Sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 5, 2011, Pages 1157-1162

  Liu, Wei ^a   Zheng, Zhijie ^a   Liu, Xi ^a   Gao, Song ^b   Ye, Ling ^a   Yang, Zhen ^b   Hu, Ming ^a,b   Liu, Zhongqiu ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

Absolute oral bioavailability; Emodin; Emodin glucuronide; Pharmacokinetics; UPLC MS MS

Indexed keywords

AGLYCONE; ANTHRACENE DERIVATIVE; EMODIN; EMODIN GLUCURONIDE; GLUCURONIDE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG STABILITY; FEMALE; FREEZE THAWING; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; SIGNAL NOISE RATIO; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, LIQUID; EMODIN; FEMALE; GLUCURONIDES; INJECTIONS, INTRAVENOUS; LIMIT OF DETECTION; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SEX CHARACTERISTICS; TANDEM MASS SPECTROMETRY;

EID: 78751702292     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.12.004     Document Type: Article

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