Increased systemic exposure to rhizoma coptidis alkaloids in lipopolysaccharide-pretreated rats attributable to enhanced intestinal absorption

Drug Metabolism and Disposition

Volumn 40, Issue 2, 2012, Pages 381-388

  Ma, Bing Liang ^a   Yao, Meng Kan ^a   Zhong, Jie ^a   Ma, Yue Ming ^a   Gao, Cheng Lu ^b   Wu, Jia Sheng ^a   Qiu, Fu Rong ^b   Wang, Chang Hong ^a   Wang, Xin Hong ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shuguang Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BERBERINE; COPTIS RHIZOME EXTRACT; COPTISINE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; JATRORRHIZINE; LIPOPOLYSACCHARIDE; PALMATINE; RHODAMINE 123; VINBLASTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EXPOSURE; DRUG METABOLISM; DRUG TRANSPORT; EPITHELIUM CELL; FEMALE; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE INJURY; INTESTINE MUCOSA; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TIGHT JUNCTION;

ALKALOIDS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BERBERINE; BIOLOGICAL AVAILABILITY; DRUGS, CHINESE HERBAL; FEMALE; GLUCURONIDES; ILEUM; INFLAMMATION; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; LIPOPOLYSACCHARIDES; MALE; MICROSOMES, LIVER; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RATTUS;

EID: 84862962484     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.041152     Document Type: Article

References (43)

