Intestinal permeability of sesquiterpenes in the caco-2 cell monolayer model

Planta Medica

Volumn 76, Issue 4, 2010, Pages 319-324

  Wu, Qi ^a   Zhao, Bo ^b   Yang, Xiu Wei ^a   Xu, Wei ^a   Zhang, Peng ^a   Zou, Lei ^c   Zhang, Lian Xue ^b  

^a PEKING UNIVERSITY   (China)

^b JILIN AGRICULTURAL UNIVERSITY   (China)

^c National Pharmaceutical R and D Co Ltd   (China)

Author keywords

Caco2 cell monolayer; Intestinal permeability; Sesquiterpenes

Indexed keywords

ARTESIN; ATENOLOL; ATRACTYLON; BISABOLANGELONE; CROSSOSTEPHIN; DES O METHYL LASIODIPLODIN; ISOCALAMENEDIOL; MAGNOLIALIDE; PROPRANOLOL; SESQUITERPENE DERIVATIVE; TANACETIN; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CELL STRAIN CACO 2; DIFFUSION; ELECTRIC RESISTANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTESTINE MUCOSA PERMEABILITY; MONOLAYER CULTURE; NONHUMAN; TRANSCYTOSIS;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIFFUSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; HUMANS; INTESTINAL ABSORPTION; PROPRANOLOL; SESQUITERPENES;

EID: 77749343660     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1186195     Document Type: Article

References (28)

1. Guo Q L., Yang J S. Sesquiterpenes in Inula L. plants and their pharmacological activities. Nat Prod Res Dev 2005 17 804-808
2. Suo M R., Yang J S. Survey in studies on chemical constituents of sesquiterpene and their physiological activities in plants of Helianthus L. Chin Tradit Herb Drugs 2006 37 135-140
3. Ding Z H., Liu J K., Ding J K., Gu K. Sesquiterpene components from Eupatorium genus. Nat Prod Res Dev 2001 13 76-83
4. Wang L, Zhao F, He E Q., Wang S, Liu K. Effects of eighteen sesquiterpenes from Saussurea lappa on the proliferation of six human cancer cell lines. Nat Prod Res Dev 2008 20 808-812
5. Dornelles Vieira C M., De Paris F, Fiegenbaum M, Lino von Poser G. The use of Tanacetum parthenium in treatment of migraine and rheumatoid arthritis. Rev Bras Farm 1998 79 42-44
6. Villar A, Zafra-Polo Maria C. Sesquiterpene lactones of Artemisia barrelieri. Part I. Study on their relaxant effect. Plant Med Phytother 1981 15 144-148
7. Matsuda H, Kagerura T, Toguchida I, Ueda H, Morikawa T, Yoshikawa M. Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-activated macrophages: structure requirement and role of heat shock protein induction. Life Sci 2000 66 2151-2157
8. +-ATPase activity by atractylon, a major component of Byaku-jutsu, by interaction with enzyme in the E2 state. Biochem Pharmacol 1996 51 339-343
9. Pan J H., Gareth Jones E B., She Z G., Pang J Y., Lin Y C. Review of bioactive compounds from fungi in the South China Sea. Botanica Marina 2008 51 179-190
10. Seo E K., Kim K H., Kim M K., Cho M H., Choi E, Kim K, Mar W. Inhibitors of 5alpha-reductase type I in LNCaP cells from the roots of Angelica koreana. Planta Med 2002 68 162-163
11. Muckensturm B, Duplay D, Robert P C., Simonis M T., Kienlen J C. Substances antiapptantes pour insectes phytophages prsentes dans Angelica silvestris et Heracleum sphondylium. Biochem Syst Ecol 1981 9 289-292
12. Navrot J, Harmatha J, Novotny L. Insect feeding deterrent activity of bisabolangelone and of some sesquiterpenes of eremophilanolide type. Biochem Syst Ecol 1984 12 99-101
13. Yang X W., Wu Q, Zou L, Fu D X., Chang Y, Lu Y, Zheng Q T. Characterization of NMR signals of tanacetin and artesin isolated from the whole herbs of Crossostephium chinense. Chin J Magn Reson 2008 25 117-127
14. Wu Q, Zou L, Yang X W., Fu D X. Novel sesquiterpene and coumarin constituents from the whole herbs of Crossostephium chinense. J Asian Nat Prod Res 2009 11 85-90
15. Zhang P, Yang X W. Studies on chemical constituents in roots and rhizomes of Notopterygium incisum. China J Chin Mater Med 2008 33 2918-2921
16. Zhang C Y., Zhang B G., Yang X W. Studies on the chemical constituents of the root of Angelica pubescens f. biserrata. Pharm J Chin PLA 2007 23 241-245
17. Wu Q, Yang X W., Yang S H., Zou L, Yan J. Chemical constituents of Cibotium barometz. Nat Prod Res Dev 2007 19 240-243
18. Yang X W., Yang X D., Wang Y, Ma L, Zhang Y, Yang X G., Wang K. Establishment of Caco-2 cell monolayer model and standard operation procedure for assessing intestinal absorption of chemical components of traditional Chinese medicine. J Chin Integr Med 2007 5 634-641
19. Ma L, Yang X W. Absorption of papaverine, laudanosine and cepharanthine across human intestine by using human Caco-2 cells monolayers model. Acta Pharm Sin 2008 43 202-207
20. Artursson P, Palm K, Luthman K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Deliv Rev 2001 46 27-43 (Pubitemid 33653412)
21. Artursson P, Karlsson J. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun 1991 175 880-885
22. Alemdaroglu N C., Wolffram S, Boissel J P., Closs E, Spahn-Langguth H, Langguth P. Inhibition of folic acid uptake by catechins and tea extracts in Caco-2 cells. Planta Med 2007 73 27-32
23. Yee S. In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man fact or myth. Pharm Res 1997 14 763-766
24. Wu Q, Yang X W. The constituents of Cibotium barometz and their permeability in the human Caco-2 monolayer cell model. J Ethnopharmacol 2009 125 417-422
25. Chaves J S., Leal P C., Pianowisky L, Calixto J B. Pharmacokinetics and tissue distribution of the sesquiterpene -humulene in mice. Planta Med 2008 74 1678-1683
26. Augustijnsx P, D'Hulst A, Van Daele J, Kinget R. Transport of artemisinin and sodium artesunate in Caco-2 intestinal epithelial cells. J Pharm Sci 1996 85 577-579
27. Khan S I., Abourashed E A., Khan I A., Walker L A. Transport of parthenolide across human intestinal cells (Caco-2). Planta Med 2003 69 1009-1012
28. Anderle P, Niederer E, Rubas W, Hilgendorf C, Spahn-Langguth H, Wunderli-Allenspach H, Merkle H P., Langguth P. P-glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels. J Pharm Sci 2000 87 757-762