus 로고
    • RP-HPLC in plasma and study on its pharmacokinetics in mice
    • [in Chinese].
    • Lu XH, et al. RP-HPLC in plasma and study on its pharmacokinetics in mice. Chin J Pharm Anal 2004; 2: 140-143 [in Chinese].
    • (2004) Chin J Pharm Anal , vol.2 , pp. 140-143
    • Lu, X.H.1
  • 89
    • 84887261811 scopus 로고    scopus 로고
    • Influence of different composition of Liuwei Dihuang Tang on the pharmacokinetics of loganin
    • Xie YS, et al. Influence of different composition of Liuwei Dihuang Tang on the pharmacokinetics of loganin. Chin J Coal Ind Med 2004; 7: 779-780.
    • (2004) Chin J Coal Ind Med , vol.7 , pp. 779-780
    • Xie, Y.S.1
  • 90
    • 1542497833 scopus 로고    scopus 로고
    • Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats
    • Zuo F, et al. Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats. Biol Pharm Bull 2003; 26: 911-919.
    • (2003) Biol Pharm Bull , vol.26 , pp. 911-919
    • Zuo, F.1
  • 91
    • 10944259517 scopus 로고    scopus 로고
    • Pharmacokinetics of icariin in Chinese medicine prescriptions
    • [in Chinese].
    • Zou JM, et al. Pharmacokinetics of icariin in Chinese medicine prescriptions. Chin Traditional Herbal Drugs 2002; 33: 55-58 [in Chinese].
    • (2002) Chin Traditional Herbal Drugs , vol.33 , pp. 55-58
    • Zou, J.M.1
  • 92
    • 84876499587 scopus 로고    scopus 로고
    • Research progress on the absorption and pharmacokinetics of baicalin
    • [in Chinese].
    • Wang Y,. Research progress on the absorption and pharmacokinetics of baicalin. Chin J Curr Pract Med 2005; 4: 44-45 [in Chinese].
    • (2005) Chin J Curr Pract Med , vol.4 , pp. 44-45
    • Wang, Y.1
  • 93
    • 84887261797 scopus 로고    scopus 로고
    • Pharmacokinetics of baicalin in Xiaochaihu Tang in rats
    • Wang X, et al. Pharmacokinetics of baicalin in Xiaochaihu Tang in rats. Traditional Chin Drug Res Clin Pharmacol 2001; 12: 84-88.
    • (2001) Traditional Chin Drug Res Clin Pharmacol , vol.12 , pp. 84-88
    • Wang, X.1
  • 94
    • 41549102309 scopus 로고    scopus 로고
    • Aristolochic acid nephropathy: A worldwide problem
    • Debelle FD, et al. Aristolochic acid nephropathy: a worldwide problem. Kidney Int 2008; 74: 158-169.
    • (2008) Kidney Int , vol.74 , pp. 158-169
    • Debelle, F.D.1
  • 95
    • 44349116738 scopus 로고    scopus 로고
    • The Caco-2 cell monolayer: Usefulness and limitations
    • Sun H, et al. The Caco-2 cell monolayer: usefulness and limitations. Expert Opin Drug Metab Toxicol 2008; 4: 395-411.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , pp. 395-411
    • Sun, H.1
  • 96
    • 44649156499 scopus 로고    scopus 로고
    • A quality control and improvement system based on the total control methodology (TCM)
    • Kwok KY, Tummala VMR,. A quality control and improvement system based on the total control methodology (TCM). Int J Qual Reliab Manage 1998; 15: 13-48.
    • (1998) Int J Qual Reliab Manage , vol.15 , pp. 13-48
    • Kwok, K.Y.1    Tummala, V.M.R.2
  • 97
    • 84855441308 scopus 로고    scopus 로고
    • Comparative study on absorption kinetics in intestines of rats of epimedii foliunm of Xianlinggubao capsules prepared by different processes
    • Wu H, et al. Comparative study on absorption kinetics in intestines of rats of epimedii foliunm of Xianlinggubao capsules prepared by different processes. Zhongguo Zhong Yao Za Zhi 2011; 36: 2648-2652.
    • (2011) Zhongguo Zhong Yao Za Zhi , vol.36 , pp. 2648-2652
    • Wu, H.1
  • 98
    • 0028877755 scopus 로고
    • The validation of the intestinal permeability approach to predict oral fraction of dose absorbed in humans and rats
    • Chiou WL,. The validation of the intestinal permeability approach to predict oral fraction of dose absorbed in humans and rats. Biopharm Drug Dispos 1995; 16: 71-75.
    • (1995) Biopharm Drug Dispos , vol.16 , pp. 71-75
    • Chiou, W.L.1
  • 99
    • 51349086819 scopus 로고    scopus 로고
    • Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers
    • Dai JY, et al. Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers. Acta Pharmacol Sin 2008; 29: 1086-1093.
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 1086-1093
    • Dai, J.Y.1
  • 100
    • 79960367897 scopus 로고    scopus 로고
    • Study on transportation of Xiaochaihu Tang in Caco-2 cell model
    • Yan L, et al. Study on transportation of Xiaochaihu Tang in Caco-2 cell model. Zhongguo Zhong yao za zhi 2011; 36: 1087-1090.
    • (2011) Zhongguo Zhong Yao Za Zhi , vol.36 , pp. 1087-1090
    • Yan, L.1
  • 101
    • 79251561193 scopus 로고    scopus 로고
    • TCM Database@Taiwan: The world's largest traditional Chinese medicine database for drug screening in silico
    • Chen CY,. TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico. PLoS ONE 2011; 6: e15939.
    • (2011) PLoS ONE , vol.6
    • Chen, C.Y.1
  • 102
    • 60749091589 scopus 로고    scopus 로고
    • Permeability for intestinal absorption: Caco-2 assay and related issues
    • Press B, Di Grandi D,. Permeability for intestinal absorption: Caco-2 assay and related issues. Curr Drug Metab 2008; 9: 893-900.
    • (2008) Curr Drug Metab , vol.9 , pp. 893-900
    • Press, B.1    Di Grandi, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.