1. Amati L, Caradonna L, Leandro G, Magrone T, Minenna M, Faleo G, Pellegrino NM, Jirillo E, and Caccavo D (2003) Immune abnormalities and endotoxemia in patients with ulcerative colitis and in their first degree relatives: attempts at neutralizing endotoxin-mediated effects. Curr Pharm Des 9:1937-1945. (Pubitemid 37010098)
2. Balzan S, de Almeida Quadros C, de Cleva R, Zilberstein B, and Cecconello I (2007) Bacterial translocation: overview of mechanisms and clinical impact. J Gastroenterol Hepatol 22:464-471. (Pubitemid 46435001)
3. Chen J, Zhao H, Wang X, Lee FS, Yang H, and Zheng L (2008) Analysis of major alkaloids in Rhizoma coptidis by capillary electrophoresis-electrospray- time of flight mass spectrometry with different background electrolytes. Electrophoresis 29:2135-2147. (Pubitemid 351781210)
4. Chung HJ, Kang HE, Bae EJ, Lee I, Kim SG, and Lee MG (2008) Effects of E. coli lipopolysaccharide on the pharmacokinetics of ipriflavone and its metabolites, M1 and M5, after intravenous and oral administration of ipriflavone to rats: decreased metabolism of ipriflavone due to decreased expression of hepatic CYP1A2 and 2C11. J Pharm Sci 97:5024-5036.
5. Fearon WF and Fearon DT (2008) Inflammation and cardiovascular disease: role of the interleukin- 1 receptor antagonist. Circulation 117:2577-2579.
6. Goldfine AB, Fonseca V, and Shoelson SE (2011) Therapeutic approaches to target inflammation in type 2 diabetes. Clin Chem 57:162-167.
7. Grivennikov SI and Karin M (2011) Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis 70 (Suppl 1):i104 -i108.
8. Hang CH, Shi JX, Li JS, Wu W, and Yin HX (2003) Alterations of intestinal mucosa structure and barrier function following traumatic brain injury in rats. World J Gastroenterol 9:2776-2781. (Pubitemid 38054459)
9. Hauser AB, Stinghen AE, Gonçalves SM, Bucharles S, and Pecoits-Filho R (2011) A gut feeling on endotoxemia: causes and consequences in chronic kidney disease. Nephron Clin Pract 118:c165-c172.
10. Hill JR (2003) In vitro drug metabolism using liver microsomes, in Current Protocols in Pharmacology (Enna SJ ed), pp 7.8.1-7.8.11, Wiley, Malden.
11. Kou ZS (1997) Ben Cao Yan Yi (Augmented Materia Medica), in Ben Cao Jing Dian Bu Yi (A supplemented Materia Medica Classics) (Ye XC ed), pp 30, Shanghai University of Traditional Chinese Medicine Press, Shanghai, China.
12. Li H, Cai X, and Li XF (2008) New applications and the side effects of Rhizoma coptidis in clinic. Med J Chin People's Armed Police Forces 19:661-663.
13. Li Y, Ren G, Wang YX, Kong WJ, Yang P, Wang YM, Li YH, Yi H, Li ZR, Song DQ, et al. (2011) Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes. J Transl Med 9:62.
14. Lin HC, Yang YY, Tsai TH, Huang CM, Huang YT, Lee FY, Liu TT, and Lee SD (2011) The relationship between endotoxemia and hepatic endocannabinoids in cirrhotic rats with portal hypertension. J Hepatol 54:1145-1153.
15. Liu Y, Hao H, Xie H, Lv H, Liu C, and Wang G (2009) Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats. J Pharm Sci 98:4391-4401.
16. Liu YT, Hao HP, Xie HG, Lai L, Wang Q, Liu CX, and Wang GJ (2010) Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats. Drug Metab Dispos 38:1779-1784.
17. Lu SS, Yu YL, Zhu HJ, Liu XD, Liu L, Liu YW, Wang P, Xie L, and Wang GJ (2009) Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats. J Endocrinol 200:159-165.
18. Ma BL, Ma YM, Gao CL, Wu JS, Qiu FR, Wang CH, and Wang XH (2011) Lipopolysaccharide increased the acute toxicity of the Rhizoma coptidis extract in mice by increasing the systemic exposure to Rhizoma coptidis alkaloids. J Ethnopharmacol 138:169-174.
19. Ma BL, Ma YM, Shi R, Wang TM, Zhang N, Wang CH, and Yang Y (2010) Identification of the toxic constituents in Rhizoma Coptidis. J Ethnopharmacol 128:357-364.
20. Masaki K, Hashimoto M, and Imai T (2007) Intestinal first-pass metabolism via carboxylesterase in rat jejunum and ileum. Drug Metab Dispos 35:1089-1095. (Pubitemid 46956428)
21. Morgan ET, Goralski KB, Piquette-Miller M, Renton KW, Robertson GR, Chaluvadi MR, Charles KA, Clarke SJ, Kacevska M, Liddle C, et al. (2008) Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer. Drug Metab Dispos 36:205-216. (Pubitemid 351185732)
22. Mou SS, Haudek SB, Lequier L, Peña O, Leonard S, Nikaidoh H, Giroir BP, and Stromberg D (2002) Myocardial inflammatory activation in children with congenital heart disease. Crit Care Med 30:827-832. (Pubitemid 34297802)
23. National Pharmacopoeia Committee (2010) The Pharmacopoeia of People's Republic of China (Part 1). China Medical Science Press, Beijing, China.
24. Ogihara T, Kamiya M, Ozawa M, Fujita T, Yamamoto A, Yamashita S, Ohnishi S, and Isomura Y (2006) What kinds of substrates show P-glycoprotein-dependent intestinal absorption? Comparison of verapamil with vinblastine. Drug Metab Pharmacokinet 21:238-244.
25. Pandolfi F, Cianci R, Pagliari D, Landolfi R, and Cammarota G (2009) Cellular mediators of inflammation: Tregs and TH17 cells in gastrointestinal diseases. Mediators Inflamm 2009:132028.
26. Panwala CM, Jones JC, and Viney JL (1998) A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J Immunol 161:5733-5744. (Pubitemid 28519142)
27. Pussinen PJ, Havulinna AS, Lehto M, Sundvall J, and Salomaa V (2011) Endotoxemia is associated with an increased risk of incident diabetes. Diabetes Care 34:392-397.
28. Sewer MB and Morgan ET (1998) Down-regulation of the expression of three major rat liver cytochrome P450s by endotoxin in vivo occurs independently of nitric oxide production. J Pharmacol Exp Ther 287:352-358. (Pubitemid 29140220)
29. Shanghai Food and Drug Administration (2008) The Preparing Standardization of the Crude Traditional Chinese Medicine of Shanghai. Shanghai Scientific and Technical Publishers, Shanghai, China.
30. Tang J, Feng Y, Tsao S, Wang N, Curtain R, and Wang Y (2009) Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. J Ethnopharmacol 126:5-17.
31. Tomita M, Kanbayashi A, Murata H, Tanaka A, Nakaike M, Hatanaka M, and Hayashi M (2010) Effect of lipopolysaccharide on P-glycoprotein-mediated intestinal and biliary excretion of rhodamine123 in rats. Int J Pharm 392:35-41.
32. Tsai PL and Tsai TH (2004) Hepatobiliary excretion of berberine. Drug Metab Dispos 32:405-412.
33. Veau C, Leroy C, Banide H, Auchère D, Tardivel S, Farinotti R, and Lacour B (2001) Effect of chronic renal failure on the expression and function of rat intestinal P-glycoprotein in drug excretion. Nephrol Dial Transplant 16:1607-1614. (Pubitemid 32750452)
34. Vuddanda PR, Chakraborty S, and Singh S (2010) Berberine: a potential phytochemical with multispectrum therapeutic activities. Expert Opin Investig Drugs 19:1297-1307.
35. Xu JT, Wang LQ, and Xu B (2004) [Research development of Coptis chinensis]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 26:704-707.
36. Yang KH and Lee MG (2008) Effects of endotoxin derived from Escherichia coli lipopolysaccharide on the pharmacokinetics of drugs. Arch Pharm Res 31:1073-1086.
37. Yang Y, Kang N, Xia H, Li J, Chen L, and Qiu F (2010) Metabolites of protoberberine alkaloids in human urine following oral administration of Coptidis Rhizoma decoction. Planta Med 76:1859-1863.
38. Yu S, Pang X, Deng Y, Liu L, Liang Y, Liu X, Xie L, Wang G, and Wang X (2007) A sensitive and specific liquid chromatography mass spectrometry method for simultaneous determination of berberine, palmatine, coptisine, epiberberine and jatrorrhizine from Coptidis Rhizoma in rat plasma. Int J Mass Spectrom 268:30-37.
39. Yu S, Yu Y, Liu L, Wang X, Lu S, Liang Y, Liu X, Xie L, and Wang G (2010) Increased plasma exposures of five protoberberine alkaloids from Coptidis Rhizoma in streptozotocin-induced diabetic rats: is P-GP involved? Planta Med 76:876-881.
40. Yu YY, Wang BC, Peng L, Wang JB, and Zeng C (2006) Advances in pharmacological studies of Coptis chinensis. J Chongqing Univ (Nat Sci Ed) 29:107-111.
41. Zhang L, Sun W, Wang J, Zhang M, Yang S, Tian Y, Vidyasagar S, Peña LA, Zhang K, Cao Y, et al. (2010) Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiation. Int J Radiat Oncol Biol Phys 77:261-268.
42. Zhang X, Qiu F, Jiang J, Gao C, and Tan Y (2011) Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein. Xenobiotica 41:290-296.
43. Zuo F, Nakamura N, Akao T, and Hattori M (2006) Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry. Drug Metab Dispos 34:2064-2072. (Pubitemid 44837767)